LOCUS       NM_177690               3404 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus NLR family, pyrin domain containing 2 (Nlrp2), mRNA.
ACCESSION   NM_177690
VERSION     NM_177690.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3404)
  AUTHORS   Pham,A.H., Emori,C., Ishikawa-Yamauchi,Y., Tokuhiro,K.,
            Kamoshita,M., Fujihara,Y. and Ikawa,M.
  TITLE     Thirteen Ovary-Enriched Genes Are Individually Not Essential for
            Female Fertility in Mice
  JOURNAL   Cells 13 (10), 802 (2024)
   PUBMED   38786026
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3404)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3404)
  AUTHORS   Jin,L., Li,T., Hong,Y., Mao,R., Li,X., Zhu,C., Mu,J., Zhou,J.,
            Pan,L., Que,Y., Xia,Y., Zhang,Y. and Li,S.
  TITLE     Activation of NLRP2 in Triple-Negative Breast Cancer sensitizes
            chemotherapeutic therapy through facilitating hnRNPK function
  JOURNAL   Biochem Pharmacol 215, 115703 (2023)
   PUBMED   37499769
  REMARK    GeneRIF: Activation of NLRP2 in Triple-Negative Breast Cancer
            sensitizes chemotherapeutic therapy through facilitating hnRNPK
            function.
REFERENCE   4  (bases 1 to 3404)
  AUTHORS   Anvar,Z., Chakchouk,I., Sharif,M., Mahadevan,S., Nasiotis,E.T.,
            Su,L., Liu,Z., Wan,Y.W. and Van den Veyver,I.B.
  TITLE     Loss of the Maternal Effect Gene Nlrp2 Alters the Transcriptome of
            Ovulated Mouse Oocytes and Impacts Expression of Histone
            Demethylase KDM1B
  JOURNAL   Reprod Sci 30 (9), 2780-2793 (2023)
   PUBMED   36976514
  REMARK    GeneRIF: Loss of the Maternal Effect Gene Nlrp2 Alters the
            Transcriptome of Ovulated Mouse Oocytes and Impacts Expression of
            Histone Demethylase KDM1B.
REFERENCE   5  (bases 1 to 3404)
  AUTHORS   Arian,S., Rubin,J., Chakchouk,I., Sharif,M., Mahadevan,S.K.,
            Erfani,H., Shelly,K., Liao,L., Lorenzo,I., Ramakrishnan,R. and Van
            den Veyver,I.B.
  TITLE     Reproductive Outcomes from Maternal Loss of Nlrp2 Are Not Improved
            by IVF or Embryo Transfer Consistent with Oocyte-Specific Defect
  JOURNAL   Reprod Sci 28 (7), 1850-1865 (2021)
   PUBMED   33090377
  REMARK    GeneRIF: Reproductive Outcomes from Maternal Loss of Nlrp2 Are Not
            Improved by IVF or Embryo Transfer Consistent with Oocyte-Specific
            Defect.
REFERENCE   6  (bases 1 to 3404)
  AUTHORS   Hiemstra,I.H., Bouma,G., Geerts,D., Kraal,G. and den Haan,J.M.
  TITLE     Nod2 improves barrier function of intestinal epithelial cells via
            enhancement of TLR responses
  JOURNAL   Mol Immunol 52 (3-4), 264-272 (2012)
   PUBMED   22750073
REFERENCE   7  (bases 1 to 3404)
  AUTHORS   Peng,H., Chang,B., Lu,C., Su,J., Wu,Y., Lv,P., Wang,Y., Liu,J.,
            Zhang,B., Quan,F., Guo,Z. and Zhang,Y.
  TITLE     Nlrp2, a maternal effect gene required for early embryonic
            development in the mouse
  JOURNAL   PLoS One 7 (1), e30344 (2012)
   PUBMED   22295082
  REMARK    GeneRIF: Nlrp2 is a member of the mammalian maternal effect genes
            and required for early embryonic development in the mouse.
REFERENCE   8  (bases 1 to 3404)
  AUTHORS   Atianand,M.K. and Harton,J.A.
