LOCUS       NM_145431               1771 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus notchless homolog 1 (Nle1), mRNA.
ACCESSION   NM_145431
VERSION     NM_145431.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1771)
  AUTHORS   Ren,Z., Ni,F., Zhang,T., Yuan,X., Li,J. and Xiao,W.
  TITLE     Knockdown of NLE1 inhibits development of malignant melanoma in
            vitro and in vivo NLE1 promotes development of malignant melanoma
  JOURNAL   Exp Cell Res 404 (2), 112636 (2021)
   PUBMED   34019907
  REMARK    GeneRIF: Knockdown of NLE1 inhibits development of malignant
            melanoma in vitro and in vivo NLE1 promotes development of
            malignant melanoma.
            Erratum:[Exp Cell Res. 2021 Aug 15;405(2):112733. doi:
            10.1016/j.yexcr.2021.112733.. PMID: 34274105]
REFERENCE   2  (bases 1 to 1771)
  AUTHORS   Gayraud-Morel,B., Le Bouteiller,M., Commere,P.H.,
            Cohen-Tannoudji,M. and Tajbakhsh,S.
  TITLE     Notchless defines a stage-specific requirement for ribosome
            biogenesis during lineage progression in adult skeletal myogenesis
  JOURNAL   Development 145 (23) (2018)
   PUBMED   30478226
  REMARK    GeneRIF: activated skeletal muscle satellite cells in conditional
            Nle mutant mice are arrested in proliferation; however, deletion of
            Nle in myofibres does not impair myogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1771)
  AUTHORS   Stedman,A., Beck-Cormier,S., Le Bouteiller,M., Raveux,A.,
            Vandormael-Pournin,S., Coqueran,S., Lejour,V., Jarzebowski,L.,
            Toledo,F., Robine,S. and Cohen-Tannoudji,M.
  TITLE     Ribosome biogenesis dysfunction leads to p53-mediated apoptosis and
            goblet cell differentiation of mouse intestinal stem/progenitor
            cells
  JOURNAL   Cell Death Differ 22 (11), 1865-1876 (2015)
   PUBMED   26068591
REFERENCE   4  (bases 1 to 1771)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 1771)
  AUTHORS   Beck-Cormier,S., Escande,M., Souilhol,C., Vandormael-Pournin,S.,
            Sourice,S., Pilet,P., Babinet,C. and Cohen-Tannoudji,M.
  TITLE     Notchless is required for axial skeleton formation in mice
  JOURNAL   PLoS One 9 (5), e98507 (2014)
   PUBMED   24875805
  REMARK    GeneRIF: These data demonstrate an essential role for Nle1 during
            organogenesis and in particular during axial development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1771)
  AUTHORS   Hentges,K.E., Nakamura,H., Furuta,Y., Yu,Y., Thompson,D.M.,
            O'Brien,W., Bradley,A. and Justice,M.J.
  TITLE     Novel lethal mouse mutants produced in balancer chromosome screens
  JOURNAL   Gene Expr Patterns 6 (6), 653-665 (2006)
   PUBMED   16466971
REFERENCE   7  (bases 1 to 1771)
  AUTHORS   Kile,B.T., Hentges,K.E., Clark,A.T., Nakamura,H., Salinger,A.P.,
            Liu,B., Box,N., Stockton,D.W., Johnson,R.L., Behringer,R.R.,
            Bradley,A. and Justice,M.J.
  TITLE     Functional genetic analysis of mouse chromosome 11
  JOURNAL   Nature 425 (6953), 81-86 (2003)
   PUBMED   12955145
REFERENCE   8  (bases 1 to 1771)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1771)
  AUTHORS   Le Bras,S., Cohen-Tannoudji,M., Guyot,V., Vandormael-Pournin,S.,
            Coumailleau,F., Babinet,C. and Baldacci,P.
