LOCUS       NM_133946               4438 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Mus musculus NLR family, pyrin domain containing 6 (Nlrp6), mRNA.
ACCESSION   NM_133946
VERSION     NM_133946.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4438)
  AUTHORS   Pearson JA, Peng J, Huang J, Yu X, Tai N, Hu Y, Sha S, Flavell RA,
            Zhao H, Wong FS and Wen L.
  TITLE     NLRP6 deficiency expands a novel CD103+ B cell population that
            confers immune tolerance in NOD mice
  JOURNAL   Front Immunol 14, 1147925 (2023)
   PUBMED   36911699
  REMARK    GeneRIF: NLRP6 deficiency expands a novel CD103[+] B cell
            population that confers immune tolerance in NOD mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4438)
  AUTHORS   Chenuet P, Marquant Q, Fauconnier L, Youness A, Mellier M, Marchiol
            T, Rouxel N, Messaoud-Nacer Y, Maillet I, Ledru A, Quesniaux VFJ,
            Ryffel B, Horsnell W, Vegran F, Apetoh L and Togbe D.
  TITLE     NLRP6 negatively regulates type 2 immune responses in mice
  JOURNAL   Allergy 77 (11), 3320-3336 (2022)
   PUBMED   35615773
  REMARK    GeneRIF: NLRP6 negatively regulates type 2 immune responses in
            mice.
REFERENCE   3  (bases 1 to 4438)
  AUTHORS   Rao X, Zhou X, Wang G, Jie X, Xing B, Xu Y, Chen Y, Li J, Zhu K, Wu
            Z, Wu G, Wu C and Zhou R.
  TITLE     NLRP6 is required for cancer-derived exosome-modified macrophage M2
            polarization and promotes metastasis in small cell lung cancer
  JOURNAL   Cell Death Dis 13 (10), 891 (2022)
   PUBMED   36270983
  REMARK    GeneRIF: NLRP6 is required for cancer-derived exosome-modified
            macrophage M2 polarization and promotes metastasis in small cell
            lung cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4438)
  AUTHORS   Wu X, Zeng Z, Tian H, Peng L, Xu D, Wang Y, Ye C, Peng Y and Fang
            R.
  TITLE     The important role of NLRP6 inflammasome in Pasteurella multocida
            infection
  JOURNAL   Vet Res 53 (1), 81 (2022)
   PUBMED   36224650
  REMARK    GeneRIF: The important role of NLRP6 inflammasome in Pasteurella
            multocida infection.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4438)
  AUTHORS   Fan W, Ding C, Liu S, Gao X, Shen X, De Boevre M, Gao Z, Li M,
            Zhang S, Miao Y, Guan W, Liu G, Yan L, De Saeger S and Song S.
  TITLE     Estrogen receptor beta activation inhibits colitis by promoting
            NLRP6-mediated autophagy
  JOURNAL   Cell Rep 41 (2), 111454 (2022)
   PUBMED   36223738
  REMARK    GeneRIF: Estrogen receptor beta activation inhibits colitis by
            promoting NLRP6-mediated autophagy.
REFERENCE   6  (bases 1 to 4438)
  AUTHORS   Anderson JP, Mueller JL, Rosengren S, Boyle DL, Schaner P, Cannon
            SB, Goodyear CS and Hoffman HM.
  TITLE     Structural, expression, and evolutionary analysis of mouse CIAS1
  JOURNAL   Gene 338 (1), 25-34 (2004)
   PUBMED   15302403
REFERENCE   7  (bases 1 to 4438)
  AUTHORS   Albrecht M, Domingues FS, Schreiber S and Lengauer T.
  TITLE     Identification of mammalian orthologs associates PYPAF5 with
            distinct functional roles
  JOURNAL   FEBS Lett 538 (1-3), 173-177 (2003)
   PUBMED   12633874
REFERENCE   8  (bases 1 to 4438)
  AUTHORS   Ruiz-Opazo N, Lopez LV and Herrera VL.
  TITLE     The dual AngII/AVP receptor gene N119S/C163R variant exhibits
            sodium-induced dysfunction and cosegregates with salt-sensitive
            hypertension in the Dahl salt-sensitive hypertensive rat model
  JOURNAL   Mol Med 8 (1), 24-32 (2002)
   PUBMED   11984003
  REMARK    GeneRIF: The dual AngII/AVP receptor gene N119S/C163R variant
            exhibits sodium-induced dysfunction and cosegregates with
            salt-sensitive hypertension in the Dahl salt-sensitive hypertensive
            rat model.
REFERENCE   9  (bases 1 to 4438)
  AUTHORS   Gonzalez CB, Herrera VL and Ruiz-Opazo N.
