LOCUS       NM_145827               4033 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus NLR family, pyrin domain containing 3 (Nlrp3),
            transcript variant 1, mRNA.
ACCESSION   NM_145827 XM_917697
VERSION     NM_145827.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4033)
  AUTHORS   Wright,S.S., Kumari,P., Fraile-Agreda,V., Wang,C., Shivcharan,S.,
            Kappelhoff,S., Margheritis,E.G., Matz,A., Vasudevan,S.O., Rubio,I.,
            Bauer,M., Zhou,B., Vanaja,S.K., Cosentino,K., Ruan,J. and
            Rathinam,V.A.
  TITLE     Transplantation of gasdermin pores by extracellular vesicles
            propagates pyroptosis to bystander cells
  JOURNAL   Cell 188 (2), 280-291 (2025)
   PUBMED   39742811
REFERENCE   2  (bases 1 to 4033)
  AUTHORS   Saller,B.S., Wohrle,S., Fischer,L., Dufossez,C., Ingerl,I.L.,
            Kessler,S., Mateo-Tortola,M., Gorka,O., Lange,F., Cheng,Y.,
            Neuwirt,E., Marada,A., Koentges,C., Urban,C., Aktories,P.,
            Reuther,P., Giese,S., Kirschnek,S., Mayer,C., Pilic,J.,
            Falquez-Medina,H., Oelgeklaus,A., Deepagan,V.G., Shojaee,F.,
            Zimmermann,J.A., Weber,D., Tai,Y.H., Crois,A., Ciminski,K.,
            Peyronnet,R., Brandenburg,K.S., Wu,G., Baumeister,R.,
            Heimbucher,T., Rizzi,M., Riedel,D., Helmstadter,M., Buescher,J.,
            Neumann,K., Misgeld,T., Kerschensteiner,M., Walentek,P., Kreutz,C.,
            Maurer,U., Rambold,A.S., Vince,J.E., Edlich,F., Malli,R.,
            Hacker,G., Kierdorf,K., Meisinger,C., Kottgen,A., Jakobs,S.,
            Weber,A.N.R., Schwemmle,M., Gross,C.J. and Gross,O.
  TITLE     Acute suppression of mitochondrial ATP production prevents
            apoptosis and provides an essential signal for NLRP3 inflammasome
            activation
  JOURNAL   Immunity 58 (1), 90-107 (2025)
   PUBMED   39571574
REFERENCE   3  (bases 1 to 4033)
  AUTHORS   Wang,Y., Zhang,Y., Kim,K., Han,J., Okin,D., Jiang,Z., Yang,L.,
            Subramaniam,A., Means,T.K., Nestle,F.O., Fitzgerald,K.A.,
            Randolph,G.J., Lesser,C.F., Kagan,J.C., Mathis,D. and Benoist,C.
  TITLE     A pan-family screen of nuclear receptors in immunocytes reveals
            ligand-dependent inflammasome control
  JOURNAL   Immunity 57 (12), 2737-2754 (2024)
   PUBMED   39571575
REFERENCE   4  (bases 1 to 4033)
  AUTHORS   Maeda,T., Shirakami,Y., Taguchi,D., Miwa,T., Kubota,M., Sakai,H.,
            Ibuka,T., Mori,K., Tomita,H. and Shimizu,M.
  TITLE     Glyburide Suppresses Inflammation-Related Colorectal Tumorigenesis
            Through Inhibition of NLRP3 Inflammasome
  JOURNAL   Int J Mol Sci 25 (21), 11640 (2024)
   PUBMED   39519191
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4033)
  AUTHORS   Zhang,Z., Li,M., Li,X., Feng,Z., Luo,G., Wang,Y. and Gao,X.
  TITLE     Glutamine metabolism modulates microglial NLRP3 inflammasome
            activity through mitophagy in Alzheimer's disease
  JOURNAL   J Neuroinflammation 21 (1), 261 (2024)
   PUBMED   39407211
  REMARK    GeneRIF: Glutamine metabolism modulates microglial NLRP3
            inflammasome activity through mitophagy in Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4033)
  AUTHORS   Martinon,F., Petrilli,V., Mayor,A., Tardivel,A. and Tschopp,J.
  TITLE     Gout-associated uric acid crystals activate the NALP3 inflammasome
  JOURNAL   Nature 440 (7081), 237-241 (2006)
   PUBMED   16407889
  REMARK    GeneRIF: Macrophages deficient in various components of the
            inflammasome such as caspase-1, ASC and NALP3 are defective in
            crystal-induced IL-1beta activation; insight into the molecular
            processes underlying the inflammatory conditions of gout and
            pseudogout
REFERENCE   7  (bases 1 to 4033)
  AUTHORS   Kanneganti,T.D., Ozoren,N., Body-Malapel,M., Amer,A., Park,J.H.,
            Franchi,L., Whitfield,J., Barchet,W., Colonna,M., Vandenabeele,P.,
            Bertin,J., Coyle,A., Grant,E.P., Akira,S. and Nunez,G.
