LOCUS       NP_035450                440 aa            linear   ROD 06-APR-2024
DEFINITION  NK1 transcription factor-related protein 1 [Mus musculus].
ACCESSION   NP_035450 XP_001473685 XP_006543999
VERSION     NP_035450.1
DBSOURCE    REFSEQ: accession NM_011320.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 440)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   2  (residues 1 to 440)
  AUTHORS   Simon,R., Britsch,S. and Bergemann,A.
  TITLE     Ablation of Sax2 gene expression prevents diet-induced obesity
  JOURNAL   FEBS J 278 (2), 371-382 (2011)
   PUBMED   21126319
  REMARK    GeneRIF: Sax2 gene expression plays a critical role in diet-induced
            obesity.
REFERENCE   3  (residues 1 to 440)
  AUTHORS   Simon,R., Lufkin,T. and Bergemann,A.D.
  TITLE     Homeobox gene Sax2 deficiency causes an imbalance in energy
            homeostasis
  JOURNAL   Dev Dyn 236 (10), 2792-2799 (2007)
   PUBMED   17879320
  REMARK    GeneRIF: These data strongly suggest that Sax2 is required for the
            coordinated crosstalk of factors involved in the maintenance of
            energy homeostasis.
REFERENCE   4  (residues 1 to 440)
  AUTHORS   Simon,R. and Lufkin,T.
  TITLE     Postnatal lethality in mice lacking the Sax2 homeobox gene
            homologous to Drosophila S59/slouch: evidence for positive and
            negative autoregulation
  JOURNAL   Mol Cell Biol 23 (24), 9046-9060 (2003)
   PUBMED   14645517
  REMARK    GeneRIF: Sax2 gene expression occurs early during embryogenesis in
            the midbrain, the midbrain-hindbrain boundary, the ventral neural
            tube, the developing eye, and the apical ectodermal ridge of the
            limb.
REFERENCE   5  (residues 1 to 440)
  AUTHORS   Chen,X. and Lufkin,T.
  TITLE     Linkage mapping of Sax2 to mouse chromosome 5
  JOURNAL   Mamm Genome 8 (9), 697-698 (1997)
   PUBMED   9271676
REFERENCE   6  (residues 1 to 440)
  AUTHORS   Yamada,G., Kioussi,C., Schubert,F.R., Eto,Y., Chowdhury,K.,
            Pituello,F. and Gruss,P.
  TITLE     Regulated expression of Brachyury(T), Nkx1.1 and Pax genes in
            embryoid bodies
  JOURNAL   Biochem Biophys Res Commun 199 (2), 552-563 (1994)
   PUBMED   7907867
REFERENCE   7  (residues 1 to 440)
  AUTHORS   Bober,E., Baum,C., Braun,T. and Arnold,H.H.
  TITLE     A novel NK-related mouse homeobox gene: expression in central and
            peripheral nervous structures during embryonic development
  JOURNAL   Dev Biol 162 (1), 288-303 (1994)
   PUBMED   7510254
REFERENCE   8  (residues 1 to 440)
  AUTHORS   Kim,Y. and Nirenberg,M.
  TITLE     Drosophila NK-homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 7716-7720 (1989)
   PUBMED   2573058
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC145072.9.
            
            On or before Feb 22, 2014 this sequence version replaced
            XP_001473685.2, XP_006543999.1.
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.65 cM"
     Protein         1..440
                     /product="NK1 transcription factor-related protein 1"
                     /note="spinal cord axial homeobox gene 2; NK1
                     transcription factor related, locus 1; homeobox protein
                     SAX-2"
                     /calculated_mol_wt=43480
     Region          1..82
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (G3UXB3.2)"
     Region          145..291
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (G3UXB3.2)"
     Region          289..345
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          342..387
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (G3UXB3.2)"
     CDS             1..440
                     /gene="Nkx1-1"
                     /gene_synonym="Nkx-1.1; Sax2"
                     /coded_by="NM_011320.1:1..1323"
                     /db_xref="GeneID:672284"
                     /db_xref="MGI:MGI:109346"
ORIGIN      
        1 mstsgpaapg dvpalppppp gpgsgpappa paatardtmd graelpifpr agvpplaasd
       61 tvpavpegag aarpaapprp tsfsvldild pnkfnsrrrr cvllgpvvpa tcapcapaac
      121 vavpaasgrs praelerral saatgvaaaa gaeptsagds yradeaeang yssgsgrspt
      181 adsedeaped edeeeapevq daqgteeprg gsgglgargs gcpgaaevea spvddtaapg
      241 prgnspgapg ppatatgags agstpqgaav ttkpkrkrtg sdsksgkprr artaftyeql
      301 valenkfkat rylsvcerln lalslsltet qvkiwfqnrr tkwkkqnpga dtsaptgggg
      361 gpgpgagpga glpgglspls psppmgapla lhgpagypah spgglvcaaq lpflsspavl
      421 spfvlgsqty gapafyaphl
//
