LOCUS       NM_194058               3346 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus NLR family, pyrin domain containing 9B (Nlrp9b), mRNA.
ACCESSION   NM_194058 XM_486028
VERSION     NM_194058.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3346)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3346)
  AUTHORS   Kanzaki,S., Tamura,S., Ito,T., Wakabayashi,M., Saito,K., Kato,S.,
            Ohta,Y., Sekita,Y. and Kimura,T.
  TITLE     Involvement of Nlrp9a/b/c in mouse preimplantation development
  JOURNAL   Reproduction 160 (2), 181-191 (2020)
   PUBMED   32413845
REFERENCE   3  (bases 1 to 3346)
  AUTHORS   Amoushahi,M., Steffensen,L.L., Galieva,A., Agger,J., Heuck,A.,
            Siupka,P., Ernst,E., Nielsen,M.S., Sunde,L. and Lykke-Hartmann,K.
  TITLE     Maternally contributed Nlrp9b expressed in human and mouse ovarian
            follicles contributes to early murine preimplantation development
  JOURNAL   J Assist Reprod Genet 37 (6), 1355-1365 (2020)
   PUBMED   32399794
  REMARK    GeneRIF: Maternally contributed Nlrp9b expressed in human and mouse
            ovarian follicles contributes to early murine preimplantation
            development.
REFERENCE   4  (bases 1 to 3346)
  AUTHORS   Yanling,Q., Xiaoning,C., Fei,B., Liyun,F., Huizhong,H. and
            Daqing,S.
  TITLE     Inhibition of NLRP9b attenuates acute lung injury through
            suppressing inflammation, apoptosis and oxidative stress in murine
            and cell models
  JOURNAL   Biochem Biophys Res Commun 503 (2), 436-443 (2018)
   PUBMED   29655793
  REMARK    GeneRIF: The findings indicated that NLRP9b(-/-) improved the
            survival rate of cecal ligation and puncture -induced acute lung
            injury mice, and inhibited pulmonary histopathological alterations,
            inflammation, and apoptosis.
REFERENCE   5  (bases 1 to 3346)
  AUTHORS   Zhu,S., Ding,S., Wang,P., Wei,Z., Pan,W., Palm,N.W., Yang,Y.,
            Yu,H., Li,H.B., Wang,G., Lei,X., de Zoete,M.R., Zhao,J., Zheng,Y.,
            Chen,H., Zhao,Y., Jurado,K.A., Feng,N., Shan,L., Kluger,Y., Lu,J.,
            Abraham,C., Fikrig,E., Greenberg,H.B. and Flavell,R.A.
  TITLE     Nlrp9b inflammasome restricts rotavirus infection in intestinal
            epithelial cells
  JOURNAL   Nature 546 (7660), 667-670 (2017)
   PUBMED   28636595
  REMARK    GeneRIF: uncovering and mechanistic characterization of the NLR
            Nlrp9b that is specifically expressed in intestinal epithelial
            cells and restricts rotavirus infection
REFERENCE   6  (bases 1 to 3346)
  AUTHORS   Peng,H., Lin,X., Liu,F., Wang,C. and Zhang,W.
  TITLE     NLRP9B protein is dispensable for oocyte maturation and early
            embryonic development in the mouse
  JOURNAL   J Reprod Dev 61 (6), 559-564 (2015)
   PUBMED   26411641
  REMARK    GeneRIF: provide the first evidence that the NLRP9B protein is
            dispensable for oocyte maturation and early embryonic development
            in the mouse
REFERENCE   7  (bases 1 to 3346)
  AUTHORS   Madissoon,E., Tohonen,V., Vesterlund,L., Katayama,S., Unneberg,P.,
            Inzunza,J., Hovatta,O. and Kere,J.
  TITLE     Differences in gene expression between mouse and human for
            dynamically regulated genes in early embryo
  JOURNAL   PLoS One 9 (8), e102949 (2014)
   PUBMED   25089626
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3346)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 3346)
  AUTHORS   Dade,S., Callebaut,I., Paillisson,A., Bontoux,M., Dalbies-Tran,R.
            and Monget,P.
  TITLE     In silico identification and structural features of six new genes
            similar to MATER specifically expressed in the oocyte
  JOURNAL   Biochem Biophys Res Commun 324 (2), 547-553 (2004)
   PUBMED   15474461
REFERENCE   10 (bases 1 to 3346)
  AUTHORS   Hamatani,T., Falco,G., Carter,M.G., Akutsu,H., Stagg,C.A.,
            Sharov,A.A., Dudekula,D.B., VanBuren,V. and Ko,M.S.
