LOCUS       NM_029891               5383 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus NF-kappaB repressing factor (Nkrf), mRNA.
ACCESSION   NM_029891 XM_006541409 XM_895314 XM_918653
VERSION     NM_029891.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5383)
  AUTHORS   Guo,C., Ji,W., Yang,W., Deng,Q., Zheng,T., Wang,Z., Sui,W.,
            Zhai,C., Yu,F., Xi,B., Yu,X., Xu,F., Zhang,Q., Zhang,W., Kong,J.,
            Zhang,M. and Zhang,C.
  TITLE     NKRF in Cardiac Fibroblasts Protects against Cardiac Remodeling
            Post-Myocardial Infarction via Human Antigen R
  JOURNAL   Adv Sci (Weinh) 10 (30), e2303283 (2023)
   PUBMED   37667861
  REMARK    GeneRIF: NKRF in Cardiac Fibroblasts Protects against Cardiac
            Remodeling Post-Myocardial Infarction via Human Antigen R.
REFERENCE   2  (bases 1 to 5383)
  AUTHORS   Zhou,Q., Costinean,S., Croce,C.M., Brasier,A.R., Merwat,S.,
            Larson,S.A., Basra,S. and Verne,G.N.
  TITLE     MicroRNA 29 targets nuclear factor-kappaB-repressing factor and
            Claudin 1 to increase intestinal permeability
  JOURNAL   Gastroenterology 148 (1), 158-169 (2015)
   PUBMED   25277410
  REMARK    GeneRIF: MIR29 targets and reduces expression of CLDN1 and NKRF to
            increase intestinal permeability in inflammatory bowel disease.
REFERENCE   3  (bases 1 to 5383)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 5383)
  AUTHORS   Reboll,M.R., Oumard,A., Gazdag,A.C., Renger,I., Ritter,B.,
            Schwarzer,M., Hauser,H., Wood,M., Yamada,M., Resch,K. and
            Nourbakhsh,M.
  TITLE     NRF IRES activity is mediated by RNA binding protein JKTBP1 and a
            14-nt RNA element
  JOURNAL   RNA 13 (8), 1328-1340 (2007)
   PUBMED   17592041
  REMARK    GeneRIF: The data of this study show that JKTBP1 and the 14-nt
            element act independently to mediate NRF internal ribosome entry
            segment activity.
REFERENCE   5  (bases 1 to 5383)
  AUTHORS   Froese,N., Schwarzer,M., Niedick,I., Frischmann,U., Koster,M.,
            Kroger,A., Mueller,P.P., Nourbakhsh,M., Pasche,B., Reimann,J.,
            Staeheli,P. and Hauser,H.
  TITLE     Innate immune responses in NF-kappaB-repressing factor-deficient
            mice
  JOURNAL   Mol Cell Biol 26 (1), 293-302 (2006)
   PUBMED   16354699
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450399.16.
            
            On or before Aug 16, 2019 this sequence version replaced
            XM_006541409.4, NM_029891.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138829.1, AK042690.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-730               AL450399.16        113112-113841       c
            731-861             AL450399.16        102001-102131       c
            862-5383            AL450399.16        96367-100888        c
FEATURES             Location/Qualifiers
     source          1..5383
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 21.3 cM"
     gene            1..5383
                     /gene="Nkrf"
                     /gene_synonym="9430034D17Rik"
                     /note="NF-kappaB repressing factor"
                     /db_xref="GeneID:77286"
                     /db_xref="MGI:MGI:1924536"
     exon            1..730
                     /gene="Nkrf"
                     /gene_synonym="9430034D17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             465..2819
                     /gene="Nkrf"
                     /gene_synonym="9430034D17Rik"
