LOCUS       NM_011320               1323 bp    mRNA    linear   ROD 06-APR-2024
DEFINITION  Mus musculus NK1 homeobox 1 (Nkx1-1), mRNA.
ACCESSION   NM_011320 XM_001473635 XM_006543936
VERSION     NM_011320.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1323)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   2  (bases 1 to 1323)
  AUTHORS   Simon,R., Britsch,S. and Bergemann,A.
  TITLE     Ablation of Sax2 gene expression prevents diet-induced obesity
  JOURNAL   FEBS J 278 (2), 371-382 (2011)
   PUBMED   21126319
  REMARK    GeneRIF: Sax2 gene expression plays a critical role in diet-induced
            obesity.
REFERENCE   3  (bases 1 to 1323)
  AUTHORS   Simon,R., Lufkin,T. and Bergemann,A.D.
  TITLE     Homeobox gene Sax2 deficiency causes an imbalance in energy
            homeostasis
  JOURNAL   Dev Dyn 236 (10), 2792-2799 (2007)
   PUBMED   17879320
  REMARK    GeneRIF: These data strongly suggest that Sax2 is required for the
            coordinated crosstalk of factors involved in the maintenance of
            energy homeostasis.
REFERENCE   4  (bases 1 to 1323)
  AUTHORS   Simon,R. and Lufkin,T.
  TITLE     Postnatal lethality in mice lacking the Sax2 homeobox gene
            homologous to Drosophila S59/slouch: evidence for positive and
            negative autoregulation
  JOURNAL   Mol Cell Biol 23 (24), 9046-9060 (2003)
   PUBMED   14645517
  REMARK    GeneRIF: Sax2 gene expression occurs early during embryogenesis in
            the midbrain, the midbrain-hindbrain boundary, the ventral neural
            tube, the developing eye, and the apical ectodermal ridge of the
            limb.
REFERENCE   5  (bases 1 to 1323)
  AUTHORS   Chen,X. and Lufkin,T.
  TITLE     Linkage mapping of Sax2 to mouse chromosome 5
  JOURNAL   Mamm Genome 8 (9), 697-698 (1997)
   PUBMED   9271676
REFERENCE   6  (bases 1 to 1323)
  AUTHORS   Yamada,G., Kioussi,C., Schubert,F.R., Eto,Y., Chowdhury,K.,
            Pituello,F. and Gruss,P.
  TITLE     Regulated expression of Brachyury(T), Nkx1.1 and Pax genes in
            embryoid bodies
  JOURNAL   Biochem Biophys Res Commun 199 (2), 552-563 (1994)
   PUBMED   7907867
REFERENCE   7  (bases 1 to 1323)
  AUTHORS   Bober,E., Baum,C., Braun,T. and Arnold,H.H.
  TITLE     A novel NK-related mouse homeobox gene: expression in central and
            peripheral nervous structures during embryonic development
  JOURNAL   Dev Biol 162 (1), 288-303 (1994)
   PUBMED   7510254
REFERENCE   8  (bases 1 to 1323)
  AUTHORS   Kim,Y. and Nirenberg,M.
  TITLE     Drosophila NK-homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 7716-7720 (1989)
   PUBMED   2573058
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC145072.9.
            
            On or before Feb 22, 2014 this sequence version replaced
            XM_001473635.2, XM_006543936.1.
