LOCUS       NM_001033431            4329 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus NLR family, pyrin domain containing 12 (Nlrp12), mRNA.
ACCESSION   NM_001033431 XM_001476888 XM_904112
VERSION     NM_001033431.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4329)
  AUTHORS   Niethamer,T.K., Planer,J.D., Morley,M.P., Babu,A., Zhao,G.,
            Basil,M.C., Cantu,E., Frank,D.B., Diamond,J.M., Nottingham,A.N.,
            Li,S., Sharma,A., Hallquist,H., Levin,L.I., Zhou,S., Vaughan,A.E.
            and Morrisey,E.E.
  TITLE     Longitudinal single-cell profiles of lung regeneration after viral
            infection reveal persistent injury-associated cell states
  JOURNAL   Cell Stem Cell 32 (2), 302-321 (2025)
   PUBMED   39818203
REFERENCE   2  (bases 1 to 4329)
  AUTHORS   Callahan,J.W., Morales,J.C., Atherton,J.F., Wang,D., Kostic,S. and
            Bevan,M.D.
  TITLE     Movement-related increases in subthalamic activity optimize
            locomotion
  JOURNAL   Cell Rep 43 (8), 114495 (2024)
   PUBMED   39068661
REFERENCE   3  (bases 1 to 4329)
  AUTHORS   Jiang,J., Shen,W., He,Y., Liu,J., Ouyang,J., Zhang,C. and Hu,K.
  TITLE     Overexpression of NLRP12 enhances antiviral immunity and alleviates
            herpes simplex keratitis via pyroptosis/IL-18/IFN-gamma signaling
  JOURNAL   Int Immunopharmacol 137, 112428 (2024)
   PUBMED   38908077
  REMARK    GeneRIF: Overexpression of NLRP12 enhances antiviral immunity and
            alleviates herpes simplex keratitis via pyroptosis/IL-18/IFN-gamma
            signaling.
REFERENCE   4  (bases 1 to 4329)
  AUTHORS   Jiang,J., Zhang,D., Liu,W., Yang,J., Yang,F., Liu,J. and Hu,K.
  TITLE     Overexpression of NLRP12 enhances macrophage immune response and
            alleviates herpes simplex keratitis
  JOURNAL   Front Cell Infect Microbiol 14, 1416105 (2024)
   PUBMED   39119293
  REMARK    GeneRIF: Overexpression of NLRP12 enhances macrophage immune
            response and alleviates herpes simplex keratitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4329)
  AUTHORS   Sirbulescu,R.F., Nicholson,K., Kawai,K., Hilton,O.M., Sobell,D.,
            Jin,G., Verrill,D.E., Dwyer,L.J., Xiong,Y., Bachanova,P., Kim,S.E.,
            Gallup,S., Gelevski,D., Daley,H., Hernandez Rodriguez,D.E.,
            Negre,H., Sturtevant,O., Nikiforow,S., Ritz,J., Chen,Y.B.,
            Reeves,P.M., Sluder,A.E., Berry,J.D., Sadri-Vakili,G., Cudkowicz,M.
            and Poznansky,M.C.
  TITLE     Allogeneic B cell immunomodulatory therapy in amyotrophic lateral
            sclerosis
  JOURNAL   FASEB J 38 (13), e23796 (2024)
   PUBMED   38967302
REFERENCE   6  (bases 1 to 4329)
  AUTHORS   Allen,I.C., Lich,J.D., Arthur,J.C., Jania,C.M., Roberts,R.A.,
            Callaway,J.B., Tilley,S.L. and Ting,J.P.
  TITLE     Characterization of NLRP12 during the development of allergic
            airway disease in mice
  JOURNAL   PLoS One 7 (1), e30612 (2012)
   PUBMED   22291998
  REMARK    GeneRIF: NLRP12 does not play a vital role in regulating Th2 driven
            airway inflammation using common model systems that are
            physiologically relevant to human disease.