  TITLE     Renal immunocytochemical distribution and pharmacological
            properties of the dual angiotensin II/AVP receptor
  JOURNAL   Hypertension 29 (4), 957-961 (1997)
   PUBMED   9095083
  REMARK    GeneRIF: This publication deals with the rat ortholog of the mouse
            Nlrp6 gene.
REFERENCE   10 (bases 1 to 4438)
  AUTHORS   Ruiz-Opazo N, Akimoto K and Herrera VL.
  TITLE     Identification of a novel dual angiotensin II/vasopressin receptor
            on the basis of molecular recognition theory
  JOURNAL   Nat Med 1 (10), 1074-1081 (1995)
   PUBMED   7489366
  REMARK    GeneRIF: This publication deals with the rat ortholog of the mouse
            Nlrp6 gene.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB869957.1, FJ222825.1 and
            AY355343.1.
            
            [WARNING] On Apr 27, 2023 this sequence was replaced by
            NM_133946.3.
            
            On Feb 27, 2013 this sequence version replaced NM_133946.1.
            
            Summary: The protein encoded by this gene binds
            arginine-vasopressin and may be involved in the
            arginine-vasopressin-mediated regulation of renal salt-water
            balance. The encoded protein also mediates inflammatory responses
            in the colon to allow recovery from intestinal epithelial damage
            and protects against tumorigenesis and the development of colitis.
            Finally, this protein can increase activation of NF-kappa-B,
            activation of CASP1 through interaction with ASC, and cAMP
            accumulation. [provided by RefSeq, Feb 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ222825.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                BB869957.1         2-52
            52-1440             FJ222825.1         1-1389
            1441-4438           AY355343.1         379-3376
FEATURES             Location/Qualifiers
     source          1..4438
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7"
     gene            1..4438
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR;
                     Pypaf5"
                     /note="NLR family, pyrin domain containing 6"
                     /db_xref="GeneID:101613"
                     /db_xref="MGI:MGI:2141990"
     exon            1..185
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR;
                     Pypaf5"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..2766
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR;
                     Pypaf5"
                     /note="PYRIN-containing APAF1-like protein 5; NACHT,
                     leucine rich repeat and PYD containing 6; NACHT/LRR/pyrin
                     domain-containing protein 6; non-angiotensin-vasopressin
                     receptor; angiotensin II/vasopressin receptor"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 6"
                     /protein_id="NP_598707.2"
                     /db_xref="CCDS:CCDS40178.2"
                     /db_xref="GeneID:101613"
                     /db_xref="MGI:MGI:2141990"
                     /translation="MDAAGASCSSVDAVARELLMATLEELSQEQLKRFRHKLRDAPLD
                     GRSIPWGRLERSDAVDLVDKLIEFYEPVPAVEMTRQVLKRSDIRDVASRLKQQQLQKL
                     GPTSVLLSVSAFKKKYREHVLRQHAKVKERNARSVKINKRFTKLLIAPGTGAVEDELL
                     GPLGEPEPERARRSDTHTFNRLFRGNDEESSQPLTVVLQGPAGIGKTMAAKKILYDWA
                     AGKLYHSQVDFAFFMPCGELLERPGKRSLADLVLDQCPDRAWPVKRILAQPNRLLFIL
                     DGADELPTLPSSEATPCKDPLEATSGLRVLSGLLSQELLPGARLLVTTRHAATGRLQG
                     RLCSPQCAEIRGFSDKDKKKYFFKFFRDERKAERAYRFVKENETLFALCFVPFVCWIV
                     CTVLQQQLELGRDLSRTSKTTTSVYLLFITSMLKSAGTNGPRVQGELRTLCRLAREGI
                     LDHHKAQFSEEDLEKLKLRGSQVQTIFLNKKEIPGVLKTEVTYQFIDQSFQEFLAALS
