LOCUS       NM_001162414            4565 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus NLR family, pyrin domain containing 1B (Nlrp1b),
            transcript variant 3, mRNA.
ACCESSION   NM_001162414 XM_003689265
VERSION     NM_001162414.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4565)
  AUTHORS   Han,J.H., Karki,R., Malireddi,R.K.S., Mall,R., Sarkar,R.,
            Sharma,B.R., Klein,J., Berns,H., Pisharath,H., Pruett-Miller,S.M.,
            Bae,S.J. and Kanneganti,T.D.
  TITLE     NINJ1 mediates inflammatory cell death, PANoptosis, and lethality
            during infection conditions and heat stress
  JOURNAL   Nat Commun 15 (1), 1739 (2024)
   PUBMED   38409108
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4565)
  AUTHORS   Kumar,S.R.P., Biswas,M., Cao,D., Arisa,S., Munoz-Melero,M.,
            Lam,A.K., Pineros,A.R., Kapur,R., Kaisho,T., Kaufman,R.J., Xiao,W.,
            Shayakhmetov,D.M., Terhorst,C., de Jong,Y.P. and Herzog,R.W.
  TITLE     TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer
            through IL-1R1-MyD88 signaling
  JOURNAL   Mol Ther 32 (2), 325-339 (2024)
   PUBMED   38053332
REFERENCE   3  (bases 1 to 4565)
  AUTHORS   Spurlock,M., An,W., Reshetnikova,G., Wen,R., Wang,H., Braha,M.,
            Solis,G., Kurtenbach,S., Galindez,O.J., de Rivero Vaccari,J.P.,
            Chou,T.H., Porciatti,V. and Shestopalov,V.I.
  TITLE     The Inflammasome-Dependent Dysfunction and Death of Retinal
            Ganglion Cells after Repetitive Intraocular Pressure Spikes
  JOURNAL   Cells 12 (22), 2626 (2023)
   PUBMED   37998361
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4565)
  AUTHORS   Murase,Y., Takeichi,T., Koseki,J., Miyasaka,Y., Muro,Y., Ohno,T.,
            Shimamura,T. and Akiyama,M.
  TITLE     UVB-Induced Skin Autoinflammation Due to Nlrp1b Mutation and Its
            Inhibition by Anti-IL-1beta Antibody
  JOURNAL   Front Immunol 13, 876390 (2022)
   PUBMED   35784371
  REMARK    GeneRIF: UVB-Induced Skin Autoinflammation Due to Nlrp1b Mutation
            and Its Inhibition by Anti-IL-1beta Antibody.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4565)
  AUTHORS   Chiaranunt,P., Burrows,K., Ngai,L., Cao,E.Y., Liang,H., Tai,S.L.,
            Streutker,C.J., Girardin,S.E. and Mortha,A.
  TITLE     NLRP1B and NLRP3 Control the Host Response following Colonization
            with the Commensal Protist Tritrichomonas musculis
  JOURNAL   J Immunol 208 (7), 1782-1789 (2022)
   PUBMED   35256512
  REMARK    GeneRIF: NLRP1B and NLRP3 Control the Host Response following
            Colonization with the Commensal Protist Tritrichomonas musculis.
REFERENCE   6  (bases 1 to 4565)
  AUTHORS   Moayeri,M., Crown,D., Newman,Z.L., Okugawa,S., Eckhaus,M.,
            Cataisson,C., Liu,S., Sastalla,I. and Leppla,S.H.
  TITLE     Inflammasome sensor Nlrp1b-dependent resistance to anthrax is
            mediated by caspase-1, IL-1 signaling and neutrophil recruitment
  JOURNAL   PLoS Pathog 6 (12), e1001222 (2010)
   PUBMED   21170303
  REMARK    GeneRIF: data confirm an inverse relationship between murine
            macrophage sensitivity to lethal toxin and mouse susceptibility to
            spore infection, and establish roles for Nlrp1b(S), caspase-1, and
            IL-1beta in countering anthrax infection.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4565)
  AUTHORS   Terra,J.K., Cote,C.K., France,B., Jenkins,A.L., Bozue,J.A.,
            Welkos,S.L., LeVine,S.M. and Bradley,K.A.
