LOCUS       NM_001004194            3382 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus NLR family, pyrin domain containing 4E (Nlrp4e), mRNA.
ACCESSION   NM_001004194 XM_910536
VERSION     NM_001004194.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3382)
  AUTHORS   Shi,L.Y., Wang,Y., Yang,Y.J., Li,Q., Yang,Z.X., Sun,L.H., Luo,F.Q.,
            He,Y.H., Zhang,S.P., Su,N., Liu,J.Q., He,Y., Guan,Y.C., Wei,Z.L.,
            Cao,Y.X. and Zhang,D.
  TITLE     NLRP4E regulates actin cap formation through SRC and CDC42 during
            oocyte meiosis
  JOURNAL   Cell Mol Biol Lett 29 (1), 68 (2024)
   PUBMED   38730334
  REMARK    GeneRIF: NLRP4E regulates actin cap formation through SRC and CDC42
            during oocyte meiosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3382)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3382)
  AUTHORS   Lin,M., Zhao,Z., Yang,Z., Meng,Q., Tan,P., Xie,W., Qin,Y.,
            Wang,R.F. and Cui,J.
  TITLE     USP38 Inhibits Type I Interferon Signaling by Editing TBK1
            Ubiquitination through NLRP4 Signalosome
  JOURNAL   Mol Cell 64 (2), 267-281 (2016)
   PUBMED   27692986
  REMARK    GeneRIF: USP38 inhibits type I interferon signaling by editing TBK1
            ubiquitination through NLRP4 signalosome.
REFERENCE   4  (bases 1 to 3382)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3382)
  AUTHORS   Madissoon,E., Tohonen,V., Vesterlund,L., Katayama,S., Unneberg,P.,
            Inzunza,J., Hovatta,O. and Kere,J.
  TITLE     Differences in gene expression between mouse and human for
            dynamically regulated genes in early embryo
  JOURNAL   PLoS One 9 (8), e102949 (2014)
   PUBMED   25089626
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3382)
  AUTHORS   Chang,B.H., Liu,X., Liu,J., Quan,F.S., Guo,Z.K. and Zhang,Y.
  TITLE     Developmental expression and possible functional roles of mouse
            Nlrp4e in preimplantation embryos
  JOURNAL   In Vitro Cell Dev Biol Anim 49 (7), 548-553 (2013)
   PUBMED   23708922
  REMARK    GeneRIF: that Nlrp4e, a maternal-zygotic-effect gene, may not be
            involved in oocyte maturation but may play a critical role in early
            embryogenesis.
REFERENCE   7  (bases 1 to 3382)
  AUTHORS   DeSantis,D.A., Ko,C.W., Liu,Y., Liu,X., Hise,A.G., Nunez,G. and
            Croniger,C.M.
  TITLE     Alcohol-induced liver injury is modulated by Nlrp3 and Nlrc4
            inflammasomes in mice
  JOURNAL   Mediators Inflamm 2013, 751374 (2013)
   PUBMED   24453428
  REMARK    GeneRIF: suggest that Hmgb1-IL-23-IL-17-IL-6-Stat3 axis plays a
            pivotal role in tumor development in murine models of melanoma
REFERENCE   8  (bases 1 to 3382)
  AUTHORS   Hamatani,T., Falco,G., Carter,M.G., Akutsu,H., Stagg,C.A.,
            Sharov,A.A., Dudekula,D.B., VanBuren,V. and Ko,M.S.
  TITLE     Age-associated alteration of gene expression patterns in mouse
            oocytes
  JOURNAL   Hum Mol Genet 13 (19), 2263-2278 (2004)
   PUBMED   15317747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC150900.5.
