LOCUS       NM_001403580            2534 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus NK2 homeobox 1 (Nkx2-1), transcript variant 2, mRNA.
ACCESSION   NM_001403580 XM_011244101
VERSION     NM_001403580.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2534)
  AUTHORS   Warren,R., Klinkhammer,K., Lyu,H., Knopp,J., Yuan,T., Yao,C.,
            Stripp,B. and De Langhe,S.P.
  TITLE     Cell competition drives bronchiolization and pulmonary fibrosis
  JOURNAL   Nat Commun 15 (1), 10624 (2024)
   PUBMED   39639058
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2534)
  AUTHORS   Zeng,H., Ali,S., Sebastian,A., Ramos-Medero,A.S., Albert,I.,
            Dean,C. and Liu,A.
  TITLE     CPLANE protein INTU regulates growth and patterning of the mouse
            lungs through cilia-dependent Hh signaling
  JOURNAL   Dev Biol 515, 92-101 (2024)
   PUBMED   39029571
REFERENCE   3  (bases 1 to 2534)
  AUTHORS   He,H., Bell,S.M., Davis,A.K., Zhao,S., Sridharan,A., Na,C.L.,
            Guo,M., Xu,Y., Snowball,J., Swarr,D.T., Zacharias,W.J. and
            Whitsett,J.A.
  TITLE     PRDM3/16 regulate chromatin accessibility required for NKX2-1
            mediated alveolar epithelial differentiation and function
  JOURNAL   Nat Commun 15 (1), 8112 (2024)
   PUBMED   39284798
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2534)
  AUTHORS   Zhao,R., Ren,B., Xiao,Y., Tian,J., Zou,Y., Wei,J., Qi,Y., Hu,A.,
            Xie,X., Huang,Z.J., Shu,Y., He,M., Lu,J. and Tai,Y.
  TITLE     Axo-axonic synaptic input drives homeostatic plasticity by tuning
            the axon initial segment structurally and functionally
  JOURNAL   Sci Adv 10 (31), eadk4331 (2024)
   PUBMED   39093969
REFERENCE   5  (bases 1 to 2534)
  AUTHORS   Raudales,R., Kim,G., Kelly,S.M., Hatfield,J., Guan,W., Zhao,S.,
            Paul,A., Qian,Y., Li,B. and Huang,Z.J.
  TITLE     Specific and comprehensive genetic targeting reveals brain-wide
            distribution and synaptic input patterns of GABAergic axo-axonic
            interneurons
  JOURNAL   Elife 13, 93481 (2024)
   PUBMED   39012795
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2534)
  AUTHORS   Qiu,M., Bulfone,A., Martinez,S., Meneses,J.J., Shimamura,K.,
            Pedersen,R.A. and Rubenstein,J.L.
  TITLE     Null mutation of Dlx-2 results in abnormal morphogenesis of
            proximal first and second branchial arch derivatives and abnormal
            differentiation in the forebrain
  JOURNAL   Genes Dev 9 (20), 2523-2538 (1995)
   PUBMED   7590232
REFERENCE   7  (bases 1 to 2534)
  AUTHORS   Bober,E., Baum,C., Braun,T. and Arnold,H.H.
  TITLE     A novel NK-related mouse homeobox gene: expression in central and
            peripheral nervous structures during embryonic development
  JOURNAL   Dev Biol 162 (1), 288-303 (1994)
   PUBMED   7510254
REFERENCE   8  (bases 1 to 2534)
  AUTHORS   Price,M., Lazzaro,D., Pohl,T., Mattei,M.G., Ruther,U., Olivo,J.C.,
            Duboule,D. and Di Lauro,R.
  TITLE     Regional expression of the homeobox gene Nkx-2.2 in the developing
            mammalian forebrain
  JOURNAL   Neuron 8 (2), 241-255 (1992)
   PUBMED   1346742
REFERENCE   9  (bases 1 to 2534)
  AUTHORS   Guazzi,S., Price,M., De Felice,M., Damante,G., Mattei,M.G. and Di
            Lauro,R.
  TITLE     Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and
            displays a novel DNA binding specificity
  JOURNAL   EMBO J 9 (11), 3631-3639 (1990)
   PUBMED   1976511
REFERENCE   10 (bases 1 to 2534)
  AUTHORS   Kim,Y. and Nirenberg,M.
  TITLE     Drosophila NK-homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 7716-7720 (1989)
   PUBMED   2573058
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160393.2.