                     /note="NFkB-repressing factor; transcription factor NRF"
                     /codon_start=1
                     /product="NF-kappa-B-repressing factor"
                     /protein_id="NP_084167.3"
                     /db_xref="CCDS:CCDS30065.1"
                     /db_xref="GeneID:77286"
                     /db_xref="MGI:MGI:1924536"
                     /translation="MAGGRLLLGGDFLSPPPLPPLPPPPLPPLPPPPPEPVLEQWRYS
                     HESDWQWALRRSFICRHLHSYPGAALDQLLALSAAWTNHVFLGCRYSPHLMEKILHMA
                     EGIDIGEMPSYDLMLPKPSKGQKRYLSTYDGQNPPKKQAGSKFHVRARFEPVHFVASS
                     SKAERQEDPYGPQTKDVNGRTHFASMPRNFYQDYTQDSFSIQDGNSQYCNSSGFIFTK
                     DQPVATNMYFDSGNPAPSSTSQQANCQPAPEPPPSQMYPESLVAEKQYFIEKLTATIW
                     KNLSNPEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGY
                     ACEVRCQNIYLTTGYAGSKNGSRDRATELAVKLLQKRIEVRVVRRKFKHIIGEDLVVC
                     QIGMLSYEFPPALKPPEDLVVLGKDASGQPIFNSSAKHWTNFVITENANDAIGILNNS
                     ASFNKMSIEYKYEMMPNRTWRCRVFLQDHCLAEGYGTKKTSKHAAADEALKVLQKTQP
                     TYPSVKSSQCHSGSSPKGSGKKKDIKDLVVYENSSNPVCTLNDTAQFNRMTVEYVYER
                     MTGLRWKCKVILESEVIAEAVGVKKSVKYEAAGEAVKTLKKTQPTVINNLKKGTVEDV
                     ISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEGIREPISVKEQHKR
                     EGLGLDVERVNKIAKRDIEQIIRNYARSESHSDLTFSTELTNDERKQIHQIAQKYGLK
                     SKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQAN"
     exon            731..861
                     /gene="Nkrf"
                     /gene_synonym="9430034D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            862..5383
                     /gene="Nkrf"
                     /gene_synonym="9430034D17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3807..3812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkrf"
                     /gene_synonym="9430034D17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3834
                     /gene="Nkrf"
                     /gene_synonym="9430034D17Rik"
                     /note="major polyA site"
     regulatory      4915..4920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkrf"
                     /gene_synonym="9430034D17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4939
                     /gene="Nkrf"
                     /gene_synonym="9430034D17Rik"
     regulatory      5356..5361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkrf"
                     /gene_synonym="9430034D17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5383
                     /gene="Nkrf"
                     /gene_synonym="9430034D17Rik"
ORIGIN      
        1 ctcacaacct cagggtggca cgcggggagg tagggtgaga gacccgagcc ggggagcgca
       61 gcgtgctggt gcttctcctc cttcttttct tcttcttttt attttttttt tttattcttg
      121 ccgctactct ctcagtgtgt gggtcccagg gtccgcagag gtgctgtgtg gcagggccca
      181 agtccgctgc ctagtgtgcc ccatatataa ggaagccctc acgtccccac attagttgga
      241 gccgtgcggc tggcgtggcg acaacgacca ttgacccccc atccccgttt ctctgtaagc
      301 gtagcccccg ccccccccag gcacataccc ccagcccccc cagtctcagc cctgagcgtc
      361 cctcacacac aggttgcccc cccccaaccc cagccgcctc gcttgccccc ggccagttgg
      421 taggcatcgt ccccgggggc cgtccccact ctgaagcaga gaagatggct ggaggacgtc
      481 tgttgctggg gggcgacttc ctgtcgccgc cgccgctgcc ccccctcccg ccgccgccgc
      541 tgccgcccct cccgccgccc ccgcctgagc cagtgctgga gcagtggcgc tatagccacg
      601 aaagtgactg gcagtgggct ctgcggcgga gcttcatctg ccggcacctg cacagctatc
