LOCUS       NM_001081280            6006 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus NLR family, CARD domain containing 3 (Nlrc3),
            transcript variant 1, mRNA.
ACCESSION   NM_001081280 XM_884556
VERSION     NM_001081280.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6006)
  AUTHORS   Ren,L., Liu,G., Bai,Y., Gu,L., Wang,Y. and Sun,L.
  TITLE     NLRC3 attenuates osteoclastogenesis by limiting TNFalpha+ Th17 cell
            response in osteoporosis
  JOURNAL   J Mol Med (Berl) 102 (5), 655-665 (2024)
   PUBMED   38436712
  REMARK    GeneRIF: NLRC3 attenuates osteoclastogenesis by limiting
            TNFalpha[+] Th17 cell response in osteoporosis.
REFERENCE   2  (bases 1 to 6006)
  AUTHORS   Kang,H.R., Han,J.H., Ng,Y.C., Ryu,S., Park,J.Y., Chung,W.C.,
            Song,Y.J., Chen,S.T., Brickey,W.J., Ting,J.P. and Song,M.J.
  TITLE     Dynamic bidirectional regulation of NLRC3 and gammaherpesviruses
            during viral latency in B lymphocytes
  JOURNAL   J Med Virol 96 (3), e29504 (2024)
   PUBMED   38445794
  REMARK    GeneRIF: Dynamic bidirectional regulation of NLRC3 and
            gammaherpesviruses during viral latency in B lymphocytes.
REFERENCE   3  (bases 1 to 6006)
  AUTHORS   Han,J.H., Karki,R., Malireddi,R.K.S., Mall,R., Sarkar,R.,
            Sharma,B.R., Klein,J., Berns,H., Pisharath,H., Pruett-Miller,S.M.,
            Bae,S.J. and Kanneganti,T.D.
  TITLE     NINJ1 mediates inflammatory cell death, PANoptosis, and lethality
            during infection conditions and heat stress
  JOURNAL   Nat Commun 15 (1), 1739 (2024)
   PUBMED   38409108
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6006)
  AUTHORS   Li,R., Zhao,Y., Zhang,X., Yang,L. and Zou,X.
  TITLE     NLRC3 Participates in Inhibiting the Pulmonary Inflammatory
            Response of Sepsis-Induced Acute Lung Injury
  JOURNAL   Immunol Invest 52 (5), 567-582 (2023)
   PUBMED   37139806
  REMARK    GeneRIF: NLRC3 Participates in Inhibiting the Pulmonary
            Inflammatory Response of Sepsis-Induced Acute Lung Injury.
REFERENCE   5  (bases 1 to 6006)
  AUTHORS   Maimaitiaili,N., Zeng,Y., Ju,P., Zhakeer,G., E,G., Yao,H., Shi,Y.,
            Zhai,M., Zhuang,J., Peng,W., Zhuoga,D. and Yu,Q.
  TITLE     NLRC3 deficiency promotes hypoxia-induced pulmonary hypertension
            development via IKK/NF-kappaB p65/HIF-1alpha pathway
  JOURNAL   Exp Cell Res 431 (2), 113755 (2023)
   PUBMED   37586455
  REMARK    GeneRIF: NLRC3 deficiency promotes hypoxia-induced pulmonary
            hypertension development via IKK/NF-kappaB p65/HIF-1alpha pathway.
            Review article
REFERENCE   6  (bases 1 to 6006)
  AUTHORS   Karki,R., Man,S.M., Malireddi,R.K.S., Kesavardhana,S., Zhu,Q.,
            Burton,A.R., Sharma,B.R., Qi,X., Pelletier,S., Vogel,P.,
            Rosenstiel,P. and Kanneganti,T.D.
  TITLE     NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer
  JOURNAL   Nature 540 (7634), 583-587 (2016)
   PUBMED   27951586
REFERENCE   7  (bases 1 to 6006)
  AUTHORS   Aachoui,Y., Kajiwara,Y., Leaf,I.A., Mao,D., Ting,J.P., Coers,J.,
            Aderem,A., Buxbaum,J.D. and Miao,E.A.
  TITLE     Canonical Inflammasomes Drive IFN-gamma to Prime Caspase-11 in
            Defense against a Cytosol-Invasive Bacterium
  JOURNAL   Cell Host Microbe 18 (3), 320-332 (2015)
   PUBMED   26320999
REFERENCE   8  (bases 1 to 6006)
  AUTHORS   Zhang,L., Mo,J., Swanson,K.V., Wen,H., Petrucelli,A., Gregory,S.M.,
            Zhang,Z., Schneider,M., Jiang,Y., Fitzgerald,K.A., Ouyang,S.,
            Liu,Z.J., Damania,B., Shu,H.B., Duncan,J.A. and Ting,J.P.
