LOCUS       NM_001033367            3838 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus NLR family, CARD domain containing 4 (Nlrc4), mRNA.
ACCESSION   NM_001033367 XM_197335
VERSION     NM_001033367.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3838)
  AUTHORS   Wen,Z., Yuan,T., Liu,J., Wang,D., Ni,J., Yan,X., Tang,J., Tang,J.,
            Wu,X. and Wang,Z.
  TITLE     Atg16l2 augments Nlrc4 inflammasome activation by facilitating
            NAIPs-NLRC4 association
  JOURNAL   Eur J Immunol 54 (11), e2451078 (2024)
   PUBMED   39175123
  REMARK    GeneRIF: Atg16l2 augments Nlrc4 inflammasome activation by
            facilitating NAIPs-NLRC4 association.
REFERENCE   2  (bases 1 to 3838)
  AUTHORS   Hu,S., Lin,T., Chen,Y., Guo,Y., Sun,X., Shi,L. and Pan,J.
  TITLE     NLRC4-mediated pyroptosis was involved in coagulation disorders of
            acute pancreatitis
  JOURNAL   J Gene Med 26 (4), e3683 (2024)
   PUBMED   38571451
  REMARK    GeneRIF: NLRC4-mediated pyroptosis was involved in coagulation
            disorders of acute pancreatitis.
REFERENCE   3  (bases 1 to 3838)
  AUTHORS   Gul,E., Huuskonen,J., Abi Younes,A., Maurer,L., Enz,U.,
            Zimmermann,J., Sellin,M.E., Bakkeren,E. and Hardt,W.D.
  TITLE     Salmonella T3SS-2 virulence enhances gut-luminal colonization by
            enabling chemotaxis-dependent exploitation of intestinal
            inflammation
  JOURNAL   Cell Rep 43 (3), 113925 (2024)
   PUBMED   38460128
REFERENCE   4  (bases 1 to 3838)
  AUTHORS   Han,J.H., Karki,R., Malireddi,R.K.S., Mall,R., Sarkar,R.,
            Sharma,B.R., Klein,J., Berns,H., Pisharath,H., Pruett-Miller,S.M.,
            Bae,S.J. and Kanneganti,T.D.
  TITLE     NINJ1 mediates inflammatory cell death, PANoptosis, and lethality
            during infection conditions and heat stress
  JOURNAL   Nat Commun 15 (1), 1739 (2024)
   PUBMED   38409108
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3838)
  AUTHORS   Amaral,M.P., Cardoso,F.D., de Farias,I.S., de Souza,R.Q.,
            Matteucci,K.C., Torrecilhas,A.C. and Bortoluci,K.R.
  TITLE     NAIP/NLRC4 inflammasome participates in macrophage responses to
            Trypanosoma cruzi by a mechanism that relies on cathepsin-dependent
            caspase-1 cleavage
  JOURNAL   Front Immunol 14, 1282856 (2023)
   PUBMED   38124741
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3838)
  AUTHORS   Miao,E.A., Alpuche-Aranda,C.M., Dors,M., Clark,A.E., Bader,M.W.,
            Miller,S.I. and Aderem,A.
  TITLE     Cytoplasmic flagellin activates caspase-1 and secretion of
            interleukin 1beta via Ipaf
  JOURNAL   Nat Immunol 7 (6), 569-575 (2006)
   PUBMED   16648853
REFERENCE   7  (bases 1 to 3838)
  AUTHORS   Franchi,L., Amer,A., Body-Malapel,M., Kanneganti,T.D., Ozoren,N.,
            Jagirdar,R., Inohara,N., Vandenabeele,P., Bertin,J., Coyle,A.,
            Grant,E.P. and Nunez,G.
  TITLE     Cytosolic flagellin requires Ipaf for activation of caspase-1 and
            interleukin 1beta in salmonella-infected macrophages
  JOURNAL   Nat Immunol 7 (6), 576-582 (2006)
   PUBMED   16648852
REFERENCE   8  (bases 1 to 3838)
  AUTHORS   Mariathasan,S., Weiss,D.S., Newton,K., McBride,J., O'Rourke,K.,
            Roose-Girma,M., Lee,W.P., Weinrauch,Y., Monack,D.M. and Dixit,V.M.
