LOCUS       NM_008702               4507 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus nemo like kinase (Nlk), mRNA.
ACCESSION   NM_008702 XM_903159 XM_905012 XM_919106 XM_919120 XM_919133
VERSION     NM_008702.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4507)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4507)
  AUTHORS   Tejwani,L., Jung,Y., Kokubu,H., Sowmithra,S., Ni,L., Lee,C.,
            Sanders,B., Lee,P.J., Xiang,Y., Luttik,K., Soriano,A., Yoon,J.,
            Park,J., Ro,H.H., Ju,H., Liao,C., Tieze,S.M., Rigo,F.,
            Jafar-Nejad,P. and Lim,J.
  TITLE     Reduction of nemo-like kinase increases lysosome biogenesis and
            ameliorates TDP-43-related neurodegeneration
  JOURNAL   J Clin Invest 133 (16), e138207 (2023)
   PUBMED   37384409
  REMARK    GeneRIF: Reduction of nemo-like kinase increases lysosome
            biogenesis and ameliorates TDP-43-related neurodegeneration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4507)
  AUTHORS   Dong,T., Tejwani,L., Jung,Y., Kokubu,H., Luttik,K., Driessen,T.M.
            and Lim,J.
  TITLE     Microglia regulate brain progranulin levels through the
            endocytosis/lysosomal pathway
  JOURNAL   JCI Insight 6 (22), e136147 (2021)
   PUBMED   34618685
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4507)
  AUTHORS   Ji,Y.X., Wang,Y., Li,P.L., Cai,L., Wang,X.M., Bai,L., Liu,Z.,
            Tian,H., Tian,S., Zhang,P., Zhang,X.J., Cheng,X., Yuan,Y.,
            She,Z.G., Hu,Y. and Li,H.
  TITLE     A kinome screen reveals that Nemo-like kinase is a key suppressor
            of hepatic gluconeogenesis
  JOURNAL   Cell Metab 33 (6), 1171-1186 (2021)
   PUBMED   33951476
REFERENCE   5  (bases 1 to 4507)
  AUTHORS   Wilkes,M.C., Siva,K., Chen,J., Varetti,G., Youn,M.Y., Chae,H.,
            Ek,F., Olsson,R., Lundback,T., Dever,D.P., Nishimura,T., Narla,A.,
            Glader,B., Nakauchi,H., Porteus,M.H., Repellin,C.E., Gazda,H.T.,
            Lin,S., Serrano,M., Flygare,J. and Sakamoto,K.M.
  TITLE     Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase
  JOURNAL   Nat Commun 11 (1), 3344 (2020)
   PUBMED   32620751
  REMARK    GeneRIF: Diamond Blackfan anemia is mediated by hyperactive
            Nemo-like kinase.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4507)
  AUTHORS   Kehrer-Sawatzki,H., Moschgath,E., Maier,C., Legius,E., Elgar,G. and
            Krone,W.
  TITLE     Characterization of the Fugu rubripes NLK and FN5 genes flanking
            the NF1 (Neurofibromatosis type 1) gene in the 5' direction and
            mapping of the human counterparts
  JOURNAL   Gene 251 (1), 63-71 (2000)
   PUBMED   10863097
REFERENCE   7  (bases 1 to 4507)
  AUTHORS   Bulfone,A., Gattuso,C., Marchitiello,A., Pardini,C., Boncinelli,E.,
            Borsani,G., Banfi,S. and Ballabio,A.
  TITLE     The embryonic expression pattern of 40 murine cDNAs homologous to
            Drosophila mutant genes (Dres): a comparative and topographic
            approach to predict gene function
  JOURNAL   Hum Mol Genet 7 (13), 1997-2006 (1998)
   PUBMED   9817915
REFERENCE   8  (bases 1 to 4507)
  AUTHORS   Zambrowicz,B.P., Friedrich,G.A., Buxton,E.C., Lilleberg,S.L.,
            Person,C. and Sands,A.T.