  TITLE     NLRC3, a member of the NLR family of proteins, is a negative
            regulator of innate immune signaling induced by the DNA sensor
            STING
  JOURNAL   Immunity 40 (3), 329-341 (2014)
   PUBMED   24560620
  REMARK    GeneRIF: NLRC3, a member of the NLR family of proteins, is a
            negative regulator of innate immune signaling induced by the DNA
            sensor STING.
REFERENCE   9  (bases 1 to 6006)
  AUTHORS   Schneider,M., Zimmermann,A.G., Roberts,R.A., Zhang,L.,
            Swanson,K.V., Wen,H., Davis,B.K., Allen,I.C., Holl,E.K., Ye,Z.,
            Rahman,A.H., Conti,B.J., Eitas,T.K., Koller,B.H. and Ting,J.P.
  TITLE     The innate immune sensor NLRC3 attenuates Toll-like receptor
            signaling via modification of the signaling adaptor TRAF6 and
            transcription factor NF-kappaB
  JOURNAL   Nat Immunol 13 (9), 823-831 (2012)
   PUBMED   22863753
  REMARK    GeneRIF: NLRC3 inhibited Toll-like receptor (TLR)-dependent
            activation of the transcription factor NF-kappaB by interacting
            with the TLR signaling adaptor TRAF6
REFERENCE   10 (bases 1 to 6006)
  AUTHORS   Conti,B.J., Davis,B.K., Zhang,J., O'connor,W. Jr., Williams,K.L.
            and Ting,J.P.
  TITLE     CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that
            negatively regulates T cell function
  JOURNAL   J Biol Chem 280 (18), 18375-18385 (2005)
   PUBMED   15705585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087900.19 and AC129021.4.
            
            On Mar 17, 2018 this sequence version replaced NM_001081280.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.864984.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               AC087900.19        73043-73346
            305-544             AC087900.19        84036-84275
            545-2294            AC087900.19        84373-86122
            2295-2381           AC087900.19        87135-87221
            2382-2465           AC087900.19        90201-90284
            2466-2549           AC087900.19        90662-90745
            2550-2633           AC087900.19        92323-92406
            2634-2717           AC087900.19        94447-94530
            2718-2801           AC087900.19        95036-95119
            2802-2885           AC087900.19        95660-95743
            2886-2969           AC087900.19        96164-96247
            2970-3053           AC087900.19        96729-96812
            3054-3137           AC087900.19        97205-97288
            3138-3221           AC087900.19        100222-100305
            3222-3305           AC087900.19        100688-100771
            3306-3389           AC087900.19        101332-101415
            3390-3473           AC087900.19        101766-101849
            3474-6006           AC129021.4         78-2610
FEATURES             Location/Qualifiers
     source          1..6006
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.32 cM"
     gene            1..6006
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /note="NLR family, CARD domain containing 3"
                     /db_xref="GeneID:268857"
                     /db_xref="MGI:MGI:2444070"
     exon            1..304
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..3564
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /note="isoform 1 is encoded by transcript variant 1;
                     caterpillar 16.2; protein NLRC3"
                     /codon_start=1
                     /product="protein NLRC3 isoform 1"
                     /protein_id="NP_001074749.1"