  TITLE     Cryopyrin activates the inflammasome in response to toxins and ATP
  JOURNAL   Nature 440 (7081), 228-232 (2006)
   PUBMED   16407890
REFERENCE   9  (bases 1 to 3838)
  AUTHORS   Mariathasan,S., Weiss,D.S., Dixit,V.M. and Monack,D.M.
  TITLE     Innate immunity against Francisella tularensis is dependent on the
            ASC/caspase-1 axis
  JOURNAL   J Exp Med 202 (8), 1043-1049 (2005)
   PUBMED   16230474
REFERENCE   10 (bases 1 to 3838)
  AUTHORS   Mariathasan,S., Newton,K., Monack,D.M., Vucic,D., French,D.M.,
            Lee,W.P., Roose-Girma,M., Erickson,S. and Dixit,V.M.
  TITLE     Differential activation of the inflammasome by caspase-1 adaptors
            ASC and Ipaf
  JOURNAL   Nature 430 (6996), 213-218 (2004)
   PUBMED   15190255
  REMARK    GeneRIF: cell death triggered by stimuli that engage caspase-1 was
            ablated in macrophages lacking either ASC or Ipaf, suggesting a
            coupling between the inflammatory and cell death pathways [IPAF]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT033749.8.
            
            On May 2, 2007 this sequence version replaced NM_001033367.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143864.1, AK171624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               CT033749.8         62027-62129
            104-217             CT033749.8         67969-68082
            218-478             CT033749.8         72917-73177
            479-2473            CT033749.8         74011-76005
            2474-2566           CT033749.8         79149-79241
            2567-2737           CT033749.8         83601-83771
            2738-2830           CT033749.8         85035-85127
            2831-2998           CT033749.8         87233-87400
            2999-3838           CT033749.8         94001-94840
FEATURES             Location/Qualifiers
     source          1..3838
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 45.64 cM"
     gene            1..3838
                     /gene="Nlrc4"
                     /gene_synonym="9530011P19Rik; Card12; CLAN; CLAN1; CLANA;
                     CLANB; CLANC; CLAND; IPAF"
                     /note="NLR family, CARD domain containing 4"
                     /db_xref="GeneID:268973"
                     /db_xref="MGI:MGI:3036243"
     exon            1..103
                     /gene="Nlrc4"
                     /gene_synonym="9530011P19Rik; Card12; CLAN; CLAN1; CLANA;
                     CLANB; CLANC; CLAND; IPAF"
                     /inference="alignment:Splign:2.1.0"
     exon            104..217
                     /gene="Nlrc4"
                     /gene_synonym="9530011P19Rik; Card12; CLAN; CLAN1; CLANA;
                     CLANB; CLANC; CLAND; IPAF"
                     /inference="alignment:Splign:2.1.0"
     exon            218..478
                     /gene="Nlrc4"
                     /gene_synonym="9530011P19Rik; Card12; CLAN; CLAN1; CLANA;
                     CLANB; CLANC; CLAND; IPAF"
                     /inference="alignment:Splign:2.1.0"
     exon            479..2473
                     /gene="Nlrc4"
                     /gene_synonym="9530011P19Rik; Card12; CLAN; CLAN1; CLANA;
                     CLANB; CLANC; CLAND; IPAF"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2566
