LOCUS       NM_001364137            5567 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus neuroligin 2 (Nlgn2), transcript variant 1, mRNA.
ACCESSION   NM_001364137 XM_006532901
VERSION     NM_001364137.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5567)
  AUTHORS   Wutikeli,H., Yu,Y., Zhang,T., Cao,J., Nawy,S. and Shen,Y.
  TITLE     Role of Elavl-like RNA-binding protein in retinal development and
            signal transduction
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167518 (2025)
   PUBMED   39307290
REFERENCE   2  (bases 1 to 5567)
  AUTHORS   Xu,N., Cao,R., Chen,S.Y., Gou,X.Z., Wang,B., Luo,H.M., Gao,F. and
            Tang,A.H.
  TITLE     Structural and functional reorganization of inhibitory synapses by
            activity-dependent cleavage of neuroligin-2
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2314541121 (2024)
   PUBMED   38657049
  REMARK    GeneRIF: Structural and functional reorganization of inhibitory
            synapses by activity-dependent cleavage of neuroligin-2.
REFERENCE   3  (bases 1 to 5567)
  AUTHORS   Leduc,T., El Alami,H., Bougadir,K., Belanger-Nelson,E. and
            Mongrain,V.
  TITLE     Neuroligin-2 shapes individual slow waves during slow-wave sleep
            and the response to sleep deprivation in mice
  JOURNAL   Mol Autism 15 (1), 13 (2024)
   PUBMED   38570872
  REMARK    GeneRIF: Neuroligin-2 shapes individual slow waves during slow-wave
            sleep and the response to sleep deprivation in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5567)
  AUTHORS   Benner,O., Cast,T.P., Minamide,L.S., Lenninger,Z., Bamburg,J.R. and
            Chanda,S.
  TITLE     Multiple N-linked glycosylation sites critically modulate the
            synaptic abundance of neuroligin isoforms
  JOURNAL   J Biol Chem 299 (12), 105361 (2023)
   PUBMED   37865312
REFERENCE   5  (bases 1 to 5567)
  AUTHORS   Groisman,A.I., Aguilar-Arredondo,A., Giacomini,D. and Schinder,A.F.
  TITLE     Neuroligin-2 controls the establishment of fast GABAergic
            transmission in adult-born granule cells
  JOURNAL   Hippocampus 33 (4), 424-441 (2023)
   PUBMED   36709408
  REMARK    GeneRIF: Neuroligin-2 controls the establishment of fast GABAergic
            transmission in adult-born granule cells.
REFERENCE   6  (bases 1 to 5567)
  AUTHORS   Chih,B., Engelman,H. and Scheiffele,P.
  TITLE     Control of excitatory and inhibitory synapse formation by
            neuroligins
  JOURNAL   Science 307 (5713), 1324-1328 (2005)
   PUBMED   15681343
  REMARK    Erratum:[Science. 2005 Jun 3;308(5727):1413]
REFERENCE   7  (bases 1 to 5567)
  AUTHORS   Graf,E.R., Zhang,X., Jin,S.X., Linhoff,M.W. and Craig,A.M.
  TITLE     Neurexins induce differentiation of GABA and glutamate postsynaptic
            specializations via neuroligins
  JOURNAL   Cell 119 (7), 1013-1026 (2004)
   PUBMED   15620359
REFERENCE   8  (bases 1 to 5567)
  AUTHORS   Varoqueaux,F., Jamain,S. and Brose,N.
  TITLE     Neuroligin 2 is exclusively localized to inhibitory synapses
  JOURNAL   Eur J Cell Biol 83 (9), 449-456 (2004)
   PUBMED   15540461
  REMARK    GeneRIF: The neuroligin 2 is as a new cell adhesion protein
            specific for inhibitory synapses and open new avenues for
            identifiying the constituents of this unique type of postsynaptic
            specialization.
REFERENCE   9  (bases 1 to 5567)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 5567)
  AUTHORS   Kurschner,C., Mermelstein,P.G., Holden,W.T. and Surmeier,D.J.
  TITLE     CIPP, a novel multivalent PDZ domain protein, selectively interacts
            with Kir4.0 family members, NMDA receptor subunits, neurexins, and
            neuroligins
  JOURNAL   Mol Cell Neurosci 11 (3), 161-172 (1998)
   PUBMED   9647694
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK136883.1 and AL603707.5.
