LOCUS       NM_029002               2236 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus NK6 homeobox 3 (Nkx6-3), mRNA.
ACCESSION   NM_029002 XM_486090 XM_910682
VERSION     NM_029002.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2236)
  AUTHORS   Zinina,V.V., Sauer,M., Nigmatullina,L., Kreim,N. and Soshnikova,N.
  TITLE     TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small
            Intestine
  JOURNAL   Cells 12 (11), 1452 (2023)
   PUBMED   37296573
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2236)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   3  (bases 1 to 2236)
  AUTHORS   Du,A., McCracken,K.W., Walp,E.R., Terry,N.A., Klein,T.J., Han,A.,
            Wells,J.M. and May,C.L.
  TITLE     Arx is required for normal enteroendocrine cell development in mice
            and humans
  JOURNAL   Dev Biol 365 (1), 175-188 (2012)
   PUBMED   22387004
REFERENCE   4  (bases 1 to 2236)
  AUTHORS   Chung,Y.C., Tsai,Y.J., Shiu,T.Y., Sun,Y.Y., Wang,P.F. and Chen,C.L.
  TITLE     Screening large numbers of expression patterns of transcription
            factors in late stages of the mouse thymus
  JOURNAL   Gene Expr Patterns 11 (1-2), 84-92 (2011)
   PUBMED   20932939
REFERENCE   5  (bases 1 to 2236)
  AUTHORS   Schaffer,A.E., Freude,K.K., Nelson,S.B. and Sander,M.
  TITLE     Nkx6 transcription factors and Ptf1a function as antagonistic
            lineage determinants in multipotent pancreatic progenitors
  JOURNAL   Dev Cell 18 (6), 1022-1029 (2010)
   PUBMED   20627083
  REMARK    GeneRIF: Thus, cross-antagonism between Nkx6 and Ptf1a in
            multipotent progenitors governs the equilibrium between endocrine
            and acinar cell neogenesis required for normal pancreas
            development.
REFERENCE   6  (bases 1 to 2236)
  AUTHORS   Hafler,B.P., Choi,M.Y., Shivdasani,R.A. and Rowitch,D.H.
  TITLE     Expression and function of Nkx6.3 in vertebrate hindbrain
  JOURNAL   Brain Res 1222, 42-50 (2008)
   PUBMED   18586225
  REMARK    GeneRIF: Nkx6.3 function is dispensable for CNS development and
            lead to the proposal that absence of overt defects is due to
            functional compensation from a related homeodomain transcription
            factor.
REFERENCE   7  (bases 1 to 2236)
  AUTHORS   Choi,M.Y., Romer,A.I., Wang,Y., Wu,M.P., Ito,S., Leiter,A.B. and
            Shivdasani,R.A.
  TITLE     Requirement of the tissue-restricted homeodomain transcription
            factor Nkx6.3 in differentiation of gastrin-producing G cells in
            the stomach antrum
  JOURNAL   Mol Cell Biol 28 (10), 3208-3218 (2008)
   PUBMED   18347062
  REMARK    GeneRIF: Nkx6.3 transcripts localize in the epithelium of the most
            distal stomach region, the antrum and pylorus; expression in the
            adult intestine is lower and confined to the proximal duodenum.
REFERENCE   8  (bases 1 to 2236)
  AUTHORS   Jacob,J., Ferri,A.L., Milton,C., Prin,F., Pla,P., Lin,W.,
            Gavalas,A., Ang,S.L. and Briscoe,J.
  TITLE     Transcriptional repression coordinates the temporal switch from
            motor to serotonergic neurogenesis
  JOURNAL   Nat Neurosci 10 (11), 1433-1439 (2007)
   PUBMED   17922007
REFERENCE   9  (bases 1 to 2236)
  AUTHORS   Alanentalo,T., Chatonnet,F., Karlen,M., Sulniute,R., Ericson,J.,
            Andersson,E. and Ahlgren,U.