                     /gene="Nlrc4"
                     /gene_synonym="9530011P19Rik; Card12; CLAN; CLAN1; CLANA;
                     CLANB; CLANC; CLAND; IPAF"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2737
                     /gene="Nlrc4"
                     /gene_synonym="9530011P19Rik; Card12; CLAN; CLAN1; CLANA;
                     CLANB; CLANC; CLAND; IPAF"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2830
                     /gene="Nlrc4"
                     /gene_synonym="9530011P19Rik; Card12; CLAN; CLAN1; CLANA;
                     CLANB; CLANC; CLAND; IPAF"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..2998
                     /gene="Nlrc4"
                     /gene_synonym="9530011P19Rik; Card12; CLAN; CLAN1; CLANA;
                     CLANB; CLANC; CLAND; IPAF"
                     /inference="alignment:Splign:2.1.0"
     exon            2999..3838
                     /gene="Nlrc4"
                     /gene_synonym="9530011P19Rik; Card12; CLAN; CLAN1; CLANA;
                     CLANB; CLANC; CLAND; IPAF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3803..3808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nlrc4"
                     /gene_synonym="9530011P19Rik; Card12; CLAN; CLAN1; CLANA;
                     CLANB; CLANC; CLAND; IPAF"
                     /note="hexamer: AATAAA"
     polyA_site      3825
                     /gene="Nlrc4"
                     /gene_synonym="9530011P19Rik; Card12; CLAN; CLAN1; CLANA;
                     CLANB; CLANC; CLAND; IPAF"
                     /note="major polyA site"
ORIGIN      
        1 ttctacagtt gtctctcatg gacaaagaag tttggattaa gaaagaaaga aaattacttt
       61 taagacgact tttccttcga aggcaactgg attgcttggc caggagagcc ttgccaagag
      121 aagaggacaa cagtatgata gtctttggcc ttcccatttg gaaaaggaat attttctact
      181 gagatctagg aacgtgggac gctttgactc accacaatga actttataag gaacaacaga
      241 cgagccctta ttcaaaggat gggcttaaca gttaccaagc aaatctgcga tgacctcttt
      301 gcattgaacg ttctcaacaa tcaagaagct aatgtcattt actgtgagcc cttggagcag
      361 gaagccgccc gaaagatcat ccatatgact atgcagaagg gctcagcggc ctgcaacctc
      421 tttcttaaga gtcttgaaaa ctgggactat tttgtgtatc aggacttaac tggacaaaat
      481 ctttcttatc aggtcacaga agaagacctg aatgttttgg cccagaattt aaaggacttg
      541 tacaacagcc ctgcttttct gaacttctac cccctgggtg aagatatcga cataattttt
      601 aatctggaga aaaccttcac agaacctatc atgtggaaga aggaccatcg tcatcaccgt
      661 gtggagcagc tgactttggg cagcctgctc gaggctctga agagcccctg cctgattgaa
      721 ggcgagtctg gcaaagggaa gtccaccctg ctgcagagaa tcgctatgct ctgggcctct
      781 gggggctgca gggctctgaa ggggttcaga ttagtcttct tcatccacct gagaagcgcc
      841 agggggggac tattcgaaac actgtacgat cagctcctga acatacccga cttcatcagc
      901 aagccgacct tcaaggctct gctgctgaag ctacacaagg aggtcctctt tcttctcgat
      961 ggttacaatg aattccatcc ccagaactgc ccagaaattg aagccctgat aaaggaaaac
     1021 catcgcttca agaacatggt cattgtcacc accaccacgg agtgcctgag gcatatcaga
     1081 catgttggcg ccctgactgc ggaggtggga gatatgaccg aagacagtgc caaagatctc
     1141 atcgaggcag tgctggtacc tgatcaggtt gaacgcctgt gggcccaaat ccaggagtcc
     1201 aggtgcctga gaaatctgat gaagacccct ctcttcgtgg tgatcacctg tgcaattcag