  TITLE     Disruption and sequence identification of 2,000 genes in mouse
            embryonic stem cells
  JOURNAL   Nature 392 (6676), 608-611 (1998)
   PUBMED   9560157
REFERENCE   9  (bases 1 to 4507)
  AUTHORS   Brott,B.K., Pinsky,B.A. and Erikson,R.L.
  TITLE     Nlk is a murine protein kinase related to Erk/MAP kinases and
            localized in the nucleus
  JOURNAL   Proc Natl Acad Sci U S A 95 (3), 963-968 (1998)
   PUBMED   9448268
REFERENCE   10 (bases 1 to 4507)
  AUTHORS   Chambers,D.M. and Abbott,C.M.
  TITLE     Isolation and mapping of novel mouse brain cDNA clones containing
            trinucleotide repeats, and demonstration of novel alleles in
            recombinant inbred strains
  JOURNAL   Genome Res 6 (8), 715-723 (1996)
   PUBMED   8858346
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY137033.1, BY237029.1, BU923375.1, AK078118.1, CB234984.1,
            AK160340.1 and CO042120.1.
            
            On Jun 22, 2007 this sequence version replaced NM_008702.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058652.1, SRR1660819.30727.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               BY137033.1         1-312
            313-471             BY237029.1         175-333
            472-889             BU923375.1         60-477
            890-1754            AK078118.1         1-865
            1755-2229           CB234984.1         233-707
            2230-2840           AK078118.1         1339-1949
            2841-3993           AK160340.1         183-1335
            3994-4507           CO042120.1         1-514               c
FEATURES             Location/Qualifiers
     source          1..4507
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..4507
                     /gene="Nlk"
                     /note="nemo like kinase"
                     /db_xref="GeneID:18099"
                     /db_xref="MGI:MGI:1201387"
     exon            1..1617
                     /gene="Nlk"
                     /inference="alignment:Splign:2.1.0"
     CDS             1160..2743
                     /gene="Nlk"
                     /EC_number="2.7.11.24"
                     /codon_start=1
                     /product="serine/threonine-protein kinase NLK"
                     /protein_id="NP_032728.3"
                     /db_xref="CCDS:CCDS25113.2"
                     /db_xref="GeneID:18099"
                     /db_xref="MGI:MGI:1201387"
                     /translation="MSLCGTRANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLH
                     HHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQA
                     PGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRD
                     GKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVV
                     TELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNC
                     VLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAEL
                     LGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTL
                     SSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRV
                     YTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSF
                     ISSTVAQPSEMPPSPLVWE"
     exon            1618..1747
                     /gene="Nlk"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1803