  TITLE     Cutting edge: resistance to Bacillus anthracis infection mediated
            by a lethal toxin sensitive allele of Nalp1b/Nlrp1b
  JOURNAL   J Immunol 184 (1), 17-20 (2010)
   PUBMED   19949100
  REMARK    GeneRIF: animals expressing a lethal toxin (LT)-sensitive allele of
            Nlrp1b showed an early inflammatory response to LT and increased
            resistance to infection by B. anthracis
REFERENCE   8  (bases 1 to 4565)
  AUTHORS   Liao,K.C. and Mogridge,J.
  TITLE     Expression of Nlrp1b inflammasome components in human fibroblasts
            confers susceptibility to anthrax lethal toxin
  JOURNAL   Infect Immun 77 (10), 4455-4462 (2009)
   PUBMED   19651869
  REMARK    GeneRIF: The authors demonstrate that transfection of human
            fibroblasts with plasmids encoding murine Nlrp1b and procaspase-1
            was sufficient to confer susceptibility to lethal toxin-mediated
            death on the cells.
REFERENCE   9  (bases 1 to 4565)
  AUTHORS   Lamkanfi,M., Kanneganti,T.D., Franchi,L. and Nunez,G.
  TITLE     Caspase-1 inflammasomes in infection and inflammation
  JOURNAL   J Leukoc Biol 82 (2), 220-225 (2007)
   PUBMED   17442855
  REMARK    Review article
REFERENCE   10 (bases 1 to 4565)
  AUTHORS   Boyden,E.D. and Dietrich,W.F.
  TITLE     Nalp1b controls mouse macrophage susceptibility to anthrax lethal
            toxin
  JOURNAL   Nat Genet 38 (2), 240-244 (2006)
   PUBMED   16429160
  REMARK    GeneRIF: an extremely polymorphic gene in this locus, Nalp1b, is
            the primary mediator of mouse macrophage susceptibility to LeTx
            (lethal toxin)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663042.5 and AL662908.7.
            
            On Jun 15, 2022 this sequence version replaced NM_001162414.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AL663042.5         15783-15840         c
            59-324              AL663042.5         14134-14399         c
            325-1999            AL662908.7         88291-89965         c
            2000-2170           AL662908.7         80060-80230         c
            2171-2341           AL662908.7         79166-79336         c
            2342-2431           AL662908.7         76833-76922         c
            2432-2514           AL662908.7         75904-75986         c
            2515-2614           AL662908.7         72668-72767         c
            2615-2838           AL662908.7         71074-71297         c
            2839-3101           AL662908.7         68774-69036         c
            3102-3227           AL662908.7         68167-68292         c
            3228-3369           AL662908.7         67170-67311         c
            3370-3414           AL662908.7         63826-63870         c
            3415-3712           AL662908.7         63096-63393         c
            3713-4565           AL662908.7         59784-60636         c
FEATURES             Location/Qualifiers
     source          1..4565
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.23 cM"
     gene            1..4565
