LOCUS       NM_172932               3899 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus neuroligin 3 (Nlgn3), mRNA.
ACCESSION   NM_172932 XM_986670
VERSION     NM_172932.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3899)
  AUTHORS   Lin,S., Fan,C.Y., Wang,H.R., Li,X.F., Zeng,J.L., Lan,P.X., Li,H.X.,
            Zhang,B., Hu,C., Xu,J. and Luo,J.H.
  TITLE     Frontostriatal circuit dysfunction leads to cognitive inflexibility
            in neuroligin-3 R451C knockin mice
  JOURNAL   Mol Psychiatry 29 (8), 2308-2320 (2024)
   PUBMED   38459194
  REMARK    GeneRIF: Frontostriatal circuit dysfunction leads to cognitive
            inflexibility in neuroligin-3 R451C knockin mice.
            Erratum:[Mol Psychiatry. 2025 Jan;30(1):365-366. doi:
            10.1038/s41380-024-02658-7.. PMID: 39043844]
REFERENCE   2  (bases 1 to 3899)
  AUTHORS   Sun,H., Shen,Y., Ni,P., Liu,X., Li,Y., Qiu,Z., Su,J., Wang,Y.,
            Wu,M., Kong,X., Cao,J.L., Xie,W. and An,S.
  TITLE     Autism-associated neuroligin 3 deficiency in medial septum causes
            social deficits and sleep loss in mice
  JOURNAL   J Clin Invest 134 (19), e176770 (2024)
   PUBMED   39058792
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3899)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3899)
  AUTHORS   Diamanti,T., Trobiani,L., Mautone,L., Serafini,F., Gioia,R.,
            Ferrucci,L., Lauro,C., Bianchi,S., Perfetto,C., Guglielmo,S.,
            Sollazzo,R., Giorda,E., Setini,A., Ragozzino,D., Miranda,E.,
            Comoletti,D., Di Angelantonio,S., Cacci,E. and De Jaco,A.
  TITLE     Glucocorticoids rescue cell surface trafficking of R451C
            Neuroligin3 and enhance synapse formation
  JOURNAL   Traffic 25 (1), e12930 (2024)
   PUBMED   38272450
  REMARK    GeneRIF: Glucocorticoids rescue cell surface trafficking of R451C
            Neuroligin3 and enhance synapse formation.
REFERENCE   5  (bases 1 to 3899)
  AUTHORS   Xu,Y., Cui,T.L., Li,J.Y., Chen,B. and Wang,J.H.
  TITLE     Associative memory neurons of encoding multi-modal signals are
            recruited by neuroligin-3-mediated new synapse formation
  JOURNAL   Elife 12, 87969 (2023)
   PUBMED   38047770
  REMARK    GeneRIF: Associative memory neurons of encoding multi-modal signals
            are recruited by neuroligin-3-mediated new synapse formation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3899)
  AUTHORS   Olsen,O., Moore,K.A., Fukata,M., Kazuta,T., Trinidad,J.C.,
            Kauer,F.W., Streuli,M., Misawa,H., Burlingame,A.L., Nicoll,R.A. and
            Bredt,D.S.
  TITLE     Neurotransmitter release regulated by a MALS-liprin-alpha
            presynaptic complex
  JOURNAL   J Cell Biol 170 (7), 1127-1134 (2005)
   PUBMED   16186258
REFERENCE   7  (bases 1 to 3899)
  AUTHORS   Chih,B., Engelman,H. and Scheiffele,P.
  TITLE     Control of excitatory and inhibitory synapse formation by
            neuroligins
  JOURNAL   Science 307 (5713), 1324-1328 (2005)
   PUBMED   15681343
  REMARK    Erratum:[Science. 2005 Jun 3;308(5727):1413]
REFERENCE   8  (bases 1 to 3899)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 3899)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 3899)
  AUTHORS   Gilbert,M., Smith,J., Roskams,A.J. and Auld,V.J.
  TITLE     Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory
            ensheathing glia, a growth-promoting class of macroglia
  JOURNAL   Glia 34 (3), 151-164 (2001)
   PUBMED   11329178
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB619023.1, CF898143.1, AK039018.1 and BI134434.1.
