LOCUS       NM_001002894            3297 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus NLR family, pyrin domain containing 14 (Nlrp14), mRNA.
ACCESSION   NM_001002894 XM_355925
VERSION     NM_001002894.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3297)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3297)
  AUTHORS   Zhang,W., Zhang,R., Wu,L., Zhu,C., Zhang,C., Xu,C., Zhao,S.,
            Liu,X., Guo,T., Lu,Y., Gao,Z., Yu,X., Li,L., Chen,Z.J., Qin,Y. and
            Jiao,X.
  TITLE     NLRP14 deficiency causes female infertility with oocyte maturation
            defects and early embryonic arrest by impairing cytoplasmic UHRF1
            abundance
  JOURNAL   Cell Rep 42 (12), 113531 (2023)
   PUBMED   38060382
REFERENCE   3  (bases 1 to 3297)
  AUTHORS   Meng,T.G., Guo,J.N., Zhu,L., Yin,Y., Wang,F., Han,Z.M., Lei,L.,
            Ma,X.S., Xue,Y., Yue,W., Nie,X.Q., Zhao,Z.H., Zhang,H.Y., Sun,S.M.,
            Ouyang,Y.C., Hou,Y., Schatten,H., Ju,Z., Ou,X.H., Wang,Z.B.,
            Wong,C.C.L., Li,Z. and Sun,Q.Y.
  TITLE     NLRP14 Safeguards Calcium Homeostasis via Regulating the K27
            Ubiquitination of Nclx in Oocyte-to-Embryo Transition
  JOURNAL   Adv Sci (Weinh) 10 (27), e2301940 (2023)
   PUBMED   37493331
  REMARK    GeneRIF: NLRP14 Safeguards Calcium Homeostasis via Regulating the
            K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition.
REFERENCE   4  (bases 1 to 3297)
  AUTHORS   Yan,R., Cheng,X., Gu,C., Xu,Y., Long,X., Zhai,J., Sun,F., Qian,J.,
            Du,Y., Wang,H. and Guo,F.
  TITLE     Dynamics of DNA hydroxymethylation and methylation during mouse
            embryonic and germline development
  JOURNAL   Nat Genet 55 (1), 130-143 (2023)
   PUBMED   36539615
REFERENCE   5  (bases 1 to 3297)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   6  (bases 1 to 3297)
  AUTHORS   Yu,C., Zhang,Y.L., Pan,W.W., Li,X.M., Wang,Z.W., Ge,Z.J.,
            Zhou,J.J., Cang,Y., Tong,C., Sun,Q.Y. and Fan,H.Y.
  TITLE     CRL4 complex regulates mammalian oocyte survival and reprogramming
            by activation of TET proteins
  JOURNAL   Science 342 (6165), 1518-1521 (2013)
   PUBMED   24357321
  REMARK    Erratum:[Science. 2014 May 2;344(6183):370]
REFERENCE   7  (bases 1 to 3297)
  AUTHORS   Joshi,S., Davies,H., Sims,L.P., Levy,S.E. and Dean,J.
  TITLE     Ovarian gene expression in the absence of FIGLA, an oocyte-specific
            transcription factor
  JOURNAL   BMC Dev Biol 7, 67 (2007)
   PUBMED   17567914
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3297)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   9  (bases 1 to 3297)
  AUTHORS   Horikawa,M., Kirkman,N.J., Mayo,K.E., Mulders,S.M., Zhou,J.,
            Bondy,C.A., Hsu,S.Y., King,G.J. and Adashi,E.Y.
  TITLE     The mouse germ-cell-specific leucine-rich repeat protein NALP14: a
            member of the NACHT nucleoside triphosphatase family
  JOURNAL   Biol Reprod 72 (4), 879-889 (2005)
   PUBMED   15590904
  REMARK    GeneRIF: Nalp14 transcripts were continuously expressed through the
            preovulatory stage, but declined when meiotic maturation resumed,
            and they were markedly diminished by the 2-cell embryo stage.
REFERENCE   10 (bases 1 to 3297)
  AUTHORS   Lane,R.P., Cutforth,T., Young,J., Athanasiou,M., Friedman,C.,
            Rowen,L., Evans,G., Axel,R., Hood,L. and Trask,B.J.