  TITLE     Age-associated alteration of gene expression patterns in mouse
            oocytes
  JOURNAL   Hum Mol Genet 13 (19), 2263-2278 (2004)
   PUBMED   15317747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY596196.1.
            
            On or before Sep 20, 2004 this sequence version replaced
            XM_486028.1, NM_194058.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY596196.1, BC141249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3346              AY596196.1         1-3346
FEATURES             Location/Qualifiers
     source          1..3346
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.96 cM"
     gene            1..3346
                     /gene="Nlrp9b"
                     /gene_synonym="Nalp-delta; Nalp9b; Nlrp9"
                     /note="NLR family, pyrin domain containing 9B"
                     /db_xref="GeneID:243874"
                     /db_xref="MGI:MGI:2675377"
     exon            1..71
                     /gene="Nlrp9b"
                     /gene_synonym="Nalp-delta; Nalp9b; Nlrp9"
                     /inference="alignment:Splign:2.1.0"
     exon            72..404
                     /gene="Nlrp9b"
                     /gene_synonym="Nalp-delta; Nalp9b; Nlrp9"
                     /inference="alignment:Splign:2.1.0"
     exon            405..1983
                     /gene="Nlrp9b"
                     /gene_synonym="Nalp-delta; Nalp9b; Nlrp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2148
                     /gene="Nlrp9b"
                     /gene_synonym="Nalp-delta; Nalp9b; Nlrp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2313
                     /gene="Nlrp9b"
                     /gene_synonym="Nalp-delta; Nalp9b; Nlrp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2481
                     /gene="Nlrp9b"
                     /gene_synonym="Nalp-delta; Nalp9b; Nlrp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2652
                     /gene="Nlrp9b"
                     /gene_synonym="Nalp-delta; Nalp9b; Nlrp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2823
                     /gene="Nlrp9b"
                     /gene_synonym="Nalp-delta; Nalp9b; Nlrp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2994
                     /gene="Nlrp9b"
                     /gene_synonym="Nalp-delta; Nalp9b; Nlrp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3346
                     /gene="Nlrp9b"
                     /gene_synonym="Nalp-delta; Nalp9b; Nlrp9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgcatttt tgagcatgtg tgcagttgtt gcttgaaaat ggattctcag tgttgaaaat
       61 ttgggacaaa ggtatcactt atgtctttgt tttgaagatt atcaagctct ggaatctgag
      121 atcattgttg aagatggcgg gctcatctgg ctatggcttg ctgaagcttc tgcaaaaact
      181 gagtgatgag gagttccaga gatttaaaga gcttctcaga gaagagcctg aaaagtttaa
      241 actcaaacca atatcctgga cgaaaatcga gaattcttcc aaagaaagcc tggtaacgct
      301 attgaacaca cattatccag gacaggcatg gaatatgatg ttaagcctgt ttctacaggt
      361 caatcgggaa gacctctcaa tcatggctca gaaaaagaag agacataaac aaactaaata
      421 caaaaagttt atgaagacta catttgaaag gatatggaca ttggagacca acactcatat
      481 acctgataga aactaccatt taattgtaga agtccagtac aaagcattgc aggaaatatt
      541 tgattctgag tcagagccag tcactgcaat tgtagcaggt acaacaggag aaggaaaaac
      601 cactttctta agaaaagcaa tgttggattg ggcatcagga gttttactgc agaaccggtt
