LOCUS       NM_031389               3614 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus NLR family, pyrin domain containing 4C (Nlrp4c), mRNA.
ACCESSION   NM_031389
VERSION     NM_031389.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3614)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3614)
  AUTHORS   Madissoon,E., Tohonen,V., Vesterlund,L., Katayama,S., Unneberg,P.,
            Inzunza,J., Hovatta,O. and Kere,J.
  TITLE     Differences in gene expression between mouse and human for
            dynamically regulated genes in early embryo
  JOURNAL   PLoS One 9 (8), e102949 (2014)
   PUBMED   25089626
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3614)
  AUTHORS   Shin,Y.H., Choi,Y., Erdin,S.U., Yatsenko,S.A., Kloc,M., Yang,F.,
            Wang,P.J., Meistrich,M.L. and Rajkovic,A.
  TITLE     Hormad1 mutation disrupts synaptonemal complex formation,
            recombination, and chromosome segregation in mammalian meiosis
  JOURNAL   PLoS Genet 6 (11), e1001190 (2010)
   PUBMED   21079677
  REMARK    Erratum:[PLoS Genet. 2011;7(2). doi:
            10.1371/annotation/8aa656b6-55f7-4795-a441-cf243ea62175]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3614)
  AUTHORS   Horikawa,M., Kirkman,N.J., Mayo,K.E., Mulders,S.M., Zhou,J.,
            Bondy,C.A., Hsu,S.Y., King,G.J. and Adashi,E.Y.
  TITLE     The mouse germ-cell-specific leucine-rich repeat protein NALP14: a
            member of the NACHT nucleoside triphosphatase family
  JOURNAL   Biol Reprod 72 (4), 879-889 (2005)
   PUBMED   15590904
REFERENCE   5  (bases 1 to 3614)
  AUTHORS   Hamatani,T., Falco,G., Carter,M.G., Akutsu,H., Stagg,C.A.,
            Sharov,A.A., Dudekula,D.B., VanBuren,V. and Ko,M.S.
  TITLE     Age-associated alteration of gene expression patterns in mouse
            oocytes
  JOURNAL   Hum Mol Genet 13 (19), 2263-2278 (2004)
   PUBMED   15317747
REFERENCE   6  (bases 1 to 3614)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY596194.1 and AK166817.1.
            
            On Feb 8, 2008 this sequence version replaced NM_031389.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY596194.1, AK133284.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2800              AY596194.1         1-2800
            2801-3606           AK166817.1         2782-3587
            3607-3614           AY596194.1         3607-3614
FEATURES             Location/Qualifiers
     source          1..3614
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 3.5 cM"
     gene            1..3614
                     /gene="Nlrp4c"
                     /gene_synonym="Nalp-alpha; Nalp4c; Rnh2"
                     /note="NLR family, pyrin domain containing 4C"
                     /db_xref="GeneID:83564"
                     /db_xref="MGI:MGI:1890518"
     exon            1..61
                     /gene="Nlrp4c"
                     /gene_synonym="Nalp-alpha; Nalp4c; Rnh2"
                     /inference="alignment:Splign:2.1.0"
     exon            62..404
                     /gene="Nlrp4c"
                     /gene_synonym="Nalp-alpha; Nalp4c; Rnh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..3076
                     /gene="Nlrp4c"
                     /gene_synonym="Nalp-alpha; Nalp4c; Rnh2"
                     /note="ribonuclease/angiogenin inhibitor 2; VNACHT,
                     leucine rich repeat and PYD containing 4C; NACHT, leucine
                     rich repeat and PYD containing 4C"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein
                     4C"
                     /protein_id="NP_113566.2"
                     /db_xref="CCDS:CCDS51988.1"
                     /db_xref="GeneID:83564"
                     /db_xref="MGI:MGI:1890518"
