LOCUS       NM_001033207            6945 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus NLR family, CARD domain containing 5 (Nlrc5), mRNA.
ACCESSION   NM_001033207
VERSION     NM_001033207.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6945)
  AUTHORS   Guo,B., Zhu,H., Xiao,C., Zhang,J., Liu,X., Fang,Y., Wei,B.,
            Zhang,J., Cao,Y. and Zhan,L.
  TITLE     NLRC5 exerts anti-endometriosis effects through inhibiting
            ERbeta-mediated inflammatory response
  JOURNAL   BMC Med 22 (1), 351 (2024)
   PUBMED   39218863
  REMARK    GeneRIF: NLRC5 exerts anti-endometriosis effects through inhibiting
            ERbeta-mediated inflammatory response.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6945)
  AUTHORS   Sundaram,B., Pandian,N., Kim,H.J., Abdelaal,H.M., Mall,R.,
            Indari,O., Sarkar,R., Tweedell,R.E., Alonzo,E.Q., Klein,J.,
            Pruett-Miller,S.M., Vogel,P. and Kanneganti,T.D.
  TITLE     NLRC5 senses NAD+ depletion, forming a PANoptosome and driving
            PANoptosis and inflammation
  JOURNAL   Cell 187 (15), 4061-4077 (2024)
   PUBMED   38878777
  REMARK    GeneRIF: NLRC5 senses NAD[+] depletion, forming a PANoptosome and
            driving PANoptosis and inflammation.
REFERENCE   3  (bases 1 to 6945)
  AUTHORS   Han,J.H., Karki,R., Malireddi,R.K.S., Mall,R., Sarkar,R.,
            Sharma,B.R., Klein,J., Berns,H., Pisharath,H., Pruett-Miller,S.M.,
            Bae,S.J. and Kanneganti,T.D.
  TITLE     NINJ1 mediates inflammatory cell death, PANoptosis, and lethality
            during infection conditions and heat stress
  JOURNAL   Nat Commun 15 (1), 1739 (2024)
   PUBMED   38409108
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6945)
  AUTHORS   Sun,C., Shen,Y., Liu,P., Shen,Y., Hu,Y., Li,P., Zhang,Y., Miao,F.
            and Zhang,J.
  TITLE     NLRC5 Deficiency Reduces LPS-Induced Microglial Activation via
            Inhibition of NF-kappaB Signaling and Ameliorates Mice's
            Depressive-like Behavior
  JOURNAL   Int J Mol Sci 24 (17), 13265 (2023)
   PUBMED   37686068
  REMARK    GeneRIF: NLRC5 Deficiency Reduces LPS-Induced Microglial Activation
            via Inhibition of NF-kappaB Signaling and Ameliorates Mice's
            Depressive-like Behavior.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6945)
  AUTHORS   Santharam,M.A., Shukla,A., Levesque,D., Kufer,T.A., Boisvert,F.M.,
            Ramanathan,S. and Ilangumaran,S.
  TITLE     NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I
            Expression and Antitumor Immunity
  JOURNAL   Int J Mol Sci 24 (8), 7206 (2023)
   PUBMED   37108368
  REMARK    GeneRIF: NLRC5-CIITA Fusion Protein as an Effective Inducer of
            MHC-I Expression and Antitumor Immunity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6945)
  AUTHORS   Ji,J. and Wang,R.
  TITLE     Molecular cloning of large alternative transcripts based on
            comparative phylogenetic analysis and exploration of an EST
            database
  JOURNAL   Anal Biochem 424 (2), 140-141 (2012)
   PUBMED   22387390
REFERENCE   7  (bases 1 to 6945)
  AUTHORS   Kumar,H., Pandey,S., Zou,J., Kumagai,Y., Takahashi,K., Akira,S. and
            Kawai,T.