            
            On Aug 25, 2009 this sequence version replaced NM_001004194.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC139319.1, AY596197.2 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849384
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               AC150900.5         143488-143854
            368-1940            AC150900.5         162663-164235
            1941-2099           AC150900.5         178478-178636
            2100-2264           AC150900.5         179029-179193
            2265-2432           AC150900.5         182724-182891
            2433-2603           AC150900.5         185329-185499
            2604-2774           AC150900.5         195467-195637
            2775-2945           AC150900.5         197403-197573
            2946-3382           AC150900.5         204137-204573
FEATURES             Location/Qualifiers
     source          1..3382
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 10.21 cM"
     gene            1..3382
                     /gene="Nlrp4e"
                     /gene_synonym="4930406H16Rik; Nalp-epsilon; Nalp4e; Nlrp4"
                     /note="NLR family, pyrin domain containing 4E"
                     /db_xref="GeneID:446099"
                     /db_xref="MGI:MGI:3056600"
     exon            1..367
                     /gene="Nlrp4e"
                     /gene_synonym="4930406H16Rik; Nalp-epsilon; Nalp4e; Nlrp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..3027
                     /gene="Nlrp4e"
                     /gene_synonym="4930406H16Rik; Nalp-epsilon; Nalp4e; Nlrp4"
                     /note="NALP, epsilon; NACHT, leucine rich repeat and PYD
                     containing 4E; NLR family, pyrin domain containing 4"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein
                     4E"
                     /protein_id="NP_001004194.2"
                     /db_xref="CCDS:CCDS20928.1"
                     /db_xref="GeneID:446099"
                     /db_xref="MGI:MGI:3056600"
                     /translation="MASFFSDFGLMWYLEELNKKEFMKFKELLQQEILQLGLKHISWT
                     EVKKASREDLANLLLKHYEEKKAWDMTFKIFQKMNRQDLMERAGREIAGHSKLYQVHL
                     KKKLTHDYARKFNIKDQDSLKQKFTQDDCDHFENLLISKATGKKPHMVFLQGVAGIGK
                     SLMLTKLMLAWSEGMVFQNKFSYIFYFCCQDVKKMKRASLAELISKEWPNASAPIEEI
                     LSQPEKLLFVIDNLEVMECDMSEWESELCDDCMEKQPVNILMSSLLRRKMLPESSFLV
                     SATPETFEKIEDRIECTNVKMMAGFNESSIKVYFYSLFQDRNRTQEIFSLVRENEQLF
                     SVCQVPVLCWMVATCLKKEIEKGRDPVSICRRITSLYTTYIFNLFIPHSAQYPSKKSQ
                     DQLQGLCSLAAEGMWTDTFVFAEEALRRNGIMDSDISTLLDVRILEKSKESEKSYIFL
                     HPSIQEVCAAIFHLLKSHVDHPSQDVKSIEALIFTFLKKVKIQWIFFGSFIFGLLHES
                     EQKKLEAFFGHQLSQEIKRQLYQCLETISGNKELQEQIDGMKLFYCLFEMDDEAFLPQ
                     VMNCMEQIKFVAKDYSDVIVAAHCLQHCSTLKKLSLSTQNILSEGQEHSYTEKLLICW
                     HHVCSVLTSSKDIHVLQVKDTNFNERAFLVLYSHLKYPSCILKVLEVNNVTLLCDNRL
                     LFELIQNQRLQLLNLSLTFLSHNDVKLLCDVLNQAECNIEKLMVADCNLSPDDCKVFV
                     SVLISSKMLKHLNLSSNNLDKGISSLSKALCHPDCVLKNLVLAKCSLSEECWHYLSEV
