LOCUS       NM_001163743            3706 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus NLR family member X1 (Nlrx1), transcript variant 1,
            mRNA.
ACCESSION   NM_001163743 XM_003946426
VERSION     NM_001163743.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3706)
  AUTHORS   Mi,K., Wang,X., Ma,C., Tan,Y., Zhao,G., Cao,X. and Yuan,H.
  TITLE     NLRX1 attenuates endoplasmic reticulum stress via STING in cardiac
            hypertrophy
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119852 (2024)
   PUBMED   39357547
  REMARK    GeneRIF: NLRX1 attenuates endoplasmic reticulum stress via STING in
            cardiac hypertrophy.
REFERENCE   2  (bases 1 to 3706)
  AUTHORS   Ding,Y., Sun,W., Han,M., Liu,Z., Kang,H., Ma,X., Wang,J., Mu,H.,
            Huang,Y., Hou,S., Sun,D., Shen,X., Wu,X. and Liu,R.
  TITLE     NLRX1: a key regulator in mitochondrial respiration and colorectal
            cancer progression
  JOURNAL   Med Oncol 41 (6), 131 (2024)
   PUBMED   38683455
  REMARK    GeneRIF: NLRX1: a key regulator in mitochondrial respiration and
            colorectal cancer progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3706)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3706)
  AUTHORS   Liu,Y., Kors,L., Butter,L.M., Stokman,G., Claessen,N.,
            Zuurbier,C.J., Girardin,S.E., Leemans,J.C., Florquin,S. and
            Tammaro,A.
  TITLE     NLRX1 Prevents M2 Macrophage Polarization and Excessive Renal
            Fibrosis in Chronic Obstructive Nephropathy
  JOURNAL   Cells 13 (1), 23 (2023)
   PUBMED   38201227
  REMARK    GeneRIF: NLRX1 Prevents M2 Macrophage Polarization and Excessive
            Renal Fibrosis in Chronic Obstructive Nephropathy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3706)
  AUTHORS   Nagai-Singer,M.A., Woolls,M.K., Leedy,K., Hendricks-Wenger,A.,
            Brock,R.M., Coutermarsh-Ott,S., Paul,T., Morrison,H.A., Imran,K.M.,
            Tupik,J.D., Fletcher,E.J., Brown,D.A. and Allen,I.C.
  TITLE     Cellular Context Dictates the Suppression or Augmentation of
            Triple-Negative Mammary Tumor Metastasis by NLRX1
  JOURNAL   J Immunol 211 (12), 1844-1857 (2023)
   PUBMED   37909827
  REMARK    GeneRIF: Cellular Context Dictates the Suppression or Augmentation
            of Triple-Negative Mammary Tumor Metastasis by NLRX1.
REFERENCE   6  (bases 1 to 3706)
  AUTHORS   Rebsamen,M., Vazquez,J., Tardivel,A., Guarda,G., Curran,J. and
            Tschopp,J.
  TITLE     NLRX1/NOD5 deficiency does not affect MAVS signalling
  JOURNAL   Cell Death Differ 18 (8), 1387 (2011)
   PUBMED   21617692
REFERENCE   7  (bases 1 to 3706)
  AUTHORS   Allen,I.C., Moore,C.B., Schneider,M., Lei,Y., Davis,B.K.,
            Scull,M.A., Gris,D., Roney,K.E., Zimmermann,A.G., Bowzard,J.B.,
            Ranjan,P., Monroe,K.M., Pickles,R.J., Sambhara,S. and Ting,J.P.
  TITLE     NLRX1 protein attenuates inflammatory responses to infection by
            interfering with the RIG-I-MAVS and TRAF6-NF-kappaB signaling
            pathways
  JOURNAL   Immunity 34 (6), 854-865 (2011)
   PUBMED   21703540
  REMARK    GeneRIF: NLRX1 interacts with TRAF6 and inhibits NF-kappaB
            activation
REFERENCE   8  (bases 1 to 3706)
  AUTHORS   Xia,X., Cui,J., Wang,H.Y., Zhu,L., Matsueda,S., Wang,Q., Yang,X.,
            Hong,J., Songyang,Z., Chen,Z.J. and Wang,R.F.
