LOCUS       NM_144955               1808 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus NK6 homeobox 1 (Nkx6-1), mRNA.
ACCESSION   NM_144955 XM_979399 XM_983030
VERSION     NM_144955.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1808)
  AUTHORS   Bosquez Huerta,N.A., Lee,Z.F., Christine Song,E.A., Woo,J.,
            Cheng,Y.T., Sardar,D., Sert,O., Maleki,E., Yu,K., Akdemir,E.S.,
            Sanchez,K., Jo,J., Rasband,M.N., Lee,H.K., Harmanci,A.S. and
            Deneen,B.
  TITLE     Sex-specific astrocyte regulation of spinal motor circuits by
            Nkx6.1
  JOURNAL   Cell Rep 44 (1), 115121 (2025)
   PUBMED   39731735
REFERENCE   2  (bases 1 to 1808)
  AUTHORS   Li,Y., Zheng,R., Jiang,L., Yan,C., Liu,R., Chen,L., Jin,W., Luo,Y.,
            Zhang,X., Tang,J., Dai,Z. and Jiang,W.
  TITLE     A noncoding variant confers pancreatic differentiation defect and
            contributes to diabetes susceptibility by recruiting RXRA
  JOURNAL   Nat Commun 15 (1), 9771 (2024)
   PUBMED   39532884
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1808)
  AUTHORS   Kim,S.E., Kim,H.Y., Wlodarczyk,B.J. and Finnell,R.H.
  TITLE     Linkage between Fuz and Gpr161 genes regulates sonic hedgehog
            signaling during mouse neural tube development
  JOURNAL   Development 151 (19) (2024)
   PUBMED   39369306
REFERENCE   4  (bases 1 to 1808)
  AUTHORS   Liu,B., Hua,D., Shen,L., Li,T., Tao,Z., Fu,C., Tang,Z., Yang,J.,
            Zhang,L., Nie,A., Jiang,Y., Wang,J., Li,Y., Gu,Y. and Ning,G.
  TITLE     NPC1 is required for postnatal islet beta cell differentiation by
            maintaining mitochondria turnover
  JOURNAL   Theranostics 14 (5), 2058-2074 (2024)
   PUBMED   38505613
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1808)
  AUTHORS   Darrigrand,J.F., Salowka,A., Torres-Cano,A., Tapia-Rojo,R., Zhu,T.,
            Garcia-Manyes,S. and Spagnoli,F.M.
  TITLE     Acinar-ductal cell rearrangement drives branching morphogenesis of
            the murine pancreas in an IGF/PI3K-dependent manner
  JOURNAL   Dev Cell 59 (3), 326-338 (2024)
   PUBMED   38237591
REFERENCE   6  (bases 1 to 1808)
  AUTHORS   Nardelli,J., Thiesson,D., Fujiwara,Y., Tsai,F.Y. and Orkin,S.H.
  TITLE     Expression and genetic interaction of transcription factors GATA-2
            and GATA-3 during development of the mouse central nervous system
  JOURNAL   Dev Biol 210 (2), 305-321 (1999)
   PUBMED   10357893
REFERENCE   7  (bases 1 to 1808)
  AUTHORS   Briscoe,J., Sussel,L., Serup,P., Hartigan-O'Connor,D.,
            Jessell,T.M., Rubenstein,J.L. and Ericson,J.
  TITLE     Homeobox gene Nkx2.2 and specification of neuronal identity by
            graded Sonic hedgehog signalling
  JOURNAL   Nature 398 (6728), 622-627 (1999)
   PUBMED   10217145
REFERENCE   8  (bases 1 to 1808)
  AUTHORS   Oster,A., Jensen,J., Edlund,H. and Larsson,L.I.
  TITLE     Homeobox gene product Nkx 6.1 immunoreactivity in nuclei of
            endocrine cells of rat and mouse stomach
  JOURNAL   J Histochem Cytochem 46 (6), 717-721 (1998)
   PUBMED   9603782
REFERENCE   9  (bases 1 to 1808)
  AUTHORS   Sussel,L., Kalamaras,J., Hartigan-O'Connor,D.J., Meneses,J.J.,
            Pedersen,R.A., Rubenstein,J.L. and German,M.S.
  TITLE     Mice lacking the homeodomain transcription factor Nkx2.2 have
            diabetes due to arrested differentiation of pancreatic beta cells
  JOURNAL   Development 125 (12), 2213-2221 (1998)
   PUBMED   9584121
REFERENCE   10 (bases 1 to 1808)
  AUTHORS   Qiu,M., Shimamura,K., Sussel,L., Chen,S. and Rubenstein,J.L.
  TITLE     Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene
            expression relative to other Nkx genes during vertebrate CNS
            development
  JOURNAL   Mech Dev 72 (1-2), 77-88 (1998)
   PUBMED   9533954
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC105976.13.
