LOCUS       NM_001004142            4806 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus NLR family, pyrin domain containing 1A (Nlrp1a), mRNA.
ACCESSION   NM_001004142 XM_111100
VERSION     NM_001004142.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4806)
  AUTHORS   Jia,J., Liu,H., Sun,L., Xu,Y. and Zeng,X.
  TITLE     Thioredoxin-1 Protects Neurons Through Inhibiting NLRP1-Mediated
            Neuronal Pyroptosis in Models of Alzheimer's Disease
  JOURNAL   Mol Neurobiol 61 (11), 9723-9734 (2024)
   PUBMED   38976128
  REMARK    GeneRIF: Thioredoxin-1 Protects Neurons Through Inhibiting
            NLRP1-Mediated Neuronal Pyroptosis in Models of Alzheimer's
            Disease.
            Erratum:[Mol Neurobiol. 2024 Sep 28. doi:
            10.1007/s12035-024-04523-8.. PMID: 39333348]
REFERENCE   2  (bases 1 to 4806)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4806)
  AUTHORS   Zhu,Y.J., Huang,J., Chen,R., Zhang,Y., He,X., Duan,W.X., Zou,Y.L.,
            Sun,M.M., Sun,H.L., Cheng,S.M., Wang,H.C., Zhang,H. and Wu,W.N.
  TITLE     Autophagy dysfunction contributes to NLRP1 inflammasome-linked
            depressive-like behaviors in mice
  JOURNAL   J Neuroinflammation 21 (1), 6 (2024)
   PUBMED   38178196
  REMARK    GeneRIF: Autophagy dysfunction contributes to NLRP1
            inflammasome-linked depressive-like behaviors in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4806)
  AUTHORS   Jung,E., Kim,Y.E., Jeon,H.S., Yoo,M., Kim,M., Kim,Y.M., Koh,S.H.
            and Choi,Y.K.
  TITLE     Chronic hypoxia of endothelial cells boosts HIF-1alpha-NLRP1
            circuit in Alzheimer's disease
  JOURNAL   Free Radic Biol Med 204, 385-393 (2023)
   PUBMED   37245530
  REMARK    GeneRIF: Chronic hypoxia of endothelial cells boosts
            HIF-1alpha-NLRP1 circuit in Alzheimer's disease.
REFERENCE   5  (bases 1 to 4806)
  AUTHORS   Li,M., Hu,L., Ke,Q., Ruan,C. and Liu,X.
  TITLE     miR-122-3p Alleviates LPS-Induced Pyroptosis of Macrophages via
            Targeting NLRP1
  JOURNAL   Ann Clin Lab Sci 53 (4), 578-586 (2023)
   PUBMED   37625833
  REMARK    GeneRIF: miR-122-3p Alleviates LPS-Induced Pyroptosis of
            Macrophages via Targeting NLRP1.
REFERENCE   6  (bases 1 to 4806)
  AUTHORS   Rosenzweig,H.L., Martin,T.M., Planck,S.R., Galster,K., Jann,M.M.,
            Davey,M.P., Kobayashi,K., Flavell,R.A. and Rosenbaum,J.T.
  TITLE     Activation of NOD2 in vivo induces IL-1beta production in the eye
            via caspase-1 but results in ocular inflammation independently of
            IL-1 signaling
  JOURNAL   J Leukoc Biol 84 (2), 529-536 (2008)
   PUBMED   18495787
  REMARK    GeneRIF: New in vivo function of NOD2 within the eye which yet
            distinguishes NOD2-dependent from NALP3-dependent inflammation.
REFERENCE   7  (bases 1 to 4806)
  AUTHORS   Hsu,L.C., Ali,S.R., McGillivray,S., Tseng,P.H., Mariathasan,S.,
            Humke,E.W., Eckmann,L., Powell,J.J., Nizet,V., Dixit,V.M. and
            Karin,M.
  TITLE     A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta
            secretion in response to Bacillus anthracis infection and muramyl
            dipeptide
  JOURNAL   Proc Natl Acad Sci U S A 105 (22), 7803-7808 (2008)
   PUBMED   18511561
  REMARK    GeneRIF: NOD2 can associate with NALP1 to form a complex that
            activates caspase-1 in response to muramyl dipeptide.
REFERENCE   8  (bases 1 to 4806)
  AUTHORS   Boyden,E.D. and Dietrich,W.F.