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /note="NLR family, pyrin domain containing 1B"
                     /db_xref="GeneID:637515"
                     /db_xref="MGI:MGI:3582959"
     exon            1..58
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            59..324
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..3707
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /note="isoform 3 is encoded by transcript variant 3;
                     NACHT-, LRR-, and PYD-containing protein 1 paralog b;
                     NACHT, LRR and PYD domains-containing protein 1b"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 1b
                     allele 2 isoform 3"
                     /protein_id="NP_001155886.1"
                     /db_xref="CCDS:CCDS48839.1"
                     /db_xref="GeneID:637515"
                     /db_xref="MGI:MGI:3582959"
                     /translation="MEESQYKQEHNKKVAQDEGQEDKDTIFETIEAIEAKLMELKTNP
                     ESTFNYGIFPEVYMNQGEEILYPAWSLKEENLFQTFKSLRLFQKLCPRGSGNLVKKSW
                     YPCVPEEGGHIINIQDLFGPNIGTQKEPQLVIIEGAAGIGKSTLARQVKRAWMEGELY
                     RDHFQHVFFFSCRELAQCKKLSLAELITQGQDVPTAPINQILSHPEKLLFILDGIDEP
                     AWVLADQNPELCLYWSQTQPVHTLLGSLLGKSILPEASFLLTTRTTALQKFIPSLPQS
                     CQVEVLGFSDFEQEIYIYKYFAKQIFGIKALMMVESNPVLLTLCEVPWVCWLVCNCLK
                     KQMEQGGDVSLTSQTTTAICLKYISLTIPVHHMRTQLRALCSLAAEGIWKRRTLFSES
                     DLCKQGLDEDAVAIFLKTGVLQKQASSLSYSFAHLCLQEFFASMSCILEDSEERHGDM
                     EMDRIVETLVERYGRQNLFEAPTVRFLFGLLSKEGLKEMEKLFSCSLPGKTKLKLLWH
                     ILGKSQPHQPPCLGLLHCLYENQDMKLLTHVMHDLQGTIVPDTDDITHTVLQTNVKHL
                     VVRTDMELMVVTFCIQFCSHMRSLQLNMEGQQGYALTAPRMVLYRWTPITNASWKILF
                     YNLKFNSNLEGLDLSGNPLSYSAVQYLCDAMIYPGCQLKTLWLVECGLTPTYCSLLAS
                     VLSACSSLRELDLQLNDLCDDGVRMLCEGLRNRACNLRILRLDLYSLSAQVITELRTL
                     EENNLKLHISSIWMPQMMVPTENMDEEDILTSFKQQRQQSGANPMEILGTEEDFWGPI
                     GPVATEVVYRERNLYRVQLPMAGSYHCPSTRLHFVVTRAVTIEIEFCAWSQFLDKTPL
                     QQSHMVVGPLFDIKAEQGAVTAVYLPHFVSLKDTKASTFDFKVAHFQEHGMVLETPDR
                     VKPGYTVLKNPSFSPMGVVLRIIPAARHFIPITSITLIYYRVNQEEVTLHLYLVPNDC
                     TIQKAIDDEEMKFQFVRINKPPPVDNLFIGSRYIVSGSENLEITPKELELCYRSSKEF
                     QLFSEIYVGNMGSEIKLQIKNKKHMKLIWEALLKPGDLRPALPRIAQALKDAPSLLHF
                     MDQHREQLVARVTSVDPLLDKLHGLVLNEESYEAVRAENTNQDKMRKLFNLSRSWSRA
                     CKDLFYQALKETHPHLVMDLLEKSGGVSLGS"
     exon            325..1999
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2170
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2341
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2431
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2514
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2614
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2838
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..3101
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3102..3227
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3369
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..3414
