LOCUS       NM_029447               3780 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus neurolysin (metallopeptidase M3 family) (Nln), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_029447
VERSION     NM_029447.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3780)
  AUTHORS   Wang,X., Zhang,Y., Yu,J., Ma,Y., Xu,Y., Shi,J., Qi,Z. and Liu,X.
  TITLE     Identification and analysis of key circRNAs in the mouse embryonic
            ovary provides insight into primordial follicle development
  JOURNAL   BMC Genomics 25 (1), 139 (2024)
   PUBMED   38310234
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3780)
  AUTHORS   Caprioli,B., Eichler,R.A.S., Silva,R.N.O., Martucci,L.F.,
            Reckziegel,P. and Ferro,E.S.
  TITLE     Neurolysin Knockout Mice in a Diet-Induced Obesity Model
  JOURNAL   Int J Mol Sci 24 (20), 15190 (2023)
   PUBMED   37894869
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3780)
  AUTHORS   Jayaraman,S., Al Shoyaib,A., Kocot,J., Villalba,H., Alamri,F.F.,
            Rashid,M., Wangler,N.J., Chowdhury,E.A., German,N., Arumugam,T.V.,
            Abbruscato,T.J. and Karamyan,V.T.
  TITLE     Peptidase neurolysin functions to preserve the brain after ischemic
            stroke in male mice
  JOURNAL   J Neurochem 153 (1), 120-137 (2020)
   PUBMED   31486527
  REMARK    GeneRIF: Peptidase neurolysin functions to preserve the brain after
            ischemic stroke in male mice.
REFERENCE   4  (bases 1 to 3780)
  AUTHORS   Speth,R.C., Carrera,E.J., Breton,C., Linares,A.,
            Gonzalez-Reiley,L., Swindle,J.D., Santos,K.L., Schadock,I.,
            Bader,M. and Karamyan,V.T.
  TITLE     Distribution of non-AT1, non-AT2 binding of 125I-sarcosine1,
            isoleucine8 angiotensin II in neurolysin knockout mouse brains
  JOURNAL   PLoS One 9 (8), e105762 (2014)
   PUBMED   25147932
  REMARK    GeneRIF: These results confirm the identity of neurolysin as a
            novel Ang II binding site, suggesting that neurolysin may play a
            significant role in opposing the pathophysiological actions of the
            brain RAS and influencing brain morphology.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3780)
  AUTHORS   Guo,L., Zheng,Z., Ai,J., Huang,B. and Li,X.A.
  TITLE     Hepatic scavenger receptor BI protects against
            polymicrobial-induced sepsis through promoting LPS clearance in
            mice
  JOURNAL   J Biol Chem 289 (21), 14666-14673 (2014)
   PUBMED   24719333
REFERENCE   6  (bases 1 to 3780)
  AUTHORS   Paschoalin,T., Carmona,A.K., Rodrigues,E.G., Oliveira,V.,
            Monteiro,H.P., Juliano,M.A., Juliano,L. and Travassos,L.R.
  TITLE     Characterization of thimet oligopeptidase and neurolysin activities
            in B16F10-Nex2 tumor cells and their involvement in angiogenesis
            and tumor growth
  JOURNAL   Mol Cancer 6, 44 (2007)
   PUBMED   17620116
  REMARK    GeneRIF: Melanoma cells secrete neurolysin which may have an
            important role in tumor proliferation/angiogenesis in vitro and in
            vivo.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3780)
  AUTHORS   Huang,T.T., Naeemuddin,M., Elchuri,S., Yamaguchi,M., Kozy,H.M.,
            Carlson,E.J. and Epstein,C.J.
  TITLE     Genetic modifiers of the phenotype of mice deficient in
            mitochondrial superoxide dismutase
  JOURNAL   Hum Mol Genet 15 (7), 1187-1194 (2006)
   PUBMED   16497723
REFERENCE   8  (bases 1 to 3780)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   9  (bases 1 to 3780)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3780)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK079090.1.