                     YLLEAERTPGTPAGGVQKLLNSDAELRGHLALTTRFLFGLLNTEGLRDIGNHFGCVVP
                     DHVKKDTLRWVQGQSHPKGPPVGAKKTAELEDIEDAEEEEEEEEDLNFGLELLYCLYE
                     TQEEDFVRQALSSLPEIVLERVRLTRMDLEVLNYCVQCCPDGQALRLVSCGLVAAKEK
                     KKKKKSLVKRLKGSQSTKKQPPVSLLRPLCETMTTPKCHLSVLILSHCRLPDAVCRDL
                     SEALKVAPALRELGLLQSRLTNTGLRLLCEGLAWPKCQVKTLRMQLPDLQEVINYLVI
                     VLQQSPVLTTLDLSGCQLPGVIVEPLCAALKHPKCSLKTLSLTSVELSENSLRDLQAV
                     KTSKPDLSIIYSK"
     exon            186..457
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR;
                     Pypaf5"
                     /inference="alignment:Splign:2.1.0"
     exon            458..493
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR;
                     Pypaf5"
                     /inference="alignment:Splign:2.1.0"
     exon            494..2240
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR;
                     Pypaf5"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2333
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR;
                     Pypaf5"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2504
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR;
                     Pypaf5"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2672
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR;
                     Pypaf5"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..4436
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR;
                     Pypaf5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3409..3414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR;
                     Pypaf5"
     polyA_site      3431
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR;
                     Pypaf5"
     regulatory      4416..4421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR;
                     Pypaf5"
     polyA_site      4436
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR;
                     Pypaf5"
ORIGIN      
        1 tgggagcctc ttgactgtca gcaagagtcc agctgagcca gaatgaacaa gactgagaaa
       61 caccctcaca cccagaatga gaccagttta gcccagaaag gatcacctct gctcccagct
      121 tctgcatctg agagttagat cctgagataa gactccatgg atgccgctgg agcctcctgc
      181 tccagcgtgg atgcagtggc aagggagctg cttatggcta cactggagga gctgagccag
      241 gagcagctga agcgcttccg ccacaagcta agggatgcgc ccctggatgg ccgcagcatc
      301 ccgtgggggc gactggagcg ctcagacgct gtggaccttg tcgacaagct cattgagttc
      361 tatgagccag tgccagctgt agaaatgacc cggcaggtcc tgaagaggtc ggatattcga
      421 gatgtggcct cgcgacttaa gcaacagcag ctacagaagc tcggccccac ctcggtgctt
      481 ctctccgtgt cagcgttcaa gaagaagtac cgcgagcacg tgctacgaca gcatgctaag
      541 gtgaaggaga ggaatgctcg ctctgtgaag atcaacaagc gcttcaccaa gctgctcatc
      601 gctccgggga ccggcgctgt ggaggacgag ctgctggggc cgttggggga gccggagccc
      661 gaacgcgctc ggcgctcgga cacgcacact tttaatcggc tcttccgggg aaatgatgaa
      721 gagagctcgc agccgctgac cgtggtgctg cagggcccgg caggcatcgg caaaaccatg
      781 gccgccaaga aaatcctcta tgactgggca gcaggtaagc tataccacag ccaggtggac
      841 tttgccttct tcatgccgtg cggcgagctg ctggagcggc cgggaaagcg cagcttggcg
      901 gacctggtgc tggaccagtg cccggaccgc gcttggccag tgaagcggat actggcgcaa
      961 cccaatcgcc tactgttcat cctggacggt gcagacgagc tgcctacttt accatcctca
     1021 gaggccactc cctgcaaaga ccctttggag gctacaagtg gcttgagagt gctgagcggg
     1081 ctgctgagcc aggagctgtt accaggagct cgcttgctag tgactacacg ccatgccgct
     1141 acagggaggc tgcagggcag attgtgctcg ccacagtgcg cagaaatacg cggcttctca
     1201 gacaaagaca aaaaaaagta tttcttcaag ttcttccggg acgagaggaa ggcagagcgc
     1261 gcttaccgct tcgtgaaaga gaacgagacg ctgtttgcac tgtgctttgt gcccttcgtg
     1321 tgctggatcg tgtgcacagt gctgcagcag cagctagagc tgggccggga tctctctcgt
     1381 acctccaaga ccactacttc tgtgtacctg ctcttcatca ccagcatgct gaagtctgca