  TITLE     Genomic analysis of orthologous mouse and human olfactory receptor
            loci
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7390-7395 (2001)
   PUBMED   11416212
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ053047.1, BC141199.1 and DV644607.1.
            
            On Apr 29, 2009 this sequence version replaced NM_001002894.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY673647.1, BC141199.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849381 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                CJ053047.1         2-17
            17-3249             BC141199.1         1-3233
            3250-3297           DV644607.1         384-431
FEATURES             Location/Qualifiers
     source          1..3297
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 56.1 cM"
     gene            1..3297
                     /gene="Nlrp14"
                     /gene_synonym="4921520L01Rik; GC-LRR; Nalp-iota; Nalp14;
                     Nalp14l"
                     /note="NLR family, pyrin domain containing 14"
                     /db_xref="GeneID:76858"
                     /db_xref="MGI:MGI:1924108"
     exon            1..92
                     /gene="Nlrp14"
                     /gene_synonym="4921520L01Rik; GC-LRR; Nalp-iota; Nalp14;
                     Nalp14l"
                     /inference="alignment:Splign:2.1.0"
     exon            93..179
                     /gene="Nlrp14"
                     /gene_synonym="4921520L01Rik; GC-LRR; Nalp-iota; Nalp14;
                     Nalp14l"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..3088
                     /gene="Nlrp14"
                     /gene_synonym="4921520L01Rik; GC-LRR; Nalp-iota; Nalp14;
                     Nalp14l"
                     /note="NACHT, leucine rich repeat and PYD containing 14;
                     RNI-like protein; germ-cell specific leucine rich repeat
                     NTPase"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein
                     14"
                     /protein_id="NP_001002894.2"
                     /db_xref="CCDS:CCDS21688.1"
                     /db_xref="GeneID:76858"
                     /db_xref="MGI:MGI:1924108"
                     /translation="MKTEDDEMEYEASKEETVSEDKDFDDGIDYRTVIKENIFTMWYK
                     TSLHGEFATLNCVITPKDQNLLQHIFDEDIQTSEAPQTVVLQGAAGIGKTTLLKKAVL
                     EWADGNLYQQFTHVFYLNGKEISQVKEKSFAQLISKHWPSSEGPIEQVLSKPSSLLFI
                     IDSFDELDFSFEEPQFALCKDWTQISPVSFLISSLLRKVMLPESYLLVATRSTAWKRL
                     VPLLQKPQRVKLSGLSKNARMDYIHHLLKDKAWATSAIYSLRMNWRLFHMCHVCHMCQ
                     MICAVLKGQVEKGGRVEETCKTSTALFTYYICSLFPRIPVGCVTLPNETLLRSLCKAA
                     VEGIWTMKHVLYQQNLRKHELTREDILLFLDAKVLQQDTEYENCYMFTHLHVQEFFAA
                     LFYLLRENLEEQDYPSEPFENLYLLLESNHIHDPHLEQMKCFLFGLLNKDRVRQLEET
                     FNLTISMEVREELLACLEGLEKDDSSLSQLRFQDLLHCIYETQDQEFITQALMYFQKI
                     IVRVDEEPQLRIYSFCLKHCHTLKTMRLTARADLKNMLDTAEMCLEGAAVQVIHYWQD
                     LFSVLHTNESLIEMDLYESRLDESLMKILNEELSHPKCKLQKLIFRAVDFLNGCQDFT
                     FLASNKKVTHLDLKETDLGVNGLKTLCEALKCKGCKLRVLRLASCDLNVARCQKLSNA
                     LQTNRSLVFLNLSLNNLSNDGVKSLCEVLENPNSSLERLALASCGLTKAGCKVLSSAL
                     TKSKRLTHLCLSDNVLEDEGIKLLSHTLKHPQCTLQSLVLRSCSFTPIGSEHLSTALL
