LOCUS       NM_011860               3521 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus NLR family, pyrin domain containing 5 (Nlrp5),
            transcript variant 1, mRNA.
ACCESSION   NM_011860
VERSION     NM_011860.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3521)
  AUTHORS   Han,Z., Wang,R., Chi,P., Zhang,Z., Min,L., Jiao,H., Ou,G., Zhou,D.,
            Qin,D., Xu,C., Gao,Z., Qi,Q., Li,J., Lu,Y., Wang,X., Chen,J.,
            Yu,X., Hu,H., Li,L. and Deng,D.
  TITLE     The subcortical maternal complex modulates the cell cycle during
            early mammalian embryogenesis via 14-3-3
  JOURNAL   Nat Commun 15 (1), 8887 (2024)
   PUBMED   39406751
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3521)
  AUTHORS   Yao,X., Wang,C., Yu,W., Sun,L., Lv,Z., Xie,X., Tian,S., Yan,L.,
            Li,L. and Liu,J.
  TITLE     BCAS2 regulates oocyte meiotic prophase I by participating in mRNA
            alternative splicing
  JOURNAL   FASEB J 38 (1), e23361 (2024)
   PUBMED   38085152
REFERENCE   3  (bases 1 to 3521)
  AUTHORS   Kim,B., Zhang,X., Kan,R., Cohen,R., Mukai,C., Travis,A.J. and
            Coonrod,S.A.
  TITLE     The role of MATER in endoplasmic reticulum distribution and calcium
            homeostasis in mouse oocytes
  JOURNAL   Dev Biol 386 (2), 331-339 (2014)
   PUBMED   24374158
  REMARK    GeneRIF: MATER is required for endoplasmic reticulum distribution
            and Ca2+ homeostasis in oocytes, likely due to defects in
            lattice-mediated ER positioning and/or redistribution.
REFERENCE   4  (bases 1 to 3521)
  AUTHORS   Fernandes,R., Tsuda,C., Perumalsamy,A.L., Naranian,T., Chong,J.,
            Acton,B.M., Tong,Z.B., Nelson,L.M. and Jurisicova,A.
  TITLE     NLRP5 mediates mitochondrial function in mouse oocytes and embryos
  JOURNAL   Biol Reprod 86 (5), 138,1-10 (2012)
   PUBMED   22357545
  REMARK    GeneRIF: It was concluded that lack of Nlrp5 in oocytes triggers
            premature activation of the mitochondrial pool, causing
            mitochondrial damage that cannot be rescued by inactivation of Bax.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3521)
  AUTHORS   Otsuka,N., Tong,Z.B., Vanevski,K., Tu,W., Cheng,M.H. and
            Nelson,L.M.
  TITLE     Autoimmune oophoritis with multiple molecular targets mitigated by
            transgenic expression of mater
  JOURNAL   Endocrinology 152 (6), 2465-2473 (2011)
   PUBMED   21447630
  REMARK    GeneRIF: Transgenic expression of MATER induces antigen-specific
            tolerance with a significant reduction in ovarian autoimmunity.
REFERENCE   6  (bases 1 to 3521)
  AUTHORS   Li,L., Baibakov,B. and Dean,J.
  TITLE     A subcortical maternal complex essential for preimplantation mouse
            embryogenesis
  JOURNAL   Dev Cell 15 (3), 416-425 (2008)
   PUBMED   18804437
  REMARK    GeneRIF: Results describe a subcortical maternal complex,
            containing Mater, Floped, TLE6, and Filia, that is essential for
            preimplantation mouse embryogenesis.
REFERENCE   7  (bases 1 to 3521)
  AUTHORS   Roper,R.J., Ma,R.Z., Biggins,J.E., Butterfield,R.J., Michael,S.D.,
            Tung,K.S., Doerge,R.W. and Teuscher,C.
  TITLE     Interacting quantitative trait loci control loss of peripheral
            tolerance and susceptibility to autoimmune ovarian dysgenesis after
            day 3 thymectomy in mice
  JOURNAL   J Immunol 169 (3), 1640-1646 (2002)
   PUBMED   12133995
REFERENCE   8  (bases 1 to 3521)
  AUTHORS   Tong,Z.B., Gold,L., Pfeifer,K.E., Dorward,H., Lee,E., Bondy,C.A.,
            Dean,J. and Nelson,L.M.