     1261 atgggcagac aggaattcca agctcacacc caaaccatgc tgttccaaac cttctacgac
     1321 ctcctgatac agaaaaacag ccacagatat agaggtggag cttcaggtga ttttgccagg
     1381 agcctagact actgtggaga cctggcccta gaaggtgtgt tcgcccacaa atttgatttt
     1441 gaacccgagc atgggtccag catgaacgag gacgtcctgg tgacaatagg gctcctctgt
     1501 aagtacacag ctcagaggct gaagcccacg tataaattct ttcataaatc atttcaggag
     1561 tacacggcag gtcggagact cagcagtttg ctgacgtcca aagagccaga ggaggtgagc
     1621 aaagggaaca gctacttaaa caaaatggtt tccatctctg acatcacatc cctatatggc
     1681 aatctgctcc tctacacgtg tgggtcgtcc acagaagcaa ccagggcggt catgaggcac
     1741 cttgcaatgg tttatcagca cggcagccta caaggacttt cagtcaccaa gaggcctctc
     1801 tggaggcagg aatcaatcca gagtctgaga aataccactg agcaagatgt tctgaaagcc
     1861 atcaatgtaa attccttcgt agagtgtggc atcaatttgt tctcagagag tatgtctaaa
     1921 tcagacctga gccaagaatt tgaagctttc tttcaaggta aaagtttata catcaactca
     1981 gagaacatcc ctgactattt atttgacttc tttgaatact tgcctaattg tgcaagcgca
     2041 ttggacttcg tgaagttgga tttctatgaa agagctacag agtcacagga caaggcagaa
     2101 gagaatgtcc ctggagttca cacagaaggg ccctcagaaa cctacattcc ccccagggct
     2161 gtgtctttgt tcttcaactg gaagcaggaa ttcaagactc tagaggtcac actccgagat
     2221 attaacaagt tgaataagca agatatcaaa tatctgggga agatattcag ctctgccacc
     2281 aacctccggc tgcatatcaa gagatgtgca gccatggctg gaagactcag ctcagtcctc
     2341 agaacctgca agaacatgca taccctcatg gtggaagcca gtcccctcac cacggatgac
     2401 gaacagtaca tcacatctgt gacaggcctc cagaacttaa gtattcaccg cttgcacact
     2461 caacagctgc caggtggtct gattgacagc ttgggtaatc tgaagaacct cgagagactc
     2521 atactggatg acatcaggat gaacgaggaa gatgctaaaa acctagccga aggcctacga
     2581 agcctgaaga agatgcgttt actccatttg actcatttgt ctgacattgg ggaggggatg
     2641 gactacatag tcaagtctct ctcagaagaa tcctgtgatc tccaagagat gaagttggtg
     2701 gcctgctgtc tgactgcaaa ctctgtgaaa gttctagcac agaatcttca caatttgatc
     2761 aagctgagca ttcttgatat atcagaaaat tacctggaaa aggatgggaa tgaagctcta
     2821 caggaactga tcggcaggct tggcgttctg ggagagctca ctacattgat gctgccttgg
     2881 tgctgggatg tgcacaccag cctgcccaag ctgttgaagc agttggaggg gaccccagga
     2941 cttgccaaac ttggattgaa aaactggaga ctcagagacg aagagattaa aagtttaggt
     3001 gaatttctgg agatgaatcc tctgagagac ttgcagcagt tggatttagc ggggcactgt
     3061 gtgagcagtg acggatggct ttacttcatg aatgtgtttg agaatctgaa gcagttagtg
     3121 ttttttgact ttagcactga ggagttctta ccggatgcag cactggtgag gaaacttagt
     3181 caagtgttat ccaagttaac tcttctgcaa gaggtaaagc tcacgggctg ggagtttgat
     3241 gactatgata ttagcgctat taaaggcacc tttaaactag tgactgctta atgcacccgt
     3301 gccaccaaat actccaggac tccctcactt ccagcaaatc attaaaaact acgcagaagt
     3361 ggggccacag agctggctca ggggttaaga gcactggctg ctcttccaga ggacctggga
     3421 ttgattcgca ccacctacaa ggtggctcac aaccatctgt aactccagtt ccaggggatc
     3481 caacattttc tgatctctat gggtaccacg caggcaaaac actcatatac attaaataaa
     3541 aatttaaaat gcttaaaaaa aaaatctcga agaaggaagt caaagaagga aaagaagagg
     3601 aattggcttg agaaacgagt ttggtctcat ctctccacac aggacaatct ctgtgccctt
     3661 caggcgtgtt tgtgttactt gaccccaaga atactgggtc aaaaaacctt gcgataccct
     3721 gttcatctgt ccttagtaca gtacctggcc tatctagact caacaagtac ttgataagta
     3781 tgtgacaact aaattaccaa gaaataaaat tgtctagaga acagatttca tatatgct
//
