LOCUS       NM_172896               3792 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus NLR family, pyrin domain containing 4A (Nlrp4a),
            transcript variant 1, mRNA.
ACCESSION   NM_172896
VERSION     NM_172896.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3792)
  AUTHORS   Madissoon,E., Tohonen,V., Vesterlund,L., Katayama,S., Unneberg,P.,
            Inzunza,J., Hovatta,O. and Kere,J.
  TITLE     Differences in gene expression between mouse and human for
            dynamically regulated genes in early embryo
  JOURNAL   PLoS One 9 (8), e102949 (2014)
   PUBMED   25089626
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3792)
  AUTHORS   Joshi,S., Davies,H., Sims,L.P., Levy,S.E. and Dean,J.
  TITLE     Ovarian gene expression in the absence of FIGLA, an oocyte-specific
            transcription factor
  JOURNAL   BMC Dev Biol 7, 67 (2007)
   PUBMED   17567914
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3792)
  AUTHORS   Dade,S., Callebaut,I., Paillisson,A., Bontoux,M., Dalbies-Tran,R.
            and Monget,P.
  TITLE     In silico identification and structural features of six new genes
            similar to MATER specifically expressed in the oocyte
  JOURNAL   Biochem Biophys Res Commun 324 (2), 547-553 (2004)
   PUBMED   15474461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132428.3.
            
            On Mar 31, 2023 this sequence version replaced NM_172896.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY355341.1, AK087843.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC132428.3         105641-105785
            146-245             AC132428.3         106414-106513
            246-584             AC132428.3         114678-115016
            585-2157            AC132428.3         119775-121347
            2158-2316           AC132428.3         123885-124043
            2317-2481           AC132428.3         124563-124727
            2482-2649           AC132428.3         127554-127721
            2650-2820           AC132428.3         130167-130337
            2821-2991           AC132428.3         132970-133140
            2992-3162           AC132428.3         134622-134792
            3163-3792           AC132428.3         145574-146203
FEATURES             Location/Qualifiers
     source          1..3792
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 14.78 cM"
     gene            1..3792
                     /gene="Nlrp4a"
                     /gene_synonym="E330021B02; E330028A19Rik; Nalp-eta;
                     Nalp-ita; NALP4; Nalp4a"
                     /note="NLR family, pyrin domain containing 4A"
                     /db_xref="GeneID:243880"
                     /db_xref="MGI:MGI:2443697"
     exon            1..145
                     /gene="Nlrp4a"
                     /gene_synonym="E330021B02; E330028A19Rik; Nalp-eta;
                     Nalp-ita; NALP4; Nalp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            146..245
                     /gene="Nlrp4a"
                     /gene_synonym="E330021B02; E330028A19Rik; Nalp-eta;
                     Nalp-ita; NALP4; Nalp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            246..584
                     /gene="Nlrp4a"
                     /gene_synonym="E330021B02; E330028A19Rik; Nalp-eta;
                     Nalp-ita; NALP4; Nalp4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..3256
                     /gene="Nlrp4a"
                     /gene_synonym="E330021B02; E330028A19Rik; Nalp-eta;
                     Nalp-ita; NALP4; Nalp4a"
                     /note="NACHT, leucine rich repeat and PYD containing 4A;
                     NACHT/LRR/pyrin domain-containing protein 4"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein
                     4A"
                     /protein_id="NP_766484.1"
                     /db_xref="CCDS:CCDS21003.1"
                     /db_xref="GeneID:243880"
                     /db_xref="MGI:MGI:2443697"
                     /translation="MASFFSDFGLMWYLEELNKKEFVKFKEFLKQEVLQLGLKQVSWT
                     EVKKASRQDLASLLLKHYEEKPAWDMTFRFFQKINRKDLIERAKREIDGCPKLYRAHM
