LOCUS       NP_918947               1003 aa            linear   ROD 30-APR-2024
DEFINITION  NACHT, LRR and PYD domains-containing protein 9B [Mus musculus].
ACCESSION   NP_918947 XP_486028
VERSION     NP_918947.2
DBSOURCE    REFSEQ: accession NM_194058.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1003)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1003)
  AUTHORS   Kanzaki,S., Tamura,S., Ito,T., Wakabayashi,M., Saito,K., Kato,S.,
            Ohta,Y., Sekita,Y. and Kimura,T.
  TITLE     Involvement of Nlrp9a/b/c in mouse preimplantation development
  JOURNAL   Reproduction 160 (2), 181-191 (2020)
   PUBMED   32413845
REFERENCE   3  (residues 1 to 1003)
  AUTHORS   Amoushahi,M., Steffensen,L.L., Galieva,A., Agger,J., Heuck,A.,
            Siupka,P., Ernst,E., Nielsen,M.S., Sunde,L. and Lykke-Hartmann,K.
  TITLE     Maternally contributed Nlrp9b expressed in human and mouse ovarian
            follicles contributes to early murine preimplantation development
  JOURNAL   J Assist Reprod Genet 37 (6), 1355-1365 (2020)
   PUBMED   32399794
  REMARK    GeneRIF: Maternally contributed Nlrp9b expressed in human and mouse
            ovarian follicles contributes to early murine preimplantation
            development.
REFERENCE   4  (residues 1 to 1003)
  AUTHORS   Yanling,Q., Xiaoning,C., Fei,B., Liyun,F., Huizhong,H. and
            Daqing,S.
  TITLE     Inhibition of NLRP9b attenuates acute lung injury through
            suppressing inflammation, apoptosis and oxidative stress in murine
            and cell models
  JOURNAL   Biochem Biophys Res Commun 503 (2), 436-443 (2018)
   PUBMED   29655793
  REMARK    GeneRIF: The findings indicated that NLRP9b(-/-) improved the
            survival rate of cecal ligation and puncture -induced acute lung
            injury mice, and inhibited pulmonary histopathological alterations,
            inflammation, and apoptosis.
REFERENCE   5  (residues 1 to 1003)
  AUTHORS   Zhu,S., Ding,S., Wang,P., Wei,Z., Pan,W., Palm,N.W., Yang,Y.,
            Yu,H., Li,H.B., Wang,G., Lei,X., de Zoete,M.R., Zhao,J., Zheng,Y.,
            Chen,H., Zhao,Y., Jurado,K.A., Feng,N., Shan,L., Kluger,Y., Lu,J.,
            Abraham,C., Fikrig,E., Greenberg,H.B. and Flavell,R.A.
  TITLE     Nlrp9b inflammasome restricts rotavirus infection in intestinal
            epithelial cells
  JOURNAL   Nature 546 (7660), 667-670 (2017)
   PUBMED   28636595
  REMARK    GeneRIF: uncovering and mechanistic characterization of the NLR
            Nlrp9b that is specifically expressed in intestinal epithelial
            cells and restricts rotavirus infection
REFERENCE   6  (residues 1 to 1003)
  AUTHORS   Peng,H., Lin,X., Liu,F., Wang,C. and Zhang,W.
  TITLE     NLRP9B protein is dispensable for oocyte maturation and early
            embryonic development in the mouse
  JOURNAL   J Reprod Dev 61 (6), 559-564 (2015)
   PUBMED   26411641
  REMARK    GeneRIF: provide the first evidence that the NLRP9B protein is
            dispensable for oocyte maturation and early embryonic development
            in the mouse
REFERENCE   7  (residues 1 to 1003)
  AUTHORS   Madissoon,E., Tohonen,V., Vesterlund,L., Katayama,S., Unneberg,P.,
            Inzunza,J., Hovatta,O. and Kere,J.
  TITLE     Differences in gene expression between mouse and human for
            dynamically regulated genes in early embryo
  JOURNAL   PLoS One 9 (8), e102949 (2014)
   PUBMED   25089626
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 1003)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (residues 1 to 1003)
  AUTHORS   Dade,S., Callebaut,I., Paillisson,A., Bontoux,M., Dalbies-Tran,R.
            and Monget,P.