  TITLE     Mater, a maternal effect gene required for early embryonic
            development in mice
  JOURNAL   Nat Genet 26 (3), 267-268 (2000)
   PUBMED   11062459
REFERENCE   9  (bases 1 to 3521)
  AUTHORS   Tong,Z.B., Nelson,L.M. and Dean,J.
  TITLE     Mater encodes a maternal protein in mice with a leucine-rich repeat
            domain homologous to porcine ribonuclease inhibitor
  JOURNAL   Mamm Genome 11 (4), 281-287 (2000)
   PUBMED   10754103
REFERENCE   10 (bases 1 to 3521)
  AUTHORS   Tong,Z.B. and Nelson,L.M.
  TITLE     A mouse gene encoding an oocyte antigen associated with autoimmune
            premature ovarian failure
  JOURNAL   Endocrinology 140 (8), 3720-3726 (1999)
   PUBMED   10433232
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK087774.1, BC053384.1 and
            AC159288.4.
            
            On Apr 4, 2015 this sequence version replaced NM_011860.2.
            
            Summary: This gene encodes a member of the NACHT, leucine-rich
            repeat, and pyrin domain containing family. Members of this family
            have a pyrin domain at the N-terminus, a central NACHT domain, and
            a C-terminal leucine-rich repeat domain. This gene encodes a
            maternal-effect factor that is essential for early embryonic
            development in the mouse. Homozygous null mutant females are
            sterile, and embryos die following the first cleavage. This gene is
            required for endoplasmic reticulum redistribution and calcium
            homeostasis in oocytes. In addition, ovulated oocytes mutant for
            this gene have abnormal mitochondrial localization and increased
            mitochondrial activity, which results in mitochondrial damage and
            early embryonic lethality. Pseudogenes of this gene have been found
            on chromosomes 7 and 12. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053384.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               AK087774.1         2-461
            461-1442            BC053384.1         461-1442
            1443-2080           AK087774.1         1398-2035
            2081-2081           BC053384.1         2081-2081
            2082-3519           AK087774.1         2037-3474
            3520-3521           AC159288.4         137522-137523
FEATURES             Location/Qualifiers
     source          1..3521
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 10.22 cM"
     gene            1..3521
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /note="NLR family, pyrin domain containing 5"
                     /db_xref="GeneID:23968"
                     /db_xref="MGI:MGI:1345193"
     exon            1..67
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /inference="alignment:Splign:2.1.0"
     exon            68..145
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..3411
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /note="isoform a is encoded by transcript variant 1;
                     NACHT, leucine rich repeat and PYD containing 5; NACHT,
                     LRR and PYD domains-containing protein 5; ooplasm-specific
                     protein 1; maternal antigen that embryos require"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 5
                     isoform a"
                     /protein_id="NP_035990.1"
                     /db_xref="CCDS:CCDS20930.1"
                     /db_xref="GeneID:23968"
                     /db_xref="MGI:MGI:1345193"
                     /translation="MGPPEKESKAILKARGLEEEQKSERKMTSPENDSKSIQKDQGPE
                     QEQTSESTMGPPEKDSKAILKARGLEEEQKSESTMSPSENVSRAILKDSGSEEVEQAS