  TITLE     Cloning and analysis of Nkx6.3 during CNS and gastrointestinal
            development
  JOURNAL   Gene Expr Patterns 6 (2), 162-170 (2006)
   PUBMED   16326147
  REMARK    GeneRIF: Nkx6.3 shows a remarkably selective expression in a
            subpopulation of differentiating V2 neurons at caudal hindbrain
            levels.
REFERENCE   10 (bases 1 to 2236)
  AUTHORS   Pedersen,J.K., Nelson,S.B., Jorgensen,M.C., Henseleit,K.D.,
            Fujitani,Y., Wright,C.V., Sander,M. and Serup,P.
  CONSRTM   Beta Cell Biology Consortium
  TITLE     Endodermal expression of Nkx6 genes depends differentially on Pdx1
  JOURNAL   Dev Biol 288 (2), 487-501 (2005)
   PUBMED   16297379
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126445.5, AK018683.1 and AK147163.1.
            
            On Apr 28, 2009 this sequence version replaced NM_029002.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147163.1, AK018683.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC126445.5         40589-40611         c
            24-202              AK018683.1         25-203
            203-2236            AK147163.1         175-2208
FEATURES             Location/Qualifiers
     source          1..2236
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 11.42 cM"
     gene            1..2236
                     /gene="Nkx6-3"
                     /gene_synonym="9130417I07Rik; Nkx6.3"
                     /note="NK6 homeobox 3"
                     /db_xref="GeneID:74561"
                     /db_xref="MGI:MGI:1921811"
     exon            1..699
                     /gene="Nkx6-3"
                     /gene_synonym="9130417I07Rik; Nkx6.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..1103
                     /gene="Nkx6-3"
                     /gene_synonym="9130417I07Rik; Nkx6.3"
                     /note="NK6 transcription factor related, locus 3"
                     /codon_start=1
                     /product="homeobox protein Nkx-6.3"
                     /protein_id="NP_083278.1"
                     /db_xref="CCDS:CCDS52524.1"
                     /db_xref="GeneID:74561"
                     /db_xref="MGI:MGI:1921811"
                     /translation="MESNLQGTFLLNNTQLAQFSEMKAPMCQYSVQNSFYKLSPPGLG
                     PQLAAGTPHGITDILSRPVATPNSSLLSGYPHVAGFGGLSSQGVYYGPQVGSFSKAGN
                     EYPTRTRNCWADTGQDWRGSARPCSNTPDPLSDTIHKKKHTRPTFTGHQIFALEKTFE
                     QTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKSALEPSSSTPRAPGGASGDR
                     AASENEDDEYNKPLDPDSDDEKIRLLLRKHRAAFSVLSLGAHSV"
     exon            700..869
                     /gene="Nkx6-3"
                     /gene_synonym="9130417I07Rik; Nkx6.3"
                     /inference="alignment:Splign:2.1.0"
     exon            870..2236
                     /gene="Nkx6-3"
                     /gene_synonym="9130417I07Rik; Nkx6.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1900..1905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkx6-3"
                     /gene_synonym="9130417I07Rik; Nkx6.3"
                     /note="hexamer: AATAAA"
     polyA_site      1927
                     /gene="Nkx6-3"
                     /gene_synonym="9130417I07Rik; Nkx6.3"
                     /note="major polyA site"
     regulatory      2172..2177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkx6-3"
                     /gene_synonym="9130417I07Rik; Nkx6.3"