            
            On Nov 17, 2006 this sequence version replaced NM_144955.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF357883.1, BC138020.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1150              AC105976.13        169292-170441       c
            1151-1323           AC105976.13        167564-167736       c
            1324-1808           AC105976.13        164914-165398       c
FEATURES             Location/Qualifiers
     source          1..1808
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 48.84 cM"
     gene            1..1808
                     /gene="Nkx6-1"
                     /gene_synonym="Nkx6.1; NKX6A"
                     /note="NK6 homeobox 1"
                     /db_xref="GeneID:18096"
                     /db_xref="MGI:MGI:1206039"
     exon            1..1150
                     /gene="Nkx6-1"
                     /gene_synonym="Nkx6.1; NKX6A"
                     /inference="alignment:Splign:2.1.0"
     CDS             478..1575
                     /gene="Nkx6-1"
                     /gene_synonym="Nkx6.1; NKX6A"
                     /note="homeodomain transcription factor Nkx6.1; homeobox
                     protein NK-6 homolog A; Drosophila NK transcription factor
                     related, gene family 6, locus 1; NK6 transcription factor
                     related, locus 1"
                     /codon_start=1
                     /product="homeobox protein Nkx-6.1"
                     /protein_id="NP_659204.1"
                     /db_xref="CCDS:CCDS19471.1"
                     /db_xref="GeneID:18096"
                     /db_xref="MGI:MGI:1206039"
                     /translation="MLAVGAMEGPRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLP
                     TGPPSSSSSSSSSSSPSPPLGSHNPGGLKPPAAGGLSSLGSPPQQLSAATPHGINDIL
                     SRPSMPVASGAALPSASPSGSSSSSSSSASATSASAAAAAAAAAAAAAASSPAGLLAG
                     LPRFSSLSPPPPPPGLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDA
                     RLACTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGM
                     TESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKGTSENEEDDDDYNKPLDPN
                     SDDEKITQLLKKHKSSGGSLLLHASEAEGSS"
     exon            1151..1323
                     /gene="Nkx6-1"
                     /gene_synonym="Nkx6.1; NKX6A"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1808
                     /gene="Nkx6-1"
                     /gene_synonym="Nkx6.1; NKX6A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgccgggag agcggagcgt ccgagcgaga tcagaggcgc gcaccgggcg gaacgccgcc
       61 cgctttgaag ctcccccagg cgagcgagcc ggcccccgcc ctcctacatc aaagcgaacg
      121 ctccgcgcct cccaaccttg ttgcaaactc tctgggtcgg ctgcggggta cgtcttgctg
      181 atttcccgcg ggggtggaga agatgagaag cagagcgctc tgagccggga acgagggacc
      241 agcgcctggg atcgaatccg ggactcccga agccgaggaa gcgctgagcc cgcccgcgcc
      301 cccgcagccc tcgcccctgc cgcctcccgc ggggcgtttg gacatttttg ctgcgcagct
      361 cccggagccc gcggccgatc cacacttcgc ttgcgcgcgc ccccggcacc tcgggttctc
      421 ccgagccccg gcggggccac cgacctgcgt ggctgcgggt tcgggtctgg ctgtgggatg
      481 ttagctgtgg gggcgatgga gggccctcgg cagagcgcgt tcctgctcag cagcccgccc
      541 ctggccgccc tgcacagtat ggccgagatg aagaccccgc tctaccccgc cgcttatccc
      601 ccgctgccca ccgggccccc ctcctcctcg tcctcgtcct cctcgtcctc gtcgccctcc
      661 ccacctttgg gctcacataa cccgggcggc ttgaagcccc cggccgcggg gggcctctcg
      721 tccctgggca gtcccccgca gcagctttcg gcggccaccc cacacggcat caacgacatc
      781 ctgagccggc cctctatgcc ggtggcctcg ggggccgccc tgccctccgc ctcgccctcc
      841 gggtcttcct cctcctcctc ctcgtccgcc tccgccacct cggcctctgc ggcggccgcc
      901 gccgccgctg ctgctgccgc cgctgccgcc tcgtcgcccg ctgggctgct ggccggcctg
      961 ccccgcttca gcagcctgag ccctccgcca ccgccgcccg ggctctactt tagccccagc
     1021 gccgcggctg tggccgccgt gggccggtac cccaagcccc tggccgagct gcccggtcgg
     1081 acgcccatct tctggcccgg agtgatgcag agtccgccgt ggagggacgc gcgccttgcc
     1141 tgtacccccc atcaaggatc cattttgttg gacaaagatg ggaagagaaa acacaccaga
     1201 cccacgttct ctggacagca aatcttcgcc ctggagaaga ctttcgaaca aacgaagtac
     1261 ttggcaggac cagagagagc acgcttggcc tattctctgg ggatgacgga gagtcaggtc
     1321 aaggtctggt tccagaaccg caggaccaag tggagaaaga agcacgcagc cgagatggcc
     1381 acggccaaga agaagcagga ctcggagacc gagaggctca aggggacttc ggagaatgag
     1441 gaggatgacg acgattacaa caaacctctg gacccgaact ctgacgacga gaaaatcact
     1501 cagctgctga aaaagcacaa atcgagcggt ggcagcctcc tgctgcacgc gtcggaggcc
     1561 gagggctcgt cctgagcgcg accagcaccg cggggatcgc gaccgcgtcc cacagccggt
     1621 tcccccggcc cccagtatcc tggctgctcg ccgggccttt actattttct aagatgtaca
     1681 tatctatttt tttaacctag aaattgtggc ggggagggtg cgggtcggta gcacggtgcg
     1741 ctgatgagga gaaaaggagc ccgccaagtg cactgctcaa aaaaacaaaa aacaaaaaaa
     1801 aaaaaaaa
//
