LOCUS       NM_009123               1903 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus NK1 homeobox 2 (Nkx1-2), mRNA.
ACCESSION   NM_009123
VERSION     NM_009123.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1903)
  AUTHORS   Nakagawa,S., Carnevali,D., Tan,X., Alvarez,M.J., Parfitt,D.E., Di
            Vicino,U., Arumugam,K., Shin,W., Aranda,S., Normanno,D.,
            Sebastian-Perez,R., Cannata,C., Cortes,P., Neguembor,M.V.,
            Shen,M.M., Califano,A. and Cosma,M.P.
  TITLE     The Wnt-dependent master regulator NKX1-2 controls mouse
            pre-implantation development
  JOURNAL   Stem Cell Reports 19 (5), 689-709 (2024)
   PUBMED   38701778
  REMARK    GeneRIF: The Wnt-dependent master regulator NKX1-2 controls mouse
            pre-implantation development.
REFERENCE   2  (bases 1 to 1903)
  AUTHORS   Galea,G.L., Maniou,E., Edwards,T.J., Marshall,A.R., Ampartzidis,I.,
            Greene,N.D.E. and Copp,A.J.
  TITLE     Cell non-autonomy amplifies disruption of neurulation by mosaic
            Vangl2 deletion in mice
  JOURNAL   Nat Commun 12 (1), 1159 (2021)
   PUBMED   33608529
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3301. doi:
            10.1038/s41467-021-23714-8.. PMID: 34050195]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1903)
  AUTHORS   Dias,A., Lozovska,A., Wymeersch,F.J., Novoa,A., Binagui-Casas,A.,
            Sobral,D., Martins,G.G., Wilson,V. and Mallo,M.
  TITLE     A Tgfbr1/Snai1-dependent developmental module at the core of
            vertebrate axial elongation
  JOURNAL   Elife 9, e56615 (2020)
   PUBMED   32597756
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1903)
  AUTHORS   Chen,N., Schill,R.L., O'Donnell,M., Xu,K., Bagchi,D.P.,
            MacDougald,O.A., Koenig,R.J. and Xu,B.
  TITLE     The transcription factor NKX1-2 promotes adipogenesis and may
            contribute to a balance between adipocyte and osteoblast
            differentiation
  JOURNAL   J Biol Chem 294 (48), 18408-18420 (2019)
   PUBMED   31615896
  REMARK    GeneRIF: Results suggest a role for NK1 homeobox 2 (NKX1-2) in
            promoting adipogenesis and possibly in regulating the balance
            between adipocyte and osteoblast differentiation of bone marrow
            mesenchymal precursor cells.
REFERENCE   5  (bases 1 to 1903)
  AUTHORS   Tahara,N., Kawakami,H., Chen,K.Q., Anderson,A., Yamashita
            Peterson,M., Gong,W., Shah,P., Hayashi,S., Nishinakamura,R.,
            Nakagawa,Y., Garry,D.J. and Kawakami,Y.
  TITLE     Sall4 regulates neuromesodermal progenitors and their descendants
            during body elongation in mouse embryos
  JOURNAL   Development 146 (14) (2019)
   PUBMED   31235634
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1903)
  AUTHORS   Rovescalli,A.C., Cinquanta,M., Ferrante,J., Kozak,C.A. and
            Nirenberg,M.
  TITLE     The mouse Nkx-1.2 homeobox gene: alternative RNA splicing at
            canonical and noncanonical splice sites
  JOURNAL   Proc Natl Acad Sci U S A 97 (5), 1982-1987 (2000)
   PUBMED   10681422
REFERENCE   7  (bases 1 to 1903)
  AUTHORS   Kim,Y.H., Choi,C.Y., Lee,S.J., Conti,M.A. and Kim,Y.
  TITLE     Homeodomain-interacting protein kinases, a novel family of
            co-repressors for homeodomain transcription factors
  JOURNAL   J Biol Chem 273 (40), 25875-25879 (1998)
   PUBMED   9748262
REFERENCE   8  (bases 1 to 1903)
  AUTHORS   Tang,S.J., Hoodless,P.A., Lu,Z., Breitman,M.L., McInnes,R.R.,
            Wrana,J.L. and Buchwald,M.
  TITLE     The Tlx-2 homeobox gene is a downstream target of BMP signalling
            and is required for mouse mesoderm development
  JOURNAL   Development 125 (10), 1877-1887 (1998)
   PUBMED   9550720
REFERENCE   9  (bases 1 to 1903)
  AUTHORS   Gavalas,A., Davenne,M., Lumsden,A., Chambon,P. and Rijli,F.M.
  TITLE     Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning
  JOURNAL   Development 124 (19), 3693-3702 (1997)
   PUBMED   9367425
REFERENCE   10 (bases 1 to 1903)
  AUTHORS   Schubert,F.R., Fainsod,A., Gruenbaum,Y. and Gruss,P.
  TITLE     Expression of the novel murine homeobox gene Sax-1 in the
            developing nervous system
  JOURNAL   Mech Dev 51 (1), 99-114 (1995)
   PUBMED   7669696
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF222444.1.