                     HNRSLVHLDLGQNKLADNGVKLLCHSLQQPHCNLQELELMSCVLTSKACGDLASVLVN
                     NSNLWSLDLGHNILDDAGLNILCDALRNPNCHVQRLGLENCGLTPGCCQDLLGILSNN
                     KSVIQMNLMKNALDHESIKNLCKVLRSPTCKMEFLALDKKEILKKKIKKFLVDVRINN
                     PHLVIGPECPNTESGCWWNYF"
     exon            180..1761
                     /gene="Nlrp14"
                     /gene_synonym="4921520L01Rik; GC-LRR; Nalp-iota; Nalp14;
                     Nalp14l"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1935
                     /gene="Nlrp14"
                     /gene_synonym="4921520L01Rik; GC-LRR; Nalp-iota; Nalp14;
                     Nalp14l"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2100
                     /gene="Nlrp14"
                     /gene_synonym="4921520L01Rik; GC-LRR; Nalp-iota; Nalp14;
                     Nalp14l"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2271
                     /gene="Nlrp14"
                     /gene_synonym="4921520L01Rik; GC-LRR; Nalp-iota; Nalp14;
                     Nalp14l"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2442
                     /gene="Nlrp14"
                     /gene_synonym="4921520L01Rik; GC-LRR; Nalp-iota; Nalp14;
                     Nalp14l"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2613
                     /gene="Nlrp14"
                     /gene_synonym="4921520L01Rik; GC-LRR; Nalp-iota; Nalp14;
                     Nalp14l"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2784
                     /gene="Nlrp14"
                     /gene_synonym="4921520L01Rik; GC-LRR; Nalp-iota; Nalp14;
                     Nalp14l"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2955
                     /gene="Nlrp14"
                     /gene_synonym="4921520L01Rik; GC-LRR; Nalp-iota; Nalp14;
                     Nalp14l"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3282
                     /gene="Nlrp14"
                     /gene_synonym="4921520L01Rik; GC-LRR; Nalp-iota; Nalp14;
                     Nalp14l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3257..3262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nlrp14"
                     /gene_synonym="4921520L01Rik; GC-LRR; Nalp-iota; Nalp14;
                     Nalp14l"
                     /note="hexamer: AGTAAA"
     polyA_site      3282
                     /gene="Nlrp14"
                     /gene_synonym="4921520L01Rik; GC-LRR; Nalp-iota; Nalp14;
                     Nalp14l"
                     /note="major polyA site"
ORIGIN      
        1 agcgaacccg tggaggcttc tcgggcaggt gtttgacttg tttctcagcg caaggactta
       61 actttcatca ctaacatcga cccagactag aggaacacca aagaccatga agactgagga
      121 tgatgagatg gaatacgaag cttctaaaga ggaaaccgtg agtgaggaca aagactttga
      181 tgatggaata gactacagaa ctgtaataaa ggaaaacatt tttactatgt ggtataagac
      241 ctctttgcat ggagaatttg caactttaaa ttgtgtaatt acacctaaag accaaaatct
      301 gctgcagcat atatttgatg aggatatcca aacttccgag gctccacaaa cggtagtcct
      361 tcaaggagct gctggaattg ggaagacaac attgttgaaa aaggcagtct tagaatgggc
      421 agatggcaat ctctatcagc agtttaccca tgtattttat ctcaatggga aagagattag
      481 ccaagtaaag gagaaaagct ttgctcagtt aatatcaaag cactggccta gcagcgaggg
      541 ccccattgaa caggtcctgt ctaaacccag cagtctcctc tttataatcg atagttttga
      601 tgaactggat ttctcctttg aagagccaca gtttgcactg tgtaaagact ggacccagat