  TITLE     NLRC5 deficiency does not influence cytokine induction by virus and
            bacteria infections
  JOURNAL   J Immunol 186 (2), 994-1000 (2011)
   PUBMED   21148033
  REMARK    GeneRIF: NLRC5 overexpression promotes interleukin (IL)-1beta
            production via caspase-1 and is dispensable for cytokine induction
            in virus and bacterial infections under physiologic conditions.
REFERENCE   8  (bases 1 to 6945)
  AUTHORS   Meissner,T.B., Li,A., Biswas,A., Lee,K.H., Liu,Y.J., Bayir,E.,
            Iliopoulos,D., van den Elsen,P.J. and Kobayashi,K.S.
  TITLE     NLR family member NLRC5 is a transcriptional regulator of MHC class
            I genes
  JOURNAL   Proc Natl Acad Sci U S A 107 (31), 13794-13799 (2010)
   PUBMED   20639463
REFERENCE   9  (bases 1 to 6945)
  AUTHORS   Benko,S., Magalhaes,J.G., Philpott,D.J. and Girardin,S.E.
  TITLE     NLRC5 limits the activation of inflammatory pathways
  JOURNAL   J Immunol 185 (3), 1681-1691 (2010)
   PUBMED   20610642
  REMARK    GeneRIF: NLRC5 expression is critical for
            lipopolysaccharide-induced interleukin (IL)-10 production in
            RAW264.7 macrophages.
REFERENCE   10 (bases 1 to 6945)
  AUTHORS   Cui,J., Zhu,L., Xia,X., Wang,H.Y., Legras,X., Hong,J., Ji,J.,
            Shen,P., Zheng,S., Chen,Z.J. and Wang,R.F.
  TITLE     NLRC5 negatively regulates the NF-kappaB and type I interferon
            signaling pathways
  JOURNAL   Cell 141 (3), 483-496 (2010)
   PUBMED   20434986
  REMARK    GeneRIF: Study identifies NLRC5 as a negative regulator that blocks
            two central components of the NF-kappaB and type I interferon
            signaling pathways and suggest an important role for NLRC5 in
            homeostatic control of innate immunity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121866.2.
            
            On Jul 25, 2009 this sequence version replaced NM_001033207.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ889356.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               AC121866.2         104073-104364
            293-352             AC121866.2         105295-105354
            353-421             AC121866.2         105942-106010
            422-2084            AC121866.2         107005-108667
            2085-2168           AC121866.2         110778-110861
            2169-2252           AC121866.2         111001-111084
            2253-2336           AC121866.2         113090-113173
            2337-2426           AC121866.2         113286-113375
            2427-2486           AC121866.2         113877-113936
            2487-2549           AC121866.2         115380-115442
            2550-2633           AC121866.2         115848-115931
            2634-2717           AC121866.2         117942-118025
            2718-2807           AC121866.2         118962-119051
            2808-2876           AC121866.2         119893-119961
            2877-2945           AC121866.2         120823-120891
            2946-3038           AC121866.2         121640-121732
            3039-3122           AC121866.2         122135-122218
            3123-3212           AC121866.2         122791-122880
            3213-3257           AC121866.2         123641-123685
            3258-3335           AC121866.2         124351-124428
            3336-3419           AC121866.2         125580-125663
            3420-3503           AC121866.2         129092-129175
            3504-3593           AC121866.2         131689-131778