  TITLE     Nalp1b controls mouse macrophage susceptibility to anthrax lethal
            toxin
  JOURNAL   Nat Genet 38 (2), 240-244 (2006)
   PUBMED   16429160
REFERENCE   9  (bases 1 to 4806)
  AUTHORS   Martinon,F. and Tschopp,J.
  TITLE     NLRs join TLRs as innate sensors of pathogens
  JOURNAL   Trends Immunol 26 (8), 447-454 (2005)
   PUBMED   15967716
  REMARK    Review article
REFERENCE   10 (bases 1 to 4806)
  AUTHORS   Stehlik,C., Hayashi,H., Pio,F., Godzik,A. and Reed,J.C.
  TITLE     CARD6 is a modulator of NF-kappa B activation by Nod1- and
            Cardiak-mediated pathways
  JOURNAL   J Biol Chem 278 (34), 31941-31949 (2003)
   PUBMED   12775719
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662908.7, DQ117601.1 and AL596136.5.
            
            On Jun 23, 2009 this sequence version replaced NM_001004142.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.1886341.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AL662908.7         51750-51805         c
            57-59               AL662908.7         49627-49629         c
            60-3767             DQ117601.1         1-3708
            3768-4806           AL596136.5         250414-251452       c
FEATURES             Location/Qualifiers
     source          1..4806
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.21 cM"
     gene            1..4806
                     /gene="Nlrp1a"
                     /gene_synonym="CARD7; DEFCAP; Gm14; Gm15; NAC; Nalp1;
                     Nalp1a; Nlrp1; PP1044"
                     /note="NLR family, pyrin domain containing 1A"
                     /db_xref="GeneID:195046"
                     /db_xref="MGI:MGI:2684861"
     exon            1..56
                     /gene="Nlrp1a"
                     /gene_synonym="CARD7; DEFCAP; Gm14; Gm15; NAC; Nalp1;
                     Nalp1a; Nlrp1; PP1044"
                     /inference="alignment:Splign:2.1.0"
     exon            57..369
                     /gene="Nlrp1a"
                     /gene_synonym="CARD7; DEFCAP; Gm14; Gm15; NAC; Nalp1;
                     Nalp1a; Nlrp1; PP1044"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..3767
                     /gene="Nlrp1a"
                     /gene_synonym="CARD7; DEFCAP; Gm14; Gm15; NAC; Nalp1;
                     Nalp1a; Nlrp1; PP1044"
                     /note="NACHT/LRR/pyrin domain-containing protein 1;
                     caspase recruitment domain protein; NACHT, LRR and PYD
                     containing protein 1; death effector filament-forming
                     Ced-4-like apoptosis protein; NLR family, pyrin domain
                     containing 1; NACHT, leucine rich repeat and PYD
                     containing 1; caspase recruitment domain-containing
                     protein 7; nucleotide-binding domain and caspase
                     recruitment domain; NLR family, pyrin domain containing
                     1A, WSB/EiJ strain specific; NLR family, pyrin domain
                     containing 1A, PWK/PhJ strain specific; NLR family, pyrin
                     domain containing 1A, CAST/EiJ strain specific"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein
                     1a"
                     /protein_id="NP_001004142.2"
                     /db_xref="CCDS:CCDS48838.1"
                     /db_xref="GeneID:195046"
                     /db_xref="MGI:MGI:2684861"
                     /translation="MEESQSKQESSTKVAQHEGQEDVDPTFKTKKLMEVELMKHRVQL
