LOCUS       NM_001359638            3945 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus NLR family, pyrin domain containing 3 (Nlrp3),
            transcript variant 2, mRNA.
ACCESSION   NM_001359638
VERSION     NM_001359638.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3945)
  AUTHORS   Wright,S.S., Kumari,P., Fraile-Agreda,V., Wang,C., Shivcharan,S.,
            Kappelhoff,S., Margheritis,E.G., Matz,A., Vasudevan,S.O., Rubio,I.,
            Bauer,M., Zhou,B., Vanaja,S.K., Cosentino,K., Ruan,J. and
            Rathinam,V.A.
  TITLE     Transplantation of gasdermin pores by extracellular vesicles
            propagates pyroptosis to bystander cells
  JOURNAL   Cell 188 (2), 280-291 (2025)
   PUBMED   39742811
REFERENCE   2  (bases 1 to 3945)
  AUTHORS   Saller,B.S., Wohrle,S., Fischer,L., Dufossez,C., Ingerl,I.L.,
            Kessler,S., Mateo-Tortola,M., Gorka,O., Lange,F., Cheng,Y.,
            Neuwirt,E., Marada,A., Koentges,C., Urban,C., Aktories,P.,
            Reuther,P., Giese,S., Kirschnek,S., Mayer,C., Pilic,J.,
            Falquez-Medina,H., Oelgeklaus,A., Deepagan,V.G., Shojaee,F.,
            Zimmermann,J.A., Weber,D., Tai,Y.H., Crois,A., Ciminski,K.,
            Peyronnet,R., Brandenburg,K.S., Wu,G., Baumeister,R.,
            Heimbucher,T., Rizzi,M., Riedel,D., Helmstadter,M., Buescher,J.,
            Neumann,K., Misgeld,T., Kerschensteiner,M., Walentek,P., Kreutz,C.,
            Maurer,U., Rambold,A.S., Vince,J.E., Edlich,F., Malli,R.,
            Hacker,G., Kierdorf,K., Meisinger,C., Kottgen,A., Jakobs,S.,
            Weber,A.N.R., Schwemmle,M., Gross,C.J. and Gross,O.
  TITLE     Acute suppression of mitochondrial ATP production prevents
            apoptosis and provides an essential signal for NLRP3 inflammasome
            activation
  JOURNAL   Immunity 58 (1), 90-107 (2025)
   PUBMED   39571574
REFERENCE   3  (bases 1 to 3945)
  AUTHORS   Wang,Y., Zhang,Y., Kim,K., Han,J., Okin,D., Jiang,Z., Yang,L.,
            Subramaniam,A., Means,T.K., Nestle,F.O., Fitzgerald,K.A.,
            Randolph,G.J., Lesser,C.F., Kagan,J.C., Mathis,D. and Benoist,C.
  TITLE     A pan-family screen of nuclear receptors in immunocytes reveals
            ligand-dependent inflammasome control
  JOURNAL   Immunity 57 (12), 2737-2754 (2024)
   PUBMED   39571575
REFERENCE   4  (bases 1 to 3945)
  AUTHORS   Maeda,T., Shirakami,Y., Taguchi,D., Miwa,T., Kubota,M., Sakai,H.,
            Ibuka,T., Mori,K., Tomita,H. and Shimizu,M.
  TITLE     Glyburide Suppresses Inflammation-Related Colorectal Tumorigenesis
            Through Inhibition of NLRP3 Inflammasome
  JOURNAL   Int J Mol Sci 25 (21), 11640 (2024)
   PUBMED   39519191
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3945)
  AUTHORS   Zhang,Z., Li,M., Li,X., Feng,Z., Luo,G., Wang,Y. and Gao,X.
  TITLE     Glutamine metabolism modulates microglial NLRP3 inflammasome
            activity through mitophagy in Alzheimer's disease
  JOURNAL   J Neuroinflammation 21 (1), 261 (2024)
   PUBMED   39407211
  REMARK    GeneRIF: Glutamine metabolism modulates microglial NLRP3
            inflammasome activity through mitophagy in Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3945)
  AUTHORS   Martinon,F., Petrilli,V., Mayor,A., Tardivel,A. and Tschopp,J.
  TITLE     Gout-associated uric acid crystals activate the NALP3 inflammasome
  JOURNAL   Nature 440 (7081), 237-241 (2006)
   PUBMED   16407889
  REMARK    GeneRIF: Macrophages deficient in various components of the
            inflammasome such as caspase-1, ASC and NALP3 are defective in
            crystal-induced IL-1beta activation; insight into the molecular
            processes underlying the inflammatory conditions of gout and
            pseudogout
REFERENCE   7  (bases 1 to 3945)
  AUTHORS   Kanneganti,T.D., Ozoren,N., Body-Malapel,M., Amer,A., Park,J.H.,
            Franchi,L., Whitfield,J., Barchet,W., Colonna,M., Vandenabeele,P.,
            Bertin,J., Coyle,A., Grant,E.P., Akira,S. and Nunez,G.