  TITLE     Uncoupling of Pyrin-only protein 2 (POP2)-mediated dual regulation
            of NF-kappaB and the inflammasome
  JOURNAL   J Biol Chem 286 (47), 40536-40547 (2011)
   PUBMED   21976665
  REMARK    GeneRIF: POP2 acts as a regulator of inflammatory signals and
            exerts its two known functions through distinct modalities employed
            by its first alpha-helix
REFERENCE   9  (bases 1 to 3404)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   10 (bases 1 to 3404)
  AUTHORS   Anderson,J.P., Mueller,J.L., Rosengren,S., Boyle,D.L., Schaner,P.,
            Cannon,S.B., Goodyear,C.S. and Hoffman,H.M.
  TITLE     Structural, expression, and evolutionary analysis of mouse CIAS1
  JOURNAL   Gene 338 (1), 25-34 (2004)
   PUBMED   15302403
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ066881.1 and AC155171.7.
            
            On Aug 22, 2006 this sequence version replaced NM_177690.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ066881.1, AY360473.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN01164134 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3352              DQ066881.1         2-3353
            3353-3404           AC155171.7         115134-115185       c
FEATURES             Location/Qualifiers
     source          1..3404
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 3.07 cM"
     gene            1..3404
                     /gene="Nlrp2"
                     /gene_synonym="E330007A02Rik; Nalp2; NBS1; PAN1; PYPAF2"
                     /note="NLR family, pyrin domain containing 2"
                     /db_xref="GeneID:232827"
                     /db_xref="MGI:MGI:3041206"
     exon            1..33
                     /gene="Nlrp2"
                     /gene_synonym="E330007A02Rik; Nalp2; NBS1; PAN1; PYPAF2"
                     /inference="alignment:Splign:2.1.0"
     exon            34..354
                     /gene="Nlrp2"
                     /gene_synonym="E330007A02Rik; Nalp2; NBS1; PAN1; PYPAF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..3215
                     /gene="Nlrp2"
                     /gene_synonym="E330007A02Rik; Nalp2; NBS1; PAN1; PYPAF2"
                     /note="NACHT, leucine rich repeat and PYD containing 2"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 2"
                     /protein_id="NP_808358.2"
                     /db_xref="CCDS:CCDS39746.1"
                     /db_xref="GeneID:232827"
                     /db_xref="MGI:MGI:3041206"
                     /translation="MEHFDPLGFNLKDVLRKLDKTELNNFKRTLRSCSLPDTMKQINK
                     LTMDLANGAQLAEILTDHCPSAWIKRVTVQILEEINRVDLAELVVKQIEEAVLKVPEE
                     KVSSKPREPSGTLTFPWNFVQGAKRPEDKQKEEWKTRYTAKWKQNFWPKCNKEIYVVT
                     ESYKTLLALCNPKIETPFAHAIVLHGPPGSGKTTMAKQLMLEWSESKQAQIFSCAFYI
                     SCREVNNTKPCTFAHLLSMDNPSWRDCVIRDLILGKEFLFVVDGFDELTFPAGALIRD
                     LCGDWNTVKPVEVLLGSLLKRKMAPHATLLVTTRTQSLHQIFVMMDQPLLVETLGFLE
                     QEKQEYFQKYFEDEEGEEEDKGEGKALRALKEVRCNADLYQMASLPTACGIFCLCLEL
                     RMKKGEDLSLTCQTYTSMFLNFLCEVFSSETCEDHLNEEFQILFKKICILAANSLLEQ
                     VPILCEEDFLTLKLNLNNLHPMVCRHILFKDSSSTHCLSFICLGIQQLLAAIIFVQEL
                     GQESKGVSKYSIQNMLSREARLKNPDLSGLLPFVFGLLNETRIQELKTTFGCQISTEV
                     KRKFLECESGENKPLLLLMNMQEILSCLYESQEEGFVKEAMVLFEDISLHLKTSTDLI
                     HASFCLKNSQNLQTMSLKVEKAVFPENVAALESTAKHQRSPDEQRMLTFWTDFCDTFN