  TITLE     Bacterial RNA and small antiviral compounds activate caspase-1
            through cryopyrin/Nalp3
  JOURNAL   Nature 440 (7081), 233-236 (2006)
   PUBMED   16407888
  REMARK    GeneRIF: results reveal a critical role for cryopyrin (Cias1)in
            host defence through bacterial RNA-mediated activation of
            caspase-1, and provide insights regarding the pathogenesis of
            autoinflammatory syndromes
REFERENCE   8  (bases 1 to 4033)
  AUTHORS   Anderson,J.P., Mueller,J.L., Rosengren,S., Boyle,D.L., Schaner,P.,
            Cannon,S.B., Goodyear,C.S. and Hoffman,H.M.
  TITLE     Structural, expression, and evolutionary analysis of mouse CIAS1
  JOURNAL   Gene 338 (1), 25-34 (2004)
   PUBMED   15302403
  REMARK    GeneRIF: CIAS1 mRNA expression found primarily in peripheral blood
            leukocytes consistent with the postulated inflammatory function.
REFERENCE   9  (bases 1 to 4033)
  AUTHORS   Kikuchi-Yanoshita,R., Taketomi,Y., Koga,K., Sugiki,T., Atsumi,Y.,
            Saito,T., Ishii,S., Hisada,M., Suzuki-Nishimura,T., Uchida,M.K.,
            Moon,T.C., Chang,H.W., Sawada,M., Inagaki,N., Nagai,H., Murakami,M.
            and Kudo,I.
  TITLE     Induction of PYPAF1 during in vitro maturation of mouse mast cells
  JOURNAL   J Biochem 134 (5), 699-709 (2003)
   PUBMED   14688236
  REMARK    GeneRIF: MMIG-1, a likely mouse PYPAF1 ortholog, may play a role in
            mast cell-directed inflammatory diseases
REFERENCE   10 (bases 1 to 4033)
  AUTHORS   Albrecht,M., Domingues,F.S., Schreiber,S. and Lengauer,T.
  TITLE     Identification of mammalian orthologs associates PYPAF5 with
            distinct functional roles
  JOURNAL   FEBS Lett 538 (1-3), 173-177 (2003)
   PUBMED   12633874
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592522.12, BY722759.1, AY337285.1 and AW121591.1.
            
            On Jan 13, 2018 this sequence version replaced NM_145827.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY495376.1, BC116174.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AL592522.12        67058-67142         c
            86-214              BY722759.1         1-129
            215-3330            AY337285.1         1-3116
            3331-3723           AL592522.12        43170-43562         c
            3724-4033           AW121591.1         1-310               c
FEATURES             Location/Qualifiers
     source          1..4033
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.73 cM"
     gene            1..4033
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /note="NLR family, pyrin domain containing 3"
                     /db_xref="GeneID:216799"
                     /db_xref="MGI:MGI:2653833"
     exon            1..182
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            183..503
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..3328
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /note="cryopyrin; NACHT/LRR/pyrin domain-containing
                     protein 3; PYRIN-containing APAF1-like protein 1; cold
                     autoinflammatory syndrome 1 protein homolog; mast cell
                     maturation-associated-inducible protein 1"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 3"
                     /protein_id="NP_665826.1"
                     /db_xref="CCDS:CCDS24771.1"
                     /db_xref="GeneID:216799"
                     /db_xref="MGI:MGI:2653833"
                     /translation="MTSVRCKLAQYLEDLEDVDLKKFKMHLEDYPPEKGCIPVPRGQM
                     EKADHLDLATLMIDFNGEEKAWAMAVWIFAAINRRDLWEKAKKDQPEWNDTCTSHSSM