            3594-3656           AC121866.2         131928-131990
            3657-3740           AC121866.2         133529-133612
            3741-3824           AC121866.2         135691-135774
            3825-3914           AC121866.2         136416-136505
            3915-3980           AC121866.2         136772-136837
            3981-4064           AC121866.2         137806-137889
            4065-4148           AC121866.2         137977-138060
            4149-4235           AC121866.2         141754-141840
            4236-4316           AC121866.2         142525-142605
            4317-4400           AC121866.2         143562-143645
            4401-4493           AC121866.2         143864-143956
            4494-4577           AC121866.2         146911-146994
            4578-4661           AC121866.2         147533-147616
            4662-4745           AC121866.2         150505-150588
            4746-4829           AC121866.2         152133-152216
            4830-4913           AC121866.2         152326-152409
            4914-4997           AC121866.2         152520-152603
            4998-5081           AC121866.2         152713-152796
            5082-5165           AC121866.2         153030-153113
            5166-5243           AC121866.2         153227-153304
            5244-5327           AC121866.2         153979-154062
            5328-5399           AC121866.2         154145-154216
            5400-5483           AC121866.2         154459-154542
            5484-5567           AC121866.2         156293-156376
            5568-5651           AC121866.2         156730-156813
            5652-6945           AC121866.2         157289-158582
FEATURES             Location/Qualifiers
     source          1..6945
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 46.55 cM"
     gene            1..6945
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /note="NLR family, CARD domain containing 5"
                     /db_xref="GeneID:434341"
                     /db_xref="MGI:MGI:3612191"
     CDS             1..5748
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /codon_start=1
                     /product="protein NLRC5"
                     /protein_id="NP_001028379.2"
                     /db_xref="CCDS:CCDS59741.1"
                     /db_xref="GeneID:434341"
                     /db_xref="MGI:MGI:3612191"
                     /translation="MDAESIRLNNENLWAWLVRLLSKNPEWLSAKLRSFLPTMDLDCS
                     YEPSNPEVIHRQLNRLFAQGMATWKSFINDLCFELDVPLDMEIPLVSIWGPRDEFSKQ
                     LGAGEESCPGPQLYHGAKRPFQSYGSSPRRKNSKKQQLELAKKYLKLLKTSAQQWHGG
                     VCPGAWLTPHSPQTYIPPVLQWSRATAPLDAQEGATLGDPEAADNIDVSIQDLFSFKA
                     HKGPRVTVLLGKAGMGKTTLAYRLRWRWAQGQLDRFQALFLFEFRQLNMITQLPTLPQ
                     LLFDLYLMPESEPDAVFQYLKENAQEVLLIFDGLDEALHADSVGTDNAGSALTLFSEL
                     CHGNLLPGCWVMTTSRPGKLPSCVPTEAATVHMWGFDGLRVEKYVTCFFSDLLSQELA
                     LKEMRTNARLRGMCAIPALCTVTCFCLRRLLPGSSPGQSAALLPTITQLYLQMVETFS
                     PSETLLDTSILGFGKVALRGLDTGKVVFSVEDISPQLMSFGAVHSLLTSFCIHTRPGH
                     EEIGYAFVHLSLQEFFAALYLMASHTVDKDTLVEYVTLNSHWVLRTKGRLGLSDHLPA
                     FLAGLASHTCHMFLCQLAQQDRAWVGSRQAAVIQVLRKLASRKLTGPKMIELYHCVAE
                     TQDLELARFTAQSLPSRLSFHNFPLTHADLAALANILEHRDDPIHLDFDGCPLEPHCP
                     EALVGCGQVENLSFKSRKCGDAFAEALCRSLPTMGSLKTLGLTGSRITAQGISHLIQT
                     LPLCSQLEEVSLHDNQLKDPEVLSLVELLPSLPKLQKLDLSRNSFSRSILLSLVKVAI