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               AC145072.9         110004-110469
            467-1323            AC145072.9         112504-113360
FEATURES             Location/Qualifiers
     source          1..1323
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.65 cM"
     gene            1..1323
                     /gene="Nkx1-1"
                     /gene_synonym="Nkx-1.1; Sax2"
                     /note="NK1 homeobox 1"
                     /db_xref="GeneID:672284"
                     /db_xref="MGI:MGI:109346"
     CDS             1..1323
                     /gene="Nkx1-1"
                     /gene_synonym="Nkx-1.1; Sax2"
                     /note="spinal cord axial homeobox gene 2; NK1
                     transcription factor related, locus 1; homeobox protein
                     SAX-2"
                     /codon_start=1
                     /product="NK1 transcription factor-related protein 1"
                     /protein_id="NP_035450.1"
                     /db_xref="GeneID:672284"
                     /db_xref="MGI:MGI:109346"
                     /translation="MSTSGPAAPGDVPALPPPPPGPGSGPAPPAPAATARDTMDGRAE
                     LPIFPRAGVPPLAASDTVPAVPEGAGAARPAAPPRPTSFSVLDILDPNKFNSRRRRCV
                     LLGPVVPATCAPCAPAACVAVPAASGRSPRAELERRALSAATGVAAAAGAEPTSAGDS
                     YRADEAEANGYSSGSGRSPTADSEDEAPEDEDEEEAPEVQDAQGTEEPRGGSGGLGAR
                     GSGCPGAAEVEASPVDDTAAPGPRGNSPGAPGPPATATGAGSAGSTPQGAAVTTKPKR
                     KRTGSDSKSGKPRRARTAFTYEQLVALENKFKATRYLSVCERLNLALSLSLTETQVKI
                     WFQNRRTKWKKQNPGADTSAPTGGGGGPGPGAGPGAGLPGGLSPLSPSPPMGAPLALH
                     GPAGYPAHSPGGLVCAAQLPFLSSPAVLSPFVLGSQTYGAPAFYAPHL"
     exon            1..466
                     /gene="Nkx1-1"
                     /gene_synonym="Nkx-1.1; Sax2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..1323
                     /gene="Nkx1-1"
                     /gene_synonym="Nkx-1.1; Sax2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagtacca gcggcccggc ggcacccggg gacgtccccg cgctgccacc gccaccgccc
       61 gggcccggct cggggcccgc accgccggct cctgcggcta cagctcggga cactatggac
      121 ggacgagctg agctgcccat ctttccccgg gctggagtgc caccgctcgc ggccagcgac
      181 actgttcccg cggtgccaga gggggctgga gcggcccggc ccgccgcgcc cccgcgcccc
      241 acctccttct ccgtgttgga catcctagat cccaacaagt tcaacagtag gagacgccgc
      301 tgcgtgctac tgggccctgt ggtgcccgct acgtgtgccc catgcgcccc ggccgcgtgc
      361 gtcgcggtcc ccgctgcctc cggacgttcg ccgcgcgcag agctagaacg ccgagccctc
      421 tccgccgcca caggagtcgc agcggccgcg ggagctgagc ctacaagtgc tggggactct
      481 tacagggcgg acgaggccga ggccaacggc tacagcagcg gcagcggtcg cagcccgacc
      541 gcggacagcg aggatgaagc gccggaggac gaggacgagg aagaagcgcc cgaggtgcag
      601 gatgctcagg gcacggagga gcctcgggga ggcagcggcg gtctcggggc ccgcgggtcg
      661 ggctgccccg gagcggccga ggtcgaggct tcccctgtgg acgatactgc ggccccaggg
      721 ccccgtggga actcgcccgg agccccgggc ccgcctgcaa ctgctacggg agcggggagc
      781 gcggggagta ccccgcaggg cgccgccgtg accaccaagc ccaagcggaa gcgcacgggc
      841 tcggactcga agtccgggaa gccgaggcgt gcgcgcaccg ccttcaccta cgagcagctc
      901 gtggcgctgg agaacaagtt taaggccact cgctacctgt cggtgtgcga gcgcctcaac
      961 ctggcgctgt cgctgagcct caccgagacg caggtgaaga tctggttcca gaaccgccga
     1021 accaagtgga agaagcaaaa cccaggcgct gacaccagcg cgccgaccgg cggcggcggg
     1081 ggccccggcc cgggagcggg gcccggcgcg gggctgcccg gcggcctcag tccgctcagc
     1141 ccctcgcctc ccatgggcgc tccgctcgcc ttgcacggcc cggccgggta cccggcgcac
     1201 agcccaggag ggctggtgtg tgctgcgcag ctgcccttcc tgtccagccc ggccgtgctg
     1261 tcgcccttcg tgctgggctc gcagacgtac ggcgcgcccg ccttctatgc gccccacctc
     1321 tga
//
