LOCUS       NM_010921               3137 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus NK3 homeobox 1 (Nkx3-1), mRNA.
ACCESSION   NM_010921
VERSION     NM_010921.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3137)
  AUTHORS   Zhu,S., Huo,S., Wang,Z., Huang,C., Li,C., Song,H., Yang,X., He,R.,
            Ding,C., Qiu,M. and Zhu,X.J.
  TITLE     Follistatin controls the number of murine teeth by limiting
            TGF-beta signaling
  JOURNAL   iScience 27 (9), 110785 (2024)
   PUBMED   39286503
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3137)
  AUTHORS   Kirk,J.S., Wang,J., Long,M., Rosario,S., Tracz,A., Ji,Y., Kumar,R.,
            Liu,X., Jamroze,A., Singh,P.K., Puzanov,I., Chatta,G., Cheng,Q.,
            Huang,J., Wrana,J.L., Lovell,J., Yu,H., Liu,S., Shen,M.M., Liu,T.
            and Tang,D.G.
  TITLE     Integrated single-cell analysis defines the epigenetic basis of
            castration-resistant prostate luminal cells
  JOURNAL   Cell Stem Cell 31 (8), 1203-1221 (2024)
   PUBMED   38878775
REFERENCE   3  (bases 1 to 3137)
  AUTHORS   Pakula,H., Omar,M., Carelli,R., Pederzoli,F., Fanelli,G.N.,
            Pannellini,T., Socciarelli,F., Van Emmenis,L., Rodrigues,S.,
            Fidalgo-Ribeiro,C., Nuzzo,P.V., Brady,N.J., Dinalankara,W.,
            Jere,M., Valencia,I., Saladino,C., Stone,J., Unkenholz,C.,
            Garner,R., Alexanderani,M.K., Khani,F., de Almeida,F.N.,
            Abate-Shen,C., Greenblatt,M.B., Rickman,D.S., Barbieri,C.E.,
            Robinson,B.D., Marchionni,L. and Loda,M.
  TITLE     Distinct mesenchymal cell states mediate prostate cancer
            progression
  JOURNAL   Nat Commun 15 (1), 363 (2024)
   PUBMED   38191471
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3137)
  AUTHORS   Tshering,L.F., Luo,F., Russ,S., Szenk,M., Rubel,D., Tutuska,K.,
            Rail,J.G., Balazsi,G., Shen,M.M. and Talos,F.
  TITLE     Immune mechanisms shape the clonal landscape during early
            progression of prostate cancer
  JOURNAL   Dev Cell 58 (12), 1071-1086 (2023)
   PUBMED   37148881
REFERENCE   5  (bases 1 to 3137)
  AUTHORS   Zhu,Y., Zhao,Y., Wen,J., Liu,S., Huang,T., Hatial,I., Peng,X., Al
            Janabi,H., Huang,G., Mittlesteadt,J., Cheng,M., Bhardwaj,A.,
            Ashfeld,B.L., Kao,K.R., Maeda,D.Y., Dai,X., Wiest,O., Blagg,B.S.J.,
            Lu,X., Cheng,L., Wan,J. and Lu,X.
  TITLE     Targeting the chromatin effector Pygo2 promotes cytotoxic T cell
            responses and overcomes immunotherapy resistance in prostate cancer
  JOURNAL   Sci Immunol 8 (81), eade4656 (2023)
   PUBMED   36897957
REFERENCE   6  (bases 1 to 3137)
  AUTHORS   Treier,M., Gleiberman,A.S., O'Connell,S.M., Szeto,D.P.,
            McMahon,J.A., McMahon,A.P. and Rosenfeld,M.G.
  TITLE     Multistep signaling requirements for pituitary organogenesis in
            vivo
  JOURNAL   Genes Dev 12 (11), 1691-1704 (1998)
   PUBMED   9620855
REFERENCE   7  (bases 1 to 3137)
  AUTHORS   Kos,L., Chiang,C. and Mahon,K.A.
  TITLE     Mediolateral patterning of somites: multiple axial signals,
            including Sonic hedgehog, regulate Nkx-3.1 expression
  JOURNAL   Mech Dev 70 (1-2), 25-34 (1998)
   PUBMED   9510022
REFERENCE   8  (bases 1 to 3137)
  AUTHORS   Yoshiura,K.I. and Murray,J.C.