                     TCPTVRKLQVRELDLIFYLSPVTETATQQSGASDVQGKDSLKEGQSRSLQLRLQKCQL
                     RIRDAEALVELFQKSPQLEEVNLSGNHLEDDGCRLVAEAASQLHIAQKLDLSDNGLSQ
                     TGVTYVLKAMSTCGTLEDLHISLLNNTVVLTFAQEPREQEGSCKGRAPLISFVSPVTS
                     ELSQRSRRIRLTHCGFLAKHTETLCEALRASCQTHNLDHLDLSDNSLGGKGVILLTEL
                     LPGLGPLKSLNLSRNGLSMDAVFSLVQCLSSLQWVFHLDVSLESDCIFLRGAGTSRDA
                     LEPKFQTGVQVLELSQRYTSRSFCLQECQLEPTSLTFLCATLEKSPGPLEVQLSCKSL
                     SDDSLKILLQCLPQLPQLSLLQLRHTVLSSRSPFLLADIFNLCPRVRKVTLRSLCHAV
                     LHFDSNEEQEGVCCGFPGCSLSQEHMETLCCALSKCNALSQLDLTDNLLGDIGLRCLL
                     ECLPQLPISGWLDLSHNNISQEGILYLLETLPSYPNIQEVSVSLSSEQIFRMCFSKKE
                     GAGTSLRLCECSFSPEQVSKLASSLSQAQQLTELWLTKCHLDLPQLTMLLNLVNRPTG
                     LLGLRLEEPWVDSVSLPALMEVCAQASGCLTELSISEIQRKLWLQLEFPHQEGNSDSM
                     ALRLAHCDLETEHSHLMIQLVETYARLQQLSLSQVSFNDNDGTSSKLLQNILLSSCEL
                     KSFRLTFSQVSTKSLTHLAFGLGHCHHLEELDFSNNSLREEDTELLMGALQGTCRLKK
                     LHLSFLPLGASSLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLAAILPKLPELRKFD
                     LSHNQIGDVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLS
                     RNQIGDVGTQCLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNN
                     ALGEPTALELAQRLPPQLRVLCLPSSHLGPEGALGLAQALEQCPHIEEVSLAENNLAG
                     GVPRFSKRLPLLRQIDLEFCKIEDQAARHLAANLTLFPALEKLLLSGNLLGDEVAAEL
                     AQVLPQMGQLKKVNLEWNRITARGAQLLAQGLVQGSCVPVIRLWNNPILNDVAQSLQS
                     QEPRLDFSITDQQTL"
     exon            1..292
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            293..352
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            353..421
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            422..2084
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2168
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2252
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2336
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2426
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2486
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2549
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2633
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2717
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2807
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2876
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..2945
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3038
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            3039..3122
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3212
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            3213..3257
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            3258..3335
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..3419
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3503
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            3504..3593
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            3594..3656
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            3657..3740
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            3741..3824
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            3825..3914
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            3915..3980
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            3981..4064
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            4065..4148