                     KTKMTHDSSRAFTISIQNFLKEKFTEDDYDCFENLFQSKGTESKPQVVFLSGGAGVGK
                     TLMLKRLMLAWIESPVFLHKFSYIFYFCCREVKQLKTASLAELISREWPGPSAPIEEI
                     LSKPEKLLFIIDSLEGMECDLFKWESELCDNCTEKQPVNVLLSSLLRRKMLPESSLLI
                     SATPESFEKMENRIEYTHVKIIKGLKERNIKMSFHRLFQDRNRAHEAFSLVRENEQLF
                     TVCQVPVLCWMVATCLKEEIEKGRDPVSICRCTTSLYTTHIFNLFIPQNAHSPSKKSQ
                     DQLQGLCSLAAEGMWTDTFVFGEEALRRNGIMDSDIPILLDIGMLINIRESEKSYIFL
                     HPSVQEVCAAIFYLLKSHVDHPSQEVKSIEKLMFAFLKKVKVQWIFFGSFIFGLLHES
                     EQKKLEAFFGHQLSQEIKRQLYQCLETISGNEELQEQIDGMKLFYCLFEMDDDTFLVE
                     AMNCMEQINFVAKDYSDVIVAAHCLKHCFTLKKLSFSTQNVLSGAQEHSYMERLLTAW
                     NHICSVFIISKDIQELRMKDTNLSESAFSVLYNNLKYHNYTLNVLVANNVFFVCEKYL
                     FFELIQNCNLQHLNLSLTILSHSDVKLLCDVLSQAECNIEELVVAACSISSDDCKVFA
                     SVLISNKTLKHLNLASNTLDKGIASLCKSLCHPDCILEHLVLANCSLNEKCWDYLSEV
                     LRRNKTLSHLDISSNDLKDEGLKVLCRALTLPDSVLKSLSLRHCLITISGCQDLAEVL
                     RNNQNLVSLQVSNNKLEDTGVKLLCDAIKHPNCHLEDLGLEACELTGACCEDLASTFT
                     QCKTLWAMNLLKNALDYNGLVVLCEALKQQTCATYVLGLQITDFDTETQAFLVAEQEK
                     NPCLRILSSL"
     exon            585..2157
                     /gene="Nlrp4a"
                     /gene_synonym="E330021B02; E330028A19Rik; Nalp-eta;
                     Nalp-ita; NALP4; Nalp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2316
                     /gene="Nlrp4a"
                     /gene_synonym="E330021B02; E330028A19Rik; Nalp-eta;
                     Nalp-ita; NALP4; Nalp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2481
                     /gene="Nlrp4a"
                     /gene_synonym="E330021B02; E330028A19Rik; Nalp-eta;
                     Nalp-ita; NALP4; Nalp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2649
                     /gene="Nlrp4a"
                     /gene_synonym="E330021B02; E330028A19Rik; Nalp-eta;
                     Nalp-ita; NALP4; Nalp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2820
                     /gene="Nlrp4a"
                     /gene_synonym="E330021B02; E330028A19Rik; Nalp-eta;
                     Nalp-ita; NALP4; Nalp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2991
                     /gene="Nlrp4a"
                     /gene_synonym="E330021B02; E330028A19Rik; Nalp-eta;
                     Nalp-ita; NALP4; Nalp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2992..3162
                     /gene="Nlrp4a"
                     /gene_synonym="E330021B02; E330028A19Rik; Nalp-eta;
                     Nalp-ita; NALP4; Nalp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3163..3792
                     /gene="Nlrp4a"
                     /gene_synonym="E330021B02; E330028A19Rik; Nalp-eta;
                     Nalp-ita; NALP4; Nalp4a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3773..3778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nlrp4a"
                     /gene_synonym="E330021B02; E330028A19Rik; Nalp-eta;
                     Nalp-ita; NALP4; Nalp4a"
                     /note="hexamer: ATTAAA"
     polyA_site      3792
                     /gene="Nlrp4a"
                     /gene_synonym="E330021B02; E330028A19Rik; Nalp-eta;
                     Nalp-ita; NALP4; Nalp4a"
                     /note="major polyA site"
ORIGIN      
        1 aggaagcgcc ttagtaatca tagttagaac ttgaaattta ggcacaagtg ttgtacacac
       61 ttgcaatcct agcattccag attctgagag tagaggagcc tgatttccat cccagcctga
      121 actaactgga tcaagacgga ctgaggaaaa caaaaatcat tacttgtcca aatcctccaa
      181 ctcttgcttc agctggatcc acagacaatc ctagcgactt tatctggctg tttttcgact
      241 ttgaaatcct gttttttaat cctgatactc atctctctga agacgagtct atcttcctta
      301 agacacaatg gcatctttct tttctgattt tggccttatg tggtacttgg aagagctaaa
      361 caagaaggaa ttcgtaaagt ttaaggagtt cctcaaacag gaggttttgc agttgggcct
      421 gaaacaggtt tcttggacag aagtgaagaa ggcatctcgg caagaccttg ccagcttact
      481 gttgaaacat tatgaagaga agccagcctg ggatatgacc ttcagatttt tccagaagat