  TITLE     Bacterial RNA and small antiviral compounds activate caspase-1
            through cryopyrin/Nalp3
  JOURNAL   Nature 440 (7081), 233-236 (2006)
   PUBMED   16407888
  REMARK    GeneRIF: results reveal a critical role for cryopyrin (Cias1)in
            host defence through bacterial RNA-mediated activation of
            caspase-1, and provide insights regarding the pathogenesis of
            autoinflammatory syndromes
REFERENCE   8  (bases 1 to 3945)
  AUTHORS   Anderson,J.P., Mueller,J.L., Rosengren,S., Boyle,D.L., Schaner,P.,
            Cannon,S.B., Goodyear,C.S. and Hoffman,H.M.
  TITLE     Structural, expression, and evolutionary analysis of mouse CIAS1
  JOURNAL   Gene 338 (1), 25-34 (2004)
   PUBMED   15302403
  REMARK    GeneRIF: CIAS1 mRNA expression found primarily in peripheral blood
            leukocytes consistent with the postulated inflammatory function.
REFERENCE   9  (bases 1 to 3945)
  AUTHORS   Kikuchi-Yanoshita,R., Taketomi,Y., Koga,K., Sugiki,T., Atsumi,Y.,
            Saito,T., Ishii,S., Hisada,M., Suzuki-Nishimura,T., Uchida,M.K.,
            Moon,T.C., Chang,H.W., Sawada,M., Inagaki,N., Nagai,H., Murakami,M.
            and Kudo,I.
  TITLE     Induction of PYPAF1 during in vitro maturation of mouse mast cells
  JOURNAL   J Biochem 134 (5), 699-709 (2003)
   PUBMED   14688236
  REMARK    GeneRIF: MMIG-1, a likely mouse PYPAF1 ortholog, may play a role in
            mast cell-directed inflammatory diseases
REFERENCE   10 (bases 1 to 3945)
  AUTHORS   Albrecht,M., Domingues,F.S., Schreiber,S. and Lengauer,T.
  TITLE     Identification of mammalian orthologs associates PYPAF5 with
            distinct functional roles
  JOURNAL   FEBS Lett 538 (1-3), 173-177 (2003)
   PUBMED   12633874
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592522.12, BY186774.1, AY337285.1 and AW121591.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY495377.1, AF486632.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AL592522.12        68240-68259         c
            21-126              BY186774.1         1-106
            127-3242            AY337285.1         1-3116
            3243-3635           AL592522.12        43170-43562         c
            3636-3945           AW121591.1         1-310               c
FEATURES             Location/Qualifiers
     source          1..3945
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.73 cM"
     gene            1..3945
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /note="NLR family, pyrin domain containing 3"
                     /db_xref="GeneID:216799"
                     /db_xref="MGI:MGI:2653833"
     exon            1..35
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            36..94
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            95..415
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..3240
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /note="cryopyrin; NACHT/LRR/pyrin domain-containing
                     protein 3; PYRIN-containing APAF1-like protein 1; cold
                     autoinflammatory syndrome 1 protein homolog; mast cell
                     maturation-associated-inducible protein 1"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 3"
                     /protein_id="NP_001346567.1"
                     /db_xref="CCDS:CCDS24771.1"
                     /db_xref="GeneID:216799"
                     /db_xref="MGI:MGI:2653833"
                     /translation="MTSVRCKLAQYLEDLEDVDLKKFKMHLEDYPPEKGCIPVPRGQM
                     EKADHLDLATLMIDFNGEEKAWAMAVWIFAAINRRDLWEKAKKDQPEWNDTCTSHSSM