     1441 ggcaccaatg gaccccgggt tcagggagag ctgagaacgc tgtgtcgcct ggccagggag
     1501 ggcatcctgg atcatcataa agcacaattc tcagaagagg acctggagaa attgaagctt
     1561 cggggttccc aagttcagac aatatttctc aacaagaaag agataccagg agtgctaaaa
     1621 actgaggtca cctaccagtt cattgaccag agcttccagg agttcttggc tgcattgtca
     1681 tacctactag aagctgagcg aactccgggg acgcccgcag gcggtgtgca gaagctcctg
     1741 aactctgacg cggagctacg tggtcatctt gcactgacca cccgattcct ctttggcctg
     1801 ctaaatacag aggggcttcg tgacattgga aaccattttg gctgtgtggt gccagatcat
     1861 gtgaaaaagg acaccctgcg gtgggtacaa ggacagagcc accccaaggg gccaccagta
     1921 ggggcaaaaa agactgctga gctggaggac atcgaggacg cagaggagga ggaggaggaa
     1981 gaggaggacc tcaattttgg actggagctg ctgtactgcc tgtatgagac acaggaggag
     2041 gattttgttc gacaggctct cagcagcctt ccagagatag tactggagcg agtcaggttg
     2101 acccgcatgg accttgaagt tctgaattac tgcgtgcagt gctgcccaga tggccaggct
     2161 ctgagactgg tgagctgtgg gctggtggcg gcaaaggaga agaagaagaa gaagaagagc
     2221 ctggtgaagc ggctgaaggg ctctcaaagc accaagaaac aacccccagt ctccttgctg
     2281 cgtccactct gtgagacaat gactaccccg aaatgtcatc tgagtgttct gatcttgtca
     2341 cactgcagac tccctgatgc agtttgccga gacctttccg aggccctgaa ggtagctcct
     2401 gccctaaggg agttgggcct cctccagagc cggctcacca acacaggcct gcgtttactg
     2461 tgcgaaggcc tggcttggcc caagtgccag gtgaagacac tcaggatgca gctgcctgac
     2521 ctccaagagg tgatcaatta cttggtcatc gtgctccagc agagcccagt cctgaccact
     2581 ctggacctca gtggctgtca gctgcctggc gtcattgtgg aacctctgtg tgcagccctg
     2641 aagcacccta aatgctccct aaagaccctc agtctgacct ctgtggagct gagtgagaac
     2701 tcactgaggg atcttcaagc tgtgaagaca tcaaagccag atctgtccat catatattca
     2761 aaataaggca cacctcaccg gcctcggaag ggtgaggcag tgtcttctga agctccggag
     2821 tccagaacac gatgaaagat gctgtagccc aaagtccctc tgaatatgac ctccccattc
     2881 aaaagcaaga agatgccagc ttctccctcc aggcaagtct ttcaagccac agaagggcaa
     2941 gcaaaagacc caggtagata caggcccttg atagctcctg gatagacctg gcacgtgccc
     3001 tgccctggac actctgcggt tggtcttccc tcagtcccac aaccagcaat gccttccttt
     3061 ctgagcctac cattctgtcc cttgacgata tcccaacagt aatagaagca ttcagcagct
     3121 gagcgtgttg ctgaatgttg tcactcatgt gtgatctggc ccccagctgt catatgggtg
     3181 aacataggtt cccagagttc tgccctctgt aggcaggaga taggtggatc actattgcca
     3241 tctggaattt tgggcgttgg cttttgggag gatgctgtcc ctgaaacctt aggcctttag
     3301 tccggaggga tccacttgct gcctgagaga tacagggaag gagccagaag agtgacagct
     3361 tccactgatg gtgggagctg gcacagcaca gtgaatctct cccaacataa taaattttct
     3421 tttggattcc cttttgttga tctctgtaac acttgtcaag gtaccaaagt aggtgttaac
     3481 atcatcttcc ctataagcac aaatacaagc caaggtttaa atccgcagtc ctccactgaa
     3541 gaaacagggt tggcctactg gcctgagcac agaaagtctt caagaaaggc ttggccttca
     3601 gagctggggc gagccctgaa taccccagac ttgagtctta tgatgaccat ggacagatcc
     3661 tcagaaagcc tgagcccagc actgctggct cagagcactc tgcagtgagc ccctttactt
     3721 cccaggggaa attccctcca ccatcgcacc attgcaataa atgcatccct tcatccttcc
     3781 aaacctcctg tctctgttac ttttccatgg ctgtgataag ataccgtgac ccggagcaac
     3841 tcacagaatc cagagtggcc tttagctgac agttccgagg gataagcggt cagcatggct
     3901 gagaagtgag gtaacaagac agctggagca gaagctgagg gttcacatct tgcgttgcag
     3961 gcacagagca aagaatgaac tgggaatgga catgtcttca agctctcaaa gccacctcca
     4021 gtgacatact ttctctaagc aagccatacc ctctaagcca cccccaaaca gtgccatcaa
     4081 ctgaaaatca agggtgcaaa tattttggta gtttgaatga gaagccccac ccccaccccc
     4141 ataggctcaa atagttgaac gcctacttcc ccagttggtg gaactgtttg ggaaggatta
     4201 gaaagtgtgc tgttggagac atgtcattgg agctagggca gacgttgagc tgccaaaagc
     4261 ctatgccagg cccacccttg ctttctgtct acctcggact tgcagatcag aagcgaggtc
     4321 tcagctccag ctccagcgcc atgcctgctg ctgtactact cgctactcgc catgatgacc
     4381 atggactgat cctcagaaag tctaagcaag gcccaattaa atgttttctt ctataaaa
//