  TITLE     Transcript map of the Ovum mutant (Om) locus: isolation by exon
            trapping of new candidate genes for the DDK syndrome
  JOURNAL   Gene 296 (1-2), 75-86 (2002)
   PUBMED   12383505
REFERENCE   10 (bases 1 to 1771)
  AUTHORS   Royet,J., Bouwmeester,T. and Cohen,S.M.
  TITLE     Notchless encodes a novel WD40-repeat-containing protein that
            modulates Notch signaling activity
  JOURNAL   EMBO J 17 (24), 7351-7360 (1998)
   PUBMED   9857191
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY149184.1, AK141230.1, AI852473.1 and BX631936.1.
            
            On May 29, 2009 this sequence version replaced NM_145431.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018399.1, AK170853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               BY149184.1         2-325
            325-1461            AK141230.1         300-1436
            1462-1761           AI852473.1         18-317              c
            1762-1771           BX631936.1         1-10                c
FEATURES             Location/Qualifiers
     source          1..1771
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 50.3 cM"
     gene            1..1771
                     /gene="Nle1"
                     /gene_synonym="l11Jus1; l11Jus4; Nle"
                     /note="notchless homolog 1"
                     /db_xref="GeneID:217011"
                     /db_xref="MGI:MGI:2429770"
     exon            1..57
                     /gene="Nle1"
                     /gene_synonym="l11Jus1; l11Jus4; Nle"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1497
                     /gene="Nle1"
                     /gene_synonym="l11Jus1; l11Jus4; Nle"
                     /note="novel WD40 repeat containing protein; Notchless
                     gene homolog"
                     /codon_start=1
                     /product="notchless protein homolog 1"
                     /protein_id="NP_663406.2"
                     /db_xref="CCDS:CCDS25152.1"
                     /db_xref="GeneID:217011"
                     /db_xref="MGI:MGI:2429770"
                     /translation="MAAAVVEEAAAGDVQRLLVQFQDEGGQLLGSPFDVPVDITPDKL
                     QLVCNALLAQEEPLPLAFYVHDAEIVSSLGKTLESQSVETEKIVDIIYQPQAVFRVRA
                     VTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVL
                     SISWSPDGKKLASGCKNGQVLLWDPSTGLQVGRTLTGHSKWITGLSWEPLHMNPECRY
                     VASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHD
                     GVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEATVNAQDLQGSLKELKERASSRYN
                     LVRGQGPERLVSGSDDFTLFLWSPAEDKKPLARMTGHQALINQVLFSPDSRIVASASF
                     DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAT
                     DLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR"
     exon            58..201
                     /gene="Nle1"
                     /gene_synonym="l11Jus1; l11Jus4; Nle"
                     /inference="alignment:Splign:2.1.0"
     exon            202..419
                     /gene="Nle1"
                     /gene_synonym="l11Jus1; l11Jus4; Nle"
                     /inference="alignment:Splign:2.1.0"
     exon            420..499
                     /gene="Nle1"
                     /gene_synonym="l11Jus1; l11Jus4; Nle"
                     /inference="alignment:Splign:2.1.0"
     exon            500..576
                     /gene="Nle1"
                     /gene_synonym="l11Jus1; l11Jus4; Nle"
                     /inference="alignment:Splign:2.1.0"
     exon            577..674
                     /gene="Nle1"
                     /gene_synonym="l11Jus1; l11Jus4; Nle"
                     /inference="alignment:Splign:2.1.0"