                     VCQEDSLEEEWMGLLGYLSRISICKKKKDYCKMYRRHVRSRFYSIKDRNARLGESVDL
                     NSRYTQLQLVKEHPSKQEREHELLTIGRTKMRDSPMSSLKLELLFEPEDGHSEPVHTV
                     VFQGAAGIGKTILARKIMLDWALGKLFKDKFDYLFFIHCREVSLRTPRSLADLIVSCW
                     PDPNPPVCKILRKPSRILFLMDGFDELQGAFDEHIGEVCTDWQKAVRGDILLSSLIRK
                     KLLPKASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSNELQAREAF
                     RLIQENEVLFTMCFIPLVCWIVCTGLKQQMETGKSLAQTSKTTTAVYVFFLSSLLQSR
                     GGIEEHLFSDYLQGLCSLAADGIWNQKILFEECDLRKHGLQKTDVSAFLRMNVFQKEV
                     DCERFYSFSHMTFQEFFAAMYYLLEEEAEGETVRKGPGGCSDLLNRDVKVLLENYGKF
                     EKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQVRLELLKWIEVKAKAKKLQWQPS
                     QLELFYCLYEMQEEDFVQSAMDHFPKIEINLSTRMDHVVSSFCIKNCHRVKTLSLGFF
                     HNSPKEEEEERRGGRPLDQVQCVFPDTHVACSSRLVNCCLTSSFCRGLFSSLSTNRSL
                     TELDLSDNTLGDPGMRVLCEALQHPGCNIQRLWLGRCGLSHQCCFDISSVLSSSQKLV
                     ELDLSDNALGDFGIRLLCVGLKHLLCNLQKLWLVSCCLTSACCQDLALVLSSNHSLTR
                     LYIGENALGDSGVQVLCEKMKDPQCNLQKLGLVNSGLTSICCSALTSVLKTNQNFTHL
                     YLRSNALGDTGLRLLCEGLLHPDCKLQMLELDNCSLTSHSCWNLSTILTHNHSLRKLN
                     LGNNDLGDLCVVTLCEVLKQQGCLLQSLQLGEMYLNRETKRALEALQEEKPELTIVFE
                     ISW"
     exon            416..529
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..2285
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2456
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2627
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2798
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2969
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3140
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3932
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3908..3913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /note="hexamer: AATAAA"
     polyA_site      3932
                     /gene="Nlrp3"
                     /gene_synonym="AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1;
                     MWS; NALP3; Pypaf1"
                     /note="major polyA site"
ORIGIN      
        1 tttccccttt atttgtaccc aaggctgcta tctggaggaa cttttcttcc atggctcagg
       61 acatacgtct ggatcaagct aagagaactt tctgtgtgga cctaagcccc gagaccctcg
      121 aaagggctgc tgctgaagat gacgagtgtc cgttgcaagc tggctcagta tctagaggac
      181 cttgaagatg tggacctcaa gaaattcaaa atgcatttgg aagattaccc gcccgagaaa
      241 ggctgtatcc cagtccccag gggccagatg gagaaggcag atcacttgga tctagccaca
      301 ctcatgattg acttcaatgg cgaggagaag gcctgggcca tggctgtgtg gatctttgct
      361 gcgatcaaca ggcgagacct ctgggaaaaa gctaagaagg accagccaga gtggaatgac
      421 acgtgtacat cacattcctc tatggtatgc caggaggaca gccttgaaga agagtggatg
      481 ggtttgctgg gatatctctc ccgcatctcc atttgtaaaa agaagaaaga ttactgtaag
      541 atgtacagac gacatgtgag aagcaggttc tactctatca aggacaggaa cgcgcgtcta
      601 ggtgagagtg tggacctcaa cagtcgctac acgcagctcc aactggtcaa ggagcatcca
      661 agcaagcagg agcgggagca tgaactcctg accatcggcc ggactaaaat gcgggacagc
      721 cccatgagtt cccttaagct ggagctgctg tttgagcccg aggacgggca ctcggagcct
      781 gtgcacacag tggtgttcca gggagcagca ggcatcggga aaaccatcct agccaggaag
      841 attatgttgg actgggcact gggaaagctc ttcaaagaca aatttgacta tttgttcttt
      901 atccactgcc gagaggtgag cctcaggacg ccaaggagtc tagcagacct gattgtcagc
      961 tgctggcctg acccaaaccc accagtgtgc aagatcctgc gcaagccttc caggatcctc
     1021 ttcctcatgg atggctttga tgagctacaa ggggcctttg acgagcacat tggggaggtc
     1081 tgcacagact ggcaaaaggc tgtgcgggga gacattctgc taagcagcct catccgaaag
