LOCUS       NM_008699               2145 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus NK2 homeobox 3 (Nkx2-3), mRNA.
ACCESSION   NM_008699 XM_129268
VERSION     NM_008699.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2145)
  AUTHORS   Gao,X., Mukaibo,T., Wei,X., Faustoferri,R.C., Oei,M.S., Hwang,S.K.,
            Yan,A.J., Melvin,J.E. and Ovitt,C.E.
  TITLE     Nkx2.3 transcription factor is a key regulator of mucous cell
            identity in salivary glands
  JOURNAL   Dev Biol 509, 1-10 (2024)
   PUBMED   38311164
REFERENCE   2  (bases 1 to 2145)
  AUTHORS   Qiu,C., Martin,B.K., Welsh,I.C., Daza,R.M., Le,T.M., Huang,X.,
            Nichols,E.K., Taylor,M.L., Fulton,O., O'Day,D.R., Gomes,A.R.,
            Ilcisin,S., Srivatsan,S., Deng,X., Disteche,C.M., Noble,W.S.,
            Hamazaki,N., Moens,C.B., Kimelman,D., Cao,J., Schier,A.F.,
            Spielmann,M., Murray,S.A., Trapnell,C. and Shendure,J.
  TITLE     A single-cell time-lapse of mouse prenatal development from
            gastrula to birth
  JOURNAL   Nature 626 (8001), 1084-1093 (2024)
   PUBMED   38355799
REFERENCE   3  (bases 1 to 2145)
  AUTHORS   Hu,M., Chen,N., Chen,M., Chen,F., Lu,Y., Xu,Y., Yang,L., Zeng,H.,
            Shen,M., Chen,X., Chen,S., Wang,F., Wang,S. and Wang,J.
  TITLE     Transcription factor Nkx2-3 maintains the self-renewal of
            hematopoietic stem cells by regulating mitophagy
  JOURNAL   Leukemia 37 (6), 1361-1374 (2023)
   PUBMED   37095209
  REMARK    GeneRIF: Transcription factor Nkx2-3 maintains the self-renewal of
            hematopoietic stem cells by regulating mitophagy.
REFERENCE   4  (bases 1 to 2145)
  AUTHORS   Gabris,F., Kiss,G., Szirmay,B., Szomor,A., Berta,G., Jakus,Z.,
            Kellermayer,Z. and Balogh,P.
  TITLE     Absence of Nkx2-3 induces ectopic lymphatic endothelial
            differentiation associated with impaired extramedullary stress
            hematopoiesis in the spleen
  JOURNAL   Front Cell Dev Biol 11, 1170389 (2023)
   PUBMED   37091975
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2145)
  AUTHORS   Khanfar,E., Olasz,K., Gabris,F., Gajdocsi,E., Botz,B., Kiss,T.,
            Kugyelka,R., Berki,T., Balogh,P. and Boldizsar,F.
  TITLE     Ameliorated Autoimmune Arthritis and Impaired B Cell
            Receptor-Mediated Ca2+ Influx in Nkx2-3 Knock-out Mice
  JOURNAL   Int J Mol Sci 21 (17), 6162 (2020)
   PUBMED   32859051
  REMARK    GeneRIF: Ameliorated Autoimmune Arthritis and Impaired B Cell
            Receptor-Mediated Ca(2+) Influx in Nkx2-3 Knock-out Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2145)
  AUTHORS   Hansen,G.M. and Justice,M.J.
  TITLE     Pten, a candidate tumor suppressor gene, maps to mouse chromosome
            19
  JOURNAL   Mamm Genome 9 (1), 88-90 (1998)
   PUBMED   9434957
REFERENCE   7  (bases 1 to 2145)
  AUTHORS   Yoshiura,K.I. and Murray,J.C.