            
            On Nov 18, 2011 this sequence version replaced NM_172932.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK039018.1, SRR7974084.9340.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-311               BB619023.1         1-311
            312-679             CF898143.1         287-654
            680-3740            AK039018.1         650-3710
            3741-3881           AK039018.1         3713-3853
            3882-3899           BI134434.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..3899
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 43.95 cM"
     gene            1..3899
                     /gene="Nlgn3"
                     /gene_synonym="A230085M13Rik; HNL3; NL3; NLG3"
                     /note="neuroligin 3"
                     /db_xref="GeneID:245537"
                     /db_xref="MGI:MGI:2444609"
     exon            1..118
                     /gene="Nlgn3"
                     /gene_synonym="A230085M13Rik; HNL3; NL3; NLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            119..765
                     /gene="Nlgn3"
                     /gene_synonym="A230085M13Rik; HNL3; NL3; NLG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..2795
                     /gene="Nlgn3"
                     /gene_synonym="A230085M13Rik; HNL3; NL3; NLG3"
                     /note="neuroligin 3 protein; gliotactin homolog"
                     /codon_start=1
                     /product="neuroligin-3 precursor"
                     /protein_id="NP_766520.2"
                     /db_xref="CCDS:CCDS30313.1"
                     /db_xref="GeneID:245537"
                     /db_xref="MGI:MGI:2444609"
                     /translation="MWLQPSLSLSPTPTVGRSLCLTLGFLSLVLRASTQAPAPTVNTH
                     FGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPV
                     CPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDGSGAKKQGEDL
                     ADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGNVIVITLNYRVGV
                     LGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTL
                     SHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSA
                     KELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVE
                     GVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKT
                     LVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVF
                     GVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFE
                     EVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTKV
                     PPPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAPGSWNGDQDAGPLLVENPRDYS
                     TELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGTGAPELGTAPEEEL
                     AALQLGPTHHECEAGPPHDTLRLTALPDYTLTLRRSPDDIPLMTPNTITMIPNSLVGL
                     QTLHPYNTFAAGFNSTGLPHSHSTTRV"
     exon            766..825
                     /gene="Nlgn3"
                     /gene_synonym="A230085M13Rik; HNL3; NL3; NLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            826..975
                     /gene="Nlgn3"
                     /gene_synonym="A230085M13Rik; HNL3; NL3; NLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1161
                     /gene="Nlgn3"
                     /gene_synonym="A230085M13Rik; HNL3; NL3; NLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1951
                     /gene="Nlgn3"
                     /gene_synonym="A230085M13Rik; HNL3; NL3; NLG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..3883
                     /gene="Nlgn3"
                     /gene_synonym="A230085M13Rik; HNL3; NL3; NLG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3857..3862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nlgn3"
                     /gene_synonym="A230085M13Rik; HNL3; NL3; NLG3"
                     /note="hexamer: AATAAA"
     polyA_site      3883
                     /gene="Nlgn3"
                     /gene_synonym="A230085M13Rik; HNL3; NL3; NLG3"
                     /note="major polyA site"
ORIGIN      
        1 acagcagcca ggctgccgga gagctgatct cggagattcg ggtgcggagc ccttggcctg
       61 gaggcgatat gggtggtccg tggcctggtt caatcgtttg cagccgccta gggaacaggc
      121 ctgtctggcc ctaagggagc cctctttcga agtggtggtg ctcggaagac ctgctctctg
      181 cattgctggg cacctgtagg tgtccctcga gagctcagtt ttgaggttca agtcagtgtg
      241 gccatgaagg ggctgcctat tgggctgatg ctgtgacccc ggagtcttcc tctcctgcca