      661 tcagtatgtt ttcttcttct ctgtcttctc acttaacaat accacagagt taagcttagc
      721 cgagcttatc tcaagtacgt tgcctgaatc ttcagagaca gtggatgata ttttatctga
      781 tccaaaaaga atcttgttta tcctggatgg atttgattac ctgaaatttg acttggaact
      841 caggacaaac ttgtgcaatg actggaggaa gaggctgcca acacaaatcg tcttgagtag
      901 tttgctacag aaaataatgc tcccgggatg ttctctgctt cttgaattgg gacaaataag
      961 tgtaccaaaa atccgtcatt tgctgaagta tccaagggtg ataactatgc aaggattctc
     1021 tgagcggtct gtagagttct attgtatgtc cttctttgat aaccagagag gcatagaagt
     1081 agctgagaat ttaaggaata atgaagtact ccatttatgc agcaatcctt atctatgctg
     1141 gatgttctgt agttgtttaa agtggcagtt tgacagggag gaggaagggt actttaaggc
     1201 taaaacagat gcggctttct tcacaaactt tatggtgagt gcattcaaat caacatatgc
     1261 ccatagtccg tccaaacaga acagagcccg attaaagacc ctgtgtacct tggctgtaga
     1321 aggaatgtgg aaagagttgt ttgtctttga ctctgaagat ctcaggagga atgggatatc
     1381 tgaatccgat aaggcagtgt ggctgaaaat gcaatttctc cagactcacg gtaaccacac
     1441 tgtgttttat catcctacac tacagtcata ttttgctgcc atgttctatt tcctcaaaca
     1501 agacaaagac atatgtgtcc cagtcattgg aagcatacct caacttctag gaaacatgta
     1561 tgctcgtggc cagacccagt ggctccagtt aggcacattt ttgtttggac tcatcaatga
     1621 acaagtcgcc gccttactcc aaccatgctt tggctttata caacccatat atgtaagaca
     1681 ggaaatcatt tgttacttta agtgtcttgg tcaacaagag tgcaatgaga aactggaaag
     1741 atcccagact ttgttctcct gtctgcgtga cagccaggag gaaagatttg ttagacaagt
     1801 ggtggatcta cttgaagaaa ttactgttga tattagtagt tcagatgtat tatcagtgac
     1861 tgcatatgct ctgcagaaat cctccaaatt aaagaaactt catctgcata tacaaaagac
     1921 agttttttca gaaatctact gcccagacca ttgtaaaaca agaacttcta taggcaaaag
     1981 acgaaataca gccgaatatt ggaaaacatt atgtggcatt ttctgcaact tatatgtgtt
     2041 ggatctggac agctgtcagt tcaataaaag ggccatacag gacctctgta attcgatgtc
     2101 tccaactcct acggtgcccc tgactgcttt taagctccaa agcttgtcgt gttccttcat
     2161 ggctgacttt ggagatggtt cattatttca cacccttctt cagctacctc acctgaaata
     2221 cctgaacctg tatggcactt atctctccat ggatgtgact gagaagctgt gtgctgctct
     2281 gagatgctca gcatgcagag tggaggagct gctgttgggt aaatgtggca tctcaagtaa
     2341 ggcctgtggc ataattgcga tttcccttat caactctaaa gtgaaacacc tctcattggt
     2401 tgaaaatccc ttgaagaaca aaggagtgat gtcactgtgt gaaatgctga aggatccaag
     2461 ctgtgtcctg cagtcactga tgttgtctta ctgctgcctc acattcattg cctgtggaca
     2521 tctctatgaa gcacttttga gcaacaaaca cctctccctg cttgatctgg gatcaaattt
     2581 cctggaagat actggagtga accttctgtg tgaagctttg aaagatccaa actgcaccct
     2641 caaggagtta tggttgccgg gttgcttttt aacttcacaa tgctgtgagg agatctcggc
     2701 tgtcctcatt tgcaatagaa atctaaagac cctgaaactg ggcaacaata acatacaaga
     2761 cactggtgtc agacagttat gtgaagctct gagtcatccc aactgtaact tggagtgtct
     2821 tgggttagac ctgtgtgagt tcaccagtga ctgttgtaag gacctagcct tggctctcac
     2881 cacctgcaaa acactgaata gcttaaatct ggactggaaa accttggacc actctgggct
     2941 ggtggtgctc tgtgaggctt tgaatcacaa aagatgtaac ctgaagatgc ttggactgga
     3001 caaatctgcg ttttccgagg aatcacagac attactgcaa gatgtggaaa agaaaaataa
     3061 taatctgaat attttgcatc atccctggtt tgaggcggaa cgcaacaaga ggggtactcg
     3121 tctggtatgg aacagcagga attgatctgt gacaaaggct tatcctctgt tatgtttctc
     3181 ccatataccc tgccccaagt tgcacaccat ggtactggtg gctgtttcca gggctgttct
     3241 tccacattgt cccaccccca cccccaccca tctacacatc tccccgcatc actttgcaat
     3301 gtttatatta caagcacatt taataaacac taagcgtgtt tgaaaa
//