            
            On Jun 19, 2003 this sequence version replaced NM_009123.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF222444.1, BC139757.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1903
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 76.3 cM"
     gene            1..1903
                     /gene="Nkx1-2"
                     /gene_synonym="Nkx-1.1; Nkx-1.2; Sax1"
                     /note="NK1 homeobox 2"
                     /db_xref="GeneID:20231"
                     /db_xref="MGI:MGI:104806"
     exon            1..325
                     /gene="Nkx1-2"
                     /gene_synonym="Nkx-1.1; Nkx-1.2; Sax1"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1029
                     /gene="Nkx1-2"
                     /gene_synonym="Nkx-1.1; Nkx-1.2; Sax1"
                     /note="homeobox protein SAX-1; homeobox protein
                     Nkx1.2E427; spinal cord axial homeobox gene 1; NK1
                     transcription factor related, locus 2"
                     /codon_start=1
                     /product="NK1 transcription factor-related protein 2"
                     /protein_id="NP_033149.1"
                     /db_xref="CCDS:CCDS21924.1"
                     /db_xref="GeneID:20231"
                     /db_xref="MGI:MGI:104806"
                     /translation="MLAWQDVGAKAAPSHHKISFSVLDILDPQKFTRAALPPVRLAAL
                     EAKKSLEEVEAGQDACSGNPIGSQETPDAVGRGIDPGSPVEGSEAEEEEEAEDAGRAH
                     QPERWQGVHEGSPEARAVAVGTEESGAEGLPASPGSPGSPRPRRRRAESSCAKPRRAR
                     TAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGA
                     DGAVQAGGGAPQPGTPGAVAGGGGSATGSSPGPPVPGALPYQTFPTYPATNVLFPAAS
                     FPLTTAANGSPFTPFLGPSYLTPFYAPHL"
     exon            326..1903
                     /gene="Nkx1-2"
                     /gene_synonym="Nkx-1.1; Nkx-1.2; Sax1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aattccagtt cgcggctgga gagctgtggc caaaccactg cagaagacag cggctgagcg
       61 catccagccc cgaccccagt acggctggcc tcgggcccgc gggaggcggg catgttggca
      121 tggcaggacg tcggggccaa ggcggccccc tctcaccaca agatctcctt ctctgtcttg
      181 gacatcttgg atccgcaaaa attcacgcga gctgccctcc cgccggtgcg tctcgctgcc
      241 ctggaagcca agaaaagttt agaagaggtg gaagcagggc aagatgcttg ttcggggaat
      301 ccaatcgggt cacaggagac ccctgatgcg gtgggccgag gcattgaccc cgggtctccg
      361 gtggagggct ccgaggcaga ggaggaggag gaagctgagg atgcggggcg cgcgcaccag
      421 ccagagcgct ggcagggggt ccatgagggc tcaccagagg cccgggcagt agcggtggga
      481 acggaagaga gcggcgcgga aggcctcccg gcgtccccgg gctctcccgg ttccccgcgg
      541 ccccgacgcc ggcgagccga gtccagctgc gccaagccaa ggcgcgcgcg cactgccttc
      601 acttacgagc agctggtggc cctagagaac aagtttcgag ccacgcgcta tctgtcggtg
      661 tgcgaacgcc tgaacctggc gctgtcgctc agcctcacgg agacgcaggt caaaatttgg
      721 ttccagaacc gcaggaccaa gtggaagaag cagaacccag gggccgacgg cgccgtgcag
      781 gcgggaggcg gtgcgcctca gcctgggaca ccgggcgcgg tagcgggggg cggtggcagt
      841 gccactggga gtagtcctgg ccctccggtt cctggcgctc tgccctatca gactttcccc
      901 acctatcctg ccaccaacgt cctcttccct gccgcctcct tcccgctgac gaccgccgcc
      961 aacgggagtc ccttcactcc attccttggg ccctcctact tgaccccttt ctatgctcca
     1021 cacctatgaa tccggtactg ctgctcagtc agaattcacg agtgatcagt atgatgacgc
     1081 gggtccccgc ttcacagagg ggcactgacc gccccctcct ggtgtgcccc ttccctccga
     1141 ctgctggtga cgccaccaga gggcgaggag aagtcacctg cagactacaa ccacacaagc
     1201 cactgagggg tcgaggcgat gtccgtccag accaggctgt tttaaacgtt tccagcttct
     1261 ggacctcatt cttccctttg atttacttcg agggctctgt tctttaccgt gtctggctaa
     1321 taagggttcc caggatggag accagaggga gccaagatgc cctgggcacc agttgctagc
     1381 accaaggact gaatctttaa aggtggcagg acttatgaag aggaagaaac ttttcttcct
     1441 ggcgttggaa gtggctcagc acggaactcc caaatcctga acaaagctgg agcacgagga
     1501 acccaaagca gatgcagttg ttgagtgggc tggtttcaag atgcacgacc ttagtgtgtg
     1561 tgtgtgtgtg tgtgtgtgtg tgtgtgtaga ctccattgtt gagtgggctg gtttcaagat
     1621 gcacgacctt agtgtgtgtg tgtgtgtgtg tgtagactcc atttgtggcc cgaagttgtt
     1681 cagcgctgta cctatattca cccagagaag acacggggca actctgttac ctcacaggtt
     1741 ttgagaacag cttggacaga ccacagcggt gtcctaaaat gcacaaaaag gacagaaaag
     1801 ggagcgatga cccaaaggct ctcctgaagt ctgtgtgtga gtctttgtga tgtacagtgc
     1861 ttggcgccca tctgtccgtt ctgctacact ttcacggact tca
//