                     ERNLKLRTFPGARTKQVKEALYPLLTWSSKSKNLFQNFTKLLLFKKLCQRGSENLVRE
                     SWYPCVPEEEAHMIDIQDLFGPNLGTQKKPQLVIIEGAAGIGKSTLARLVKRAWKEGK
                     LYRNDFHHVFFFSCRELAQYEQLSLAELIVQGQEVPTAPIRQILSHPEKLLFILDGID
                     EPAWVLADQNPELCLHWSQTQPVHTLLGSLLGKSILPGASFLLTTRTTALQKFIPSLE
                     QPCQVEVLGFTLFERKNYFYKYFGKKKGGVTTFTLVKSNSALLTLCEVPWVCWLVCTC
                     LKKQMEQGGELSLTSQTTTALCLKYLSLTIPGQHMRTQLRDLCSLAAEGVCQRRTLFS
                     ESDLCKQGLDEHAIASFLKIGVLQKQASSLSYSFAHLCLQEFFAAMSYILDDSEERHA
                     DMKNDRIVETLVERYGRQNLFEAPTVRFLFGLLSKEELKKIEKLFSCSLHGKTKLKLL
                     WHILGKSQPHQPPCLGLLHCLYENQDMELLTHVMHDLQGTIVPGPDDLAHTVLQTNVK
                     HLVIQTDMDLMVVTFCIKFCCHVRSLQLNRKVQQGHKFTAPGMVLYRWTPITDASWKI
                     FFSNLKLARNLEELDLSGNPLSYYAVHSLCTTLRKRGCQLKTLWLVECGLTSTYCSLL
                     ASVLSARSSLTELDLQLNDLGDGGVKMLCEGLRNPACNLSILWLDQASLSDQVIAELR
                     TLEAKNPKLLISSTWKPHVMVPTMNMDKEEVGDSQALLKQQRQQSGDKHMEPLGTEDE
                     FWGPTGPVTTEVVDRERNLYRVQLPMAGSYHCPSTGLHFVVTRAVTIEIEFCAWSQYL
                     DKTPLQQSHMVVGPLFDIKAEQGAVTAVYLPHFVALQEGIVDSSLFHVAHFQEHGMVL
                     ETPARVEQHYAVLENPSFSPMGILLRMIPAVGHFIPITSTTLIYYHLYLEDVTFHLYL
                     VPNDCSIRKAIDDEEMKFQFVRINKPPPVDALYLGSRYIVSSSKLVEIIPKELELCYR
                     SPGESQLFSEIDIGHMDSEIKLQIKDKRHMNLKWEALLKPGDLRPALPKIATAPKDAP
                     SLLHFMDQHREQLVARVTSVDPLLDKLHGLVLSEDSYEVVRSETTNQDKMRKLFSLSR
                     SWSWDCKDQFYQALKETHPHLVMDILEKLGGVSVKS"
     exon            370..2050
                     /gene="Nlrp1a"
                     /gene_synonym="CARD7; DEFCAP; Gm14; Gm15; NAC; Nalp1;
                     Nalp1a; Nlrp1; PP1044"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2221
                     /gene="Nlrp1a"
                     /gene_synonym="CARD7; DEFCAP; Gm14; Gm15; NAC; Nalp1;
                     Nalp1a; Nlrp1; PP1044"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2392
                     /gene="Nlrp1a"
                     /gene_synonym="CARD7; DEFCAP; Gm14; Gm15; NAC; Nalp1;
                     Nalp1a; Nlrp1; PP1044"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2482
                     /gene="Nlrp1a"
                     /gene_synonym="CARD7; DEFCAP; Gm14; Gm15; NAC; Nalp1;
                     Nalp1a; Nlrp1; PP1044"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2574
                     /gene="Nlrp1a"
                     /gene_synonym="CARD7; DEFCAP; Gm14; Gm15; NAC; Nalp1;
                     Nalp1a; Nlrp1; PP1044"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2674
                     /gene="Nlrp1a"
                     /gene_synonym="CARD7; DEFCAP; Gm14; Gm15; NAC; Nalp1;
                     Nalp1a; Nlrp1; PP1044"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2898
                     /gene="Nlrp1a"
                     /gene_synonym="CARD7; DEFCAP; Gm14; Gm15; NAC; Nalp1;
                     Nalp1a; Nlrp1; PP1044"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3161
                     /gene="Nlrp1a"
                     /gene_synonym="CARD7; DEFCAP; Gm14; Gm15; NAC; Nalp1;
                     Nalp1a; Nlrp1; PP1044"
                     /inference="alignment:Splign:2.1.0"
     exon            3162..3287
                     /gene="Nlrp1a"
                     /gene_synonym="CARD7; DEFCAP; Gm14; Gm15; NAC; Nalp1;