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            4149..4235
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            4236..4316
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            4317..4400
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            4401..4493
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            4494..4577
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            4578..4661
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            4662..4745
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            4746..4829
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            4830..4913
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            4914..4997
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            4998..5081
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            5082..5165
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            5166..5243
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            5244..5327
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            5328..5399
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            5400..5483
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            5484..5567
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            5568..5651
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     exon            5652..6945
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6908..6913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /note="hexamer: AATAAA"
     polyA_site      6941
                     /gene="Nlrc5"
                     /gene_synonym="NOD27"
                     /note="major polyA site"
ORIGIN      
        1 atggacgctg agagcatccg actgaacaat gaaaacctgt gggcctggct tgtgaggctg
       61 ctgagcaaaa acccagaatg gctgagtgcc aagcttaggt ccttcctccc gaccatggac
      121 ctggactgca gctatgagcc ctccaaccct gaggtcatcc accgtcagct caacaggctg
      181 ttcgcccaag gcatggccac ctggaagtct ttcatcaatg atctgtgctt cgagcttgat
      241 gtacctttgg acatggagat accactagtg agcatctggg gcccaagaga tgaattctct
      301 aagcagctag gggcaggaga ggagagctgc cctggacctc agctgtacca tggtgccaaa
      361 cgtccttttc agagctatgg gtcctcaccc cgtcggaaga acagcaagaa gcagcagctc
      421 gagttggcca agaagtatct gaagctcctg aagacctctg cccaacagtg gcatggtggt
      481 gtgtgcccag gagcatggct tactcctcac tccccacaga cctacatccc cccagttctt
      541 cagtggagcc gggctacagc acccttggat gctcaggagg gagccacttt aggagaccct
      601 gaagcagccg acaacattga tgtgagcatc caggatctct tcagcttcaa ggctcacaag
      661 ggacctcgag tgacagtact actgggaaag gctgggatgg gtaagaccac tctggcatat
      721 cggctccgct ggaggtgggc tcaaggtcag ctggaccgct tccaggctct gttcctgttt
      781 gagttccgcc agctcaacat gatcacacag ttgccgaccc tgccccagct cctctttgat
      841 ctgtacttga tgccagagtc agagcctgat gctgtttttc agtacctaaa ggagaatgct
      901 caggaagtcc tactgatctt tgatgggttg gatgaggctc tccatgctga ttctgtgggt
      961 actgacaatg caggctcggc cctcaccctc ttttctgaac tctgccatgg gaacctcctg
     1021 ccaggctgct gggtgatgac cacctcccgt cctgggaaac tgccttcctg tgtgcccaca
     1081 gaagcagcca cggtacacat gtggggcttt gatgggctac gagtagagaa gtatgttacc
     1141 tgcttcttca gtgatcttct gtctcaggaa ttggccttga aggaaatgag aaccaatgca
     1201 cgtctccggg gtatgtgtgc aatacctgcg ttgtgcacag tcacctgctt ctgccttcgc
     1261 cgtctgcttc ctggaagctc cccagggcag tctgcagccc tcctgcccac cataacccag
     1321 ttgtacctgc agatggtgga aacttttagc cccagtgaga ctctgcttga cacatccatt