  TITLE     NLRX1 negatively regulates TLR-induced NF-kappaB signaling by
            targeting TRAF6 and IKK
  JOURNAL   Immunity 34 (6), 843-853 (2011)
   PUBMED   21703539
  REMARK    GeneRIF: study identifies a previously unrecognized role for NLRX1
            in the negative regulation of TLR-induced NF-kappaB activation by
            dynamically interacting with TRAF6 and the IKK complex
REFERENCE   9  (bases 1 to 3706)
  AUTHORS   Abdul-Sater,A.A., Said-Sadier,N., Lam,V.M., Singh,B.,
            Pettengill,M.A., Soares,F., Tattoli,I., Lipinski,S., Girardin,S.E.,
            Rosenstiel,P. and Ojcius,D.M.
  TITLE     Enhancement of reactive oxygen species production and chlamydial
            infection by the mitochondrial Nod-like family member NLRX1
  JOURNAL   J Biol Chem 285 (53), 41637-41645 (2010)
   PUBMED   20959452
  REMARK    GeneRIF: the presence of NLRX1 is required for optimal chlamydial
            growth and reactive oxygen species production
REFERENCE   10 (bases 1 to 3706)
  AUTHORS   Ting,J.P., Lovering,R.C., Alnemri,E.S., Bertin,J., Boss,J.M.,
            Davis,B.K., Flavell,R.A., Girardin,S.E., Godzik,A., Harton,J.A.,
            Hoffman,H.M., Hugot,J.P., Inohara,N., Mackenzie,A., Maltais,L.J.,
            Nunez,G., Ogura,Y., Otten,L.A., Philpott,D., Reed,J.C., Reith,W.,
            Schreiber,S., Steimle,V. and Ward,P.A.
  TITLE     The NLR gene family: a standard nomenclature
  JOURNAL   Immunity 28 (3), 285-287 (2008)
   PUBMED   18341998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124577.5 and BC035045.1.
            
            On Oct 10, 2012 this sequence version replaced XM_003946426.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170088.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AC124577.5         158327-158534       c
            209-322             AC124577.5         156091-156204       c
            323-392             AC124577.5         155511-155580       c
            393-481             AC124577.5         155050-155138       c
            482-1101            AC124577.5         153976-154595       c
            1102-1923           AC124577.5         152579-153400       c
            1924-2519           AC124577.5         146679-147274       c
            2520-2606           AC124577.5         145778-145864       c
            2607-2858           AC124577.5         144339-144590       c
            2859-3680           AC124577.5         143065-143886       c
            3681-3706           BC035045.1         882-907
FEATURES             Location/Qualifiers
     source          1..3706
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..3706
                     /gene="Nlrx1"
                     /gene_synonym="NOD9"
                     /note="NLR family member X1"
                     /db_xref="GeneID:270151"
                     /db_xref="MGI:MGI:2429611"
     exon            1..208
                     /gene="Nlrx1"
                     /gene_synonym="NOD9"
                     /inference="alignment:Splign:2.1.0"
     exon            209..322
                     /gene="Nlrx1"
                     /gene_synonym="NOD9"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..3180
                     /gene="Nlrx1"
                     /gene_synonym="NOD9"
                     /note="nucleotide-binding domain and leucine-rich repeat
                     containing"
                     /codon_start=1
                     /product="NLR family member X1"
                     /protein_id="NP_001157215.1"
                     /db_xref="CCDS:CCDS23100.1"
                     /db_xref="GeneID:270151"
                     /db_xref="MGI:MGI:2429611"
                     /translation="MRWGCHLPRTSWGSGLGRTPQLPDEHISFLIQWSWPFKGVHPLR