            
            On Jun 8, 2018 this sequence version replaced XM_006532901.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136883.1, SRR7974084.25964.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3243              AK136883.1         2-3244
            3244-5567           AL603707.5         202352-204675       c
FEATURES             Location/Qualifiers
     source          1..5567
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.89 cM"
     gene            1..5567
                     /gene="Nlgn2"
                     /gene_synonym="NL2; NLG2"
                     /note="neuroligin 2"
                     /db_xref="GeneID:216856"
                     /db_xref="MGI:MGI:2681835"
     exon            1..737
                     /gene="Nlgn2"
                     /gene_synonym="NL2; NLG2"
                     /inference="alignment:Splign:2.1.0"
     exon            738..1433
                     /gene="Nlgn2"
                     /gene_synonym="NL2; NLG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             977..3487
                     /gene="Nlgn2"
                     /gene_synonym="NL2; NLG2"
                     /note="ortholog of human and rat neuroligin 2 NLGN2"
                     /codon_start=1
                     /product="neuroligin-2 precursor"
                     /protein_id="NP_001351066.1"
                     /db_xref="CCDS:CCDS24914.1"
                     /db_xref="GeneID:216856"
                     /db_xref="MGI:MGI:2681835"
                     /translation="MWLLALCLVGLAGAQRGGGGPGGGAPGGPGLGLGSLGEERFPVV
                     NTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTL
                     PPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRD
                     EATLNPPDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVVTLNYRLGV
                     LGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLIL
                     SHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSTEAVECLRRKSS
                     RELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVE
                     DSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKT
                     LLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVF
                     GVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFE
                     EVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPP
                     YATRWPPRTPGPGTSGTRRPPPPATLPPESDIDLGPRAYDRFPGDSRDYSTELSVTVA
                     VGASLLFLNILAFAALYYKRDRRQELRCRRLSPPGGSGSGVPGGGPLLPTAGRELPPE
                     EELVSLQLKRGGGVGADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGP
                     PPPPPPPSLHPFGPFPPPPPTATSHNNTLPHPHSTTRV"
     exon            1434..1484
                     /gene="Nlgn2"
                     /gene_synonym="NL2; NLG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1634
                     /gene="Nlgn2"
                     /gene_synonym="NL2; NLG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1820
                     /gene="Nlgn2"
                     /gene_synonym="NL2; NLG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..2013
                     /gene="Nlgn2"
                     /gene_synonym="NL2; NLG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2610
                     /gene="Nlgn2"
                     /gene_synonym="NL2; NLG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..5567
                     /gene="Nlgn2"
                     /gene_synonym="NL2; NLG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5550..5555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nlgn2"