                     VCQEDSLEEEWMGLLGYLSRISICKKKKDYCKMYRRHVRSRFYSIKDRNARLGESVDL
                     NSRYTQLQLVKEHPSKQEREHELLTIGRTKMRDSPMSSLKLELLFEPEDGHSEPVHTV
                     VFQGAAGIGKTILARKIMLDWALGKLFKDKFDYLFFIHCREVSLRTPRSLADLIVSCW
                     PDPNPPVCKILRKPSRILFLMDGFDELQGAFDEHIGEVCTDWQKAVRGDILLSSLIRK
                     KLLPKASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSNELQAREAF
                     RLIQENEVLFTMCFIPLVCWIVCTGLKQQMETGKSLAQTSKTTTAVYVFFLSSLLQSR
                     GGIEEHLFSDYLQGLCSLAADGIWNQKILFEECDLRKHGLQKTDVSAFLRMNVFQKEV
                     DCERFYSFSHMTFQEFFAAMYYLLEEEAEGETVRKGPGGCSDLLNRDVKVLLENYGKF
                     EKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQVRLELLKWIEVKAKAKKLQWQPS
                     QLELFYCLYEMQEEDFVQSAMDHFPKIEINLSTRMDHVVSSFCIKNCHRVKTLSLGFF
                     HNSPKEEEEERRGGRPLDQVQCVFPDTHVACSSRLVNCCLTSSFCRGLFSSLSTNRSL
                     TELDLSDNTLGDPGMRVLCEALQHPGCNIQRLWLGRCGLSHQCCFDISSVLSSSQKLV
                     ELDLSDNALGDFGIRLLCVGLKHLLCNLQKLWLVSCCLTSACCQDLALVLSSNHSLTR
                     LYIGENALGDSGVQVLCEKMKDPQCNLQKLGLVNSGLTSICCSALTSVLKTNQNFTHL
                     YLRSNALGDTGLRLLCEGLLHPDCKLQMLELDNCSLTSHSCWNLSTILTHNHSLRKLN
                     LGNNDLGDLCVVTLCEVLKQQGCLLQSLQLGEMYLNRETKRALEALQEEKPELTIVFE
                     ISW"
     exon            504..617
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..2373
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2544
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2715
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2886
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..3057
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3228
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3229..4020
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3996..4001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /note="hexamer: AATAAA"
     polyA_site      4020
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /note="major polyA site"
ORIGIN      
        1 ccaggtccta gcctcgtcac catgggttct ggtcagacac gagtcctggt gactttgtat
       61 atgcgtgttc tctgtatacc acatctgatt gtgttaatgg ctttcttatt tttatctcta
      121 cagaggaact tttcttccat ggctcaggac atacgtctgg atcaagctaa gagaactttc
      181 tgtgtggacc taagccccga gaccctcgaa agggctgctg ctgaagatga cgagtgtccg
      241 ttgcaagctg gctcagtatc tagaggacct tgaagatgtg gacctcaaga aattcaaaat
      301 gcatttggaa gattacccgc ccgagaaagg ctgtatccca gtccccaggg gccagatgga
      361 gaaggcagat cacttggatc tagccacact catgattgac ttcaatggcg aggagaaggc
      421 ctgggccatg gctgtgtgga tctttgctgc gatcaacagg cgagacctct gggaaaaagc
      481 taagaaggac cagccagagt ggaatgacac gtgtacatca cattcctcta tggtatgcca
      541 ggaggacagc cttgaagaag agtggatggg tttgctggga tatctctccc gcatctccat
      601 ttgtaaaaag aagaaagatt actgtaagat gtacagacga catgtgagaa gcaggttcta
      661 ctctatcaag gacaggaacg cgcgtctagg tgagagtgtg gacctcaaca gtcgctacac
      721 gcagctccaa ctggtcaagg agcatccaag caagcaggag cgggagcatg aactcctgac
      781 catcggccgg actaaaatgc gggacagccc catgagttcc cttaagctgg agctgctgtt
      841 tgagcccgag gacgggcact cggagcctgt gcacacagtg gtgttccagg gagcagcagg
      901 catcgggaaa accatcctag ccaggaagat tatgttggac tgggcactgg gaaagctctt
      961 caaagacaaa tttgactatt tgttctttat ccactgccga gaggtgagcc tcaggacgcc
     1021 aaggagtcta gcagacctga ttgtcagctg ctggcctgac ccaaacccac cagtgtgcaa
     1081 gatcctgcgc aagccttcca ggatcctctt cctcatggat ggctttgatg agctacaagg
     1141 ggcctttgac gagcacattg gggaggtctg cacagactgg caaaaggctg tgcggggaga