                     /db_xref="CCDS:CCDS49747.1"
                     /db_xref="GeneID:268857"
                     /db_xref="MGI:MGI:2444070"
                     /translation="MQAEPFSTLEQPPWQEGDNIGSPGSVLALYSQLLAANTDSTRKQ
                     EVWTDRETCLAYSVGSPAEQVKALVDLLAGKGSQLLQVRDKMPDSPLGSQSNESRIPK
                     HSEALLSRVGNDPELGSPSHRLASLMLVEGLTDLQLKEHDFTQVEATRGVWHPARVIT
                     LDRLFLPLSRVSIPPRVSLTIGVAGVGKTTLVRHFVHCWARGQVGKGFSRVLPLTFRD
                     LNTYEKLSADRLIQSIFSSIGEASLVATAPDRVLLVLDGLDECKTPLEFSNTMACSDP
                     KKEIQVDHLITNIIRGNLFPEISVWITSRPSAAGQIPGGLVDRMTEIRGLTEEEIKVC
                     LEQMFPEEQNLLGQVLSQVQANRALYLMCTVPAFCRLTGLALGHLYRTRLAVQDIELP
                     LPQTLCELYSWYFRMALGGEGQDKEKVSPRIKQVTQGARKMVGTLGRLAFHGLVKKKY
                     VFYEQDMKAFGVDLALLQNTLCSCLLQREETLASSVAYCFIHLSLQEFVAATYYYSAS
                     KRAIFDLFTESGMSWPRLGFLAHFRCAAQRATQAKDGRLDVFLRFLSGLLSPRVNTLL
                     AGSLLSQGEHQSYRDQVAEVLQGFLHPDAAVCARAINVLYCLSELRHTELACSVEEAM
                     RSGTLAGMTSPSHRTALAYLLQMSDICSPEADFSLCLSQHVLQSLLPQLLYCQSLRLD
                     NNQFQDPVMELLGSVLSGKDCRIRKISLAENQIGNKGAKALARSLLVNRSLITLDLRS
                     NSIGPPGAKALADALKINRTLTSLSLQSNVIKDDGVMCVAEALVSNQTISMLQLQKNL
                     IGLIGAQQMADALKQNRSLKALMFSSNTIGDRGAIALAEALKVNQILENLDLQSNSIS
                     DMGVTVLMRALCSNQTLSSLNLRENSISPEGAQALTQALCRNNTLKHLDLTANLLHDR
                     GAQAIAVAVGENHSLTHLHLQWNFIQAGAARALGQALQLNRTLTTLDLQENAIGDEGA
                     SSVAGALKVNTTLIALYLQVASIGSQGAQALGEALTVNRTLEILDLRGNDVGAAGAKA
                     LANALKLNSSLRRLNLQENSLGMDGAIFVASALSENHGLHHINLQGNPIGESAARMIS
                     EAIKTNAPTCTVEI"
     exon            305..544
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /inference="alignment:Splign:2.1.0"
     exon            545..2294
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2381
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2465
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2549
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2633
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2717
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2801
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..2885
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..2969
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3053
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..3137
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..3221
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3305
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /inference="alignment:Splign:2.1.0"
     exon            3306..3389
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3473
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /inference="alignment:Splign:2.1.0"
     exon            3474..6006
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5770..5775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
                     /note="hexamer: CATAAA"
     polyA_site      5796
                     /gene="Nlrc3"
                     /gene_synonym="CLR16.2; D230007K08Rik; mFLJ00348"
ORIGIN      
        1 gaggtggagg acaggaagag ctgaggggct gcagtgacag tgggtgggct cctggggact
       61 acaggatgtg gtaggtctgt cactcccagc cctggcgtga tcagtgtgat aaactcccct
      121 gatctcttca gagaaggttt cctcagctct ggacagacca aggtctcagc ctcagctgac
      181 ctgccactga ctacccaagg cattcagcca taaacatggc ctcccgctca ctggagcaga
      241 gctgtgccca ggagcatgca ggcggagccc tttagcaccc tggagcagcc accatggcag
      301 gaaggagaca acataggttc cccagggtca gtcctggctc tgtattcaca acttctggct