                     /gene_synonym="NL2; NLG2"
                     /note="hexamer: TATAAA"
     polyA_site      5567
                     /gene="Nlgn2"
                     /gene_synonym="NL2; NLG2"
                     /note="major polyA site"
ORIGIN      
        1 gacgcgcggg gctgctgcgg ctgctccgcc ggcggatcat cactctcgag ctgggatgga
       61 cgcggggcgg gcgggccctg gcgcgcagag ccaggagtcc gggcctcctg gctactgagc
      121 atttcccaaa gcctccccta gcccttgcct tccttcctag gagccgcacc gacctctgcc
      181 tcgaggctcg ggactcggcc cccgccctct tctgactccc cggatctccc tcccgcccgc
      241 cctcgggatc gactagatcc ctccccctcc ccgaggattc cggctggatc cctgcccctg
      301 caccgcggat tctgcgctcc ggggctccgg gcccctaggg attgccgtgg actcctcctc
      361 cagcacccga tcccttagga tctgtcgcct gaaccgcctc ctggtccctc gaagccatcc
      421 cagagaacca gtggatctcc aatctagtcc tgtcccattg ctccctcctg gctcagcctt
      481 tcccactgcg gggttccctg ttcttgagct ctctctgacc ctatacccta gctttccttt
      541 tcctggggat cgactggatt ccggccccgc cccccggggc tggggcgatc cccctccccc
      601 gccgggtgag gcgctgcagg cgggggctgg gcctgcgggg ccgcgggggc tcagaggccg
      661 ccgcccccct tctgaaaccc gtccgccccc cgctcggagc cctggatgga ggcaccacgg
      721 ccccagggct gatccaggtc gggcctccca gcaccttctt ctaccttctt ccccttcccc
      781 accccctacc ccctccatgg agagaaatag actcctcttc tgtcccttct aacccaggtc
      841 ccttcccgtc cccctcctcc ttcctttccc ccgccccctc ctccctcctg gggcgagggg
      901 ggcctccctc cctctccccc ccttctctct ctccgagggg ggggtcaggg gagggagggg
      961 gggtccccca atcagcatgt ggctcctggc gttgtgtctg gtggggctgg ctggggctca
     1021 acggggagga gggggtcccg gcggcggcgc cccgggcggc ccaggcctgg gcctcggcag
     1081 cctcggggag gagcgcttcc ccgtggtgaa cacagcctac gggcgagtgc gcggtgtgcg
     1141 gcgcgagctc aacaacgaga tcctgggccc ggtcgtgcag ttcttgggcg tgccctacgc
     1201 cacgccgccc ttgggcgccc gccgcttcca gccgcctgag gcacctgcct cgtggcccgg
     1261 cgtgcgcaac gccaccaccc tgccgcccgc ctgcccgcag aacctgcacg gggccctgcc
     1321 ggccatcatg ctgcctgtgt ggttcaccga caacttggag gcggccgcca cctacgtgca
     1381 gaaccagagc gaggactgcc tgtacctcaa cctctacgtg cccactgagg acggtccgct
     1441 cacaaaaaaa cgtgacgagg cgacgctcaa tccgccagac acagatatcc gggactctgg
     1501 gaagaaaccg gtcatgctgt ttctacacgg cggctcctac atggaaggca ccgggaacat
     1561 gtttgacggc tcagtcctgg ctgcctatgg caatgtcatc gtagtcacac tcaactaccg
     1621 tcttggggtg ctcggttttc tcagcactgg tgaccaggct gcaaaaggca actatgggct
     1681 cctggaccag atccaggccc tgcgctggct cagtgaaaac attgcccact ttggaggtga
     1741 ccctgaacgc atcactatct ttgggtctgg tgcaggggcc tcctgtgtca acttgctgat
     1801 cctttcccac cactcagaag gactgttcca gaaggccatt gctcaaagtg gtactgccat
     1861 ttccagctgg tctgtcaact accagccgct caagtacacg cggctgctgg cggccaaagt
     1921 gggctgtgac cgagaagaca gcactgaagc tgtggagtgt ctgcgccgga agtcttcccg
     1981 ggagctagtg gaccaggatg tacagcctgc ccgctaccac attgcctttg ggcctgtggt
     2041 ggacggcgac gtagtccctg atgaccccga gatcctcatg caacaggggg aattcctcaa
     2101 ctacgacatg ctcattggtg tcaaccaggg agagggtctc aagttcgtgg aggactctgc
     2161 agagagtgag gacggtgtgt ctgccagcgc ctttgacttc accgtctcca actttgtgga
     2221 caacttgtac gggtacccag aaggcaagga cgtgcttcga gagaccatca agttcatgta
     2281 cacggactgg gctgacaggg acaatggcga gatgcggcgg aagaccctgc tggcgctctt
     2341 taccgaccac cagtgggtcg ccccggctgt ggccaccgcc aagctgcatg ccgactacca
     2401 gtcccccgtc tacttttaca ctttctacca ccactgccag gcagagggcc ggccagagtg
     2461 ggcagacgca gcgcacgggg acgagctgcc ctacgtcttt ggtgtcccca tggtgggcgc
     2521 cactgacctc ttcccctgca acttctccaa gaacgatgtc atgctcagcg cagtagtcat
     2581 gacctattgg accaacttcg ccaagactgg tgaccccaac cagcctgtgc cacaggacac
     2641 caagttcatc cacaccaagc ccaaccgctt tgaagaggta gtgtggagca agttcaacag