            
            On Jun 3, 2007 this sequence version replaced NM_029447.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079090.1, SRR1660817.188455.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3780              AK079090.1         2-3781
FEATURES             Location/Qualifiers
     source          1..3780
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 56.16 cM"
     gene            1..3780
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /note="neurolysin (metallopeptidase M3 family)"
                     /db_xref="GeneID:75805"
                     /db_xref="MGI:MGI:1923055"
     exon            1..199
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..2273
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /EC_number="3.4.24.16"
                     /note="neurolysin, mitochondrial; MEP; microsomal
                     endopeptidase; neurotensin endopeptidase; mitochondrial
                     oligopeptidase M"
                     /codon_start=1
                     /product="neurolysin, mitochondrial precursor"
                     /protein_id="NP_083723.1"
                     /db_xref="CCDS:CCDS36772.1"
                     /db_xref="GeneID:75805"
                     /db_xref="MGI:MGI:1923055"
                     /translation="MITLCLSALRGLHRAGGSRIRLRMTLGREAASPLQAMSSYTAAG
                     RNVLRWDLSPEQIRTRTEELIAQTKQVYDTVGTINLEDVTYENCLQVLADIEVKYIVE
                     RTMLDFPQHVSSDREVRAASTEADKRLSRFDIEMSMREDVFQRIVHLQETCDLEKIKP
                     EARRYLEKSIKMGKRNGLHLPEHVKNEIKSMKKRMSELCIDFNKNLNEDDTSLVFSKA
                     ELGALPDDFIDSLEKTDEDKYKVTLKYPHYFPVMKKCCVPETRRKMEMAFHTRCKEEN
                     TIILQQLLPLRAQVAKLLGYNTHADFVLELNTAKSTSHVATFLDDLSQKLKPLGEAER
                     EFILSLKKKECEERGFAYDGKINAWDLHYYMTQTEELKYSVDQESLKEYFPIEVVTEG
                     LLSIYQELLGLSFEQVADAHVWNKSVSLYTVKDKATGEVLGQFYLDLYPREGKYNHAA
                     CFGLQPGCLLPDGSRMMSVAALVVNFSQPIAGRPSLLRHDEVRTYFHEFGHVMHQICA
                     QTDFARFSGTNVETDFVEVPSQMLENWVWDIDSLRKLSKHYRDGHPITDELLEKLVAS
                     RLVNTGLLTLRQIVLSKVDQSLHTNASLDAASEYAKYCTEILGVAATPGTNMPATFGH
                     LAGGYDGQYYGYLWSEVFSMDMFHSCFRKEGIMNPEVGMKYRNLILKPGGSLDGMDML
                     QNFLQREPNQKAFLMSRGLNAS"
     exon            200..459
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            460..608
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            609..716
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            717..819
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            820..980
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1116
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1483
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1685
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1872
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2001
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2138
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..3780
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2493..2498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /note="hexamer: CATAAA"
     regulatory      2518..2523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /note="hexamer: GATAAA"
     polyA_site      2519
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /note="major polyA site"
     polyA_site      2541
                     /gene="Nln"
                     /gene_synonym="4930472G13Rik"
                     /note="major polyA site"
ORIGIN      
        1 acgtgggagg gcgctggcta gcggcctcag tctcgagatc tggtctgctc cgctctgccc
       61 gctctcggct tccgggctcg cagactccac cgcccgcctc ctgcacctac caagccggag
      121 gaccacgcgc cagctgctgc cggcctcccg gcctgcccat gatcaccctg tgcctttcgg
      181 ctctgcgagg cctccacaga gctggtggtt ccaggattcg gctcagaatg acgttgggga
      241 gggaggcggc atctcctctt caggccatgt cttcctacac cgccgcaggc aggaatgttc
      301 tcagatggga cctttctcca gagcagatca ggacgaggac agaggagctc atagcacaga
      361 ccaagcaggt gtatgatacc gtggggacaa tcaacctgga ggatgtaact tacgagaact
      421 gtctgcaggt gctggctgac atagaagtga agtacatagt ggaaaggacc atgctggact