      301 gtccccctgc ccggaacatg tggctgcagc cctcgctgtc cctgagcccc acgcccacag
      361 ttggccggag cctgtgcctc accctgggct tcctcagttt ggtgctgagg gccagtaccc
      421 aggccccggc acccacagtc aatactcact ttgggaagct aaggggtgcc agagtaccat
      481 tgcccagtga aatcctgggt cctgtggacc aatacctggg ggtaccctac gcagctcccc
      541 cgatcggcga gaaacgtttc ctgccccctg aaccaccccc atcctggtcg ggcatccgga
      601 acgccacaca ctttccccca gtgtgccccc agaacatcca cacagctgtg cccgaagtca
      661 tgctgccagt ctggttcact gccaacttgg atatcgtcgc cacttatatc caggagccca
      721 acgaagattg cctctatctg aatgtgtatg tgcccacgga agatggatcc ggcgctaaga
      781 aacagggcga ggacttagcg gataatgacg gggatgaaga tgaagacatc cgagacagtg
      841 gtgctaaacc tgtcatggtc tacatccacg gaggctctta catggaagga acaggcaaca
      901 tgattgatgg cagtgttctt gcaagttacg gcaacgtcat cgtcatcacc ctcaactatc
      961 gggtcggggt gctaggtttc ctgagcactg gagatcaggc tgccaagggc aactatgggc
     1021 tccttgatca aatccaggcc cttcgctggg tgagtgagaa tattgccttc tttggaggag
     1081 atccccgtag aattactgtc tttggctctg gcatcggtgc atcctgtgtc agtctcctta
     1141 cactgtctca tcattctgag gggcttttcc agagggccat catccaaagt ggctctgctc
     1201 tatctagctg ggctgtgaac taccaaccag tgaagtatac cagcttgctg gcagacaaag
     1261 tgggctgtaa cgtcctggac actgtggata tggtggattg tcttcgacaa aagagtgcca
     1321 aggagctggt agaacaggac attcagccag cccgctacca tgtggctttt ggccctgtga
     1381 ttgatggtga tgtcattcct gatgaccctg agatccttat ggagcaggga gagttcctca
     1441 actatgatat catgctaggc gtcaaccagg gtgagggtct caagtttgtg gaaggggtgg
     1501 tggaccccga ggatggtgtc tcgggcactg actttgacta ctctgtctcc aattttgtgg
     1561 acaatctgta tggctatcct gagggtaagg acaccctgcg ggagactatc aagttcatgt
     1621 atacggactg ggcagaccga gacaaccctg agacccgccg taaaacactg gtggcactct
     1681 tcactgacca ccagtgggtg gagccttcag tggtgacagc cgatctgcac gcccgctatg
     1741 gctcacctac ctacttctac gccttctacc atcactgcca gagcctcatg aagcccgcat
     1801 ggtcagatgc agcacacggg gatgaagtgc cctatgtttt tggtgtccct atggtaggtc
     1861 ccactgacct tttcccctgc aacttctcca agaatgatgt tatgctcagt gctgtcgtca
     1921 tgacctattg gaccaacttt gccaagaccg gggatcccaa caagccggta ccccaggata
     1981 ccaagttcat tcacaccaag gccaaccgct ttgaggaagt ggcctggtcc aaatacaatc
     2041 cccgagacca gctctacctt cacatcgggc tgaaaccaag ggttcgtgat cattaccggg
     2101 ccacaaaggt agccttttgg aaacacctgg tgccccacct gtacaacctg catgacatgt
     2161 tccactatac atccacgacc accaaagtgc cgcccccgga caccacccac agctcccaca
     2221 tcacccgtag gcccaacggc aagacctgga gcaccaagcg gccggcgatt tcacctgcct
     2281 acagcaatga gaatgcccct gggtcctgga atggggacca ggatgcgggg ccactcctgg
     2341 ttgagaaccc tcgagactac tccactgaat taagtgtcac tatcgctgtg ggggcctccc
     2401 tcctgtttct caatgtgttg gcctttgctg ccctctatta ccgtaaggac aaacggcgcc
     2461 aggagcccct gaggcagcct agcccccaaa ggggaactgg tgcccctgaa ttgggaactg
     2521 ctccggagga ggagctggca gcattacagt tgggtcccac tcaccatgaa tgtgaggccg
     2581 gtcccccaca tgacacactt cgcctcacag cactgcccga ctataccctg accctgcggc
     2641 gctcccctga tgacatccca ctcatgactc ccaacaccat cactatgatt cctaattccc
     2701 tggttgggtt gcagaccttg cacccctata acacctttgc cgcagggttc aacagtactg
     2761 ggctgcccca ctcacactcc actacccgtg tatagctcta tcccggagca cagcccatct
     2821 cccagctccc tccctcccag atccacaaac acacatgcac acacatacac atatatgtac
     2881 acgcacgcac ccacacccta cagcagaccc atctgcataa acacagacag atgtggacat
     2941 gcacccgcat gtacaaaaac acaaatccag acgtgaacct gaataggccc ttcaaatggg
     3001 gacacatacg agtccttggt accaagggcc catggaacag cagctggaac cagctccttg
     3061 agcccgacca cagacactcc tggggccctg gaagccacag ccggacaccc ccttggtgct
     3121 tgccttctcg gaactgcacc tctaccaact gcagactcgg gagctttaaa gagcaggata
     3181 gctcttcctc ccccagactt ggtcttttct ctgggtcttg tttttgttga tttttttcat
     3241 ttttaaattg gaaccaatgc ttttccaacc cattgagtgc taagcagctc tggaagggag
     3301 ggctccaaga tcaggacgct ctggctctgg gactcccaat gttcatacaa tcagaccaag
     3361 gagaaggacc ttccaagaca gtgacagatg ggcacaagac tatggggtaa gaggaggaag
     3421 aggctagcaa tggatggggc ttgagggcca gcaaggacag agcaccaact ggctctgggc
     3481 ctcccagaga ggactacaga gcctacaggg tgacctgctt ctgcaaaggc cagcagcagc
     3541 agcctgcctg gagaagccta ggtttgatga actaagtact gtggaggccc tgaccttatt
     3601 gggcccctgg gtatataatc tgggttctgc ctctgccctt ggggacatga tatcagaaat
     3661 ttgccccatt ttctttacag tctctttgtg tctgtcattt ctctttcaaa acaacagtgt
     3721 tttggttttt tttttttttt cggttgttgt tggctttttt tttttttttt tttttaagaa
     3781 aagttcttaa aacactaacg gaaacccatg gagtttgtcc tttgtaaaaa ttttaaacac
     3841 agtgtcttga tataaaaata aaaaatccag ttagcactcc caaaaaaaaa aaaaaaaaa
//
