LOCUS       NM_008700               1524 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus NK2 homeobox 5 (Nkx2-5), mRNA.
ACCESSION   NM_008700
VERSION     NM_008700.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1524)
  AUTHORS   Argiro,L., Chevalier,C., Choquet,C., Nandkishore,N., Ghata,A.,
            Baudot,A., Zaffran,S. and Lescroart,F.
  TITLE     Gastruloids are competent to specify both cardiac and skeletal
            muscle lineages
  JOURNAL   Nat Commun 15 (1), 10172 (2024)
   PUBMED   39580459
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1524)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   3  (bases 1 to 1524)
  AUTHORS   Guijarro,C., Song,S., Aigouy,B., Clement,R., Villoutreix,P. and
            Kelly,R.G.
  TITLE     Single-cell morphometrics reveals T-box gene-dependent patterns of
            epithelial tension in the Second Heart field
  JOURNAL   Nat Commun 15 (1), 9512 (2024)
   PUBMED   39496595
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1524)
  AUTHORS   Abassah-Oppong,S., Zoia,M., Mannion,B.J., Rouco,R., Tissieres,V.,
            Spurrell,C.H., Roland,V., Darbellay,F., Itum,A., Gamart,J.,
            Festa-Daroux,T.A., Sullivan,C.S., Kosicki,M.,
            Rodriguez-Carballo,E., Fukuda-Yuzawa,Y., Hunter,R.D., Novak,C.S.,
            Plajzer-Frick,I., Tran,S., Akiyama,J.A., Dickel,D.E.,
            Lopez-Rios,J., Barozzi,I., Andrey,G., Visel,A., Pennacchio,L.A.,
            Cobb,J. and Osterwalder,M.
  TITLE     A gene desert required for regulatory control of pleiotropic Shox2
            expression and embryonic survival
  JOURNAL   Nat Commun 15 (1), 8793 (2024)
   PUBMED   39389973
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1524)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1524)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
REFERENCE   7  (bases 1 to 1524)
  AUTHORS   Chen,C.Y. and Schwartz,R.J.
  TITLE     Identification of novel DNA binding targets and regulatory domains
            of a murine tinman homeodomain factor, nkx-2.5
  JOURNAL   J Biol Chem 270 (26), 15628-15633 (1995)
   PUBMED   7797561
REFERENCE   8  (bases 1 to 1524)
  AUTHORS   Himmelbauer,H., Harvey,R.P., Copeland,N.G., Jenkins,N.A. and
            Silver,L.M.
  TITLE     High-resolution genetic analysis of a deletion on mouse chromosome
            17 extending over the fused, tufted, and homeobox Nkx2-5 loci
  JOURNAL   Mamm Genome 5 (12), 814-816 (1994)
   PUBMED   7894168
REFERENCE   9  (bases 1 to 1524)
  AUTHORS   Lints,T.J., Parsons,L.M., Hartley,L., Lyons,I. and Harvey,R.P.
  TITLE     Nkx-2.5: a novel murine homeobox gene expressed in early heart
            progenitor cells and their myogenic descendants
  JOURNAL   Development 119 (2), 419-431 (1993)
   PUBMED   7904557
  REMARK    Erratum:[Development. 1993 Nov;119(3):969. doi:
            10.1242/dev.119.3.969. PMID: 7910553]
REFERENCE   10 (bases 1 to 1524)
  AUTHORS   Komuro,I. and Izumo,S.
  TITLE     Csx: a murine homeobox-containing gene specifically expressed in
            the developing heart
  JOURNAL   Proc Natl Acad Sci U S A 90 (17), 8145-8149 (1993)
   PUBMED   7690144
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC144621.3 and AK142146.1.