                     LRRNKTLTHLDISFNDLKDEGLKVLCGALTLPDSVLISLSVRYCLITTSGCQDLAEVL
                     RNNQNLRNLQISNNKIEDAGVKLLCDAIKHPNCHLENIGLEACALTGACCEDLASSFT
                     HCKTLLGINLQENALDHSGLVALFEAMKQQQCTVNLRGLRITDFDKETQEFLMAEKEK
                     NPYLSI"
     exon            368..1940
                     /gene="Nlrp4e"
                     /gene_synonym="4930406H16Rik; Nalp-epsilon; Nalp4e; Nlrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2099
                     /gene="Nlrp4e"
                     /gene_synonym="4930406H16Rik; Nalp-epsilon; Nalp4e; Nlrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2264
                     /gene="Nlrp4e"
                     /gene_synonym="4930406H16Rik; Nalp-epsilon; Nalp4e; Nlrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2432
                     /gene="Nlrp4e"
                     /gene_synonym="4930406H16Rik; Nalp-epsilon; Nalp4e; Nlrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2603
                     /gene="Nlrp4e"
                     /gene_synonym="4930406H16Rik; Nalp-epsilon; Nalp4e; Nlrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2774
                     /gene="Nlrp4e"
                     /gene_synonym="4930406H16Rik; Nalp-epsilon; Nalp4e; Nlrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2945
                     /gene="Nlrp4e"
                     /gene_synonym="4930406H16Rik; Nalp-epsilon; Nalp4e; Nlrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3382
                     /gene="Nlrp4e"
                     /gene_synonym="4930406H16Rik; Nalp-epsilon; Nalp4e; Nlrp4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3360..3365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nlrp4e"
                     /gene_synonym="4930406H16Rik; Nalp-epsilon; Nalp4e; Nlrp4"
                     /note="hexamer: AATAAA"
     polyA_site      3378
                     /gene="Nlrp4e"
                     /gene_synonym="4930406H16Rik; Nalp-epsilon; Nalp4e; Nlrp4"
                     /note="major polyA site"
ORIGIN      
        1 gctgcttgcc tgattttccc acagaaccca tatgtttctt actcctggta ttcacctctc
       61 tgaagacgca tctctcttcc ttaagacacg atggcatcat ttttttctga ttttggcctt
      121 atgtggtact tggaagagct aaacaagaaa gaattcatga aatttaagga attactccaa
      181 caggagattt tgcagttggg gctgaaacac atttcttgga ccgaagtgaa gaaggcatct
      241 cgtgaagacc ttgccaactt actgttgaaa cattatgagg agaagaaagc ctgggatatg
      301 accttcaaaa tcttccagaa gatgaatagg caggatctca tggagagggc aggaagagag
      361 attgctggac actcaaagtt atatcaagtt catttgaaga agaagctgac ccatgattat
      421 gccagaaagt ttaacatcaa agatcaagat tcccttaagc agaaatttac ccaggatgac
      481 tgtgatcatt ttgagaacct tctcatatca aaggcgactg gaaagaagcc acacatggtg
      541 tttctgcaag gagtggcggg aattggcaag tcactgatgt tgacaaagtt aatgcttgcc
      601 tggtcagaag gcatggtgtt tcagaacaaa ttctcctaca tcttctactt ctgctgtcaa
      661 gatgtgaaga agatgaagag agcaagcctg gcagaattga tctccaaaga gtggcccaac
      721 gcctcagctc ccatagagga gatcctgtcc caaccggaga aactcttatt tgtcatcgac
      781 aacttggaag tgatggaatg tgatatgtct gaatgggagt cggagctgtg tgatgactgc
      841 atggagaagc agccagtgaa tatactgatg agcagtttgc tcaggaggaa gatgctccct