REFERENCE   7  (bases 1 to 4329)
  AUTHORS   Zaki,M.H., Vogel,P., Malireddi,R.K., Body-Malapel,M., Anand,P.K.,
            Bertin,J., Green,D.R., Lamkanfi,M. and Kanneganti,T.D.
  TITLE     The NOD-like receptor NLRP12 attenuates colon inflammation and
            tumorigenesis
  JOURNAL   Cancer Cell 20 (5), 649-660 (2011)
   PUBMED   22094258
  REMARK    GeneRIF: NLRP12 has a critical role in maintaining intestinal
            homeostasis and providing protection against colorectal
            tumorigenesis.
REFERENCE   8  (bases 1 to 4329)
  AUTHORS   Elinav,E., Strowig,T., Kau,A.L., Henao-Mejia,J., Thaiss,C.A.,
            Booth,C.J., Peaper,D.R., Bertin,J., Eisenbarth,S.C., Gordon,J.I.
            and Flavell,R.A.
  TITLE     NLRP6 inflammasome regulates colonic microbial ecology and risk for
            colitis
  JOURNAL   Cell 145 (5), 745-757 (2011)
   PUBMED   21565393
REFERENCE   9  (bases 1 to 4329)
  AUTHORS   Arthur,J.C., Lich,J.D., Ye,Z., Allen,I.C., Gris,D., Wilson,J.E.,
            Schneider,M., Roney,K.E., O'Connor,B.P., Moore,C.B., Morrison,A.,
            Sutterwala,F.S., Bertin,J., Koller,B.H., Liu,Z. and Ting,J.P.
  TITLE     Cutting edge: NLRP12 controls dendritic and myeloid cell migration
            to affect contact hypersensitivity
  JOURNAL   J Immunol 185 (8), 4515-4519 (2010)
   PUBMED   20861349
  REMARK    GeneRIF: NLRP12 is important in maintaining neutrophils and
            peripheral DCs in a migration-competent state
REFERENCE   10 (bases 1 to 4329)
  AUTHORS   Hornung,V., Ablasser,A., Charrel-Dennis,M., Bauernfeind,F.,
            Horvath,G., Caffrey,D.R., Latz,E. and Fitzgerald,K.A.
  TITLE     AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating
            inflammasome with ASC
  JOURNAL   Nature 458 (7237), 514-518 (2009)
   PUBMED   19158675
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC245272.2.
            
            On or before Sep 10, 2009 this sequence version replaced
            XM_904112.3, XM_001476888.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164135
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-490               AC245272.2         148183-148672       c
            491-571             AC245272.2         144261-144341       c
            572-2252            AC245272.2         138762-140442       c
            2253-2423           AC245272.2         134086-134256       c
            2424-2594           AC245272.2         132807-132977       c
            2595-2765           AC245272.2         132019-132189       c
            2766-2936           AC245272.2         129902-130072       c
            2937-3107           AC245272.2         127324-127494       c
            3108-3278           AC245272.2         124180-124350       c
            3279-4329           AC245272.2         120486-121536       c
FEATURES             Location/Qualifiers
     source          1..4329
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 1.88 cM"
     gene            1..4329
                     /gene="Nlrp12"
                     /gene_synonym="monarch-1; Nalp12; PYPAF7"