                     PPRAFIRYHGNSADSAPPPGRHGQLFRSISATEAIQRHRRNLTEWFSRLPREERQFGP
                     TFALDTVHVDPVIRESTPDELLRPSTELATGHQQTQAGLPPLALSQLFDPDSCGRRVQ
                     TVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSLGSTPASLCQLVTQ
                     RYTPLKEVLPLMTAAGSRLLFVLHGLERLNLDFRLAGTGLCSDPEEPGPPAAIIVNLL
                     RKYMLPEASILVTTRPSTISRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPDCGYG
                     AGGASVSVTPAQRDNLIQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTPAGQ
                     TLTSIYTSFLRLNFSGETLDSTHTSNLSLMSYAARTMGKLAYEGVSSRKTYFSEEDVR
                     GCLEAGIKTEEEFQLLQIFRRDALRFFLAPCVEPGHLGTFVFTVPAMQEYLAALYIVL
                     GLRKTALQRVGKEVVEFVGRVGEDVSLVLGIVAKLLPLRILPLLFNLLKVVPRVFGRM
                     VSKSREAVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRRHPDEPSEDEVFELFP
                     MFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKKKLGKLGRQVLPPSELLDHLFFH
                     YEFQNQRFSAEVLGSLRQLNLAGVRMTPLKCTVVASVLGSGRHPLDEVNLASCQLDPA
                     GLHTLMPVLLRARKLGLQLNNLGPEACRDLRDLLLHDQCQITTLRLSNNPLTAAGVGL
                     LMDGLAGNTSVTHLSLLHTDLGDEGLELLAAQLDRNKQLQELNVAYNGAGDTVALALA
                     KAAREHPSLELLHLYFNELSSEGRQVLRDLGGSGEGGARVVASLTEGTAVSEYWSVIL
                     SEVQRNVHSWDPLRVQRHLKLLLRDLEDSRGATLNPWRKAQLLRVEGEVKTLLEQLGG
                     SGH"
     exon            323..392
                     /gene="Nlrx1"
                     /gene_synonym="NOD9"
                     /inference="alignment:Splign:2.1.0"
     exon            393..481
                     /gene="Nlrx1"
                     /gene_synonym="NOD9"
                     /inference="alignment:Splign:2.1.0"
     exon            482..1101
                     /gene="Nlrx1"
                     /gene_synonym="NOD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1923
                     /gene="Nlrx1"
                     /gene_synonym="NOD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2519
                     /gene="Nlrx1"
                     /gene_synonym="NOD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2606
                     /gene="Nlrx1"
                     /gene_synonym="NOD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2858
                     /gene="Nlrx1"
                     /gene_synonym="NOD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..3685
                     /gene="Nlrx1"
                     /gene_synonym="NOD9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3659..3664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nlrx1"
                     /gene_synonym="NOD9"
                     /note="hexamer: ATTAAA"
     polyA_site      3681
                     /gene="Nlrx1"
                     /gene_synonym="NOD9"
                     /note="major polyA site"
ORIGIN      
        1 ttcccccttc tgcgggtctt tgctcagtgc cctccagtgt ccagaccggg cggggtgcca
       61 gagtgggccg ggctgcgcgc tggctggcgg gcggaggcgg cctagacgcg ccgtgccgag
      121 cgagccgggg aagctcggag ccagcgggag acgcaggcct ccttccctcc gggccacggc
      181 gacgggcacc agggcctagg caacctggga aagaaagtgg ctctaagtgt tccaggctcc
      241 agttttccta ggatgaggtg gggctgccat ttgcccagga cctcttgggg ctctggcctg
      301 ggaagaacac cccagctacc agatgagcat atctccttct tgatccagtg gagctggccc
      361 tttaaagggg tgcatcccct gaggccccct agggccttta tccgttacca tggaaactcg
      421 gcagacagtg ctcccccacc agggaggcat gggcagctgt tcaggagcat ctctgccaca
      481 gaagctatcc aaaggcatcg ccggaacctc accgagtggt ttagccgact gcccagagag
      541 gagcgccagt ttggaccaac ctttgctcta gacacagttc atgttgaccc cgtgatccga
      601 gagagcaccc cagatgagct gcttcgcccg tccacggagc tggccacggg gcatcagcaa
      661 acccaggcag ggctcccccc actggccctg tctcagcttt ttgacccgga ttcttgtggg