      361 gcaaacacag actccacgag gaagcaagag gtgtggacag acagagagac atgcctggcc
      421 tacagtgttg gctccccagc tgagcaggtg aaagcccttg tggatctgct ggctgggaag
      481 ggcagtcagc tgctacaagt ccgggacaaa atgccagact ccccactagg atcccagagc
      541 aatgagtcaa ggataccgaa gcactctgag gctctgctga gcagggtggg aaatgaccca
      601 gaactgggca gcccctcaca ccggctggcc agcctcatgc tggtcgaggg cctgacagac
      661 ctgcagctaa aggagcatga cttcacacag gtggaggcca cgcgtggggt ctggcaccct
      721 gccagagtta tcaccctgga caggctcttc ctgcctctgt cccgggtatc catcccacct
      781 cgagtctctc tcaccattgg agtggctggt gtgggcaaga ccacgctagt gaggcatttt
      841 gttcattgct gggccagagg acaggtgggc aagggcttct cacgggttct gcccttgacc
      901 tttcgggatc tcaacaccta tgagaaactg tctgcagaca gactcatcca atccatcttc
      961 tcaagcattg gggaagctag tctggtggcc acagccccag acagagtcct cctggtcctg
     1021 gatggcttgg atgagtgtaa gacacccctg gaattctcca ataccatggc ctgctcagac
     1081 ccaaagaagg agatccaggt agaccacctg atcactaaca tcatccgagg caacctcttt
     1141 ccagaaattt ctgtctggat cacctcccgg cccagtgctg ctggtcagat ccctgggggc
     1201 ctagtggacc ggatgactga gattcggggc cttactgagg aagagatcaa agtgtgtctg
     1261 gagcagatgt ttcctgagga gcagaacctc ttaggtcagg tccttagtca agtgcaggcc
     1321 aacagggctc tgtatctgat gtgcactgta ccagcctttt gtaggctcac ggggctggct
     1381 ctgggtcact tgtatcgcac caggctggcc gtccaagaca tagagctgcc attgcctcag
     1441 accctgtgtg agctctactc ttggtacttt aggatggctc ttggtgggga gggccaggat
     1501 aaggaaaagg taagtcctag gatcaagcag gtgacccagg gagctcgcaa aatggtgggg
     1561 acattgggcc gcctggcctt ccatgggctg gtcaagaaga aatacgtgtt ttatgaacaa
     1621 gacatgaagg catttggagt ggacctcgct ctgttgcaga acactctgtg cagctgtctc
     1681 ctgcagcggg aagagaccct ggcctcctct gtagcttact gcttcattca cctgtctctg
     1741 caagaatttg tggcagctac atattactat agtgcatcca agagggccat ctttgacctc
     1801 ttcaccgaga gtggcatgtc ctggcccaga ctgggtttcc tcgcccattt caggtgtgca
     1861 gcccagcggg ccacacaagc taaggatgga aggctggatg tgtttctgcg cttcctctct
     1921 ggcctcttgt ccccaagggt caatactctg ctggccggct ccctgttgtc ccaaggcgag
     1981 catcagagct accgggacca ggtggctgag gtcctacaag gcttccttca tcctgacgct
     2041 gcagtctgtg cacgtgccat caatgtcttg tactgcctaa gtgagctgcg gcacacagaa
     2101 ctggcctgca gtgtggagga ggccatgcgg agtgggacct tggctgggat gaccagcccc
     2161 tcacaccgca ctgctctggc ctacctcctg cagatgtctg acatctgctc cccagaggct
     2221 gacttctccc tgtgtctcag ccagcatgtc ctccagagcc tgctgcccca gctgctctat
     2281 tgtcaaagcc tcaggctgga caacaaccag ttccaggacc ctgtgatgga gttgctgggc
     2341 agcgtgctga gtgggaagga ctgtcgcatt cgaaagatca gcctggctga gaatcagatt
     2401 ggtaacaaag gagccaaagc cctggccaga tccctcctgg ttaacagaag cctcatcaca
     2461 ctggacctcc ggagtaacag cattggacca ccgggggcta aggctttggc cgatgctctg
     2521 aagataaacc gaacgctaac ttctctaagc ctccaaagca acgtgatcaa ggatgacggt
     2581 gtcatgtgcg tggctgaggc cctggtctcc aaccagacca tctccatgct acagctacag
     2641 aagaacttaa ttgggctcat aggagcccag cagatggcag atgccctgaa gcagaacagg
     2701 agcctgaaag cactcatgtt ttccagtaat accattggcg acagaggtgc catagccctg
     2761 gctgaggccc tgaaggtgaa ccagatcctg gagaacttag acctacagag caattccatc
     2821 agtgacatgg gagtgacggt gctgatgcga gccctctgca gtaaccagac actctccagt
     2881 ctcaacctgc gagaaaactc catcagccca gagggagccc aggccctcac tcaagctctc
     2941 tgcaggaaca acactctgaa gcacttggac ctgacagcta atctcctcca tgaccgaggt
     3001 gcccaggcca ttgcagtagc tgtgggagaa aaccactccc tcacacacct tcacctgcag
     3061 tggaacttca tccaagctgg tgcggccagg gccctgggac aagcactcca gctgaacaga
     3121 accctgacaa ccttagactt acaggagaat gccatagggg atgaaggagc ttcctcagtg