                     ERKMTSPENDSKSIQKDQGPEQEQTSETLQSKEEDEVTEADKDNGGDLQDYKAHVIAK
                     FDTSVDLHYDSPEMKLLSDAFKPYQKTFQPHTIILHGRPGVGKSALARSIVLGWAQGK
                     LFQKMSFVIFFSVREIKWTEKSSLAQLIAKECPDSWDLVTKIMSQPERLLFVIDGLDD
                     MDSVLQHDDMTLSRDWKDEQPIYILMYSLLRKALLPQSFLIITTRNTGLEKLKSMVVS
                     PLYILVEGLSASRRSQLVLENISNESDRIQVFHSLIENHQLFDQCQAPSVCSLVCEAL
                     QLQKKLGKRCTLPCQTLTGLYATLVFHQLTLKRPSQSALSQEEQITLVGLCMMAAEGV
                     WTMRSVFYDDDLKNYSLKESEILALFHMNILLQVGHNSEQCYVFSHLSLQDFFAALYY
                     VLEGLEEWNQHFCFIENQRSIMEVKRTDDTRLLGMKRFLFGLMNKDILKTLEVLFEYP
                     VIPTVEQKLQHWVSLIAQQVNGTSPMDTLDAFYCLFESQDEEFVGGALKRFQEVWLLI
                     NQKMDLKVSSYCLKHCQNLKAIRVDIRDLLSVDNTLELCPVVTVQETQCKPLLMEWWG
                     NFCSVLGSLRNLKELDLGDSILSQRAMKILCLELRNQSCRIQKLTFKSAEVVSGLKHL
                     WKLLFSNQNLKYLNLGNTPMKDDDMKLACEALKHPKCSVETLRLDSCELTIIGYEMIS
                     TLLISTTRLKCLSLAKNRVGVKSMISLGNALSSSMCLLQKLILDNCGLTPASCHLLVS
                     ALFSNQNLTHLCLSNNSLGTEGVQQLCQFLRNPECALQRLILNHCNIVDDAYGFLAMR
                     LANNTKLTHLSLTMNPVGDGAMKLLCEALKEPTCYLQELELVDCQLTQNCCEDLACMI
                     TTTKHLKSLDLGNNALGDKGVITLCEGLKQSSSSLRRLGLGACKLTSNCCEALSLAIS
                     CNPHLNSLNLVKNDFSTSGMLKLCSAFQCPVSNLGIIGLWKQEYYARVRRQLEEVEFV
                     KPHVVIDGDWYASDEDDRNWWKN"
     exon            146..223
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /inference="alignment:Splign:2.1.0"
     exon            224..301
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /inference="alignment:Splign:2.1.0"
     exon            302..382
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /inference="alignment:Splign:2.1.0"
     exon            383..460
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /inference="alignment:Splign:2.1.0"
     exon            461..508
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /inference="alignment:Splign:2.1.0"
     exon            509..2084
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2255
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2423
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2594
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2765
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2936
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3107
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3278
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /inference="alignment:Splign:2.1.0"
     exon            3279..3521
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3497..3502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /note="hexamer: AATAAA"
     polyA_site      3518
                     /gene="Nlrp5"
                     /gene_synonym="Mater; Nalp5; Op1; PAN11"
                     /note="major polyA site"
ORIGIN      
        1 agagacagaa ttggctttct ttttgcggtg gttaccggtt tgcagaaagt aggatctgca
       61 cttagagaaa gcacaatggg tcctccagaa aaagaaagta aagcaatctt gaaagcacgt
      121 ggattggaag aggaacagaa gtcagaaaga aaaatgactt ctccagaaaa cgacagtaaa
      181 tcaatccaga aagaccaagg accagagcag gagcagacat cagaaagcac aatgggtcct
      241 ccagaaaaag acagtaaagc aatcttgaaa gcacgtggat tggaagagga acagaagtca
      301 gaaagcacaa tgtctccttc agaaaatgtc agtagagcaa tcctgaaaga cagtggatca
      361 gaagaagtgg aacaggcgtc agaaagaaaa atgacttctc cagaaaacga cagtaaatca
      421 atccagaaag accaaggacc agagcaggag cagacatcag aaaccttaca atctaaggaa
      481 gaagatgaag tgacagaggc agataaagat aatggaggtg acttacaaga ctacaaggcc
      541 catgtgattg ctaagttcga cacaagtgtg gatctacact atgacagccc agagatgaaa