                     /gene="Nlk"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1910
                     /gene="Nlk"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..1996
                     /gene="Nlk"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2206
                     /gene="Nlk"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2308
                     /gene="Nlk"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2395
                     /gene="Nlk"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2594
                     /gene="Nlk"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2688
                     /gene="Nlk"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..4496
                     /gene="Nlk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4473..4478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nlk"
                     /note="hexamer: ATTAAA"
     polyA_site      4496
                     /gene="Nlk"
                     /note="major polyA site"
ORIGIN      
        1 tatccggctt tgctagggga ggtgagtccg gccgcggcgg caccggcggc tgagaaggcg
       61 gcggctgaag agaaagcggt cacggcggct gtggagaaag cgaccgtggg cacggaagcc
      121 gggtgggggg gaggggggga gacggagcag ccttgagccc tgcaggggcc gtcgcgcggg
      181 ggacccaccc gctctccccc ccaaccctcc tcagcacaag ccggcggcgg cgggggcagg
      241 agtcagcctg cttccgaccg tcccccgccc gcttcccggg gctcctattc tttggccccg
      301 ggaccctaac ctcctccggg gcggttccct gtgtctgggc gtccgagtac tgcccaccgc
      361 tctttcattc cctccctgca ccttcttccc ttcacttttg ccggggtttt ctctctcctc
      421 ttctgtcctg cctgtcgcct cttcgcctca ctctcttcct ccagcctcct tccctggctc
      481 attctgccta ggaaagtttg gtacatctcc tcagtccccc caatcaggtc aaccagactc
      541 ggagtagggg gcgatgtagg aaggcctgag agttcgaggg gagggaagct ggaagctggt
      601 ttccctgata atttcccctc atcttttttg atttagagtg gttggaattt ttttttaatt
      661 gtgtttttga ggaggtggga ggtgtttaga aaaggatgtg ggaatggaag gggtagatga
      721 gtcaaccctc ttacaagatt ccaagggtgg cgtgttacca gatccttttc gtgtgcggag
      781 ttcagggggt cgggaggttt ggcctttatt cccacattca aagttggaac ctccccccca
      841 ttaagaatgg agttttagta tccacttgtg gcaggaatcc tggggggaag gggccctttt
      901 ccctttttct tttccttttt tttttcttct tattttatgt tcttaacttt tattttgaca
      961 acccataccc ttccacacac tctcaccccc aaatcgaaca cccaagattg tcaaacttgt
     1021 ctggattgac cgatgaagac ataaagccag ttccgctcta tgttttttga ggtggagtga
     1081 gtggtttttc ttcatttttt taaatggcca aatgacagct tgacccagtt tgctttccaa
     1141 tcaaagggca tttttttgaa tgtctctttg tggcacaaga gccaacgcaa aaatgatggc
     1201 ggcttacaat ggcggtacat ctgcagctgc agcaggtcac caccaccacc atcatcacca
     1261 ccttccacac cttcctcctc ctcaccttca ccaccaccac caccctcaac accaccttca
     1321 tccggggtcg gctgctgccg tacacccagt ccagcagcat acgtcttcgg cagctgcggc
     1381 agccgccgca gcagctgcag ccgcagccat gttaaaccct gggcaacaac agccatattt
     1441 cccatccccg gcaccgggtc aggctcctgg gccagccgca gcagccccag ctcaggtaca
     1501 ggctgctgca gctgctacag ttaaggcgca ccatcatcag cactcgcatc atccgcaaca
     1561 gcagctggac attgagccgg atagaccaat tggatatgga gcctttggcg ttgtctggtc
     1621 agtaacagat ccaagagatg gaaagagagt agcactcaaa aagatgccca acgtcttcca
     1681 gaatctggtc tcttgcaaaa gagtcttccg ggaattgaag atgttgtgtt tttttaaaca
     1741 tgataatgta ctctctgccc ttgacatact ccaacctcca cacattgact attttgaaga
     1801 aatatatgtt gtcacagaat tgatgcagag tgatctacat aaaattatcg tctctcctca