     1201 cattctgcta agcagcctca tccgaaagaa actgctgccc aaggcctctc tgctcataac
     1261 gacgaggccg gtagccttgg agaaactgca gcatctcctg gaccaccccc gccatgtgga
     1321 gatcctaggt ttctctgagg ccaaaaggaa ggagtatttc tttaagtatt tctccaacga
     1381 gctgcaggcc cgggaggcct tcaggctgat ccaagagaat gaggtcctct ttaccatgtg
     1441 cttcatcccc ctggtctgct ggattgtgtg cacggggcta aagcaacaga tggagaccgg
     1501 gaagagcctg gcccagacct ccaagaccac tacggccgtc tacgtcttct tcctttccag
     1561 cctgctgcaa tcccgggggg gcattgagga gcatctcttc tctgactacc tacaggggct
     1621 ctgttcactg gctgcggatg gaatttggaa ccagaaaatc ctatttgagg agtgtgatct
     1681 gcggaagcac ggcctgcaga agactgacgt ctccgctttc ctgaggatga acgtgttcca
     1741 gaaggaagtg gactgcgaga gattctacag cttcagccac atgactttcc aggagttctt
     1801 cgctgctatg tactatttgc tggaagagga ggcagagggg gagaccgtga ggaaaggacc
     1861 aggaggttgt tcagatcttc tgaaccgaga cgtgaaggtc ctactagaaa attacggcaa
     1921 gtttgaaaaa ggctatctga tttttgttgt ccgattcctc tttggccttg taaaccagga
     1981 gagaacctct tatttggaga agaaactaag ttgcaagatc tctcagcaag tcagactgga
     2041 actactgaag tggattgaag tgaaagccaa ggccaagaag ctgcagtggc agcccagcca
     2101 actggaactg ttctactgcc tgtacgagat gcaggaggaa gactttgtgc agagtgccat
     2161 ggaccacttt cccaaaattg agatcaacct ctctaccaga atggaccacg tggtttcctc
     2221 cttttgtatt aagaactgtc atagggtcaa aacgctttcc ctgggttttt ttcacaactc
     2281 gcccaaggag gaagaagaag agaggagagg aggtcgaccc ttggaccagg ttcagtgtgt
     2341 tttcccagac actcatgttg cctgttcttc cagactggtg aactgctgcc tcacttctag
     2401 cttctgccgt ggtctcttct caagtctaag caccaaccgg agcctcactg aactggacct
     2461 cagtgacaat actctgggag acccgggcat gagggtgctg tgtgaggcac tccagcaccc
     2521 aggctgtaac attcagagac tgtggttggg gcgctgcgga ctgtcccatc aatgctgctt
     2581 cgacatctcc tctgtcctga gcagcagcca gaagctggtg gagctggacc tcagtgacaa
     2641 tgccctgggg gactttggaa tcagattgct gtgtgtggga ctgaagcacc tgctctgcaa
     2701 cctccagaaa ctgtggttgg tgagctgctg tctcacatcc gcgtgttgtc aggatctcgc
     2761 attggttctg agctccaacc attctctgac cagactgtac attggagaaa atgccttggg
     2821 agactcagga gtccaagttt tgtgtgaaaa gatgaaggac ccacagtgta acttgcagaa
     2881 gctggggttg gtgaattccg gccttacttc aatctgttgt tcagctctga cctctgtgct
     2941 caaaaccaac cagaacttca cacacctcta tctacgaagc aatgcccttg gagacacagg
     3001 actcaggctc ctctgtgagg ggcttctgca cccggactgt aaactacaga tgctggaatt
     3061 agacaactgc agcctcacct cacacagctg ctggaatctc tccacaattc tgacccacaa
     3121 ccacagcctt cggaagctga acctgggcaa caatgatctt ggcgatctgt gcgtggtgac
     3181 cctctgtgag gtgctgaaac agcagggctg cctcctgcag agcctacagt tgggtgaaat
     3241 gtacttaaat cgtgaaacaa aacgtgcctt agaagcgctc caggaagaaa agcctgagct
     3301 gactatagtc ttcgagattt cctggtaggc gtggaagcag gaccaccagg tgcctcggtc
     3361 ctgccccaag tcctgcccca agccccagtg cgcactgctc ttcactgcta tcaagccctc
     3421 cttcaccatc aggatcacag ccgaggctct tctggtatag ggtctggagc aaaggcttgt
     3481 gtgggaccaa atatttttcc tcacatcgat aacgtgaaac tgccagaggc tgcccttccc
     3541 atcatatcct cagtgggcaa ggtgttccct cttggtgact tcatggaaac agcttcaaga
     3601 aaacgccttt tctgtcctcc cccgccctcc tcttactcct gcccctcctc ctcctcctcc
     3661 tcccctcccc ccccctcctc ctccgcttct ccccccacct gtctttctct ctctgggcct
     3721 ctggtttttt gacctttgcc cataccttca gtcttgtctt cctgttaact gaccatcccg
     3781 cataaggagc tgcccgtggg ctagatggaa ggtttgtggc agcctctcag ctacattgtt
     3841 tgtttttatt ttttaatagt tatgatttct ctttagctac ctgaaaactc agagatttat
     3901 aaaacccatt tttgtattta ttgtatgttt gtactgcttt cttaatttaa aaatgtatct
     3961 agaattcttt taagttattt atccaaacta ctaaaaataa atcagtttac acatttaaaa
     4021 aaaaaaaaaa aaa
//
