LOCUS       NM_010920               1156 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus NK2 homeobox 6 (Nkx2-6), transcript variant 1, mRNA.
ACCESSION   NM_010920
VERSION     NM_010920.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1156)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1156)
  AUTHORS   Gao,R., Liang,X., Cheedipudi,S., Cordero,J., Jiang,X., Zhang,Q.,
            Caputo,L., Gunther,S., Kuenne,C., Ren,Y., Bhattacharya,S., Yuan,X.,
            Barreto,G., Chen,Y., Braun,T., Evans,S.M., Sun,Y. and Dobreva,G.
  TITLE     Pioneering function of Isl1 in the epigenetic control of
            cardiomyocyte cell fate
  JOURNAL   Cell Res 29 (6), 486-501 (2019)
   PUBMED   31024170
REFERENCE   3  (bases 1 to 1156)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 1156)
  AUTHORS   Chung,Y.C., Tsai,Y.J., Shiu,T.Y., Sun,Y.Y., Wang,P.F. and Chen,C.L.
  TITLE     Screening large numbers of expression patterns of transcription
            factors in late stages of the mouse thymus
  JOURNAL   Gene Expr Patterns 11 (1-2), 84-92 (2011)
   PUBMED   20932939
REFERENCE   5  (bases 1 to 1156)
  AUTHORS   Wei,Q. and Condie,B.G.
  TITLE     A focused in situ hybridization screen identifies candidate
            transcriptional regulators of thymic epithelial cell development
            and function
  JOURNAL   PLoS One 6 (11), e26795 (2011)
   PUBMED   22087235
REFERENCE   6  (bases 1 to 1156)
  AUTHORS   Nikolova,M., Chen,X. and Lufkin,T.
  TITLE     Nkx2.6 expression is transiently and specifically restricted to the
            branchial region of pharyngeal-stage mouse embryos
  JOURNAL   Mech Dev 69 (1-2), 215-218 (1997)
   PUBMED   9486544
REFERENCE   7  (bases 1 to 1156)
  AUTHORS   Yoshiura,K.I. and Murray,J.C.
  TITLE     Sequence and chromosomal assignment of human BAPX1, a
            bagpipe-related gene, to 4p16.1: a candidate gene for skeletal
            dysplasia
  JOURNAL   Genomics 45 (2), 425-428 (1997)
   PUBMED   9344671
REFERENCE   8  (bases 1 to 1156)
  AUTHORS   O'Brien,E.P., Zhen,L., Jiang,S.Y., Novak,E.K. and Swank,R.T.
  TITLE     High-resolution genetic mapping of the gunmetal gene which
            regulates platelet production
  JOURNAL   Mamm Genome 7 (3), 206-208 (1996)
   PUBMED   8833241
REFERENCE   9  (bases 1 to 1156)
  AUTHORS   Copeland,N.G., Jenkins,N.A. and Harvey,R.P.
  TITLE     The murine homeobox genes Nkx2.3 and Nkx2.6 are located on
            chromosomes 19 and 14, respectively
  JOURNAL   Genomics 22 (3), 655-656 (1994)
   PUBMED   8001981
REFERENCE   10 (bases 1 to 1156)
  AUTHORS   Lints,T.J., Parsons,L.M., Hartley,L., Lyons,I. and Harvey,R.P.
  TITLE     Nkx-2.5: a novel murine homeobox gene expressed in early heart
            progenitor cells and their myogenic descendants
  JOURNAL   Development 119 (2), 419-431 (1993)
   PUBMED   7904557
  REMARK    Erratum:[Development. 1993 Nov;119(3):969. doi:
            10.1242/dev.119.3.969.. PMID: 7910553]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025562.10 and BC132558.1.