            
            On Apr 1, 2022 this sequence version replaced XM_011244101.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662774.3396020.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AC160393.2         178328-178507
            181-325             AC160393.2         178993-179137
            326-711             AC160393.2         179237-179622
            712-2534            AC160393.2         180530-182352
FEATURES             Location/Qualifiers
     source          1..2534
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 24.42 cM"
     gene            1..2534
                     /gene="Nkx2-1"
                     /gene_synonym="Nkx2.1; T/EBP; Titf1; Ttf-1"
                     /note="NK2 homeobox 1"
                     /db_xref="GeneID:21869"
                     /db_xref="MGI:MGI:108067"
     exon            1..180
                     /gene="Nkx2-1"
                     /gene_synonym="Nkx2.1; T/EBP; Titf1; Ttf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..325
                     /gene="Nkx2-1"
                     /gene_synonym="Nkx2.1; T/EBP; Titf1; Ttf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            326..711
                     /gene="Nkx2-1"
                     /gene_synonym="Nkx2.1; T/EBP; Titf1; Ttf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..2534
                     /gene="Nkx2-1"
                     /gene_synonym="Nkx2.1; T/EBP; Titf1; Ttf-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2517..2522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkx2-1"
                     /gene_synonym="Nkx2.1; T/EBP; Titf1; Ttf-1"
                     /note="hexamer: ATTATA"
     polyA_site      2534
                     /gene="Nkx2-1"
                     /gene_synonym="Nkx2.1; T/EBP; Titf1; Ttf-1"
                     /note="major polyA site"
ORIGIN      
        1 agacagactg acagacacat agaccaacag tgcagcccca gggttcatcc ccagactcgc
       61 acactctttt ggtggtgact ggggctcagc gcagcgaagc ccgatgtggt ccggaggcgg
      121 tgggaaggcg cggggctggg aggccgcagc gggagggagg agcagccccg gcaggctcag
      181 cgcttatgcc ccgcctctgg tggctgccta aaacctggcg ccgggctaaa acaaacgcga
      241 ggcagccccc gagcctccac tcaagccaat taaggcggac tcggtccact ccgttacgtg
      301 tacatccaac aagatcggcg ttaagccgac gccgaatcat gtcgatgagt ccaaagcaca
      361 cgactccgtt ctcagtgtct gacatcttga gtcccctgga ggaaagctac aagaaagtgg
      421 gcatggaggg cggcggcctc ggggctccgc tcgcagcgta cagacagggc caggcggccc
      481 caccggccgc ggccatgcag cagcacgccg tggggcacca cggcgccgtc accgccgcct
      541 accacatgac ggcggcgggg gtgccccagc tctcgcactc cgccgtgggg ggctactgca
      601 acggcaacct gggcaacatg agcgagctgc cgccttacca ggacaccatg cggaacagcg
      661 cttcgggccc cggatggtac ggcgccaacc cagacccgcg cttccccgcc atctcccgct
      721 tcatgggccc ggcgagcggc atgaatatga gtggcatggg cggcctgggc tcgctggggg
      781 acgtgagcaa gaacatggcc ccgctgccca gtgcgccccg ccggaagcgc cgggtgctct
      841 tctcccaggc gcaggtgtac gagctcgagc gacgtttcaa gcaacagaag tacctgtcgg
      901 cgccggagcg cgagcatctg gccagcatga ttcacctgac acccacgcag gtcaagatct
      961 ggttccagaa ccaccgctac aagatgaagc gccaggctaa ggacaaggcg gcgcagcaac
     1021 aactgcagca ggacagcggc ggcggcggag gcggcggtgg cggtgcggga tgcccgcagc
     1081 agcagcaagc tcagcagcag tcgccgcgcc gggtggccgt gccggtccta gtcaaagacg
     1141 gcaaaccctg ccaggcgggc gcccctgccc cgggagccgc aagcctgcaa agccacgcgc
     1201 agcaacaagc tcagcagcag gcgcaggcgg cgcaagcggc tgccgcggcc atctcagtgg
     1261 gcagcggtgg cgcgggtcta ggagcacacc caggccacca gccgggcagc gcagggcagt
     1321 ccccggacct ggcgcaccac gcagccagcc ccgcggggct gcagggccag gtctccagcc
     1381 tatcccatct gaactcctcg ggctcggact atggcgccat gtcttgttct accttgcttt
     1441 atggtcggac ctggtgagac gtgagatgcg cttgagcccc gcgcgacctc aacgcttccc
     1501 ctctgccttc cgcaaagacc accattcgcc cgctgctcca cgcgcttcta ctttttttaa
     1561 gaatctgttt atgtttagac caaggaaaag tacacaaaga ccaaactgct ggacgacttc
     1621 ttcttcttct tcttcttctt cttcttcttc ttcttcttct tcttcttctt cttcttcttc
     1681 ttcttcttct tcttcttctt cttctcctcc tcctcctcct cctcctcctc ctcctcctct
     1741 tcctccttct tgtccccgct cgttcttttc tttctccccc tcctcttctg tttccttctt
     1801 ccttcatctt tccccccttc ctttctcttt actatctaaa acttgcagac tttttgtttt
     1861 ttaacataaa aagaaaatag aaacagccaa gcaaattcaa ccctttacgg attctttaaa
     1921 cagagaagga cagagaacaa atttggggtg tctttctggt agttcaaatg ggttcccaag
     1981 cttaggcatg gcacagtttt ggagcctgtt ctatgcttcc atggccctga actctaaaga
     2041 cggaaaactt ttctgtggat gcaccctgcc agcaaagtga gcttgcttgt aaataccagg
     2101 atttttcgtt tgtttgtatg tttcagaagg gaggacagac gctggagata ggaaagtctt
     2161 cagcataacc catttgtacc tgacacaaag gaagtgtccc ctcccaggcg ccctctggcc
     2221 ctacaggttc agtccaggct ggcctttcag aaaattgttt taggtttgat gtgaacttgt
     2281 agctgtaaaa tgctgttaaa agttggacta aatgcctagt ttttagtaac ctgtacatta
     2341 tgttgtaaaa agaaccccag tcccagtccc tagtccctca ctttttcaag gggcattgac
     2401 aaacctgtgt atattatttg gcagtttggt atttgcagca ccaatccttt ttttttttct
     2461 gttgtaactt atgtagatat ttggcttaaa tatagttcct aagaagcttc taataaatta
     2521 tacgaattaa aaaa
//