     exon            675..867
                     /gene="Nle1"
                     /gene_synonym="l11Jus1; l11Jus4; Nle"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1003
                     /gene="Nle1"
                     /gene_synonym="l11Jus1; l11Jus4; Nle"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1050
                     /gene="Nle1"
                     /gene_synonym="l11Jus1; l11Jus4; Nle"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1253
                     /gene="Nle1"
                     /gene_synonym="l11Jus1; l11Jus4; Nle"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1413
                     /gene="Nle1"
                     /gene_synonym="l11Jus1; l11Jus4; Nle"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1484
                     /gene="Nle1"
                     /gene_synonym="l11Jus1; l11Jus4; Nle"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1767
                     /gene="Nle1"
                     /gene_synonym="l11Jus1; l11Jus4; Nle"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1741..1746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nle1"
                     /gene_synonym="l11Jus1; l11Jus4; Nle"
                     /note="hexamer: AATAAA"
     polyA_site      1767
                     /gene="Nle1"
                     /gene_synonym="l11Jus1; l11Jus4; Nle"
                     /note="major polyA site"
ORIGIN      
        1 gtctttccgc ctcggttctc ctccacgtgg ggacgcagga tggcggcggc ggtggtggaa
       61 gaggcggcgg caggcgacgt gcagcggctg ctcgtacagt tccaggatga gggcggtcag
      121 ctgctgggct ccccgttcga cgtgccagtg gacatcacgc cggacaagct gcagctggtg
      181 tgcaacgcgc tgctggccca ggaggagccc ctgcccctgg cgttctacgt ccacgatgct
      241 gagattgtgt cctccctggg gaagacgctg gagtcccagt ctgtggagac agagaaaatc
      301 gtcgatatca tctaccagcc ccaagctgtc ttcagggtcc gggctgtgac gcggtgcacc
      361 agctcattgg agggtcacag cgaagctgtc atttctgtgg ccttcagccc cacaggaaag
      421 tacctggcca gtggttccgg agacaccact gtgcgcttct gggatctcag cactgagaca
      481 ccgcacttca catgcaaagg acaccggcac tgggtcctta gcatatcctg gtccccagat
      541 ggcaagaaac tggcctcagg ctgcaagaat ggccaggttc tgctgtggga cccaagcacg
      601 gggctgcagg tgggcaggac cctcactggc cacagcaaat ggatcacagg cctgagctgg
      661 gagccccttc acatgaaccc cgagtgccgc tacgtggcca gcagctccaa agacggcagt
      721 gtacgagtct gggatacaac cgcaggccgc tgtgaacgca tcctcacggg acacacgcag
      781 tcagtcacct gcctccgatg gggaggagat gggcttctat attctgcttc ccaggaccga
      841 accatcaaag tctggagggc ccatgacggt gtgctgtgtc gtactcttca aggtcatggc
      901 cactgggtga acactatggc acttagcaca gactatgccc tgcgcacagg ggcctttgag
      961 cctgctgaag ccacagtgaa tgcccaagac ctgcaggggt ccttgaagga gctgaaggag
     1021 agggcatcga gccgctacaa ccttgtgcgg ggccaaggcc cagagaggct ggtctctggc
     1081 tcagacgact tcaccttatt cctgtggtcc ccagcagagg acaagaagcc cctcgcccgg
     1141 atgacaggac accaggccct catcaaccag gtgctcttct ctcctgactc gcgcatcgtg
     1201 gccagtgcct ccttcgacaa gtctatcaag ctgtgggatg gccggacggg caagtaccta
     1261 gcttccctgc gtggccacgt ggcggccgtg taccagattg cctggtcagc tgacagccga
     1321 ctattagtca gcggcagcag tgacagcacg ctgaaggtgt gggatgtgaa ggcccagaaa
     1381 ctggccacgg acctgcctgg ccatgccgat gaggtatatg ctgttgactg gagtccagat
     1441 ggccagagag tagcaagcgg cgggaaagac aagtgcctcc ggatatggag aagatgactc
     1501 cacagcttat tgaccccccc tccccggatt caacccccac ctgccctgcc agagaccaag
     1561 gaatgcacac gaccacctgc ctgcccagga caggtctcca gtgtgtgaca gtcaggacat
     1621 tacagcgtgg agctaagcca tgggcacttc ctggcagtgg ggaagccagg catctggctc
     1681 ccatgtcctt ttccaagggt cagctgtgaa ggcccagacc ctaggctatg cgtgtgtcca
     1741 aataaataac ttatattttt gtgttcaaaa a
//