            
            On Mar 25, 2011 this sequence version replaced NM_010920.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007304.1, AF045150.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               CT025562.10        93874-94023
            151-905             BC132558.1         1-755
            906-1156            CT025562.10        97362-97612
FEATURES             Location/Qualifiers
     source          1..1156
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.01 cM"
     gene            1..1156
                     /gene="Nkx2-6"
                     /gene_synonym="Nkx-2.6; Nkx2.6; tinman; Tix"
                     /note="NK2 homeobox 6"
                     /db_xref="GeneID:18092"
                     /db_xref="MGI:MGI:97351"
     CDS             1..870
                     /gene="Nkx2-6"
                     /gene_synonym="Nkx-2.6; Nkx2.6; tinman; Tix"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homeobox protein Nkx-2.6; homeobox protein NK-2 homolog F;
                     Drosophila NK2 transcription factor related, locus 6"
                     /codon_start=1
                     /product="homeobox protein Nkx-2.6 isoform 1"
                     /protein_id="NP_035050.2"
                     /db_xref="CCDS:CCDS56968.1"
                     /db_xref="GeneID:18092"
                     /db_xref="MGI:MGI:97351"
                     /translation="MLSSPVASTPFSVADILRLECQQKDSKTLSQWELHRNPVKPRYL
                     RMNQESGWFESSDRAQAVPFRCTWETVLEMGSNPVGEPQTPPGTISRLGARNPMTDRG
                     VGNLSGDMRRGGPVSTRTRPQRKSRVLFSQAQVLALERRFKQQRYLTAPEREHLASAL
                     QLTSTQVKIWFQNRRYKSKSQRQDQTLELAGHPLAPRRVAVPVLVLDGKPCLDPDVAA
                     FLGPYKATSPYSCFGGYAGTPYDASYASRCTSASAGPGPLTPLASSGFSPGGQSAAPQ
                     GHLPATPQGVTAW"
     exon            1..247
                     /gene="Nkx2-6"
                     /gene_synonym="Nkx-2.6; Nkx2.6; tinman; Tix"
                     /inference="alignment:Splign:2.1.0"
     exon            248..1156
                     /gene="Nkx2-6"
                     /gene_synonym="Nkx-2.6; Nkx2.6; tinman; Tix"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1089..1094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkx2-6"
                     /gene_synonym="Nkx-2.6; Nkx2.6; tinman; Tix"
                     /note="hexamer: AATAAA"
     polyA_site      1129
                     /gene="Nkx2-6"
                     /gene_synonym="Nkx-2.6; Nkx2.6; tinman; Tix"
                     /note="major polyA site"
ORIGIN      
        1 atgctgtcga gtcctgtggc ctccacccct ttctcggtag ctgacattct caggctggag
       61 tgccaacaga aggattccaa gaccctgtca caatgggagt tgcataggaa cccagtaaag
      121 cctcggtacc taagaatgaa ccaggaatcc ggatggtttg agagcagcga cagggcacaa
      181 gcagtccctt ttcggtgcac ctgggagaca gtcctggaga tgggctcgaa tcctgtgggg
      241 gagccacaaa ctcctccggg cacgatctcc cgacttggag ccaggaaccc aatgaccgat
      301 cgcggcgtgg gcaacctgag tggcgacatg cgccgaggcg gtccggtttc aaccagaacg
      361 cggccacagc ggaagtcccg cgtgctattc tcccaggccc aagtgctggc cctggagcgg
      421 cgcttcaagc agcagcgata cctgactgcg cccgagcgtg agcacttggc cagcgcgctg
      481 cagctcacgt ccacgcaggt caagatctgg ttccaaaacc ggcgctacaa gtccaagagt
      541 cagcgccagg accagactct ggaactggcc ggccacccgt tagcaccgcg ccgggtagca
      601 gtgccagtac tggtactgga cggcaagccc tgcctggatc ccgacgtagc cgcattcctg
      661 ggtccctaca aagccacctc gccctattcc tgcttcggtg gctacgcggg cactccctac
      721 gacgctagct atgcgagccg ctgcaccagc gccagcgccg gccccgggcc gctcacacca
      781 ctggccagct ctggcttcag cccaggtggc caaagtgcgg ctccgcaggg ccatctgccc
      841 gctacgcctc agggagtcac ggcctggtga aaagcctgag ctcacctact gccattcggt
      901 gcctgatgcc tggtcccctc cccttcctgc tggtgggcgc ggggctggaa agcactgccc
      961 accttactga tctcggaact gaactgcttg gaggagcggc ccctgaagac cttgagaaca
     1021 ttctttccct cggaagtgta accacgtagc cacgtagatg ctgtgcagaa agactagcac
     1081 aagaaattaa taaatcttat tcccttgccc ttctggccta gaaaagtaat agaagcagcc
     1141 gtgtactgca ttatgg
//