  TITLE     Sequence and chromosomal assignment of human BAPX1, a
            bagpipe-related gene, to 4p16.1: a candidate gene for skeletal
            dysplasia
  JOURNAL   Genomics 45 (2), 425-428 (1997)
   PUBMED   9344671
REFERENCE   8  (bases 1 to 2145)
  AUTHORS   Pabst,O., Schneider,A., Brand,T. and Arnold,H.H.
  TITLE     The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme
            during pre- and postnatal mouse development
  JOURNAL   Dev Dyn 209 (1), 29-35 (1997)
   PUBMED   9142493
REFERENCE   9  (bases 1 to 2145)
  AUTHORS   Copeland,N.G., Jenkins,N.A. and Harvey,R.P.
  TITLE     The murine homeobox genes Nkx2.3 and Nkx2.6 are located on
            chromosomes 19 and 14, respectively
  JOURNAL   Genomics 22 (3), 655-656 (1994)
   PUBMED   8001981
REFERENCE   10 (bases 1 to 2145)
  AUTHORS   Price,M., Lazzaro,D., Pohl,T., Mattei,M.G., Ruther,U., Olivo,J.C.,
            Duboule,D. and Di Lauro,R.
  TITLE     Regional expression of the homeobox gene Nkx-2.2 in the developing
            mammalian forebrain
  JOURNAL   Neuron 8 (2), 241-255 (1992)
   PUBMED   1346742
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC072614.1.
            
            On or before Aug 30, 2004 this sequence version replaced
            XM_129268.4, NM_008699.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072614.1, AK044871.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2145
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 36.67 cM"
     gene            1..2145
                     /gene="Nkx2-3"
                     /gene_synonym="Nkx-2.3; nkx2-C; Nkx2.3; tinman"
                     /note="NK2 homeobox 3"
                     /db_xref="GeneID:18089"
                     /db_xref="MGI:MGI:97348"
     exon            1..525
                     /gene="Nkx2-3"
                     /gene_synonym="Nkx-2.3; nkx2-C; Nkx2.3; tinman"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1265
                     /gene="Nkx2-3"
                     /gene_synonym="Nkx-2.3; nkx2-C; Nkx2.3; tinman"
                     /note="homeobox protein NK-2 homolog 3; homeobox protein
                     NK-2 homolog C; NK2 transcription factor related, locus 3"
                     /codon_start=1
                     /product="homeobox protein Nkx-2.3"
                     /protein_id="NP_032725.1"
                     /db_xref="CCDS:CCDS29833.1"
                     /db_xref="GeneID:18089"
                     /db_xref="MGI:MGI:97348"
                     /translation="MMLPSPVTSTPFSVKDILNLEQQRHFHGAHLQAELEQHFHSAPC
                     MLATAEGTQFSDAGEEDEEEEGEKLSYLNSLAAAEGHGDSGLCPQSYVHTVLRDACSG
                     PKEQEEEVVSERSQKSCQLKKSLEAAGDCKTSEDGERPKPRSRRKPRVLFSQAQVFEL
                     ERRFKQQRYLSAPEREHLASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLELGTHAPPP
                     PPRRVAVPVLVRDGKPCVTPSAQTYGSPYGVGAGAYSYNSFPAYGYGNSAAAAAAAAA
                     AAAAAAAYSGSYGCAYPTGGGGGGGGTASAATTAMQPACSATGGGSFVNVSNLGGFGS
                     GGGAQPLHQGAAAGSACTQGTLQGIRAW"
     exon            526..2112
                     /gene="Nkx2-3"