      661 ctccccagtg tcttttctca ttagtagttt gctgaggaaa gtgatgcttc ctgagtccta
      721 cttattagta gcgacaagat ccacagcttg gaagcgacta gtgcctttat tgcaaaaacc
      781 tcaacgtgta aagctgtcag ggctgtctaa gaatgcaagg atggactata ttcaccattt
      841 gttgaaagat aaggcatggg ctacgagtgc aatttattca ctaagaatga attggaggct
      901 tttccacatg tgccacgtgt gccacatgtg ccagatgatc tgtgctgttc tcaagggaca
      961 agtggagaaa ggtggccgtg ttgaagagac ctgcaaaacc agcacggctc tgttcacata
     1021 ctatatctgc agcttatttc cacgcatacc tgtgggctgt gttactctgc ccaatgaaac
     1081 cctgttgagg agcctgtgca aggctgctgt tgaaggcatc tggacaatga agcatgtgct
     1141 ttaccagcaa aatctccgaa agcatgaatt aaccagagag gacattttgc ttttcctgga
     1201 tgcaaaggtt cttcagcaag acactgagta tgaaaactgc tacatgttca ctcacctcca
     1261 tgttcaggag ttttttgcag ctctttttta cttgctgaga gagaatttag aagaacaaga
     1321 ctatccctct gaaccttttg aaaacttgta tctgttgctt gaaagcaacc acattcatga
     1381 ccctcatttg gaacagatga aatgcttttt gtttggtcta ctaaataaag acagagtacg
     1441 acaactggag gaaactttca accttacaat atccatggag gtaagagaag agttacttgc
     1501 atgtctggaa ggattagaaa aggatgactc ttctctatca cagctgagat ttcaagactt
     1561 gctccactgt atatatgaga ctcaagatca agaattcatc actcaggcac tgatgtattt
     1621 ccaaaagatt atcgtgaggg ttgacgaaga accccagttg cgtatatatt cattctgtct
     1681 taagcactgc cacactctaa agactatgag actgacagca agggcagact tgaaaaatat
     1741 gttggacaca gctgaaatgt gccttgaggg tgctgctgtt caagtcattc actactggca
     1801 agatctgttt tctgtgcttc atacaaatga gtccctgata gaaatggatc tgtatgaaag
     1861 cagacttgat gaatcattga tgaaaatttt gaatgaagaa ttaagtcacc caaagtgtaa
     1921 actacaaaaa ctaatattca gagctgtcga tttcctgaat ggctgtcagg attttacttt
     1981 cttggcttcc aataagaagg tgacacatct tgacctgaaa gaaactgatt taggagtcaa
     2041 tggactaaag accttatgtg aagccttgaa atgcaaagga tgtaaattac gggtgcttag
     2101 gttggcatcc tgcgacctga atgtagcccg ttgtcaaaag ttatccaatg ctctccaaac
     2161 caataggagc ctggtatttc tgaatctgtc cctcaacaat ctatcaaatg atggagtaaa
     2221 gtcgttgtgt gaggtcttag aaaatccaaa ctcttctcta gagagactgg ccttagcaag
     2281 ctgtggcctc acaaaagctg gttgtaaagt tctttcctcg gctctcacca aaagcaagag
     2341 gctgacacat ttatgcttgt cagacaacgt cttagaagat gaagggataa agctgctcag
     2401 ccataccttg aagcatccac agtgtactct gcagagcctt gtgcttaggt cttgcagttt
     2461 cactccgatt ggcagtgagc atctctccac cgctctcctg cacaacagga gcttggtaca
     2521 tctggacctg ggacaaaaca agctggcgga taatggagtg aagcttctgt gtcactccct
     2581 ccagcagcca cactgcaatc ttcaggagct ggagttgatg agctgtgttc tcacgagtaa
     2641 ggcttgtggg gatctggctt ctgttcttgt gaacaactca aacttgtgga gcctagacct
     2701 tgggcacaat atcttggatg atgctggtct gaatattctg tgtgatgctt taagaaatcc
     2761 caactgccac gttcagaggc taggattgga aaactgtggt ttgacccctg gttgctgtca
     2821 ggatctctta ggtatcttat ctaacaacaa aagtgtgata caaatgaact taatgaagaa
     2881 tgcccttgat catgaatcaa ttaagaatct atgtaaagtc ttgagatctc caacatgcaa
     2941 aatggaattt ctagcgttag acaaaaagga aatattgaag aagaaaatca agaagtttct
     3001 ggtcgatgta agaattaata atccacattt ggtcattggg ccagagtgtc ctaatacaga
     3061 aagtgggtgc tggtggaatt atttctgaag aaccggatgt gcctgtaaaa aatttaaaaa
     3121 cctaacttcc aagtggcaaa gtctttaact tgtaagaaat actgtttatg tccagaagca
     3181 ctgaactgca ctcagtaggg gtaggttgct cacgtctctg taaaatgttt gttgggtttc
     3241 acgtggaggt tgagaaagta aagcaaagca cataaaatgc caaaaaaaaa aaaaaaa
//