      481 tccctcagca cgtgtcgtct gacagagaag tgcgggctgc aagcacagaa gcggacaaaa
      541 ggctttctcg ttttgatatt gagatgagca tgagagaaga tgtatttcag agaattgttc
      601 atttacaaga aacgtgcgat ttggagaaga taaagcctga ggccaggcga tacttggaaa
      661 aatcaattaa aatggggaaa aggaatggac tccatcttcc agaacacgta aaaaatgaaa
      721 tcaaatcaat gaagaagaga atgagtgagc tatgcattga cttcaacaaa aacctcaatg
      781 aggatgacac gtcccttgta ttttccaagg ctgaacttgg tgctcttccc gacgacttca
      841 ttgacagttt agaaaaaaca gatgaagaca agtacaaagt taccttaaag tatccccact
      901 attttcctgt catgaagaaa tgctgtgtcc ctgaaactcg aaggaagatg gaaatggctt
      961 ttcataccag gtgcaaagag gaaaacacca taattctgca acagctcctg ccgctgcgag
     1021 cacaagtggc caaactgctc ggctacaaca cccatgctga ctttgtcctt gaactgaaca
     1081 ctgcaaagag cacaagccat gtggcaacct ttctagatga tttaagccag aaattaaaac
     1141 ccttgggtga ggctgaacgg gagtttattt tgagcttgaa gaagaaggaa tgcgaagagc
     1201 gaggttttgc atacgacggg aagatcaacg catgggacct ccattactac atgacccaga
     1261 cagaggagct caagtactct gtggaccagg agtccctcaa ggagtacttt cccattgagg
     1321 tggtcactga aggcctgcta agcatctacc aggagctgtt gggactttca tttgaacaag
     1381 tggctgatgc ccatgtttgg aataagagtg tttcacttta caccgtgaag gataaagcta
     1441 ctggagaagt gctggggcag ttctacctgg acctctatcc aagggaagga aaatacaacc
     1501 atgcggcctg ctttggtctc cagccaggct gccttctccc tgatggcagt cggatgatgt
     1561 ctgtggctgc cctggtggtc aacttctctc agcccatagc aggccggccc tctctcctga
     1621 gacacgacga agtgcgaact tacttccatg agtttggtca cgtcatgcat cagatctgtg
     1681 cacagactga ctttgcacga tttagtggaa caaatgtgga aactgacttt gtagaggtgc
     1741 catcacaaat gcttgaaaac tgggtgtggg acattgactc cctgcgaaaa ctgtcaaaac
     1801 attatagaga cggacaccct atcacagacg agctgctgga gaagcttgtg gcttcgagac
     1861 tggtcaacac aggtcttctg acgcttcgcc aaattgtttt gagcaaagtt gaccagtccc
     1921 tccataccaa tgcgtcgctg gatgccgcga gcgaatacgc taaatactgc acagaaattt
     1981 tgggagttgc agctacgcca ggcacaaata tgccagctac ctttggacat ttggcaggag
     2041 ggtatgacgg ccagtattat ggatatcttt ggagtgaagt cttttccatg gacatgtttc
     2101 acagctgttt cagaaaagaa gggattatga atccagaggt tggaatgaaa tacagaaacc
     2161 taatcctgaa gcctgggggg tccctggacg gcatggacat gctccagaat ttcttgcaac
     2221 gtgagccaaa ccagaaagca ttcctgatga gtcgaggcct gaatgcttcg taaagcaggg
     2281 acgctggggg ctgtccgtgg ctggaggaca agccaacacc gtccgccatg tggtgccggc
     2341 ctggagactg aaggcagttt tacaaaggaa aacttagatt tctattcatt tgcttttgtt
     2401 tcttcatttt aaaaattata cagatgtaaa tggaattata aatactgtga cctaagaaaa
     2461 gacccactaa aaataattgt actataaagt ttcataaaaa cagatttgat ttcttttgat
     2521 aaaagtttca tatgactgta atttgatttt tttactgtta taatccagat aatataatgt
     2581 aagagggcta agacatttta aattgaatca catacatgat ataatttgat ctttcttata
     2641 tcttgaagtt ttatacttga gattcctgga ctgataagtg aatcagcatg ttctctctgg
     2701 taaatatttt ctcagagccc tgtgtcaacc ttgaccctct gcctcacaac taagtgacag
     2761 tttgcctgtg tgtgtcaagg cccgcaggat acacttcaat gctgtttgtc ttttgtagtg
     2821 agctttgtga ttctcggctt ctgtcacact tacttacata gctccactta gatttggggt
     2881 tctttccctt ctaaaattta atttctaaag ttaatattat tatttagata atatttttaa
     2941 attttgtttc aactggccta gtatataagt tttgtgtctt gcactagaag ctcaaatgtc
     3001 aagtcttcgg ttgcagtcac agtgagagaa gcagagaact taggcatctt ttgggttctc
     3061 gacttttagt atttgctatg tatttgtttc tgcttgtttt gcttatatat atatattttt
     3121 tttattttgt ttgcttgagg caccatctca ccatggagcc agattcgcct ggaactcatg
     3181 gtaattcccc tgcttcggcc tcccaagcct taggggcgca ggtgtgagct gcctcactca
     3241 gctcagttct cacgtttcta ataagactct gaccttgcct ccctgaaagt ggtaggtcgg
     3301 ccctgtagtc acagtgtgtt gaagtgccag ggggagagat gacatccact ggaacttagc
     3361 tttgaaaact ccagaaaaga gtgcgttgga gcagagcgtt tgcgaacagc tgctcccaag
     3421 tgttccgtgg gcaaccgagc tgtgggaaaa ggctgtccag caggctgttt catatggcga
     3481 ctgttaagtg aacctccaga tctccaactc cttttattgg gacctaagtt tccagctcag
     3541 agtagtgagc tcacagcatt attttagcct tgggagtcta ctccaaacgg aagccaagta
     3601 ggatagagag gagaaaatgt aaatgagctg tgatcggact ttccacaggg ctttgagttg
     3661 tttctccaca catacctgag gaatgacttt cctggcagga aacgaaatta gagcctgtct
     3721 gttctttaga cccggtggac tttgtgttca ataaaatatt atgtcgtgta ataaagttat
//