     1381 ttgggctttg gaaaggtggc ccttagggga ctggacactg ggaaagtcgt cttctctgtg
     1441 gaagacatct ctccccaact gatgtctttt ggagctgtcc acagcctcct gacctccttc
     1501 tgtatccaca cccgccctgg gcatgaagaa ataggctatg cttttgtcca ccttagcctg
     1561 caggagttct ttgctgctct gtatctgatg gccagtcaca cagtggacaa agacacactc
     1621 gtcgagtatg tcaccctcaa ttcccactgg gtgctgagga ccaaaggtag actgggcctc
     1681 tcggatcatc tccctgcctt cctggcaggc ctagcctccc acacctgcca catgttcctc
     1741 tgccaactgg ctcagcaaga cagagcctgg gtgggctcca ggcaggccgc tgtgatccag
     1801 gtgctaagga agttggctag ccggaaactc acagggccaa agatgataga gttgtatcac
     1861 tgtgtggctg agacccagga tctggagctg gcgaggttca ctgcccaaag ccttccttcc
     1921 cgcctctcct tccacaattt ccctctgacc catgcagacc tggctgcact ggctaacatt
     1981 ttggagcaca gggatgatcc cattcacctg gattttgacg gctgcccact ggagccccac
     2041 tgcccagagg ctctggtagg atgtgggcag gtggagaatc tcagctttaa aagcagaaag
     2101 tgtggggatg cctttgcaga agccctctgc aggagtttgc ctactatggg gagcctgaag
     2161 acgctggggt taacaggaag taggattaca gcccaaggca tcagccacct gatacagaca
     2221 ttgcccctct gttcccagct ggaggaggtc agtttgcatg acaaccagct caaggaccca
     2281 gaggtgctga gtcttgtgga gctgcttccc tccctgccga agctccagaa acttgacctg
     2341 agccgaaaca gcttctccag gtcaatcctc ctgtctttgg tgaaagtggc tatcacatgt
     2401 cctactgtca ggaagctgca ggtcagggaa ttggacctca tcttctatct gtccccagtc
     2461 acagagacag ctacacagca atcaggagca tcagatgtac agggcaaaga cagcctgaag
     2521 gaaggacaga gtcgaagcct gcaactcagg cttcagaaat gtcagctcag gatccgtgat
     2581 gcagaagccc ttgtggagct attccagaaa agcccccagc tggaggaagt gaatctttca
     2641 gggaaccatt tggaagatga tggctgtcga cttgtggcag aggctgcttc acagcttcac
     2701 attgcccaga aactggacct cagcgacaat ggcctctctc agactggggt gacctatgtg
     2761 ttgaaagcca tgagcacatg tgggaccctg gaagacctgc acatcagcct gctaaacaac
     2821 accgtggtac tcacatttgc ccaggagccg agggagcagg aggggagctg caaggggagg
     2881 gcaccactta tcagcttcgt gtctcctgtg acctccgagt tgtcccagag atctcgaagg
     2941 atcaggctga cacactgtgg cttcctggcc aagcacacag agacgctctg tgaggcactg
     3001 agagccagct gccagaccca caacctggat catcttgacc tatcagacaa ctctttgggg
     3061 ggcaaaggag tgatcctgct aaccgagctg ctcccaggac tgggtcccct gaagtccttg
     3121 aacctcagca ggaatggctt gtccatggat gctgtcttta gcttggtcca gtgtctgtct
     3181 tccctgcagt gggtgttcca cttagatgtc agccttgaga gtgactgcat cttccttcga
     3241 ggagctggga ccagcaggga tgcactagaa ccaaaattcc agactggagt ccaggtactg
     3301 gagctgagtc agcggtacac ctcccggagc ttctgccttc aagagtgtca gttggaaccc
     3361 acgagcctta ccttcctctg tgccactctg gagaagagcc cagggcctct ggaagtccaa
     3421 ttgtcctgca agtccctgag tgatgacagc ctgaagatcc tgctgcagtg cctgccccag
     3481 ctgcctcagc tcagcctgct gcagctgaga cacacagtcc tatcttcaag aagccccttc
     3541 ctgctggctg acatcttcaa cctgtgccca cgggttcgga aggtcactct caggtcccta
     3601 tgtcatgctg ttctgcactt tgactccaat gaggaacaag agggtgtgtg ctgtggcttc
     3661 ccgggatgca gcctcagcca ggagcatatg gaaacactgt gctgtgcact gagcaagtgc
     3721 aatgccctca gccagcttga tctcacagac aatctgctgg gtgacatcgg gctcaggtgc
     3781 cttctggagt gcctgccaca gctgcccatc tctgggtggc ttgacctcag tcacaacaat
     3841 atctctcagg aagggatcct gtacctgctg gagactctgc cttcctaccc taatatccaa
     3901 gaggtctctg tgagtctgag ctctgagcag atcttccgaa tgtgcttctc caaaaaggaa
     3961 ggagccggga catcgctgag gctatgtgaa tgcagcttca gcccagaaca agtatccaaa
     4021 ttggcttcca gcctgagcca ggcccaacag ctcacagagc tctggctgac caagtgtcac
     4081 ttggacctgc cacagctgac catgctcctg aacctggtga atcggccaac agggttgctg