                     SNKKLVFLDIHESFLNSSALEILCEKLPSASCCLQKVVLKNISPDDAYEKLCLIFNGY
                     KTISHLILQGGNLDSMHHSLCEVLKNPACNLKFLSLGSCSTAAQKWDDFFPVLKVNQS
                     LIFLDLTDNSLLDKSAKLLCNIWKEPKCILQRVSLENCQLTEACCKDLSSVLMVSRTL
                     THLSLANNKLGDNGVKNLCESISCTECNLQTLVLWSCNITNAGCHYLSKMLKQTLSLK
                     HLDLGLNRIGTKGAKFLCEALKNPKSKLKSLWLCGCSITPLNCQDFSETLRSNKSLNT
                     LDLSQNVLGTDAIKTFCEALKLQICPLQMLRLKFDEAKPSIQNLIQEMKVSHPQLRIS
                     SDQVDLKNPPLPHFIF"
     exon            355..399
                     /gene="Nlrp2"
                     /gene_synonym="E330007A02Rik; Nalp2; NBS1; PAN1; PYPAF2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..459
                     /gene="Nlrp2"
                     /gene_synonym="E330007A02Rik; Nalp2; NBS1; PAN1; PYPAF2"
                     /inference="alignment:Splign:2.1.0"
     exon            460..2062
                     /gene="Nlrp2"
                     /gene_synonym="E330007A02Rik; Nalp2; NBS1; PAN1; PYPAF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2233
                     /gene="Nlrp2"
                     /gene_synonym="E330007A02Rik; Nalp2; NBS1; PAN1; PYPAF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2398
                     /gene="Nlrp2"
                     /gene_synonym="E330007A02Rik; Nalp2; NBS1; PAN1; PYPAF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2569
                     /gene="Nlrp2"
                     /gene_synonym="E330007A02Rik; Nalp2; NBS1; PAN1; PYPAF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2740
                     /gene="Nlrp2"
                     /gene_synonym="E330007A02Rik; Nalp2; NBS1; PAN1; PYPAF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2911
                     /gene="Nlrp2"
                     /gene_synonym="E330007A02Rik; Nalp2; NBS1; PAN1; PYPAF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3082
                     /gene="Nlrp2"
                     /gene_synonym="E330007A02Rik; Nalp2; NBS1; PAN1; PYPAF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3404
                     /gene="Nlrp2"
                     /gene_synonym="E330007A02Rik; Nalp2; NBS1; PAN1; PYPAF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3334..3339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nlrp2"
                     /gene_synonym="E330007A02Rik; Nalp2; NBS1; PAN1; PYPAF2"
                     /note="hexamer: ATTAAA"
     polyA_site      3356
                     /gene="Nlrp2"
                     /gene_synonym="E330007A02Rik; Nalp2; NBS1; PAN1; PYPAF2"
                     /note="major polyA site"
ORIGIN      
        1 gtgagactga gtgaaagctg gtgtggtgga gagttctcta gagctgaaag ctcggatctc
       61 acctgtgggt caagatggaa cattttgatc ccctgggttt caacctaaaa gacgtcctga
      121 gaaagctgga caagactgag ttgaacaatt tcaagagaac attgaggagc tgttctctgc
      181 cagatacaat gaaacagatc aacaagctga caatggacct ggctaatgga gctcagctag
      241 cagaaattct cacagaccac tgccccagtg cttggataaa gagagtcacc gtccagatct
      301 tagaggaaat aaaccgtgta gatctagctg agttagtagt aaagcaaatc gaagaagcag
      361 tattaaaggt acctgaggaa aaggtttctt ctaaaccaag agaaccctcg gggacactaa
      421 ctttcccatg gaattttgtt caaggagcta aaaggccaga ggacaagcaa aaagaggaat
      481 ggaagactag atacacagct aaatggaagc agaacttctg gcctaaatgc aataaagaaa
      541 tctatgtggt taccgagagc tacaagacac tcctggcatt gtgtaaccca aagatagaaa
      601 ccccatttgc tcatgcaatt gtgctgcatg gccctccagg ctctgggaaa accacaatgg