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3712
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3713..4565
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4547..4552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /note="hexamer: ATTAAA"
     polyA_site      4565
                     /gene="Nlrp1b"
                     /gene_synonym="Nalp1b"
                     /note="major polyA site"
ORIGIN      
        1 ctagctgagg agccttgttc aaggacacac actcctgtag gcttcgtgaa agagtaggaa
       61 atttctggcc atgacaagaa gacactgctc tcctgcttgc aacatcagaa gagagtcttg
      121 aagaaataag agcacaaact gctcagagaa acagtatctg agggctctgt accatggaag
      181 aatctcagta caagcaggaa cataacaaaa aggtagctca ggatgaaggt caagaggaca
      241 aggacaccat cttcgaaaca atagaagcta tagaggcaaa gctgatggag ctcaaaacca
      301 acccagagag taccttcaat tatggaatat ttccagaagt atatatgaat cagggagaag
      361 agatacttta cccagcatgg tcattgaaag aggagaattt gtttcaaact ttcaaaagtc
      421 tacgactgtt tcaaaaattg tgcccaagag gctcagggaa cttggtcaag aaaagctggt
      481 atccatgtgt accagaagaa ggaggacata taattaatat ccaagactta tttggcccaa
      541 atataggtac tcagaaagag cctcaattag tcataataga aggggctgct gggattggga
      601 agtcaacact ggccaggcag gtgaagagag cctggatgga aggcgagctc tacagggatc
      661 acttccaaca tgtcttcttc ttcagctgca gagagctggc ccagtgcaag aagctgagtc
      721 tggctgagct cataacacaa ggccaggatg tgcccacagc tcccataaat cagatcctgt
      781 ctcaccctga gaagctgctc ttcatcctgg atggcataga tgagccagca tgggtcttgg
      841 cagaccagaa tcctgagcta tgtctgtact ggagtcaaac acagcctgtg cacacactac
      901 tgggaagttt actagggaaa tccatccttc ctgaggcttc cttcttgctc acaactcgca
      961 ccacagctct acagaagttc attccttctt tgccacagtc atgtcaggtg gaagtcctag
     1021 gattcagtga ttttgaacag gagatctata tctacaaata ttttgcaaag caaatatttg
     1081 gaattaaagc tcttatgatg gttgagtcta acccagttct cctgaccctg tgtgaggttc
     1141 cctgggtgtg ctggttggtc tgcaattgcc tgaaaaagca gatggagcag ggtggagatg
     1201 tctccctgac ctcacagaca accacagcca tctgcctaaa atacatttcc ctaacaatcc
     1261 cagtgcatca tatgaggacc cagctcagag ccctctgctc attggctgct gaaggcatct
     1321 ggaaaagaag gaccctgttc agtgaaagcg acctctgtaa gcaagggtta gacgaggatg
     1381 ccgttgccat tttcctgaag actggtgtcc ttcaaaagca ggccagctct ctgagctata
     1441 gctttgccca cttgtgtctc caggagttct ttgcatcaat gtcttgcatc ttggaggata
     1501 gtgaggaacg acatggtgat atggaaatgg acagaattgt ggaaacactg gtagaacggt
     1561 atggaagaca aaacctgttt gaggcaccca ctgtgcgctt tctctttggt cttttgagta
     1621 aagagggatt gaaagaaatg gaaaagctct tttcctgcag ccttcctggg aagacaaagt
     1681 tgaaactact atggcacatc cttgggaaat cccaacccca tcaaccacct tgcctgggtt
     1741 tgctccactg tctatatgaa aatcaggata tgaagctcct gacacatgtg atgcatgatc
     1801 ttcaaggaac aatagtgcct gacacagatg acattacaca cacagtgttg cagacaaatg
     1861 tgaagcacct ggtggtacgg acagacatgg agctcatggt ggtcactttc tgcattcagt
     1921 tctgctctca catgaggagt ctacagctga atatggaagg acaacaagga tatgcactga
     1981 cagccccaag gatggttctg tacaggtgga ccccaatcac taatgccagt tggaagattc
     2041 ttttctacaa tcttaaattc aacagtaatc tggaggggtt ggacctcagt ggaaatccac