     1141 aaactgctgc ccaaggcctc tctgctcata acgacgaggc cggtagcctt ggagaaactg
     1201 cagcatctcc tggaccaccc ccgccatgtg gagatcctag gtttctctga ggccaaaagg
     1261 aaggagtatt tctttaagta tttctccaac gagctgcagg cccgggaggc cttcaggctg
     1321 atccaagaga atgaggtcct ctttaccatg tgcttcatcc ccctggtctg ctggattgtg
     1381 tgcacggggc taaagcaaca gatggagacc gggaagagcc tggcccagac ctccaagacc
     1441 actacggccg tctacgtctt cttcctttcc agcctgctgc aatcccgggg gggcattgag
     1501 gagcatctct tctctgacta cctacagggg ctctgttcac tggctgcgga tggaatttgg
     1561 aaccagaaaa tcctatttga ggagtgtgat ctgcggaagc acggcctgca gaagactgac
     1621 gtctccgctt tcctgaggat gaacgtgttc cagaaggaag tggactgcga gagattctac
     1681 agcttcagcc acatgacttt ccaggagttc ttcgctgcta tgtactattt gctggaagag
     1741 gaggcagagg gggagaccgt gaggaaagga ccaggaggtt gttcagatct tctgaaccga
     1801 gacgtgaagg tcctactaga aaattacggc aagtttgaaa aaggctatct gatttttgtt
     1861 gtccgattcc tctttggcct tgtaaaccag gagagaacct cttatttgga gaagaaacta
     1921 agttgcaaga tctctcagca agtcagactg gaactactga agtggattga agtgaaagcc
     1981 aaggccaaga agctgcagtg gcagcccagc caactggaac tgttctactg cctgtacgag
     2041 atgcaggagg aagactttgt gcagagtgcc atggaccact ttcccaaaat tgagatcaac
     2101 ctctctacca gaatggacca cgtggtttcc tccttttgta ttaagaactg tcatagggtc
     2161 aaaacgcttt ccctgggttt ttttcacaac tcgcccaagg aggaagaaga agagaggaga
     2221 ggaggtcgac ccttggacca ggttcagtgt gttttcccag acactcatgt tgcctgttct
     2281 tccagactgg tgaactgctg cctcacttct agcttctgcc gtggtctctt ctcaagtcta
     2341 agcaccaacc ggagcctcac tgaactggac ctcagtgaca atactctggg agacccgggc
     2401 atgagggtgc tgtgtgaggc actccagcac ccaggctgta acattcagag actgtggttg
     2461 gggcgctgcg gactgtccca tcaatgctgc ttcgacatct cctctgtcct gagcagcagc
     2521 cagaagctgg tggagctgga cctcagtgac aatgccctgg gggactttgg aatcagattg
     2581 ctgtgtgtgg gactgaagca cctgctctgc aacctccaga aactgtggtt ggtgagctgc
     2641 tgtctcacat ccgcgtgttg tcaggatctc gcattggttc tgagctccaa ccattctctg
     2701 accagactgt acattggaga aaatgccttg ggagactcag gagtccaagt tttgtgtgaa
     2761 aagatgaagg acccacagtg taacttgcag aagctggggt tggtgaattc cggccttact
     2821 tcaatctgtt gttcagctct gacctctgtg ctcaaaacca accagaactt cacacacctc
     2881 tatctacgaa gcaatgccct tggagacaca ggactcaggc tcctctgtga ggggcttctg
     2941 cacccggact gtaaactaca gatgctggaa ttagacaact gcagcctcac ctcacacagc
     3001 tgctggaatc tctccacaat tctgacccac aaccacagcc ttcggaagct gaacctgggc
     3061 aacaatgatc ttggcgatct gtgcgtggtg accctctgtg aggtgctgaa acagcagggc
     3121 tgcctcctgc agagcctaca gttgggtgaa atgtacttaa atcgtgaaac aaaacgtgcc
     3181 ttagaagcgc tccaggaaga aaagcctgag ctgactatag tcttcgagat ttcctggtag
     3241 gcgtggaagc aggaccacca ggtgcctcgg tcctgcccca agtcctgccc caagccccag
     3301 tgcgcactgc tcttcactgc tatcaagccc tccttcacca tcaggatcac agccgaggct
     3361 cttctggtat agggtctgga gcaaaggctt gtgtgggacc aaatattttt cctcacatcg
     3421 ataacgtgaa actgccagag gctgcccttc ccatcatatc ctcagtgggc aaggtgttcc
     3481 ctcttggtga cttcatggaa acagcttcaa gaaaacgcct tttctgtcct cccccgccct
     3541 cctcttactc ctgcccctcc tcctcctcct cctcccctcc ccccccctcc tcctccgctt
     3601 ctccccccac ctgtctttct ctctctgggc ctctggtttt ttgacctttg cccatacctt
     3661 cagtcttgtc ttcctgttaa ctgaccatcc cgcataagga gctgcccgtg ggctagatgg
     3721 aaggtttgtg gcagcctctc agctacattg tttgttttta ttttttaata gttatgattt
     3781 ctctttagct acctgaaaac tcagagattt ataaaaccca tttttgtatt tattgtatgt
     3841 ttgtactgct ttcttaattt aaaaatgtat ctagaattct tttaagttat ttatccaaac
     3901 tactaaaaat aaatcagttt acacatttaa aaaaaaaaaa aaaaa
//