  TITLE     Sequence and chromosomal assignment of human BAPX1, a
            bagpipe-related gene, to 4p16.1: a candidate gene for skeletal
            dysplasia
  JOURNAL   Genomics 45 (2), 425-428 (1997)
   PUBMED   9344671
REFERENCE   9  (bases 1 to 3137)
  AUTHORS   Sciavolino,P.J., Abrams,E.W., Yang,L., Austenberg,L.P., Shen,M.M.
            and Abate-Shen,C.
  TITLE     Tissue-specific expression of murine Nkx3.1 in the male urogenital
            system
  JOURNAL   Dev Dyn 209 (1), 127-138 (1997)
   PUBMED   9142502
REFERENCE   10 (bases 1 to 3137)
  AUTHORS   Bieberich,C.J., Fujita,K., He,W.W. and Jay,G.
  TITLE     Prostate-specific and androgen-dependent expression of a novel
            homeobox gene
  JOURNAL   J Biol Chem 271 (50), 31779-31782 (1996)
   PUBMED   8943214
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CT025562.10.
            
            On Apr 28, 2007 this sequence version replaced NM_010921.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U88542.1, BC050109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               CT025562.10        112764-113065
            303-3137            CT025562.10        113896-116730
FEATURES             Location/Qualifiers
     source          1..3137
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.02 cM"
     gene            1..3137
                     /gene="Nkx3-1"
                     /gene_synonym="bagpipe; Bax; Nkx-3.1; NKX3.1; NKX3A"
                     /note="NK3 homeobox 1"
                     /db_xref="GeneID:18095"
                     /db_xref="MGI:MGI:97352"
     exon            1..302
                     /gene="Nkx3-1"
                     /gene_synonym="bagpipe; Bax; Nkx-3.1; NKX3.1; NKX3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..727
                     /gene="Nkx3-1"
                     /gene_synonym="bagpipe; Bax; Nkx-3.1; NKX3.1; NKX3A"
                     /note="homeobox protein NK-3 homolog A; Drosophila NK-3
                     transcription factor, locus 1"
                     /codon_start=1
                     /product="homeobox protein Nkx-3.1"
                     /protein_id="NP_035051.1"
                     /db_xref="CCDS:CCDS27237.1"
                     /db_xref="GeneID:18095"
                     /db_xref="MGI:MGI:97352"
                     /translation="MLRVAEPREPRVEAGGRSPWAAPPTQSKRLTSFLIQDILRDRAE
                     RHGGHSGNPQHSPDPRRDSAPEPDKAGGRGVAPEDPPSIRHSPAETPTEPESDAHFET
                     YLLDCEHNPGDLASAPQVTKQPQKRSRAAFSHTQVIELERKFSHQKYLSAPERAHLAK
                     NLKLTETQVKIWFQNRRYKTKRKQLSEDLGVLEKNSPLSLPALKDDSLPSTSLVSVYT
                     SYPYYPYLYCLGSWHPSFW"
     exon            303..3137
                     /gene="Nkx3-1"
                     /gene_synonym="bagpipe; Bax; Nkx-3.1; NKX3.1; NKX3A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcggagga gggatgctta gggtagcgga gccccgagag ccacgggtgg aggcgggtgg
       61 ccgcagtcct tgggcagcgc cacccacgca gtccaagcgg ctcacctcct tcctcatcca
      121 ggacatcctg cgggaccgcg cggagcggca cgggggacac tcaggcaatc cgcagcactc
      181 gccggaccct aggagggact ccgctccaga gcccgacaaa gcagggggtc gcggcgtggc
      241 tccggaggac ccaccaagta tccggcatag ccccgcggag acaccgactg aacccgagtc
      301 tgatgcacat tttgagactt atcttttgga ctgtgaacat aatccagggg acttagcaag
      361 tgccccccag gtcaccaagc agccacagaa gcgctcccgg gccgccttct ctcacactca
      421 ggtgattgag ttggagagga agttcagcca tcagaagtac ctgtctgccc ctgagagggc