     2101 tgagttactc tgcagtgcaa tatctctgtg atgccatgat ataccctggc tgccaactaa
     2161 agactttgtg gcttgttgaa tgcggcctca cacccacata ctgctcactc ctggcctcag
     2221 tgctcagtgc ctgctccagc ctgagagagc tagacctgca gctaaatgac ctgtgtgacg
     2281 atggtgtaag gatgctgtgt gaggggctca ggaatcgtgc ctgcaacctc agaatcctgc
     2341 ggctggacct gtactctctc agtgcccagg tgattacaga gctcaggaca ctggaggaaa
     2401 ataatctgaa gctgcacatc tccagcatct ggatgccaca aatgatggtc cccactgaga
     2461 acatggatga agaagatatc ctgacctcat tcaagcagca gagacaacag tcaggagcca
     2521 atcccatgga aattctgggg actgaagaag acttctgggg ccctatagga cctgtggcta
     2581 ctgaggtggt ttacagagaa aggaacctgt accgagttca attgcccatg gctggttcct
     2641 accactgtcc cagcacaaga ctccactttg tagtgacaag ggcagtgaca atagagatcg
     2701 aattctgtgc ctggagccaa ttcctggaca agactccctt gcagcagagt cacatggtgg
     2761 ttggacctct gtttgacatc aaggctgagc aaggagctgt gactgcagtg tacctccctc
     2821 attttgtgtc cctcaaagac acaaaggcaa gcacatttga cttcaaggtg gcccactttc
     2881 aagaacatgg gatggttcta gaaacgccag atagggtgaa gcctggatac acagtactga
     2941 aaaacccaag cttctcccca atgggagttg tactgagaat aatccctgct gcccggcact
     3001 tcatccccat tacttccatc acactgatct actatcgagt caatcaggaa gaagtcaccc
     3061 ttcacctcta cctagtccct aatgactgca ccatacagaa ggccatagat gatgaagaaa
     3121 tgaagtttca gtttgtgaga ataaacaagc cacccccagt agacaatctt ttcattggct
     3181 cccgctacat tgtgtctggt tctgagaacc tggaaatcac cccaaaggaa ctggagctgt
     3241 gctacaggag cagcaaggaa ttccaactct tctctgagat atacgttgga aacatgggtt
     3301 cagagattaa gctgcaaatc aaaaacaaaa agcacatgaa actcatatgg gaagccttgc
     3361 tgaaaccagg agacctcaga cctgctctgc ccaggattgc ccaagccctc aaagatgccc
     3421 cttccttgct gcacttcatg gaccagcatc gggagcagct ggtagcccga gtgacatcag
     3481 tggaccctct cttggacaag ctgcatggtc tggtgctgaa tgaagaatcc tatgaggcag
     3541 tgcgggctga gaacacaaac caagataaga tgaggaagct cttcaacctc agccggtcct
     3601 ggagtcgagc ctgcaaagac ctattctacc aagctctgaa ggagacccat cctcacctgg
     3661 tcatggacct cttagaaaag tcaggtgggg tctctttggg atcctgacat tgataggagc
     3721 ctggcatctc ttttcctgag aggcttcatc cagcgctgga tggaaacaga tacagagacc
     3781 cacagacaac atcgcatagt gcttaagagg cttccagaaa attgagggat ggaactgagc
     3841 aagctggagg gatcaaggac accacaaaaa aacctacaga gtcaactaac ctgggaccat
     3901 ggggactcac agagatggaa ctaccagcca aagagcatgc agtgactgga cctaggttcc
     3961 gtacatattt gtagcagatg tgctgcttag tcttcatatg ggtccactaa caatagaaga
     4021 ggaggttgtc tttgtctctg ttgactaatt ttggacccct ttcctttaac tgaactgcat
     4081 gaatgggtct cagtgaaaag gatgggctta ggccttctgt aagtggatgt tagaggatgg
     4141 gatggtattc aaggggaatt tccccttcac tgcggataac tggagaggtt gggggaggat
     4201 tgtgtaagtg tgcggatggg aggaaaagag ggagggaaat gcaatcagga tgtaaaatga
     4261 ataaatatat tctttaattt aaaaataaaa atgtagagtc tggcatagtg gcacatgcct
     4321 ttaatcccag cactcgggag gcagaggcag tcggatttct gagttcgagg ccaacctggt
     4381 ctataaagtg agttcaggac agccagggct atacgaagaa accttgtctc aaaaaaaaaa
     4441 atgtaaacca ctttttaatt ctaaaataat catgatgggc attaaaatgg ttgtatattt
     4501 tcaaagtatt tcactttaat ggaaacttat ctttttataa ataaacatta aatacttgaa
     4561 acaaa
//