                     Nalp1a; Nlrp1; PP1044"
                     /inference="alignment:Splign:2.1.0"
     exon            3288..3429
                     /gene="Nlrp1a"
                     /gene_synonym="CARD7; DEFCAP; Gm14; Gm15; NAC; Nalp1;
                     Nalp1a; Nlrp1; PP1044"
                     /inference="alignment:Splign:2.1.0"
     exon            3430..3474
                     /gene="Nlrp1a"
                     /gene_synonym="CARD7; DEFCAP; Gm14; Gm15; NAC; Nalp1;
                     Nalp1a; Nlrp1; PP1044"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..4806
                     /gene="Nlrp1a"
                     /gene_synonym="CARD7; DEFCAP; Gm14; Gm15; NAC; Nalp1;
                     Nalp1a; Nlrp1; PP1044"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgaggag ccttgttcaa agacacacac tccagtgggc cccatagagg agcaggcagg
       61 tctcctctat cacttctgat caaacaccca ttcacagagc agaactacct ggcagagaca
      121 agaagccact ggtctcctgc ttgcaacaac agaagagcgt cttgaagcaa taagagcaca
      181 aactgctcag agaagcagta ttcaagggct ctatcatcat ggaagaatct cagtccaagc
      241 aggaaagtag cacaaaagtg gctcagcatg aaggtcaaga ggatgtggac ccaaccttca
      301 aaacaaagaa acttatggag gtggagctaa tgaagcacag agtgcagcta gagaggaact
      361 tgaagctaag aacctttcca ggagcacgta cgaagcaagt aaaagaggct ctttaccctc
      421 ttctaacatg gtcatcaaaa agcaagaatc tgttccaaaa tttcacaaaa ctactactct
      481 ttaaaaaatt gtgccaaaga ggctcagaaa acttggtcag ggaaagctgg tatccatgtg
      541 taccagaaga agaagcacat atgattgaca tccaagattt atttggccca aacttaggta
      601 ctcagaaaaa gcctcaatta gtcataatag aaggagctgc tgggattggg aagtcaacac
      661 tggccagact tgtgaagaga gcctggaagg aaggcaagct ttacaggaat gacttccatc
      721 atgtcttctt cttcagctgc agagagctgg cccagtatga gcagctgagt ctggctgagc
      781 tcatagtaca aggccaggaa gtgcccacag ctcccattag gcagatcctg tctcaccctg
      841 agaagttgct cttcattctg gatggcatag atgagccagc atgggtctta gcagaccaga
      901 atcctgagtt atgtcttcac tggagtcaaa cccagcctgt gcacactctg ctgggcagtt
      961 tacttgggaa atccatcctt cctggggctt ccttcttgct cacaactcgc accacagctc
     1021 tacagaaatt cattccttcc ctggagcagc catgtcaagt ggaagtccta ggattcactt
     1081 tgtttgaacg gaaaaactat ttctacaaat attttgggaa gaaaaaaggt ggagttacta
     1141 cttttacatt agttaaatca aactcagcgc tcctgactct gtgtgaagtt ccctgggtgt
     1201 gctggttggt ctgcacttgc ctgaaaaagc agatggagca gggtggagag ctctcactga
     1261 cctcacagac caccacagca ctctgcctga aatacctttc cctgacgatc ccagggcagc
     1321 acatgaggac ccagctcaga gacctctgct cactggctgc tgagggggtc tgccaaagaa
     1381 ggaccctgtt cagtgaaagc gatctctgta agcaagggtt agatgagcat gccattgcca
     1441 gtttcctgaa gattggtgtc cttcaaaagc aggccagctc tctgagctac agctttgccc
     1501 acttgtgtct tcaggagttc tttgcagcaa tgtcctacat cttggatgat agtgaggaaa
     1561 gacatgctga tatgaaaaat gacagaattg tggaaacact ggtagaaagg tatggaagac
     1621 aaaacctgtt tgaggcaccc actgtgcgtt ttttatttgg tcttttgagt aaagaggaat
     1681 tgaaaaaaat agaaaagctc ttttcctgca gccttcatgg aaagacaaag ttgaaactac
     1741 tatggcacat cctagggaaa tcccaacccc atcaaccacc ttgcctgggt ttgctccact
     1801 gtctgtatga aaatcaggat atggagctcc tgacacacgt gatgcatgat ctgcaaggaa
     1861 caatagtgcc tggaccagat gatttggcac acacagtgtt gcagacaaac gtgaagcacc
     1921 tggtgataca gacagacatg gacctcatgg tggttacttt ctgcattaag ttctgctgtc
     1981 acgtgaggag tcttcagctg aacaggaagg tacagcaggg acataagttt acggcccctg
     2041 ggatggttct gtacagatgg accccaatca ctgatgccag ctggaagatt ttcttctcca
