LOCUS       NM_010919               2049 bp    mRNA    linear   ROD 07-FEB-2023
DEFINITION  Mus musculus NK2 homeobox 2 (Nkx2-2), transcript variant 1, mRNA.
ACCESSION   NM_010919 XM_001004391
VERSION     NM_010919.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2049)
  AUTHORS   Dobosz AM, Janikiewicz J, Krogulec E, Dziewulska A, Ajduk A, Szpila
            M, Nieznanska H, Szczepankiewicz AA, Wypych D and Dobrzyn A.
  TITLE     Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs
            pancreatic islet morphogenesis and promotes loss of beta-cell
            identity and alpha-cell expansion in the mature pancreas
  JOURNAL   Mol Metab 67, 101659 (2023)
   PUBMED   36529318
REFERENCE   2  (bases 1 to 2049)
  AUTHORS   Govek KW, Chen S, Sgourdou P, Yao Y, Woodhouse S, Chen T, Fuccillo
            MV, Epstein DJ and Camara PG.
  TITLE     Developmental trajectories of thalamic progenitors revealed by
            single-cell transcriptome profiling and Shh perturbation
  JOURNAL   Cell Rep 41 (10), 111768 (2022)
   PUBMED   36476860
REFERENCE   3  (bases 1 to 2049)
  AUTHORS   Inubushi T, Nakanishi Y, Abe M, Takahata Y, Nishimura R, Kurosaka
            H, Irie F, Yamashiro T and Yamaguchi Y.
  TITLE     The cell surface hyaluronidase TMEM2 plays an essential role in
            mouse neural crest cell development and survival
  JOURNAL   PLoS Genet 18 (7), e1009765 (2022)
   PUBMED   35839257
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2049)
  AUTHORS   Kirjavainen A, Singh P, Lahti L, Seja P, Lelkes Z, Makkonen A,
            Kilpinen S, Ono Y, Salminen M, Aitta-Aho T, Stenberg T, Molchanova
            S, Achim K and Partanen J.
  TITLE     Gata2, Nkx2-2 and Skor2 form a transcription factor network
            regulating development of a midbrain GABAergic neuron subtype with
            characteristics of REM-sleep regulatory neurons
  JOURNAL   Development 149 (14) (2022)
   PUBMED   35815619
REFERENCE   5  (bases 1 to 2049)
  AUTHORS   Wang YB, Song NN, Zhang L, Ma P, Chen JY, Huang Y, Hu L, Mao B and
            Ding YQ.
  TITLE     Rnf220 is Implicated in the Dorsoventral Patterning of the
            Hindbrain Neural Tube in Mice
  JOURNAL   Front Cell Dev Biol 10, 831365 (2022)
   PUBMED   35399523
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2049)
  AUTHORS   Hartigan DJ and Rubenstein JL.
  TITLE     The cDNA sequence of murine Nkx-2.2
  JOURNAL   Gene 168 (2), 271-272 (1996)
   PUBMED   8654958
REFERENCE   7  (bases 1 to 2049)
  AUTHORS   Pfaff SL, Mendelsohn M, Stewart CL, Edlund T and Jessell TM.
  TITLE     Requirement for LIM homeobox gene Isl1 in motor neuron generation
            reveals a motor neuron-dependent step in interneuron
            differentiation
  JOURNAL   Cell 84 (2), 309-320 (1996)
   PUBMED   8565076
REFERENCE   8  (bases 1 to 2049)
  AUTHORS   Shimamura K, Hartigan DJ, Martinez S, Puelles L and Rubenstein JL.
  TITLE     Longitudinal organization of the anterior neural plate and neural
            tube
  JOURNAL   Development 121 (12), 3923-3933 (1995)
   PUBMED   8575293
  REMARK    Review article
REFERENCE   9  (bases 1 to 2049)
  AUTHORS   Rubenstein JL, Martinez S, Shimamura K and Puelles L.
  TITLE     The embryonic vertebrate forebrain: the prosomeric model
  JOURNAL   Science 266 (5185), 578-580 (1994)
   PUBMED   7939711
  REMARK    Review article
REFERENCE   10 (bases 1 to 2049)
  AUTHORS   Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule
            D and Di Lauro R.
  TITLE     Regional expression of the homeobox gene Nkx-2.2 in the developing
            mammalian forebrain
  JOURNAL   Neuron 8 (2), 241-255 (1992)
   PUBMED   1346742
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929317.13.
            
            [WARNING] On May 2, 2023 this sequence was replaced by NM_010919.3.