            
            On Oct 1, 2005 this sequence version replaced NM_008700.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142146.1, X75415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC144621.3         72020-72116         c
            98-1524             AK142146.1         3-1429
FEATURES             Location/Qualifiers
     source          1..1524
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.6 cM"
     gene            1..1524
                     /gene="Nkx2-5"
                     /gene_synonym="Csx; Nkx-2.5; Nkx2.5; tinman"
                     /note="NK2 homeobox 5"
                     /db_xref="GeneID:18091"
                     /db_xref="MGI:MGI:97350"
     exon            1..541
                     /gene="Nkx2-5"
                     /gene_synonym="Csx; Nkx-2.5; Nkx2.5; tinman"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1167
                     /gene="Nkx2-5"
                     /gene_synonym="Csx; Nkx-2.5; Nkx2.5; tinman"
                     /note="homeobox protein CSX; cardiac-specific homeobox;
                     homeobox protein NK-2 homolog E; Drosophila NK2
                     transcription factor related, locus 5"
                     /codon_start=1
                     /product="homeobox protein Nkx-2.5"
                     /protein_id="NP_032726.1"
                     /db_xref="CCDS:CCDS28556.1"
                     /db_xref="GeneID:18091"
                     /db_xref="MGI:MGI:97350"
                     /translation="MFPSPALTPTPFSVKDILNLEQQQRSLASGDLSARLEATLAPAS
                     CMLAAFKPEAYSGPEAAASGLAELRAEMGPAPSPPKCSPAFPAAPTFYPGAYGDPDPA
                     KDPRADKKELCALQKAVELDKAETDGAERPRARRRRKPRVLFSQAQVYELERRFKQQR
                     YLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQRQDQTLELLGPPPPPARRIAVPV
                     LVRDGKPCLGDPAAYAPAYGVGLNAYGYNAYPYPSYGGAACSPGYSCAAYPAAPPAAQ
                     PPAASANSNFVNFGVGDLNTVQSPGMPQGNSGVSTLHGIRAW"
     exon            542..1524
                     /gene="Nkx2-5"
                     /gene_synonym="Csx; Nkx-2.5; Nkx2.5; tinman"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1503..1508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkx2-5"
                     /gene_synonym="Csx; Nkx-2.5; Nkx2.5; tinman"
                     /note="putative"
     polyA_site      1524
                     /gene="Nkx2-5"
                     /gene_synonym="Csx; Nkx-2.5; Nkx2.5; tinman"
                     /note="putative"
ORIGIN      
        1 cccaatggca ggctgaatcc cccctactcc agcctgctcc cgcctcttct gcccctggtg
       61 ctccgcgcta cctgctgccg cgcgccacat ccagggcaga gaggcgggtg cgcgggcggg
      121 cggcgggcac catgcgggga ggctgtcccc aggggtgggc agcaccactc tctgctaccc
      181 acctggcgct gtgaaacctg cgtcgccacc atgttcccca gccctgcgct cacacccacg
      241 cctttctcag tcaaagacat cctgaacctg gagcagcagc agcgtagcct ggcgtctggg
      301 gacctgtctg cgcgcctcga ggccaccctg gcccctgcct cctgcatgct ggccgccttc
      361 aagcccgagg cctactctgg ccccgaggcg gcagcgtccg gcctggcaga gctgcgcgcg
      421 gagatgggcc ccgcgccttc gccccccaag tgctctcctg ctttcccagc cgcccccaca
      481 ttttacccgg gagcctacgg tgaccctgac ccagccaaag accctcgggc ggataaaaaa
      541 gagctgtgcg cgctgcagaa ggcagtggag ctggacaaag ccgagacgga tggcgccgag
      601 agaccacgcg cacggcggcg acggaagcca cgcgtgctct tctcgcaggc gcaggtctac
      661 gagctggagc ggcgcttcaa gcaacagcgg tacctgtcgg cgccagagcg cgaccagctg
      721 gccagcgtgc tgaagctcac gtccacgcag gtcaagatct ggttccagaa ccgtcgctac
      781 aagtgcaagc gacagcggca ggaccagact ctggagcttc tggggccgcc gccgccgccc
      841 gcgcgcagga tcgcggtgcc cgtgctggtg cgcgacggga agccctgcct gggggacccc
      901 gcggcctacg ctcccgccta cggcgtgggt ctcaatgcct atggctacaa cgcctacccc
      961 taccccagct acggcggcgc ggcctgcagt cccggctaca gctgcgccgc ctaccccgct
     1021 gcgccccccg ccgcgcagcc ccccgccgcc tccgccaaca gcaacttcgt gaactttggc
     1081 gtcggggact tgaacaccgt gcagagtccc gggatgccgc agggcaattc gggcgtctcc
     1141 acgctgcacg gcatccgagc ctggtaggga aagagcccgt ttggggcgcc ccggaacgac
     1201 tcccaccttt aggagaaggg cgatgactcc ggggatggga aagctcccac tatgccctgt
     1261 ccctcagatt tcacacccac cctcgcgcag gcctgggacc tttctccgat ccatcccact
     1321 ttattgacgt agcctggtgt ctcggacctg gcagagccct tccagggtca cgggcacttt
     1381 cgacggattc cacactagga ccgggagcct gggccgggcg cccgggccct ggttgtcttg
     1441 ccgtcgccca cccacccgta tttatgtttt tacctgttgt aagaaatgag aaccctcttc
     1501 ccattaaagt gagtgcgcta acgc
//