                     /note="hexamer: AATAAA"
     polyA_site      2193
                     /gene="Nkx6-3"
                     /gene_synonym="9130417I07Rik; Nkx6.3"
                     /note="major polyA site"
     regulatory      2200..2205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkx6-3"
                     /gene_synonym="9130417I07Rik; Nkx6.3"
                     /note="hexamer: AATAAA"
     polyA_site      2218
                     /gene="Nkx6-3"
                     /gene_synonym="9130417I07Rik; Nkx6.3"
                     /note="major polyA site"
ORIGIN      
        1 aaaacttctg atggagggcc cccagactca gaggcagaga aaccgggtgc tctgagtatg
       61 gaaagcaccc ctccttaggc ccagcgggca gagagggaaa gaggaaggcc gcccaccttc
      121 tctggacacc tgacttgcca gagggctgac gtaggtgccc catctctgag gaagggccga
      181 gccagagggc agtctgaggc tcggggtggg atggggggct ctgattctcc aaacctgtca
      241 tgaggttctg ggccaccatt tgaagtgctg gcctttaagg gttcctggac caccgattcg
      301 ctgacctgga gaccatggag tccaacctgc aggggacctt cctcctgaac aacacacagc
      361 tggcccagtt ctcagaaatg aaggctccca tgtgccagta ctcggtgcag aactctttct
      421 acaagctcag ccctccggga cttggccccc agctggcggc tgggactccc catggaatca
      481 ctgacatcct gagcagaccg gttgccaccc cgaacagcag cctcctctct ggctaccccc
      541 acgtggcagg ctttggtgga ctcagctccc agggcgtcta ctatggcccc caggtgggga
      601 gcttttccaa ggctggaaat gagtacccga cccggacccg gaactgctgg gcagacacag
      661 gccaggactg gagaggcagc gctcggccat gcagcaacac tccagacccc ctgagtgaca
      721 ctatccacaa gaaaaagcac acccgcccta ccttcacggg ccaccagatc tttgccctgg
      781 agaaaacctt tgagcagacc aagtacttgg ctggcccaga gcgggcgagg ctggcttatt
      841 ccctgggcat gacggagtca caggtcaagg tgtggttcca gaaccgccgg accaagtgga
      901 ggaagaagag cgccctggag ccctcatcct ccacaccccg ggccccggga ggtgcgagcg
      961 gggaccgcgc ggcctcggag aacgaggacg atgagtacaa caagccgctg gacccggact
     1021 cggacgacga gaagatccgc ctgctgctgc gcaagcaccg ggccgccttc tccgtgctca
     1081 gcctgggcgc gcacagcgtg tgaccccggg ctagccgcgc cgaccagcct tcccctcccc
     1141 tttccgtgca gtccgctgtg ggcagggacc agagaagagg agttgggggg agggggagga
     1201 aaagacgaag gaagaagaaa gaagaagagg aggaggaagc gagagggaag gaagggaagg
     1261 agacgaggga tggtgagtgc cccgagggag aagatggcac acctctctgt cattcctccc
     1321 ctctgggccc cttgccctgt cagccctgct ctaaagtgag caggcttatt ttttgcagca
     1381 gggaacctgg ctatggagcg ctccagatgc gctgttttcc cctctaagga tcagctggtt
     1441 agggagtcac acaaagtacc gcacctagtc gtaggctggg actgcaaagc aaaagacgga
     1501 gcctgaagtc cagatgtgct ttctaatgat cccaccgctg gggggcgggt cctgaaaata
     1561 ggaactcttc taaccctgag tttcaggacc ctgtgacccc caactgcact ttactttcaa
     1621 cgcagatccc actgtaccaa ggaagactct gggaaagaga cgaggggatg ccaggcagag
     1681 gggaaacaga tgagaaaatc ctaaggtttt gttgtctctg ggaggtaccc accaaggcaa
     1741 cccagggcat ccatcagagt ttgggagcat ctcagcagga cagagagaag ggctctgaat
     1801 gccacactcc tccaataggg acaccagact gggcgaaccc taggcagaat aaggggttgg
     1861 gagtgctgct ggacaccgag gcttttaaaa caaaactaga ataaagatga aaatcccaga
     1921 aaccgtcccc gcggctcctg cacttttcta aagggaatat tggcagtgtt ctctcccgtc
     1981 atgaagttgg actggaaaga tggctcggcg gttactgctg ctcttctgga agacttggag
     2041 ctgggttcgc agctacaggc tgctcacaac ggcctgttaa ctccagctat aggtgttccg
     2101 acgccctctt ctggcctcct caggtactgc atgcatgctc acagacacac atgcactctg
     2161 tgactaataa aaataaattc tttgtaaaat aaatagataa ataaatcagt ctaaaaaaga
     2221 agaagaagca gaaacc
//