                     /note="NLR family, pyrin domain containing 12"
                     /db_xref="GeneID:378425"
                     /db_xref="MGI:MGI:2676630"
     exon            1..490
                     /gene="Nlrp12"
                     /gene_synonym="monarch-1; Nalp12; PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..3366
                     /gene="Nlrp12"
                     /gene_synonym="monarch-1; Nalp12; PYPAF7"
                     /note="PYRIN-containing APAF1-like protein 7"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein
                     12"
                     /protein_id="NP_001028603.1"
                     /db_xref="CCDS:CCDS51963.1"
                     /db_xref="GeneID:378425"
                     /db_xref="MGI:MGI:2676630"
                     /translation="MLPSTARDGLYRLSTYLEELEAGELKKFKLFLGIAEDLSQDKIP
                     WGRMEKAGPLEMAQLMVAHMGTREAWLLALSTFQRIHRKDLWERGQGEDLVRVTPNNG
                     LCLFESQSACPLDVSPNAPRKDLQTTYKDYVRRKFQLMEDRNARLGECVNLSNRYTRL
                     LLVKEHSNPIWTQQKFVDVEWERSRTRRHQTSPIQMETLFEPDEERPEPPHTVVLQGA
                     AGMGKSMLAHKVMLDWADGRLFQGRFDYVFYISCRELNRSHTQCSVQDLISSCWPERG
                     ISLEDLMQAPDRLLFIIDGFDKLHPSFHDAQGPWCLCWEEKQPTEVLLGSLIRRLLLP
                     QVSLLITTRPCALEKLHGLLEHPRHVEILGFSEEARKEYFYRYFHNTGQASRVLSFLM
                     DYEPLFTMCFVPMVSWVVCTCLKQQLESGELLRQTPRTTTAVYMFYLLSLMQPKPGTP
                     TFKVPANQRGLVSLAAEGLWNQKILFDEQDLGKHGLDGADVSTFLNVNIFQKGIKCEK
                     FYSFIHLSFQEFFAAMYCALNGREAVRRALAEYGFSERNFLALTVHFLFGLLNEEMRC
                     YLERNLGWSISPQVKEEVLAWIQNKAGSEGSTLQHGSLELLSCLYEVQEEDFIQQALS
                     HFQVVVVRSISTKMEHMVCSFCARYCRSTEVLHLHGSAYSTGMEDDPPEPSGVQTQST
                     YLQERNMLPDVYSAYLSAAVCTNSNLIELALYRNALGSQGVRLLCQGLRHASCKLQNL
                     RLKRCQISGSACQDLAAAVIANRNLIRLDLSDNSIGVPGLELLCEGLQHPRCRLQMIQ
                     LRKCLLEAAAGRSLASVLSNNSYLVELDLTGNPLEDSGLKLLCQGLRHPVCRLRTLWL
                     KICHLGQASCEDLASTLKMNQSLLELDLGLNDLGDSGVLLLCEGLSHPDCKLQTLRLG
                     ICRLGSVACVGIASVLQVNTCLQELDLSFNDLGDRGLQLLGEGLRHQTCRLQKLWLDN
                     CGLTSKACEDLSSILGISQTLHELYLTNNALGDTGVCLLCKRLRHPGCKLRVLWLFGM
                     DLNKKTHRRMAALRVTKPYLDIGC"
     exon            491..571
                     /gene="Nlrp12"
                     /gene_synonym="monarch-1; Nalp12; PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     exon            572..2252
                     /gene="Nlrp12"
                     /gene_synonym="monarch-1; Nalp12; PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2423
                     /gene="Nlrp12"
                     /gene_synonym="monarch-1; Nalp12; PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2594
                     /gene="Nlrp12"
                     /gene_synonym="monarch-1; Nalp12; PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2765
                     /gene="Nlrp12"
                     /gene_synonym="monarch-1; Nalp12; PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2936