     2101 atcttaagtt agccagaaac ctggaggagt tggacctaag tggaaatcca ctgagctact
     2161 atgcagtaca cagtctttgt acgaccctga gaaagcgtgg ctgccaacta aagactctgt
     2221 ggcttgttga atgcggcctc acatccacat actgctcact tctggcctca gtactcagtg
     2281 cccgctccag cctgactgag ctagacctgc agctgaatga cctgggtgat ggtggtgtga
     2341 agatgttgtg tgaggggctc aggaatcctg cctgcaatct cagcatcctg tggctggacc
     2401 aggcatctct cagtgaccaa gtgattgcag agctcagaac tctggaggca aagaatccaa
     2461 agctgctcat ctccagcaca tggaagccac atgtgatggt ccctacgatg aacatggata
     2521 aagaagaagt gggtgatagc caggccctac tgaagcagca gagacagcag tcaggagaca
     2581 aacacatgga acctctgggg actgaagatg agttctgggg ccctacagga cctgtgacta
     2641 ctgaggtggt tgacagagag aggaacctgt accgagttca gttacccatg gctggttcct
     2701 accactgtcc cagtacagga ctccactttg tggtgacaag ggcagtgaca atcgagattg
     2761 aattctgtgc ctggagccaa tatctcgaca agactccctt gcagcagagt cacatggtgg
     2821 ttggacctct gtttgacatc aaggctgagc aaggagctgt gactgcagtg tacctccctc
     2881 attttgtggc cctccaagag ggaatcgtgg acagctcctt gttccatgtt gcccactttc
     2941 aagaacatgg gatggtccta gaaacaccag caagggtgga acagcattac gcagtactgg
     3001 aaaacccaag cttctcccca atggggattc tactgagaat gattccggct gtcggacact
     3061 tcatccccat cacttccacc acactgatct actatcacct ctatcttgaa gacgtcacct
     3121 ttcaccttta cctggtcccc aatgactgca gtattcgaaa ggccattgat gatgaagaaa
     3181 tgaagtttca gtttgtgcgc ataaacaagc cacccccagt agacgctctt tatcttggtt
     3241 cccgctatat cgtgtcttcc tccaaattgg tggaaattat cccaaaggaa ctagagctgt
     3301 gctaccgaag ccctggggaa tcccagctct tctctgagat cgacattggg cacatggatt
     3361 cagagattaa gctgcaaatc aaagacaaga ggcacatgaa tctcaaatgg gaggccttgc
     3421 tgaaaccagg ggatctcaga cctgcactgc ccaagattgc tacagccccc aaagatgctc
     3481 cttccttgct gcacttcatg gaccagcatc gggagcagct ggtggcccga gtgacatctg
     3541 tagatcctct cttggacaag ctgcatggtc tggtgctgag tgaagattcc tatgaagtag
     3601 tgcggtctga gaccacaaac caagacaaga tgaggaagct cttcagcctc agccggtcct
     3661 ggagctggga ttgcaaagac caattctacc aagctctgaa ggagacccat cctcacctgg
     3721 tcatggatat acttgagaag ttgggtgggg tctctgtgaa atcctgacat cctggtggct
     3781 gaaaagtgag cactctcctt agagtcctgc ctctgcctga cctttccttg gtcctgagtt
     3841 gctccatctg taaccaatgg ccatctgagt ttcctttctt gtggcagtgc ttccatgaca
     3901 tttcttggtg atccatatga tcccttttgg ccttccccag ccatatgtta atgtggaata
     3961 agcatctcag aaaaaatcca gtggggccat gtctattcag acgttgtccc ccatgttctt
     4021 atgatcaaag cagccagtct agagacagcc tgacccacca tgaatgcaag cagggctgag
     4081 gatcatggga ctggaaagtg agtgtcttat gaataggaaa ggaagggggc tttttaaact
     4141 catgttgtgt gctcagaaac agaggtgtag agaagtcaca tggtgcagca tgggactcac
     4201 tgtcagaaac accccagatt cagtgcacat tgtaatttaa tcttgggcac ttgcatatac
     4261 acatgccttc tgttcttgtg atgaatttgc aaacctcgca ttttgttata tcatcccata
     4321 tggaggtgtg tgtcacagct taggaaactg atatgtgatg gtagaccaga tgactgaaca
     4381 gaggctcagt ggttagcagt tgctcttgag atggtcagag tcctattccc agcacccatt
     4441 tcaggcagct cacaactgtg aataacacca acctcactgg atccaacagc ctccttccca
     4501 cttcttggtc acccatatat acattcacat gcacaaaata ggtttttaat ttttataaaa
     4561 gaatgaataa taaaatggga ttcttctcca ttgctcaccc atctgtagtc tcccctcccc
     4621 cagcctgaaa cctgcttgct caggggtgga gcttcctgct catttgttct gccacgccca
     4681 ctgctggaac ctgaggagcc acacacgtgc acctttctac tggaccagag attattcggc
     4741 gggaatcggg tcccctcccc cttccttcat aactagtgtc gcaacaataa aatttgagct
     4801 ttgatc
//