  TITLE     In silico identification and structural features of six new genes
            similar to MATER specifically expressed in the oocyte
  JOURNAL   Biochem Biophys Res Commun 324 (2), 547-553 (2004)
   PUBMED   15474461
REFERENCE   10 (residues 1 to 1003)
  AUTHORS   Hamatani,T., Falco,G., Carter,M.G., Akutsu,H., Stagg,C.A.,
            Sharov,A.A., Dudekula,D.B., VanBuren,V. and Ko,M.S.
  TITLE     Age-associated alteration of gene expression patterns in mouse
            oocytes
  JOURNAL   Hum Mol Genet 13 (19), 2263-2278 (2004)
   PUBMED   15317747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY596196.1.
            
            On or before Sep 20, 2004 this sequence version replaced
            XP_486028.1, NP_918947.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY596196.1, BC141249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1003
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.96 cM"
     Protein         1..1003
                     /product="NACHT, LRR and PYD domains-containing protein
                     9B"
                     /note="NACHT, LRR and PYD containing protein 9b; NLR
                     family, pyrin domain containing 9"
                     /calculated_mol_wt=114672
     Region          9..86
                     /region_name="Pyrin_NALPs"
                     /note="Pyrin death domain found in NALP proteins; cd08320"
                     /db_xref="CDD:260032"
     Region          144..311
                     /region_name="NACHT"
                     /note="NACHT domain; pfam05729"
                     /db_xref="CDD:428606"
     Region          387..439
                     /region_name="NOD2_WH"
                     /note="NOD2 winged helix domain; pfam17779"
                     /db_xref="CDD:465501"
     Region          440..555
                     /region_name="NLRC4_HD2"
                     /note="NLRC4 helical domain HD2; pfam17776"
                     /db_xref="CDD:465499"
     Region          694..722
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          723..749
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          749..770
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66X22.1)"
     Region          750..778
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          752..955
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          778..799
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66X22.1)"
     Region          779..806
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          806..826
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66X22.1)"
     Region          807..835
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          835..856
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66X22.1)"
     Region          836..863
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          863..883
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66X22.1)"
     Region          864..892
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          892..913
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66X22.1)"
     Region          920..940
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66X22.1)"
     CDS             1..1003
                     /gene="Nlrp9b"
                     /gene_synonym="Nalp-delta; Nalp9b; Nlrp9"
                     /coded_by="NM_194058.2:134..3145"
                     /db_xref="CCDS:CCDS20920.1"
                     /db_xref="GeneID:243874"
                     /db_xref="MGI:MGI:2675377"
ORIGIN      
        1 magssgygll kllqklsdee fqrfkellre epekfklkpi swtkienssk eslvtllnth
       61 ypgqawnmml slflqvnred lsimaqkkkr hkqtkykkfm kttferiwtl etnthipdrn
      121 yhlivevqyk alqeifdses epvtaivagt tgegkttflr kamldwasgv llqnrfqyvf
      181 ffsvfslnnt telslaelis stlpessetv ddilsdpkri lfildgfdyl kfdlelrtnl
      241 cndwrkrlpt qivlssllqk imlpgcslll elgqisvpki rhllkyprvi tmqgfsersv
      301 efycmsffdn qrgievaenl rnnevlhlcs npylcwmfcs clkwqfdree egyfkaktda
      361 afftnfmvsa fkstyahsps kqnrarlktl ctlavegmwk elfvfdsedl rrngisesdk
      421 avwlkmqflq thgnhtvfyh ptlqsyfaam fyflkqdkdi cvpvigsipq llgnmyargq
      481 tqwlqlgtfl fglineqvaa llqpcfgfiq piyvrqeiic yfkclgqqec neklersqtl
      541 fsclrdsqee rfvrqvvdll eeitvdisss dvlsvtayal qkssklkklh lhiqktvfse
      601 iycpdhcktr tsigkrrnta eywktlcgif cnlyvldlds cqfnkraiqd lcnsmsptpt
      661 vpltafklqs lscsfmadfg dgslfhtllq lphlkylnly gtylsmdvte klcaalrcsa
      721 crveelllgk cgisskacgi iaislinskv khlslvenpl knkgvmslce mlkdpscvlq
      781 slmlsycclt fiacghlyea llsnkhlsll dlgsnfledt gvnllcealk dpnctlkelw
      841 lpgcfltsqc ceeisavlic nrnlktlklg nnniqdtgvr qlcealshpn cnleclgldl
      901 ceftsdcckd lalalttckt lnslnldwkt ldhsglvvlc ealnhkrcnl kmlgldksaf
      961 seesqtllqd vekknnnlni lhhpwfeaer nkrgtrlvwn srn
//