      661 caaagcagct aatgttagaa tggtcagaga gtaagcaggc ccagattttc tcatgtgcct
      721 tctacatcag ctgcagggaa gtaaataata ctaaaccttg cacttttgcc cacctcctct
      781 ccatggacaa tccctcctgg agggactgtg tgattcgaga tctaatcctg ggaaaggaat
      841 tcttatttgt ggtagatggt tttgatgagc tgacattccc agcaggagct ctgatccgtg
      901 acctttgtgg tgactggaac acagtgaagc ctgtagaggt cttactgggc agtttgctga
      961 agaggaagat ggcacctcat gccaccctgc tggtaaccac acggacacag tctttgcacc
     1021 aaatctttgt catgatggat cagccactac tagtagaaac tctgggcttc ttggagcaag
     1081 aaaagcagga gtactttcag aaatactttg aagatgagga gggtgaggag gaggataaag
     1141 gtgagggaaa ggcacttaga gctctcaagg aagtgagatg caatgctgat ctataccaaa
     1201 tggcctcact tcctactgca tgtgggatat tctgcctctg tctggagcta aggatgaaga
     1261 agggggaaga cctgtctctg acatgtcaga catacacctc tatgttcctg aacttcctgt
     1321 gcgaagtctt ctcatcagaa acctgtgagg accatctcaa tgaggaattc caaatcttat
     1381 tcaagaaaat atgtatcctg gctgccaata gtctcttgga acaggtgccc atactctgtg
     1441 aagaagactt cttgacatta aaattgaacc taaacaattt gcatcccatg gtgtgcaggc
     1501 acatcctctt taaggacagt tccagtacac actgtctctc tttcatctgc ctcggtatcc
     1561 agcaactcct ggctgcaata atatttgttc aggagcttgg acaggaaagc aagggtgtct
     1621 ctaaatatag tatacagaac atgctttcaa gggaagcaag attaaaaaac cctgacctgt
     1681 ctgggctgct gccatttgta tttggcctcc tgaatgagac tcgtattcaa gagttgaaga
     1741 ctacttttgg ctgccaaata tcaactgagg tcaagagaaa attcctggag tgtgagtcag
     1801 gggaaaataa acccttacta ttactgatga atatgcaaga aatcttgtcc tgtctctatg
     1861 aatctcagga ggaggggttt gtgaaggaag ccatggtcct ctttgaggac atctccttgc
     1921 atttgaaaac cagcactgac ctcattcatg cttcattctg cctcaagaac tctcagaact
     1981 tgcagacaat gtccctgaaa gtagaaaagg cggtctttcc agagaatgtt gctgcactag
     2041 agtccacagc taagcatcaa aggtccccgg atgaacaacg catgttaact ttctggacag
     2101 acttttgtga cacatttaat tcaaataaga aactggtatt tctagacatc catgaaagct
     2161 tcctcaacag ctctgcactg gagattcttt gtgaaaagct gccctctgct tcctgttgtc
     2221 tccagaaagt ggtcctcaaa aatatttccc cagatgatgc ctacgagaaa ttgtgcctca
     2281 tttttaatgg ttataaaacc atctcacatc tgatcctgca aggtggcaac ctggacagca
     2341 tgcatcactc actgtgtgag gttctgaaaa atccagcctg caacctgaag tttctcagcc
     2401 tgggatcttg ttctactgct gctcagaaat gggatgactt cttcccagtc ctgaaagtca
     2461 atcaatccct gatatttctg gatctcacag acaacagtct cttggacaaa agtgctaagc
     2521 tcctatgtaa tatttggaag gaaccaaagt gcatactgca gagggtatcg ttggagaact
     2581 gtcagctcac tgaagcctgc tgcaaggacc tctcttccgt tttgatggtc agccgaactc
     2641 tgacacacct cagcctggcc aacaataaac ttggggataa cggagtgaaa aacctgtgtg
     2701 aaagcataag ctgcacggag tgcaatctac agaccctggt gctgtggtcc tgtaacatca
     2761 ccaacgctgg ttgccactat ctctcaaaga tgctcaaaca aacactgagc ctgaaacact
     2821 tggatctggg gctaaatcgc atcggaacca aaggagcaaa gtttctgtgt gaggctttga
     2881 agaaccccaa gagtaaattg aaaagtctgt ggctgtgtgg atgctccatc actccactga
     2941 actgccaaga cttctctgag actcttagaa gcaacaagag cctgaacact ctagacctgt
     3001 ctcagaacgt cctgggaact gatgccataa agacattctg tgaagccttg aaacttcaga
     3061 tttgccccct gcaaatgctt agattgaaat ttgatgaagc taaacctagt atccagaacc
     3121 tgatccaaga gatgaaggtg agccatccac aactgagaat cagcagtgac caagtggatc
     3181 ttaagaatcc tcctcttcct catttcattt tttgaggcca ttcttctcca aaagatgtgg
     3241 gtgaagactc tctgggcacc ctctctgatt tattggcatc tgagataaat gtccttatcc
     3301 ttcccagatc tatgtataaa actcacaaat gtcattaaac aggaataaat gtaaaacatt
     3361 cgtatcactg gtatattggg gaataaaagg gaaaacatgc atga
//