      481 tcacctggcc aagaacctca aactcaccga aacccaagtc aaaatatggt tccagaacag
      541 acgctataag accaagcgaa agcagctgtc ggaagacctg ggagtcttgg agaagaactc
      601 accattgtct ttgccagccc tgaaagatga cagcctgccc agtacctcct tggtctccgt
      661 gtatactagc tatccctact acccctacct gtactgtctg ggcagctggc atccatcttt
      721 ctggtagcaa cagttctgct gataactgca tatatcagaa actgtcttcc ctgggggtct
      781 ctgggaaaaa gccacagtgg ctgatgtcaa ggagtcggaa gcaagaaatg tacagatgca
      841 aactgttggg ggttcccagg gaacactcca attcttctct ggtgggcagg tgaaagatct
      901 ggggcagtga ctatttgaag atgtagtccc agttccaagt gtcctgtagg tgactgctgc
      961 ccgctcccct gtttagagag agccaggcaa gtttgagtct tgtttccaga acttagaatg
     1021 gctacagatg caatggctat atcgttccta ggaattctgt tgtggcaact ccatcctctc
     1081 ccatgactga gtatcatgga agggccaagc aaggggaggg atggcccctt agatgaggat
     1141 ttcctcttga gttaaacttg ggtctcctgt tggccttgga ctctggccag agtttctctc
     1201 tgcccttgta aaaatgaggg taaacggaag atttgaagaa tgggggtggg agggggtgac
     1261 ccttagtgat tgaggcaggt tggcatagaa cgtgaagggg gtggaaggtg gaattttcaa
     1321 cttacccttt tcacagtgat gtgccagtcc aaggatttac agggcagcct gagtgtggca
     1381 gggtacacac gcggaggggg ttaagacaag ctgtgtaaac agtttgcctg caggggtggg
     1441 ctgcaaaaca gacttcctct ccaagacatg ggcctatggg gtttccacac gccaggtgag
     1501 cggcttccat caggacttta tattagcagg gaagaaaagg actctcctgc ccttcctgct
     1561 tagactcagg agggcctgca gcttccctgg cctgaaaatt cacactttgt gatgacagag
     1621 gtgccattag ttttaaacaa aggaccttcc aaccctcctt tttatttctt gttctttcct
     1681 acaggacctc tccgttcatg cttttcatct gtgcctgtct tatttcgtgt aagatttgct
     1741 cccacctcct cccaaggttt acctttcttg gtttaacaac ttaactagct acagacagat
     1801 tatgacatac ttttaaaaga aaaaaatgag caactcatct cttcccttta aaaatatgac
     1861 atactttaga gagagaaaaa aaacctagca actcctctct ctctttcctt taaaaatact
     1921 cagcattaaa tcccaagccc tatttaaaga catgagagct gaagatgaca ggttctttcg
     1981 cagggctgtg tgctagctct gtgttacagt tcaaaggctg atgcccattg gggtcctggg
     2041 gatccctgta ggcagaggtg gtttaggggt gcttgttttt catgtgtaag gaagaacagg
     2101 acaaaaggaa gggctggcac tgctgaggga tctgggggag atggaggggt cctgctgtca
     2161 gcccaagcta accagcaagg agaggtaaac tgtcttcaaa atacaacctc accgaggctt
     2221 ccatccacag atgtgtgtgt gtgtgtgtgc gcgcgcgcat gcacgcgcaa atgctttgga
     2281 gaactatgct taggaactac cctaaagtgg taggagtgaa aaagagaatt ggttgacctt
     2341 cccttttcca tcctgatatc tcaggtaacc tgccgaatgg gagataaagg aggtagagca
     2401 cacttataac aaatgagact ttctggggcc aggaaatccc tttatcccac cactcagtgc
     2461 tatacagtga gaaatctttt aatttcctcc ttttaaatgg gccaatttac tgttggtggc
     2521 aaaactgcca aaggaagttg atagaaagct ggcggcttgc accctgttct ttgacagccc
     2581 gggtccccat gttaaagtat tgttccgtgt cccttgttgc tgaccactgt ggtagcgtta
     2641 gaccatacca aagccggagg agtccagttc tcttctttct atccgtcttt tggctctgag
     2701 ttccctatca gtactttctc tcctctcact ctgactagaa tctttttcag cgtgcacttt
     2761 cactacgttt gaactattat agtgtgcagt gtgtggcaaa gtcagaaagg gaaaggcttg
     2821 tgtttaaaat tatgttgggg aagtctgact caattttgct ttctccatac tggaactacc
     2881 cattcaccca cacctgaact ggtagaaacg tggcctgttg tctccagcct gtgaatggga
     2941 aaggtatcgc tgtgggtatc acctgggtga catatctctg tcctgtttcg tcaatcagtt
     3001 agcaaacccc ggctctaaca gaaaagtctg tcacttggca tttagtatag tactccactc
     3061 aaaactttat ttttctacgg gttttttttt tttttgcaac ctatgagtgt tttaaaataa
     3121 agcctctatg tctttat
//