      541 caacaggaag gatctcatag agagagcaaa aagagagatt gatggatgcc caaagttata
      601 tcgagctcat atgaagacca agatgaccca tgacagttcc agagcattca ctattagtat
      661 tcagaatttt ttaaaggaga aatttactga ggatgactat gattgttttg agaacctttt
      721 ccaatcaaag ggcactgaat caaagccaca ggtggtgttc ctgagtggtg gtgctggagt
      781 tggcaagaca ctgatgttga agaggttaat gctggcctgg atagaaagcc cagtgtttct
      841 gcacaaattc tcctacatct tctacttctg ctgtcgagaa gtgaagcagt tgaagacagc
      901 tagcctggct gaattgatct ccagagaatg gcctggcccc tcagctccca tagaggagat
      961 actatccaaa cctgagaaac tcttatttat catcgacagc ttagaaggga tggaatgtga
     1021 tttgttcaaa tgggaatcag agctgtgtga taactgtaca gagaagcagc cagtgaatgt
     1081 actgctgagc agtttgctca ggaggaagat gctccctgaa tcctctctcc tcatctctgc
     1141 taccccagag agttttgaaa aaatggagaa caggattgaa tacacacatg tgaaaataat
     1201 aaagggactt aaggagagaa atattaagat gagtttccac agattattcc aagataggaa
     1261 cagagcccat gaagccttca gtctggtgag agaaaatgag cagctgttca ctgtatgtca
     1321 ggtccctgtg ctctgctgga tggtggctac ttgtctaaaa gaagagatag agaagggaag
     1381 agacccagtc tccatttgcc gttgtactac ctccctgtat accactcaca tcttcaattt
     1441 gttcattccc caaaatgccc attctccaag taagaaaagc caagaccagc tgcagggctt
     1501 atgttctctg gccgctgagg gcatgtggac tgacacgttt gtgtttggtg aggaggctct
     1561 caggagaaat gggatcatgg actctgacat ccccatacta ctggacattg gaatgcttat
     1621 aaatatcagg gaatctgaaa aatcttatat atttctccat ccatctgttc aggaggtctg
     1681 tgcagctatc ttttatctgc taaagagcca cgtggaccac cctagccagg aggttaaaag
     1741 tatagagaaa ctcatgtttg catttctaaa gaaagtcaaa gtacagtgga ttttctttgg
     1801 ctctttcatc tttggccttt tacatgaatc agaacaaaaa aagctagagg cgttttttgg
     1861 ccaccagttg tcccaagaaa taaaacgtca gttgtatcag tgcctggaaa ctataagtgg
     1921 caacgaagag cttcaagaac agatagatgg catgaagctg ttttactgtc tgtttgagat
     1981 ggacgatgac accttcttag tagaagctat gaactgtatg gaacagatta actttgtggc
     2041 taaggattat tctgatgtta ttgttgctgc ccactgctta aaacactgtt ttacactgaa
     2101 gaaactatcc ttttcaaccc agaatgtcct gagtggagct caagaacaca gctatatgga
     2161 aaggctgctc actgcttgga atcatatttg ctctgtgttc ataatcagta aggacattca
     2221 ggaactccga atgaaagaca ctaatctcag tgaatcagcc ttttcagtct tgtataataa
     2281 tttgaagtac cacaactaca cccttaacgt tcttgtggca aataatgtgt tcttcgtatg
     2341 tgaaaagtac ctgttctttg agttgattca gaactgcaat ttacagcact tgaacctcag
     2401 cctcacaatt ctctcccaca gtgatgtgaa actgttgtgt gatgtcttga gccaggcaga
     2461 gtgcaacata gaagaacttg tggtagcagc ttgtagtatt tcatctgatg actgcaaggt
     2521 gtttgcctct gtcctgatca gcaacaagac cttgaagcat cttaatttgg catccaacac
     2581 cttggacaaa ggaatagcct cactgtgcaa gtctttgtgc cacccagact gcattctcga
     2641 gcacttagtt ttggccaact gctccctcaa tgagaaatgc tgggattacc tttcagaagt
     2701 tcttaggcgg aacaaaacct tgagccacct agacatcagc tccaatgacc tgaaggatga
     2761 agggctgaag gttctctgta gggctctgac tctcccagac agtgtcctga agtcactaag
     2821 tttgagacat tgtctcatca ccattagtgg ttgccaggac ctggctgaag tcttgaggaa
     2881 caaccagaac ctggtcagcc tacaagtttc gaacaataaa ctagaagaca ctggtgtgaa
     2941 gctgctgtgt gatgctataa aacatcccaa ctgccactta gaggatcttg ggttggaagc
     3001 ctgtgagcta actggtgcct gttgtgagga ccttgcatct acatttactc agtgtaagac
     3061 tctgtgggca atgaacctac tgaagaatgc cttggactac aatgggttgg ttgtcctgtg
     3121 tgaagctttg aaacagcaaa catgtgccac atacgtactt ggattgcaaa ttactgactt
     3181 tgatactgaa acccaggcat ttctggttgc tgaacaagag aaaaatccat gcttgcgcat
     3241 cctaagcagt ctgtaagcag aagcagagaa caaggatgga aattctggtg caagaaccat
     3301 gggtgtattg gacctcaaac aacctccaaa aaaagaaagc aagatcatta ttttggtcca
     3361 ctgtaaacaa atcttataga taaataacat tctaatatga tatgatttct ttgtaccaca
     3421 tttagatgtg tcttgcaaga tagatgtggc tttttgtttg tacttcatat tcaaacaggc
     3481 cattcaaaga cattcatgct aaaatagctg gcttataatg acattttaat ttccatactg
     3541 gtatcctgaa tacctaataa agtgttaagt atctttaagt agtggtatgg aaatttccta
     3601 aaatgaaatt taccttttag tagattactg gagccataga gtaggtccaa gcagtagtgg
     3661 taccctaaaa gattgttggg gaagttttaa tgagctatgc atgagaagac tttagcagag
     3721 gccctagact ggacactcag atcatggaaa ctgttgccgt tttttgttct ttattaaatt
     3781 ataatttatg ca
//