                     /translation="MASFFSDFGLMWYLEELNKKEFMKFKEFLKQEILQLRLKQISWT
                     EVKKASREDLANLLLKHYEEKKAWDMTFKIFQKMNRKDLMERAGREIAGHSKLYQAHL
                     KKKLTHDYARKFNIKVQDFSKQKFTQDDYDRFENFLISKVTAKKPHMVFLQGAAGIGK
                     SLMLTKLMLAWSEGMVFQNKFSYIFYFCCQDVKKMKRASLAELISKEWPKTSAPIEDI
                     LSQPEKLLFVIDNLEVMECDMSERESELCDTCTEKQPVRILLSSLLRRKMLPKSSFLI
                     SATPETFEKMEGRVECTNVKIVTGFNESNIKMYFRSLFQDKTKTQEIFSLVKENQQLF
                     TVCQVPVLCWMVATCLKKEIEKGRDLVSVCRRTTSLYTTHIFNLFIPQSAQYPSKESQ
                     AQLQSLCSLAAEGMWTDTFVFGEEALRRNGIMDSDIPTLLDVRILEKSKKSEKSYIFL
                     HPSIQEVCAAIFYLLKSHMDHPSQDVKSIEALIFTFLKKVKVQWIFFGSFIFGLLHES
                     EQKKLEAFFGHQLSQEIKRQLYQCLETISGNEELQEQVDGMKLFYCLFEMDDEAFLAQ
                     AMNCMEQINFVAKDYSDVIVAAHCLQHCSTLKKLSLSTQNVLSEGQEHSYTEKLLMCW
                     HHMCSVLISSKDIYILQVKNTNLNETASLVLYSHLMYPSCTLKALVVNNVTFLCDNRL
                     FFELIQNQCLQHLDLNLTFLSHGDVKLLCDVLSQEECNIEKLMVAACNLSPDDCKVFA
                     SVLISSKMLKHLNLSSNNLDKGISSLSKALCHPDCVLKNLVLVNCSLSEQCWDYLSEV
                     LRRNKTLNHLDISSNDLKDEGLKVLCGALSLPDSVLKSLSVRYCLITTSGCQDLAEVL
                     RKNQNLRNLQVSNNKIEDAGVKLLCDAIKHPNCHLENIGLEACALTGACCEDLASAFT
                     HCKTLWGINLQENALDHSGLIVLFEALKQQQCTLHVLGLRITDFDKETQELLMAEEEK
                     NPHLSILSSV"
     exon            405..1977
                     /gene="Nlrp4c"
                     /gene_synonym="Nalp-alpha; Nalp4c; Rnh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2136
                     /gene="Nlrp4c"
                     /gene_synonym="Nalp-alpha; Nalp4c; Rnh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2301
                     /gene="Nlrp4c"
                     /gene_synonym="Nalp-alpha; Nalp4c; Rnh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2469
                     /gene="Nlrp4c"
                     /gene_synonym="Nalp-alpha; Nalp4c; Rnh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2640
                     /gene="Nlrp4c"
                     /gene_synonym="Nalp-alpha; Nalp4c; Rnh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2811
                     /gene="Nlrp4c"
                     /gene_synonym="Nalp-alpha; Nalp4c; Rnh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2982
                     /gene="Nlrp4c"
                     /gene_synonym="Nalp-alpha; Nalp4c; Rnh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2983..3614
                     /gene="Nlrp4c"
                     /gene_synonym="Nalp-alpha; Nalp4c; Rnh2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3587..3592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nlrp4c"
                     /gene_synonym="Nalp-alpha; Nalp4c; Rnh2"
                     /note="putative"
     polyA_site      3606
                     /gene="Nlrp4c"
                     /gene_synonym="Nalp-alpha; Nalp4c; Rnh2"
                     /note="putative"
ORIGIN      
        1 agacctttct gcccagttcc agctgccatg tattaaggac taacctggaa gccccagggc
       61 gatcccatca gtttcttact cctgatattc atctctctga agaggcatct ctcttcctta
      121 agacacaatg gcttcttttt tttctgattt tggccttatg tggtacttag aagagctaaa
      181 caagaaagaa ttcatgaagt ttaaggaatt cctcaaacag gagattttgc agttgagact
      241 gaaacagatt tcttggaccg aagtgaagaa ggcatctcgt gaagaccttg ccaacttact
      301 gttgaaacat tatgaggaga agaaagcctg ggatatgacc ttcaaaatct tccagaagat
      361 gaataggaag gatctcatgg agagggcagg aagagagatt gctggacact caaagttata
      421 tcaagctcat ttgaagaaga agctgaccca tgattatgcc agaaagttta acatcaaagt
      481 tcaagatttc tctaagcaga aatttaccca ggatgactat gatcgttttg agaactttct
      541 tatatcaaag gtgactgcaa agaaaccaca catggtgttc ctgcaaggag cagcgggaat
      601 tggcaagtca ttgatgttga caaaattaat gcttgcctgg tcagaaggca tggtgtttca