     1861 gccactcagc tcggatcatg tcaaagtttt tctttatcag attttgcgag gtttgaaata
     1921 tctccattca gctggcattt tgcatcgaga cattaagcca gggaacctcc ttgtgaacag
     1981 caattgtgtt ctaaagattt gtgattttgg attggccaga gtggaggaat tggatgaatc
     2041 ccgtcatatg actcaggaag tagttactca gtattaccgg gctccggaga tcctgatggg
     2101 cagccgtcat tacagcaatg ctatcgacat ctggtctgtc gggtgcatct ttgcagagct
     2161 actgggccga agaatattgt ttcaggcgca gagtcccatt cagcagttgg atttgatcac
     2221 agatctgttg ggcacaccat cactggaagc aatgaggaca gcttgtgaag gtgctaaggc
     2281 acacatactc aggggtcctc ataaacagcc atctcttcct gtgctctaca ccctctccag
     2341 ccaggccaca catgaagctg ttcacctgct ttgcaggatg ttggtctttg atccatcaaa
     2401 aagaatatcc gctaaggatg ccttagccca cccctaccta gatgaagggc ggctgagata
     2461 ccatacgtgt atgtgcaagt gctgcttttc cacctcaacg gggagagtct acaccagtga
     2521 ctttgagcct gtcaccaacc ccaaatttga tgacaccttt gagaagaacc tcagctctgt
     2581 ccgacaggtt aaagaaatta tccaccagtt cattctggaa cagcagaaag gaaacagagt
     2641 gcctctctgc atcaacccgc agtccgctgc ctttaagagc tttattagtt ccaccgtcgc
     2701 tcagccgtct gagatgccgc cgtctcctct ggtgtgggag tgactgtgga agacactgta
     2761 ctactgaaga tgtaatgtag ctttcactgg agtctgggat ttgcaattct ggagggttaa
     2821 tcatgcttgt actgtaattt tactaatgaa gttttaaatt aacaaccact acttgtatga
     2881 tatgaataat atttagaaat gttactagac ttttaatctt gtaaagtggt tgtgctttta
     2941 gaagaaaaaa aaatatttta cccagagttg cacatggtta aagaattcag tgcagctgtt
     3001 gcggctcacc tcagaacaaa tgaaaattga accaaatttg ggcatttggg gtttatgttt
     3061 ttattttatt attatttttt ttaatgaagt aagattgttc acatgtatac actcagacac
     3121 agaggacagt catacatttt gatatttgag ccattcctaa agattaaggg ttttctaaaa
     3181 ctaaagaatc tagaaagctt gccagtgacc aatcatggag cctcgtgagc taactgtggc
     3241 cgcgcctggg gcatgggcag gaggggccac ctaatgatga agccagtgat tggcttctca
     3301 ttagagccgt gctggtggtg tgtgcggtct aacctccaat gctgtgcgta gaaagaatga
     3361 gtttgtggct aggagaaact aaccctctgt ttcccttacc cggtataaat atatatatac
     3421 atatatatat ttaatctatt tttattagaa gtttttctgc tctttcttac ataaaaaaaa
     3481 aaaaagaccc aagcatgcat ctttcatgta tgtaaataat tcatttctgg gctaatttca
     3541 aaagaatccc aacactgctg tatagagaac tagcttgcac attttaggtc tgtgaaattc
     3601 tgtgagactt ttcctgcact ggacagtgaa aaataataaa taaaagacaa aaagaaattt
     3661 taaaaaaaat tacagccaca aaggcacata gggaatcatg tcaaatgtgt ttgtgtcctt
     3721 aggcaaagct gtgggagtct tgagatgtca cagtagtaaa taacttatta cttttttgac
     3781 aaattctttt tcctgctgga acactgaact ctgtgcatat gtaaatatga gcaccaatcg
     3841 aaggcctcta cctcctggag ttacacaact tggcttgtta cctccacacg ctgatgatga
     3901 ctcttttttt ttttttttaa gttcaatgtg gagacttgaa acttgaatgt cccttccaac
     3961 ttttatatta aaaataaaaa gacaagaaaa ttgaagagcg tttttcacct gtacgaggag
     4021 tactaacgga tcgtcttaaa actggtctag gaaaaagctt ggtgtgtgtg ttacggacaa
     4081 ttaactgtta aagttactgt aagttatctg tatttagcag agtattttca tcttgagtga
     4141 tctgagctga atttgaagac tattaagtta tatttggaag ttttaacttc aatgaagtaa
     4201 ttatttgctg tgaaagaaac aaacattgaa ttactaaaca aagatggtgc aatatctttg
     4261 ttgtcgttgt tgttgttgtt gtttttatga ggctcctgag aagctaccca accgaagcat
     4321 ttcagtcccc ttgactgagc atcaaaagag cccgagaaga cactggtgtg aaaggttggt
     4381 gtgaaaggta caatctcaga ggtcggtcag ttaccgtggc acacttcctg gtcactttgt
     4441 acaatgtaga tttgaagtac agtggtgaga acattaaacg tgacatttga aaacaaaaaa
     4501 aaaaaaa
//