                     /gene="Nlrp12"
                     /gene_synonym="monarch-1; Nalp12; PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3107
                     /gene="Nlrp12"
                     /gene_synonym="monarch-1; Nalp12; PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3278
                     /gene="Nlrp12"
                     /gene_synonym="monarch-1; Nalp12; PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     exon            3279..4329
                     /gene="Nlrp12"
                     /gene_synonym="monarch-1; Nalp12; PYPAF7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgttgaca ggagcaggta gcagagaagc aatgggtagg agagtataat ttctcgaaag
       61 atcttgcctc tgtcccaatc ttattcctat aaccctcacc cccttttgct tgtcaatgag
      121 gccatggcag cgtgctagct acagtgctta ttgtcctttt agagagaggt tagagcatct
      181 ggccccgtta ctttgtcccc catgttgccg tctacagcca gggatggcct ctatcgactg
      241 tctacctacc tggaagaact cgaggctggg gaactgaaga aattcaaatt attcctgggg
      301 attgcagagg acctgagcca ggacaaaatt ccctggggac gaatggagaa ggctggtcct
      361 ctggaaatgg ctcagctgat ggtggcccac atggggacaa gggaggcttg gcttctggct
      421 ctcagcacct ttcagaggat tcacaggaag gacctgtggg agcgaggaca gggagaagac
      481 ctggtgaggg tcactccaaa taatggtcta tgcctttttg agagccaatc agcgtgccct
      541 ttggatgtct ctcccaatgc tccaagaaaa gatctacaga caacctacaa agactatgtc
      601 cgaaggaaat tccagctaat ggaagaccgc aatgcacgat taggcgaatg tgtgaacctg
      661 agcaatcgtt acactcggct tctcctagta aaagaacact caaatcctat ctggacacag
      721 cagaaatttg tagatgtaga gtgggaacgc tccagaacca ggcgtcacca gactagtcct
      781 atccaaatgg agaccctctt tgagccagac gaagaacgcc ccgagccacc acacacagtg
      841 gtattacaag gggcagcggg gatggggaag tccatgctgg cccacaaagt gatgttggac
      901 tgggccgatg ggaggctctt ccaaggccgg tttgattatg tcttctatat cagctgcagg
      961 gagttgaata gaagccacac ccagtgcagt gtacaagacc tcatctccag ctgctggccg
     1021 gagcgtggta tatccctcga agacctcatg caggctcctg accgtctcct attcatcatt
     1081 gatggcttcg ataaactcca tccttctttc catgatgctc agggtccctg gtgcctctgc
     1141 tgggaggaga aacaacctac tgaagtcctc ctcggaagtc tgattcggag gttgcttctg
     1201 ccccaggtct ctctgctcat caccacacga ccctgtgcac tggagaagct gcacggcttg
     1261 ctagaacacc ccaggcacgt ggagatcctg ggcttctccg aggaagctag gaaggaatat
     1321 ttctacagat atttccacaa cactggacaa gcaagccggg tgttaagctt cttgatggac
     1381 tatgagcccc tctttaccat gtgttttgtt cccatggtgt cctgggtggt ctgcacctgc
     1441 ctaaagcagc agctggaaag tggggagctt ttaagacaaa cacctaggac caccacagct
     1501 gtttatatgt tctaccttct gagcctgatg cagcccaagc cagggactcc aaccttcaaa
     1561 gtcccagcca accagagagg cctggtctct ctggctgcag agggcctctg gaatcagaag
     1621 attctatttg atgaacagga tcttgggaaa cacggcctag atggagcaga tgtgtccact
     1681 ttcctcaacg tgaacatatt ccagaagggt atcaaatgtg agaaattcta cagcttcatc
     1741 cacctgagtt tccaggaatt cttcgcagcc atgtactgtg cactgaatgg cagagaggcg
     1801 gtgaggagag cgctggctga gtatggtttt tcggaaagga acttcttggc cctcacggtc
     1861 cactttctgt ttggcctcct caacgaagag atgagatgct accttgagag gaatctcggc