     2701 caaggaaaag cagtatctgc acataggctt gaaaccacgc gtgcgcgaca actaccgtgc
     2761 caacaaggtg gccttctggc tggagctcgt gccccacctg cacaacctgc acacagagct
     2821 cttcaccacc accactcgcc tgcctcccta tgccacacgc tggccacctc gcacacctgg
     2881 tcctggcact tccggcacac gccgtcctcc cccacctgcc actctgccac ctgagtctga
     2941 tattgaccta ggcccaaggg cctatgaccg cttccccggt gactcgaggg actactccac
     3001 ggagctaagc gtgactgtgg cagtgggtgc ctccctcctc ttcctcaaca tccttgcctt
     3061 tgccgccctc tattacaagc gggaccggcg ccaggagctg cggtgccgga ggcttagccc
     3121 accaggaggc tcaggctcag gtgtgcctgg tgggggcccc ctgcttccca ctgctggccg
     3181 tgagctaccc ccggaggagg agctagtatc gctgcagctg aagcggggtg gtggtgttgg
     3241 ggcggaccct gctgaggccc tgcgccctgc ctgtccaccc gactataccc tggccttgcg
     3301 ccgggcaccg gacgatgtgc ctctcttggc ccccggggcc ctaaccctgc tgcctagtgg
     3361 cctggggccc ccgcccccgc ccccaccccc ttctctccat ccctttgggc ccttcccacc
     3421 cccaccccct actgctacca gccacaacaa cacgctaccc catccccact ccaccactcg
     3481 ggtatagggg gcggctttgg gaggtctgcc tccctagccc tcccagccca ggccacttga
     3541 aggcagggag gaggacttgg caccgggctt tgcccccgtg gatttgtcag acttcgtgga
     3601 gcagtgttaa ggtggacatg ggattcctca ctgggaagag agtttttccc atgcagagag
     3661 ccccattatc tcctctggac ctgggccttc gaacacctgg ggggtatttt ttgccctccg
     3721 ttgggacacc agtcttcggt gtgtggaaat gtggaagtcc ttttgcccat gtgaagacat
     3781 gctttcctca gggggggggg gtgttttccc atgtgcaggg tgaggtttgt ttggtttttt
     3841 tgtttttggt tggttggttg ggtttttttt tgtttttgtt ttattcgggg gggggggttg
     3901 tttgtttgtt tgtttgtttt gccgccctgg acacatgttt gcctcctcca agaatttctg
     3961 cggggatttg tatcccatgc cttcgtcttc tcctccccgt ccaactccct ggagaccctg
     4021 gaagtgatgt gtgcacatcc ggtgaccctt ggccaccaga caatacaggg aggtacctgg
     4081 ggagcagcta ggaaatcaca ggccccctgg accccgctcc ccacccaccc ctgaatagca
     4141 tgtttctccc ccatggcaca aggcaggtga agcccgtgct ccctggaagc cctcaccttc
     4201 cacagacaac agagatttcc tgctagagga aagggggaat ctctgtgcat cccagcgctg
     4261 cctggaaact taccttccca cggcccagga cgcatttcat cgaatggaaa catgttcttg
     4321 catgtggatg tgtgtttccc aggcagaggg tcctgcgccc cccagcactc ccctgccctc
     4381 tcccacacct caggtccagc gcacacttcc tccttgcata gcaggtggga gcagacttct
     4441 aatggacaga agccacgtgg gaagtagaga cttggaggga gacgccgagg tgggaggatg
     4501 gggggcatgg cacatgtcac acaagaggcc atgcatgttt aacctaagcc ctcaaggggg
     4561 cctgaggaca gccttttcct cagtccttga gatcattgct catccgtgcc aaactgggta
     4621 gatgggttgg gagactctca aaatgtgcca aggatcccct acgttctagt ccagggaagg
     4681 gaaacgccag gagcaggtgg cagctaaggt ggtcccccgc aaccctccca cttgtgtctc
     4741 acccccatgt catttctcct tctctgcctt ggttcctctt tctccatcac tggctccttc
     4801 tttgatgctc tctccccatc tcagggtcag accagccttc tctctttacc ttctttaacc
     4861 tgtctcccct ccctggttgg ttgagttgaa gaagaagaaa gaaagctgag gagaggggga
     4921 agggaggagt cagggaaaaa ggttacatgg acaggctggg gaagagaatg aggtcagccg
     4981 taccaaggag cagatggagg ggctgtgggg gacagggcag acaccagcag gaagattttg
     5041 aaaggaaata tggggagcag ctgcctagag gtctttggat ttggacctct tggggaaaag
     5101 aacgctgtca ggaagggttt taagggacac cagtggaggt gtggctgaat cttcatgtat
     5161 tgtttggctt tctgagggat gttagtgcca aacttgtata ggagtggggt gctgtcttcc
     5221 actgacaccc aggtccagaa tccttggtct tgagcccctg tcctttctcc atcccccatg
     5281 gaaatgtagt tcttttctgg ccctttcccc tgcctggtct agcaactctt ggaacagcca
     5341 tgccttccaa aagctatcaa cctgggccct gagccctgta agcagatgcc ccagagctgg
     5401 ggtgtgagag aggggctggg ggaccccacg atacagccac ggactccaat gcccggcccc
     5461 tttccaaata atcccatgcc cccaccccaa ccctttgcgg ctctgtacac atttttaaac
     5521 ctggcaaaag atgaagagaa tattgtaaat ataaaagttt aactgtt
//