     3181 gctggcgcac tgaaggtgaa cacaaccctc attgctctct acctacaggt ggcctccatt
     3241 ggtagccaag gggcccaggc acttggggag gccctcactg tgaacagaac cttggagatt
     3301 cttgacttac gaggaaacga cgttggggca gctggagcca aggccttggc aaatgcttta
     3361 aagttaaact ccagtctccg aagactcaat ctccaggaga actcactggg gatggatggg
     3421 gccatatttg ttgcctctgc actgtctgag aaccacggtc tgcaccatat taatctccag
     3481 gggaatccca ttggggagtc tgctgccagg atgatctcag aggccatcaa gacaaacgct
     3541 cccacatgca ctgtggaaat ataaggaaag ttcctggagg accatgcaga ctcagccaga
     3601 agcttcttct cagagacctc tgctctctgc aagtcttcct ggagtcggag atgctgctgg
     3661 gccagctcta aagctgctct caacaggagg ggaaggcgct ccagcagagt tcacaggcat
     3721 cttgcctgcc cagggtcagc caaaggaaaa tggctattgt tttgggatga agaagggaag
     3781 ggtctgccac cagggtctgg cactcaggag caaagtctca aagctccaca aagtaggagg
     3841 ttggtcctgg cttactcatc cccagggtct ccacatgacc caactcaaaa gaacataaga
     3901 caagataatg acagtgttcc tgccctgcac actcacatgg ctggcaccat cagtctctgc
     3961 agtgttcctg ccctgcacac tcacacggat gttaccatca gtctctgtag tgttcctgcc
     4021 ctgcacactc ccatggctgg caccatgagt ctctgcagtg ttcctgccct gcacactcac
     4081 atggctggca ccatcagtct ctgtagtgtt cctgccctgc acactcccat ggctggcacc
     4141 atcagtctct gcagtgttcc tgccctgcac actcacacgg ttggcaccat cagtctctgc
     4201 agtgttcctg ccctgcacac tcacatggat gtcaccatca gtctctgtag tgttcctgcc
     4261 ctgcacactc ccatggctgg caccatcagt ctctgtagtg ttcctgccct gcacactccc
     4321 atggctggca ccatcagtct ctgcagtgtt cctgccctgc acactcacac ggttggcacc
     4381 atcagtctct gcagtgttcc tgccctgcac actcccatgg ctggcaccat cagtctctgc
     4441 agtgttcctg ccctgcacac tcccatggct ggcaccatca gtctctgtag tgttcctgcc
     4501 ctgcacactc ccatggctgg caccatcagt ctctgtagtg ttcctgccct gcacactccc
     4561 atggctggca ccatcagtct ctgtagtgtt cctgccctgc acactcatac agctggcacc
     4621 agtctctgca gacttcaagc ccactaagca cattaacttg cccaaaggtg acaatgggtt
     4681 cattttttca agagaagaag aaagttttgg ggtgtgatcc ttagatacat atggagaaga
     4741 tatgagaaat ctgggaagat gaacgaaagg ttaatgctaa gactctggag taagggttca
     4801 gtctccaagg ctccgcactc tttataagat ctctcaaaca tctaccatgc ctgccatagt
     4861 tggcgtccag cacactggtt gtccatagcg aattacatgt tgataccttg atgccattac
     4921 cctgatttta agctttcaaa acctctccag tggctgtagc tttccccatg gaggaaataa
     4981 gctgtgcttc cctgtggcaa atttcttcca ttgtctgact gaaacaagaa aacctaggcg
     5041 aactaaggca ctaagataaa tgcttataaa gaccacaaag tacaggcgtg gtggcacaca
     5101 cctttgatcc cagcacctgg gaggcagagg cagaggaatc tgtgagtttg aggccaacct
     5161 ggtctactta gtaaattccg ggacagcaga aactacatag tgagaccctg tcttaaaaaa
     5221 aatgaggggg ctggtgagat ggctcagtgg gtaagagcac ccgactgctc ttccgaaggt
     5281 caggagttca aatcccagca accacatggt ggctcacaac catccataac gagatctgac
     5341 tccctcttct ggagtgtctg aggacagcta cagtgtactt taaataaata aataaataag
     5401 tctaaaaaaa atgagtatgc aggagctgga catgtggaac acacttgtaa ttctagtgct
     5461 tgagaggaca agaaaggaga agcataaatt tgaggctagc taaaactaaa aagtgagttt
     5521 caaaacaaaa acctaaaact tgagtattca gaagacttat catggcagtt gacagttgat
     5581 agtgagaggt gatgctgtat atgtaggaaa aaaggcaaca cagcaagtaa cgagacaaat
     5641 gcagccttga caaagagatt agatttaagc caagaatagc ctgtaatccc agcacttggt
     5701 ggaggcagga ggatcagtag ttcaaggttg tctttggaca catagtgaat tcaagaccag
     5761 tttgtgctac ataaaatccc atctcaagaa aacaaaggaa aacaagtgac taagttggga
     5821 caagtgaaca aacatcacgt gtgaccaaga gacacagcgc tgatggagta gttctgccta
     5881 aaatgtttac ccaagcctaa ctgtagcggt atggccacac aagacccaaa caggaactgt
     5941 tgactaggca gctctgcctg cagaaagatg ttatagcagc ctggagattg ttttaaatta
     6001 aacagg
//