      721 cgccgcgtgc agaccgtggt gttgtatggg accgtgggta ctggcaagag cacgttggta
      781 cggaagatgg tcttagactg gtgttacggg agactgcctg cctttgagct tctcatcccc
      841 ttctcctgtg aggacttgtc atccctgggc tccaccccag cttccctgtg ccaacttgtg
      901 acccagcgtt acacacccct gaaagaggtg ttgcccctga tgactgctgc gggatcccgc
      961 ctgctctttg tgctccatgg cttggagcgc ctcaaccttg acttccggct ggcaggcaca
     1021 gggctttgca gtgacccgga ggaacccggg ccaccagctg ccatcatagt caacctgctg
     1081 cgcaaataca tgcttcccga ggccagcatt ctggtaacca cccggccttc caccattagc
     1141 cgaatcccta gcaagtatgt gggccgctat ggtgagatct gtggcttctc tgataccaac
     1201 ctgcagaagc tctacttcca gctccgcctt aaccagcctg actgtgggta cggtgctggg
     1261 ggtgccagtg tctcagtcac accagctcag cgcgacaacc tgattcaaat gctctcccgg
     1321 aacctggagg ggcaccacca gattgccgca gcctgctttc tgccttccta ttgctggctt
     1381 gtctgtgcta ctttgcactt cctgcatgct cccacacctg ctggtcagac cctcacaagc
     1441 atctatacca gctttctacg cctgaacttc agtggggaaa cactggacag cacccacacg
     1501 tccaatctat ccctgatgtc ctatgcagcc cggactatgg gcaagctggc ctacgagggc
     1561 gtgtcatccc gaaagaccta cttctctgaa gaggatgtcc gtggctgcct ggaagctggc
     1621 atcaagacag aggaagagtt tcaactgctt cagatcttcc gcagggacgc cctgaggttt
     1681 ttcctggccc cgtgtgtgga accagggcac ctgggtacct tcgtgttcac cgtgcccgcc
     1741 atgcaggagt atctggctgc cctctacatc gtgcttggtt tgcgcaagac agccctgcag
     1801 cgggtgggca aagaagtggt tgaatttgtg ggccgtgttg gggaagatgt cagcctggta
     1861 ttgggcattg tggccaagct gttgcccctg cggattctgc ctctgctctt caacttgctc
     1921 aaggtagttc cgcgagtgtt tgggcgcatg gtgagtaaga gccgggaggc agtggcccag
     1981 gccatggtgc tggagatgtt ccgggaggaa gactactaca atgacgatgt tctggatcag
     2041 atgggtgcca gcatcctggg tgtggagggc ccccggcgcc acccagatga accctctgag
     2101 gatgaagtct ttgagctctt ccccatgttc atgggcggac ttctctctgc ccacaaccgg
     2161 gcggtgctgg ctcagcttgg ctgtcccatc aagaacctgg atgccctgga gaatgcccag
     2221 gccatcaaga agaagctggg gaagctgggt cggcaggtgc tgcccccctc ggagcttctt
     2281 gaccatctct tcttccacta tgagttccag aaccagcgct tctcagctga ggtgctgggc
     2341 tccctacgcc agctcaattt agcaggggtg cgcatgacac ccctcaagtg cacagtggta
     2401 gcctctgtac tgggaagtgg aaggcacccc ctggatgagg tgaacttggc ctcctgccag
     2461 ctggatcccg ctgggctaca cactctcatg cctgtcctcc tgcgtgcccg gaaactgggg
     2521 ttgcaactca acaatctggg ccccgaggcc tgcagagacc tccgagacct gctcttacac
     2581 gatcaatgcc agatcaccac tcttaggctc tccaacaacc cactgacagc agctggtgtg
     2641 ggcttactga tggacgggct ggcaggaaac acttcggtga cacacctgtc tctgctgcac
     2701 actgaccttg gagacgaggg actggaactg ctggctgccc agctggaccg aaacaaacaa
     2761 ctgcaggagc tgaacgtggc ctacaacggt gctggtgaca cagtggctct ggccttggct
     2821 aaggctgctc gggagcaccc ttccctggag ctgctgcacc tctacttcaa tgagctgagt
     2881 tcagagggcc gccaggtcct gcgggatttg gggggctctg gtgaaggtgg tgcccgggtc
     2941 gtagcctcgc tgacagaagg gacggcggtg tctgagtact ggtcagtgat ccttagtgaa
     3001 gtccagcgca acgtccacag ctgggacccg ctccgggtcc agaggcatct caagctgctg
     3061 ctccgtgatc tggaggacag ccggggcgcc acccttaatc cctggcgcaa ggctcagctt
     3121 ctgcgagtgg agggcgaggt caagactctt ctggagcagc tgggaggttc tggacactga
     3181 gacagtgact gctgtgacag agctgtggga ccactggctc cctctgtggc ttcctggctt
     3241 gtacaactcc ttccagaaag atccctttaa ttctgcggtc aaagcaatgg gtgaaactgt
     3301 gctgccccca cccccaacaa gtccagccta gagttcccaa ggtcaaatgc ggtgaattga
     3361 tgttggactt ggatatggaa catgtcactt ctcccttagc ctagaaggac taagggtatg
     3421 gcacgttagt ggccacattg ccctgtgatg ccaccgccag tcttgcctct tcctcctctg
     3481 attgtgtttg ctatgctggg gggttctgcc agccagcaga tgtactggac agctctccat
     3541 cctgccttac gctcacctct gggcacagag tgccctcaca ctggtgcttt cccagtctca
     3601 aatgcacagg atcgatggct ccaaggctac tagggacaag tgggcccacc ttgctgctat
     3661 taaaaagccg tgtgtcttcc accccaaaaa aaaaaaaaaa aaaaaa
//