     4141 ggcctcaggt tggaagagcc ctgggtggac tctgtcagct taccagctct aatggaagtc
     4201 tgtgcccagg cctcaggatg tctcactgag ttaagcatct ctgagatcca aaggaagttg
     4261 tggctccagc tggaatttcc tcaccaagaa ggcaattctg attccatggc tctcaggttg
     4321 gctcactgtg acctggagac cgagcacagc catcttatga tacagttggt ggagacatat
     4381 gccagactgc agcagctgag cttgtctcag gttagcttca atgacaatga tggcaccagc
     4441 tccaagctgc tgcagaacat cctgctatca agctgtgagc tgaagagctt caggctgacc
     4501 ttcagccaag tgagcacaaa gagcctcacc catctggcat ttggtctggg acactgccac
     4561 catctggaag agctggactt ctctaacaac agtctccgtg aggaggacac agagctactg
     4621 atgggagccc ttcagggaac ctgcagactg aagaagctgc accttagttt cttaccattg
     4681 ggagcctcct ctctggcctt gctcattcaa ggactaagcc gaatgactct actacaggac
     4741 ctttgcttga gtcacaacca gatcggagat gtgggtaccc agtgcttagc tgccatcttg
     4801 ccaaaactgc cagaactcag gaaatttgac ttgagtcaca accagatcgg agatgtgggt
     4861 acccagtgct tagctgccat cttgccaaaa cttccagaac tcaggaaatt taacttgagt
     4921 cacaaccaga tcggacatgt gggtacccag tgcttagctg ccatcttgcc aaaacttcca
     4981 gaactcagga aatttgactt gagtcgcaac cagatcggag atgtgggtac ccagtgctta
     5041 gctgccatct tgccaaaact tccagaactc aggaagtttg acctctcagg gaacaggatt
     5101 ggcccagctg ggggagtgca gctggtgaag tctctcaccc atttcgagca cttggaggag
     5161 atcaaactgg gcaacaatgc tctgggggag cccacagccc tggagctggc tcagagattg
     5221 cccccacaac tcagggtcct gtgcctgcca tccagtcatc tgggtccaga gggggccctg
     5281 ggcctggccc aggccctgga gcaatgccca cacatagaag aggtcagctt ggcagagaat
     5341 aacctggctg gaggtgtccc acgtttctcc aagaggctcc cactgcttag acaaattgac
     5401 ctggagttct gcaagattga agaccaagct gccaggcacc ttgctgccaa cctcacactc
     5461 ttcccagccc tggagaaact cttgctgtcc gggaatctcc ttggagatga ggtggctgct
     5521 gagttggccc aggtcctgcc gcagatggga cagctgaaga aagtgaactt ggagtggaac
     5581 cggatcacag cacgtggagc ccaactcctg gctcaagggc tggtccaggg atcctgcgtc
     5641 ccagtcattc gcctctggaa caaccccatt cttaacgatg tggcccagag tctgcagagc
     5701 caggaaccca ggctggactt ctccatcact gaccagcaga ctctttgagg aacccaacgg
     5761 acttctcaag acttatgagt ccagtccagt gacagccaca tcacccacca ggagaggggg
     5821 ctcagaagaa cctctgttgg tgcccagcat cctacgaatg ccccaggagg aaagaacaca
     5881 tttttcctgt cacgatccct agggagcgca ttcttaggga ctgagagctt tgtttgacca
     5941 aaagagggcc atatatcata tatcatacat gacatatgtt accaatgggg cattgacatt
     6001 atgagagtat tatgaggtta tatatacagg aaaggctgtg tatggtgcac tatgacccct
     6061 tgacatggga aggtcatact cagagtaggt caaatgtaga attacatgga acttgtggca
     6121 tgacacctgg tcatagcctc ttagcactgt aattggaaat acacatgatc aggaatccac
     6181 ttatgacatg atgtccatat cacatgacac acaacttgac aggggaccac agataagtcc
     6241 aagacctaat ttattattat tttaaaaaac atgaagttag gctaatggta taggctatgt
     6301 tatatgaaca gccttttagc tgttcaggaa tctgaggcag acagatcgca agttcaaggt
     6361 caatctaggt aatttagtaa gatcctgtct caaaaggtca gaaagggctg gggatatggc
     6421 tcaatgctag agtgcttcct agcatgtgta aagccctaag ctcaatgctc ggtgcttttt
     6481 ttttttttaa gtatttataa gcaccttctg gagaaacttt ttgtcttgtg ctaggagagg
     6541 gagttaagaa ttgagtggcc caatggtccg gggtctggga catgccaagg acttagcatg
     6601 aagtcccctc ctgccagagc ctcaagtctc tcttctgtta atcgtgttct tccaaggact
     6661 tccagcccag gcttaggagt taacctgacc ttgggagagt tcgcactcat ctcttctttc
     6721 ctggtttaag ggacaaagcc gagctacagg tttagggata agtacttcca ggataatagg
     6781 caagaccact aggtctagcc tacccactac ctcagcagga ttcagaaacc acttgaaact
     6841 ccatggtgtt ttgctttgtt ttgcaacttc caaaggctaa actcacaaca ctccatatca
     6901 aatgatcaat aaacgcagat gtaactggtg tctgatgtaa acgcc
//