                     /gene_synonym="Nkx-2.3; nkx2-C; Nkx2.3; tinman"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2088..2093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkx2-3"
                     /gene_synonym="Nkx-2.3; nkx2-C; Nkx2.3; tinman"
                     /note="hexamer: AATAAA"
     polyA_site      2112
                     /gene="Nkx2-3"
                     /gene_synonym="Nkx-2.3; nkx2-C; Nkx2.3; tinman"
                     /note="major polyA site"
ORIGIN      
        1 caaaacccag acccccaggt cccggccaat ggaggggatt tagactggac cgcgtctgtc
       61 aaaagctcga ctccgcacca ccgcggagtc cagaagaaga gctggagcca ccgcactccc
      121 tccccgcccc cgccgggatt tattgagtat ttggactgga caattaagtg gccctgatga
      181 tgttaccaag cccggtcacc tccacccctt tctcagtcaa agacattttg aatctggagc
      241 agcagcggca cttccacgga gctcacttgc aggcggaatt ggagcagcac ttccactcgg
      301 caccctgcat gctggccacg gctgaaggga cgcagttttc cgatgcaggg gaggaggacg
      361 aggaagaaga gggagagaaa ctgtcctatt tgaactcact agctgctgcc gagggccatg
      421 gagattcggg tctctgtcct cagagctatg tccatacagt tctccgagac gcttgcagcg
      481 ggcccaagga acaagaagag gaggttgtga gcgaacggag ccaaaaaagc tgtcagttga
      541 agaagtctct ggaagcggcg ggagactgta agacgagcga ggacggcgag aggccgaagc
      601 cgcggagccg ccggaagccc cgggtgctct tctcgcaagc tcaggtcttt gagctggagc
      661 gcaggttcaa gcagcagcgg tacctgtcgg cgcccgagcg cgagcatctc gccagcagcc
      721 tgaagctcac gtccacgcag gtgaaaatct ggttccagaa tcgcaggtac aagtgcaaga
      781 gacagcggca ggataagtcc ctggagctgg ggacgcacgc gccgccgccg ccaccccgcc
      841 gcgtggcagt gccggtgctc gtgcgggacg gcaagccgtg cgtcacgccc agcgcacaaa
      901 cctacggctc gccctacggc gtgggcgccg gcgcctactc ctacaacagc ttccccgcct
      961 acggctacgg gaactcggcc gccgcagccg ctgcagccgc cgcagccgca gcagcagcgg
     1021 cggcttacag cggcagctac ggctgcgcct atccgaccgg tggcggcggt ggtggtggcg
     1081 gcacggcctc cgcggcgacc accgccatgc aacccgcctg cagcgccacc ggcggtggat
     1141 cctttgtgaa cgtgagcaac ctgggaggct tcggcagcgg cggcggcgcg caacccttgc
     1201 atcaaggtgc tgcagccggg tccgcgtgca cgcaggggac tttgcagggc atcagggctt
     1261 ggtaaggcct gggcgggaca cgcggcgggc gtcctactgc acgctgggca ccgcgggaat
     1321 gagacacgag aaaggacaga cccaagggcc aggtcccctc gttaaaataa aaatacagac
     1381 gtatcgctcc ttccaagggg ccatggtcgc agctcactcc aggcctgggg catggaactc
     1441 agcggagaaa ggatgccctg gtccagtcct caagactgag acagaaacac cggccaggcg
     1501 ccagggaaga ggtggcctcc catcctgact ctgcggagag tgcgggaggc tgggactccg
     1561 gctgtcgctt gctctccgga ggaggaggag ggcttttctc ttcctgcttt cccttggcct
     1621 tctccgagtg tggtccggga accggaccga acaagggggg aggggggaga aagaaagaaa
     1681 gaaagaaaaa gaacaattta aagaaaaaga aaggtagttg gagagagaac gtgaaggaga
     1741 ggaaaatggg gtactagctt gagaaattcc accgatccgc agcccctttt gcttgcccgg
     1801 agcgccacaa cgaagtggat ttttcctttt ccaactgtgt cccttccaag acagactccg
     1861 cccggatccc tagattgtca ggggactgtt cttggagacc accaccgcag tgagatcgaa
     1921 agttggggga agggaggcag ctgagcaaat ccaagacctg tccgcccaac ctaggttgtc
     1981 gccaggttgg tttcctttct gttttgtatt ctgtattccg cacattatct ctctataact
     2041 atatccacac gccgtgtaca cagccgctgt cacacactac aggagtcaat aaagaaggtg
     2101 caatatttct gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