      601 ttattgtctg atgcttttaa accataccag aaaaccttcc agcctcacac cattatccta
      661 catggaagac caggagttgg gaagtcagct ttggccagaa gtattgttct tggctgggca
      721 cagggtaaac tcttccaaaa aatgtccttt gtcatcttct tctctgttag agaaataaag
      781 tggacagaga agagcagttt ggcacagctg attgctaagg agtgtccaga ctcctgggat
      841 ctagtgacaa agatcatgtc ccaaccagaa agactcttgt ttgtcataga tggcttggat
      901 gatatggact ctgtcctcca acatgatgat atgacactat ccagagactg gaaggatgaa
      961 cagcccatat acatcctgat gtacagcctc ctgaggaagg ctctcctacc tcagtccttt
     1021 ctcatcatta ccaccagaaa cacaggctta gaaaaactca agtcaatggt tgtgtccccc
     1081 ctctatatac tggttgaagg actgtctgca tcaaggagat ctcagctggt cctcgagaac
     1141 atctccaatg agtctgatag aatacaagtc ttccattctc tgatagaaaa tcaccagctg
     1201 tttgaccaat gccaggcccc ctctgtgtgc tccctggtct gtgaggctct acagctacag
     1261 aagaaactgg gaaagagatg caccctaccc tgccagactc tcaccggttt gtatgccacg
     1321 ttggtgtttc accagctcac cttgaaaagg ccttcccaga gcgctctcag tcaggaagaa
     1381 cagattactc tagtgggttt gtgcatgatg gcagctgaag gagtgtggac catgaggtcg
     1441 gtgttctatg atgatgacct gaagaactat agcctaaagg agtctgagat cttggccctc
     1501 tttcacatga acatccttct ccaggttggc cacaacagtg agcagtgtta tgttttctcc
     1561 cacctcagcc tgcaggattt ctttgctgcc ttatattatg ttttagaagg gctggaggaa
     1621 tggaatcagc atttttgctt cattgaaaac caaaggagca tcatggaggt gaagagaact
     1681 gacgacactc gcctcctcgg gatgaagcgt ttcttatttg gcctcatgaa caaggatatc
     1741 ttgaagactc tggaggttct gtttgaatat cccgtgattc caactgttga gcagaagctc
     1801 caacactggg tctctctgat agctcagcag gtcaatggca ccagcccaat ggacaccctg
     1861 gatgccttct attgtctatt tgagtctcag gatgaagagt ttgttggcgg ggctctcaaa
     1921 cgcttccaag aagtgtggct gctgattaac cagaagatgg acttgaaggt ctcttcctac
     1981 tgtctcaagc actgtcagaa cttgaaggca atccgggtgg atatcagaga cctcctctcg
     2041 gtagataata ctctcgagct gtgccctgtt gttactgtcc aggagacaca atgtaagccc
     2101 ctcctcatgg agtggtgggg aaacttctgc tctgtgcttg gcagcctccg gaacttgaag
     2161 gagctggact tgggcgacag catcctgagt caacgggcca tgaagatact gtgcctcgag
     2221 ctgcggaatc agtcctgcag aatacagaag ctgacgttta agagtgcaga ggtagtgtct
     2281 ggcctgaaac atctctggaa gctccttttt agcaatcaaa acttaaagta cctcaatcta
     2341 gggaacactc ccatgaagga tgatgacatg aagttagcct gcgaagcgct gaaacatcca
     2401 aagtgctccg tggagactct gaggttggat tcctgtgagt taaccatcat tggttatgag
     2461 atgatctcca cgcttcttat ttcaaccacc aggctaaagt gtctcagcct ggccaaaaat
     2521 agagtgggag taaaaagcat gatatccctt gggaatgcct tgagtagctc aatgtgtcta
     2581 ctgcaaaagt tgatactgga caactgtggc ctcacacctg ccagctgcca ccttctggtc
     2641 tcagcccttt tcagcaacca gaacttgaca cacctgtgcc tgtcaaacaa cagcctgggg
     2701 actgaaggag tgcaacagct gtgtcagttc ctgaggaatc cagaatgtgc tctccagcgg
     2761 ctgatactga atcactgcaa cattgtagat gatgcttatg gcttcctggc aatgagactt
     2821 gcaaacaaca caaagctgac ccacctgagc ctgaccatga accccgtagg ggatggtgca
     2881 atgaagctac tgtgtgaagc tttaaaggaa cctacttgtt accttcaaga actggaacta
     2941 gtggactgcc aactcacaca gaactgctgc gaggacctgg cctgtatgat cacaacaacc
     3001 aagcacttaa aaagtttgga tcttggtaac aacgccctgg gtgacaaagg agtcataacc
     3061 ctgtgtgagg gactgaagca aagtagcagc tccctgagga gacttgggtt gggggcatgt
     3121 aagttgactt ccaattgctg tgaggcattg tcattggcca tctcttgcaa ccctcacctg
     3181 aacagcctaa acctggtgaa gaatgacttc agtacatcgg ggatgttgaa gctgtgctct
     3241 gcgttccaat gccctgtctc taacctgggg ataattggcc tgtggaagca ggagtactat
     3301 gcccgagtga gaagacagct ggaggaagtt gagtttgtca agccccacgt ggtgattgat
     3361 ggtgattggt atgctagtga tgaagatgac cgaaactggt ggaaaaactg aagacatgag
     3421 ccccctctcc ttcacgtcct agcactgcag tatctgtgaa atgtttgtct caccttggag
     3481 gatgtagcaa gaatgaaata aacacagcat ttagaaaagc a
//