      661 gaacaaattc tcctatatct tctacttctg ctgtcaagat gtgaagaaga tgaagagagc
      721 aagcctggca gaattgatct ccaaagagtg gcccaaaacc tcagctccca tagaggatat
      781 cctatcccaa ccggagaaac tcttatttgt catcgacaac ttggaagtga tggaatgtga
      841 tatgtctgaa cgggagtcgg agctgtgtga tacctgcacg gagaagcagc cagtgcgtat
      901 cctgctgagc agtttgctca ggaggaagat gctccccaaa tcctctttcc tcatctctgc
      961 taccccagag acttttgaga aaatggaggg cagggttgag tgcacaaatg tgaaaatagt
     1021 aacaggattc aatgagagca atattaagat gtatttccgc agcttgttcc aagataagac
     1081 caaaacacag gaaatcttca gtttggtgaa agaaaaccag cagctgttca ctgtatgtca
     1141 ggtccctgtg ctctgctgga tggtggccac ttgtctaaaa aaagagatag agaagggaag
     1201 agacctggtc tctgtctgcc gacgtaccac ttccctgtat accactcaca tcttcaattt
     1261 gttcattccc caaagtgccc aatatccaag taaggaaagc caagctcagc ttcagagctt
     1321 gtgttctctg gccgctgagg gtatgtggac tgacacattt gtgtttggtg aggaggctct
     1381 cagaagaaat gggatcatgg actccgacat ccccacactg ctggacgtaa ggatccttga
     1441 gaagagcaag aaatctgaaa aatcttacat tttcctccac ccgtctatcc aggaggtctg
     1501 tgcagccatc ttttatctgc taaagagcca catggaccac cctagccagg atgttaaaag
     1561 tatagaggca ctcatattta catttctaaa gaaagtcaaa gtacagtgga ttttttttgg
     1621 ctctttcatc tttggccttt tacatgaatc agaacaaaaa aagctagagg cattttttgg
     1681 ccaccagttg tcccaggaaa taaaacgtca gttgtatcag tgcctggaaa ccataagtgg
     1741 caacgaagag cttcaagaac aggtagatgg catgaagctg ttttactgtc tgtttgagat
     1801 ggacgatgaa gccttcttag cacaagcaat gaactgtatg gaacagatta actttgtggc
     1861 taaggattat tctgatgtta ttgttgctgc ccactgctta caacactgtt ctacactgaa
     1921 gaaactatcc ttgtcaaccc agaatgtcct gagtgaaggt caagaacaca gctatacgga
     1981 aaagctactc atgtgttggc atcatatgtg ctctgtgctc ataagcagta aggacatcta
     2041 catactccaa gtgaaaaaca ctaatctcaa tgaaacagcc tctttggtgt tatatagtca
     2101 tctgatgtac cccagctgca cccttaaagc acttgtggta aataatgtga ccttcctatg
     2161 tgataaccgc ctgttctttg agttgattca gaaccagtgt ttgcagcact tggacctcaa
     2221 cctcacattc ctgtcccatg gtgatgtgaa actgttgtgt gatgtcttga gccaggaaga
     2281 gtgcaacata gaaaagctga tggtagcagc ctgtaacctt tcaccagatg actgcaaggt
     2341 ctttgcctcc gttctgatca gcagcaagat gttaaagcat cttaatttgt catctaacaa
     2401 cttggacaaa gggatatcct ctctgtccaa ggctttgtgc cacccagact gcgttctgaa
     2461 gaacttggtg ttagtcaact gctccctcag tgagcaatgt tgggactacc tttcggaagt
     2521 tcttaggcgg aacaaaacac tgaaccacct agacatcagc tccaatgacc tgaaggatga
     2581 agggctgaag gttctctgtg gggctctgag tctcccagac agtgtcctga agtcactaag
     2641 tgtaagatat tgtctcatca ccactagtgg ttgccaggac ctggctgaag tcttgaggaa
     2701 gaaccagaac ctgaggaacc tacaggtttc aaacaataaa atagaagatg ctggtgtgaa
     2761 gctcctgtgt gatgctataa aacatcccaa ctgccactta gagaatattg gattggaagc
     2821 ctgcgcacta actggtgcct gctgtgagga ccttgcttct gcttttaccc actgtaagac
     2881 cctgtgggga atcaacctgc aggagaacgc cttggaccac agtggattga ttgtactgtt
     2941 tgaggctctg aaacagcaac agtgtaccct gcatgtactt ggacttcgaa ttactgactt
     3001 tgataaggaa acccaggagc tcctgatggc tgaggaagag aaaaacccac acttgagcat
     3061 cctaagcagt gtgtaaggca gaagcagaaa acaaaggtgg atgttctgct gcaagaaaca
     3121 tggctgtgtt ctgacctcaa actacctcca aaagaaagag agcaggatcc ttaatttggc
     3181 ccattatata caaaaattac aggtcactaa cattccaatg agatacatac agtttcttta
     3241 cctccccccc ccccattcag atgtgttttg caagatagat gtgacttttt gtttgcacta
     3301 cagattcaaa caggccattc aaagacagtt atggtaaaat gtctgccata taatgacagt
     3361 ttttcccaca cttgtattct aagcatacaa taaagtcttt aaatgtatct ttacttttaa
     3421 agataaaagt atctttagaa atcccttaag aagagatttg cctgttggtg gattactggg
     3481 cctataatgt cggtccaggc aatgatggtg ccccacaaag ttctttagag aaatggacaa
     3541 aggttgggga aatgatgatg gaaactgttg ctgttttgtg ttttttatta aataataaat
     3601 ttaggcattt tcta
//