     1921 tggagcatct cccctcaggt gaaggaggaa gtgttggcat ggatccaaaa caaggctggg
     1981 agtgaaggct ccaccctgca gcatggctcc ctggagctac tcagctgctt gtatgaggtc
     2041 caggaggagg acttcatcca gcaggccctg agccactttc aagtggttgt agtcagaagc
     2101 atctcaacaa agatggagca catggtctgc tcgttttgtg cgaggtattg cagaagtaca
     2161 gaagtgcttc acttgcatgg gagtgcttat agtacaggca tggaggacga cccaccagaa
     2221 ccttcaggag tccagactca gtccacatac ttacaggaaa ggaacatgct gcctgatgtc
     2281 tacagtgcat acctttcagc agctgtctgt accaactcca acctgatcga gctggcctta
     2341 taccgaaatg ccttgggcag ccagggtgta aggctgctct gtcaaggcct ccgacatgcc
     2401 agctgcaagc tgcagaacct gaggctgaag aggtgtcaga tctccggatc agcctgccag
     2461 gacctcgcag ccgctgtcat cgccaacagg aatttaatca ggctggacct cagtgacaac
     2521 agcattgggg tgccaggcct ggagctgctc tgtgaggggc tgcagcaccc caggtgtagg
     2581 ctgcagatga tccagctgag gaagtgtctg ttggaggctg cagctggccg atccctggct
     2641 tctgttctca gcaacaactc atatctggta gaactggatc tgacaggaaa ccccttggaa
     2701 gattcggggc tgaagttact gtgtcaaggg ctaaggcacc ctgtctgcag gctgcgtacc
     2761 ctgtggctga agatctgcca ccttggacaa gcttcctgcg aagatctggc ctctactctc
     2821 aaaatgaacc agagcctgct ggagctggac ctgggtctga atgatcttgg agattctggg
     2881 gtgcttctgc tgtgtgaagg cctcagtcat ccagattgca aactccagac ccttcggttg
     2941 ggcatttgcc gactgggctc agtcgcgtgt gtggggatcg ccagtgtgct ccaggtcaac
     3001 acatgcctcc aagagctgga cctgagcttc aatgacttgg gagacagggg cctgcagctg
     3061 ctgggggaag gcctgaggca ccagacctgc agactccaga agctgtggct ggacaactgc
     3121 ggactcacct ccaaagcatg tgaggacctt tcttctatcc tgggaatcag ccagaccctg
     3181 catgagcttt atttgaccaa taatgctctg ggggacacag gtgtctgtct gctgtgcaag
     3241 aggctgaggc atccaggctg caagcttcga gtcctgtggc tgtttgggat ggacctgaat
     3301 aaaaagactc acaggaggat ggcagcactt cgagtcacaa aaccgtacct ggatattggg
     3361 tgttgagcag taaggagaac cagaatgaag ccgaccagga tatttattcc ctctgctttg
     3421 aagcacttga ggtggaactt ttaaaggcca gcctctggta tatggtgagg tggagacaag
     3481 atcactcaag gtcatcctgt tacatgggac cgtcttaggt caggaggccc agtaagtgca
     3541 ggttgacaaa attgttctgc ttgagaccta aacactcaac ctttgatgga gctcactggg
     3601 tttgatgtag attccacgca gataatttag gacggggatt ggctggttag caggtttgaa
     3661 gatcagtaaa gaccacagaa aaggaaaaat atccagagtc ctagacattt ccatggacca
     3721 agactgccat ctactggcca agtcacagca taaagaccca caaggtaatt tttcaaaaat
     3781 tgtactcaag ggctggagtg gttaagtcag aggtcctgag ttcaattccc agcaactaca
     3841 tggtggcttg caatcatctg taatgggatc caatgccttc tttgggtgaa tctgaagata
     3901 gctacagaac acttataaat ctttaaaaag aaaaattgta ctcacacctg aattttatac
     3961 agcaggggga aaaaaaagtg ggctggggct aaaggtataa ggcaccttac aaatgaggcc
     4021 tcaaaaccca agatttgcac acctggtata gttgacagcc aatgctccca tcctatcctg
     4081 ggttattaga ttttgcccag ctgtggtggt gttcgcattg aatctcaaca ctccagaaaa
     4141 ctgagcaagg tggccaagga tgcagaaatc atggctgtgc atgactcacg acctgacact
     4201 agtgaggcct ggcagacatc attcccagca accacgtggt agctccacca cttataatgg
     4261 gataactccg cccacttcca gtacagtacc cagagatcta cctttattat attaaattca
     4321 aacgctatc
//