      901 gaatcctctt tcctcgtctc tgctacccca gagacttttg agaaaataga ggacaggatt
      961 gagtgcacaa atgtaaaaat gatggcagga ttcaatgaga gcagtattaa ggtgtatttc
     1021 tacagcttgt tccaagatag gaacagaacc caggaaattt tcagtttggt gagagaaaat
     1081 gagcagctgt tctctgtatg tcaagtccct gtgctctgct ggatggtggc tacttgtcta
     1141 aaaaaagaga tagagaaggg aagagaccca gtctcaatct gccgacgtat cacttccctg
     1201 tataccactt acatcttcaa tttgttcatt ccccacagtg cccaatatcc aagtaagaaa
     1261 agccaagacc agctgcaggg cttatgttct ctggctgctg agggcatgtg gactgacaca
     1321 tttgtgtttg ctgaggaggc tctcaggaga aatgggatca tggactctga tatctccaca
     1381 ctgctggacg taaggatcct tgaaaagagc aaggaatctg aaaaatctta cattttcctc
     1441 cacccatcta tccaggaggt ctgtgctgcc atctttcatc tgctaaagag ccatgtagac
     1501 catcctagcc aggatgtcaa aagtatagag gcactcatat ttacatttct aaagaaagtc
     1561 aaaatacagt ggattttttt tggctctttc atctttggcc ttttacatga atcagaacaa
     1621 aaaaagctag aggcattttt tggccaccag ttgtcccaag aaataaaacg tcagttgtat
     1681 cagtgcctgg aaaccataag tggcaataaa gagcttcaag aacagataga tggcatgaag
     1741 ctgttttact gtctgtttga gatggacgat gaagccttct taccacaagt tatgaactgt
     1801 atggaacaga ttaaatttgt ggctaaggat tattctgatg ttattgttgc tgcccactgc
     1861 ttacaacact gttctacact gaaaaaacta tccttgtcaa cccagaatat cctgagtgaa
     1921 ggtcaagaac acagctatac ggaaaagcta ctcatctgtt ggcatcatgt gtgctctgtg
     1981 ctcacaagca gtaaggatat ccacgtactc caagtgaaag acactaattt caatgaaaga
     2041 gcctttttgg tcttgtatag tcatctgaag taccccagct gcatccttaa agtacttgag
     2101 gtaaataatg tgactttgct ttgtgataac cgcctgttat ttgagttgat tcagaaccaa
     2161 cgtttgcagc tcttgaacct cagcctcaca ttcctgtccc acaatgatgt gaaactgttg
     2221 tgtgatgtct tgaaccaggc agagtgcaac atagaaaagc tgatggtagc agactgtaac
     2281 ctttcacctg atgactgcaa ggtctttgtc tccgtcctga tcagcagcaa gatgttgaag
     2341 catcttaatt tgtcatctaa caacttggac aaagggatat cctctctgtc caaggctttg
     2401 tgccacccag actgtgttct gaagaacttg gtgttagcca aatgttccct cagtgaggaa
     2461 tgttggcact acctttcaga agttcttagg cggaacaaaa ccttgaccca cctagatatc
     2521 agcttcaatg acctaaagga cgaagggctg aaggttctct gtggggctct cactctccca
     2581 gacagtgtcc tcatatcact gagtgtaaga tattgtctca tcaccactag tggttgccag
     2641 gacctggctg aagtcttgag aaacaaccag aacctgagga acctacagat ttcaaacaat
     2701 aaaatagaag atgctggtgt gaagctcctg tgtgatgcta taaaacatcc caactgccac
     2761 ttagaaaata ttggattgga agcctgcgca ctaactggtg cctgctgtga ggaccttgct
     2821 tcttctttta cccactgtaa gaccctgttg ggaatcaacc tgcaggagaa cgccttggac
     2881 cacagtggat tggttgcact gtttgaggct atgaaacagc aacagtgtac cgtgaattta
     2941 cgtggacttc gaattactga ctttgataag gaaacccagg agttcctgat ggctgagaaa
     3001 gagaaaaacc catacttgag catctaagca gtgtgtaagg cagaagcaga aacaagggtg
     3061 gatgttctgg tgtgagaaat atggctgtat tctgacctca aactacgtcg aactacctcc
     3121 aaaggaaaga gagcaggatc cttaatttga tccattgtat actaaactta tagatcatta
     3181 acattccagt gagatacata cagtttcttt atccacgccc ccccaacccc cattcagatg
     3241 tgttttgcaa gatagatgtg gctttttgtt tgcactacag attcaaacag gccgttcaaa
     3301 gacagcgtaa aatgaatgtt tataatgaca gtttttctac actggtatct taagcatcga
     3361 ataaaatctt taaatatatc tt
//