            
            On Nov 9, 2006 this sequence version replaced NM_010919.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U31566.1, AK141002.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142, SAMN02415127
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-643               AL929317.13        6189-6831           c
            644-2049            AL929317.13        3581-4986           c
FEATURES             Location/Qualifiers
     source          1..2049
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 72.63 cM"
     gene            1..2049
                     /gene="Nkx2-2"
                     /gene_synonym="Nkx-2.2; Nkx2.2; tinman"
                     /note="NK2 homeobox 2"
                     /db_xref="GeneID:18088"
                     /db_xref="MGI:MGI:97347"
     exon            1..643
                     /gene="Nkx2-2"
                     /gene_synonym="Nkx-2.2; Nkx2.2; tinman"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..1206
                     /gene="Nkx2-2"
                     /gene_synonym="Nkx-2.2; Nkx2.2; tinman"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homeobox protein Nkx-2.2; homeobox protein Nkx2-2;
                     homeobox protein NK-2 homolog B; Drosophila NK2
                     transcription factor related, locus 2; glycoprotein GP330,
                     renal"
                     /codon_start=1
                     /product="homeobox protein Nkx-2.2 isoform 1"
                     /protein_id="NP_035049.1"
                     /db_xref="CCDS:CCDS16834.1"
                     /db_xref="GeneID:18088"
                     /db_xref="MGI:MGI:97347"
                     /translation="MSLTNTKTGFSVKDILDLPDTNDEDGSVAEGPEEESEGPEPAKR
                     AGPLGQGALDAVQSLPLKSPFYDSSDNPYTRWLASTEGLQYSLHGLAASAPPQDSSSK
                     SPEPSADESPDNDKETQGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREH
                     LASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRVAVPVLVRDGKPCHAL
                     KAQDLAAATFQAGIPFSAYSAQSLQHMQYNAQYSSASTPQYPTAHPLVQAQQWTW"
     exon            644..2049
                     /gene="Nkx2-2"
                     /gene_synonym="Nkx-2.2; Nkx2.2; tinman"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttttcctc gccaccagcc gccaccgcgc gcggagcggc cgccggagcc ggagctgacg
       61 gcaccttggc acctctcctg gagttacaaa ctgaggccgc gcggcgctgg gcgcgcaggc
      121 ccccagtcac agcctacatt tctgcgtgct ttccgagaag agagaggcac cgggtgggct
      181 ttattttttt tcccctttcc cttttccccc cacagtgtcc tctcatttta aataataatt
      241 atcccaataa ttaaaaccca tcccccatcc ctccccccat tcctttcctt aaacccccct
      301 cccccgcccg ctggggctgg ggagagccac gaattgacca agtgaggcta caactttgtg
      361 gcataaattg cggggtccgg aaccatgtcg ctgaccaaca caaagacggg gttttcagtc
      421 aaggacatct tggaccttcc ggacaccaac gatgaagacg gctcggtggc cgaagggcca
      481 gaggaggaga gcgaagggcc ggagcccgcc aagagggccg ggccgctggg gcagggcgcc
      541 ctggacgctg tgcagagcct gccccttaag agccctttct acgacagcag cgacaacccc
      601 tacactcgct ggctggccag caccgagggc ctccaatact ccctgcacgg gctggcggcc
      661 agcgctcccc cccaagactc gagctccaaa tccccagagc cctcggctga cgagtcaccg
      721 gacaatgaca aggagaccca gggcggcggg ggggacgcag gcaagaagcg gaagcgccga
      781 gtgctcttct ccaaagcgca gacctacgag ctggagcggc gcttccggca gcagcggtac
      841 ctgtcggcgc ccgagcgcga gcacctggcc agcctcatcc gtctcacgcc gacacaggtc
      901 aagatctggt tccagaacca tcgctacaag atgaaacgtg cccgggcgga gaaaggtatg
      961 gaggtgacgc ctctgccctc gccgcgccgt gtggcagtgc cggtcttggt cagggacggc
     1021 aaaccgtgcc acgcgctcaa agcccaggac ctggcagccg ccaccttcca ggcaggcatc
     1081 cccttttccg cctacagcgc gcagtcgctg cagcacatgc agtacaacgc ccagtacagc
     1141 tcggccagca ccccccagta cccgacagca caccccctgg tccaggccca gcagtggact
     1201 tggtgagcgc cgcccctcca agactggagg ccttaggccc tggccccacc ccagcggcgc
     1261 cggtggcgag gaggactcga tccttaccac ggttgttatt attattatta taattattat
     1321 tatagagtcg agtctgactt tcgactcagt tgaggaggca cagggaggtt gcctgtgcct
     1381 ccccgagtgg cagattccat tgactctgcc ccatcgctct cccctttgaa cttttggaga
     1441 ggatagaact ctaagccgtg tttacagaat gtttgtgcag ctttgcttct ttgcctctct
     1501 ctccctgagg ggaccaaacc atcccaacgt taacgttgtc acttgaaaag agaaaggacc
     1561 aaccggcccc caccccaccc cacccccgca ctgctttcgt gaattttgta aactatgttt
     1621 gtgtgagtag cgatattgtc agccttctaa aagcaagtgg agaacacttt aaaatataga
     1681 ggatttcttt ttttataaga aaatgctaaa tatttatggc catgtacacg ttctgacaac
     1741 tggtggcaaa tttcgctctt cgttgtaaat atcgctagtg atcgttgcca aatgacgttc
     1801 tggatgggcc tgtatcccca ccgggcctgc ctctctttgt cgtttgtttt cggtgggtta
     1861 tgtttgagtt gcagcgggtt tttattttta tttttatttt tatttttaat ttgttcagtg
     1921 caaacatttt tcaactatga aaaaggaaaa tatgtgtagg gaactcaccc ccgggccccc
     1981 tttttcgtct cctgagcatc ggagcttgga actcagcagt ttcacgtggt ttccccaaga
     2041 gcgccgggc
//