      661 ccggggctgc cctggaccag ctcctcgcgc tctccgccgc ctggacaaac cacgttttcc
      721 tgggctgcag gtatagccca cacttgatgg aaaaaattct tcacatggct gaaggtattg
      781 atattgggga gatgccgtca tatgatctaa tgctgcccaa accttccaaa ggccaaaaac
      841 gctacctttc aacctacgat ggtcagaatc ctcctaaaaa gcaagccggt tccaaattcc
      901 atgtgagagc tcgttttgag cctgtacatt ttgtagctag tagttcaaaa gctgaaagac
      961 aggaagatcc gtatggccct caaacaaaag acgtaaatgg acgaacacat tttgccagca
     1021 tgccaagaaa cttctaccaa gattatactc aagactcttt cagtatccag gatggaaatt
     1081 ctcaatattg taattcatca ggatttattt tcacaaaaga ccagcctgta gcaaccaaca
     1141 tgtattttga cagtgggaac cctgccccaa gcagcacatc ccagcaggca aactgtcagc
     1201 cagctcccga gcctcctcct tcacagatgt accctgagtc cttggttgcc gagaagcagt
     1261 attttattga aaagttaaca gcaactatct ggaagaacct ttctaatcca gagatgactt
     1321 ctggatctga taagattaat tatacctata tgctaactcg ttgtattcag gcatgtaaga
     1381 caaatcctga gtatatatat gctcctttaa aagaaattcc tcctgctgac atccccaaaa
     1441 ataaaaaact tctcacggat ggttatgctt gtgaagttag atgccaaaat atctacctaa
     1501 ctacaggtta tgcaggtagc aagaatgggt ccagagatcg agctactgag ctagctgtaa
     1561 aactcttgca gaagaggatt gaggttagag ttgtccgacg gaaattcaag cacataatcg
     1621 gagaggacct tgtggtgtgt cagattggta tgctttcata tgaatttccc ccagctctga
     1681 aaccaccaga agacctggta gtactgggaa aggatgcttc tgggcagcct atttttaata
     1741 gttctgccaa acactggacc aattttgtca ttacagaaaa tgcaaatgat gcaattggca
     1801 tccttaacaa ttccgcctca ttcaacaaaa tgtcaattga gtacaaatac gagatgatgc
     1861 caaaccgcac atggcggtgt cgagtattcc tgcaagatca ctgcttagct gaaggttatg
     1921 gaaccaagaa aacaagcaaa catgcagctg ctgatgaggc tttgaaagtt cttcaaaaaa
     1981 cacaacccac ttatccatct gtcaaaagtt cccagtgtca ctcaggctct tcacccaaag
     2041 gatccggaaa gaagaaagat atcaaagatc ttgtagttta tgagaattct tccaatcctg
     2101 tgtgcacatt gaatgatacg gctcagttta accgaatgac ggttgaatat gtctatgaaa
     2161 ggatgacagg tctccgctgg aaatgcaagg tgattctaga gagcgaagtc attgcagaag
     2221 cagttggtgt gaagaaaagt gtcaaatacg aagctgctgg agaagctgta aagaccctca
     2281 aaaagaccca gccgactgtc attaacaact tgaagaaagg gactgttgaa gatgtgattt
     2341 caagaaatga aatccagggc cgctcagcag aagaagctta caaacagcaa atcaaagaag
     2401 acaacatagg gaatcaactg ctgagaaaga tgggctggac gggtggtggt ttagggaaat
     2461 ctggtgaggg catacgggag cctatctcag ttaaagagca gcataagcga gaaggccttg
     2521 gtctagatgt agagagggtc aataaaattg ctaagaggga tatagaacaa attatcagaa
     2581 actatgcccg ctctgaaagc cactcagatt tgaccttctc cacggagctg accaatgatg
     2641 aacggaagca aatccatcag attgctcaga agtatggcct gaagagtaag tctcatgggg
     2701 tgggccatga taggtacctg gtggtaggtc gaaaacggcg gaaggaagac ctactagatc
     2761 aactcaaaca ggagggccaa gtgggacatt atgagcttgt tatgccccaa gcaaactaag
     2821 attttactaa gttgtcttat aaatgcctca tgaggtagat acacaaataa caaaaaaagc
     2881 tatatgttct ggttgaagag tattcattct taagatgttt caccttgttc atttcatata
     2941 gtgctttatt aggtattgga acctagagaa ttctgtccac ttgtattctt agcttaatcc
     3001 agcagatgat attgtgcagt tactgtttgt gtctttgata tggctctgtt ccctcagatt
     3061 ttagtagttt gtacaagtaa aaacacccat ctaagtgcaa tttcaccctg aggcaaatac
     3121 ttcacattat aaagggcata gcacagccat ctgcaacaat atgtaaagtc aatgctgact
     3181 cttaactacg ctaattccag atttacttaa catgtcaggt cattttgtat caccaatttt
     3241 catctttgtg agaagccagt tgtagagcat ttaacaataa attgtgctgt acgtgtaaat
     3301 gtctttatca actaaatgat gtaaaatttt ctttaaagta attttagtgt gtgtttgttt
     3361 ataacttcta ccctgtgatt tccaggatat tggaagtgat ttactgtatc ttgtgacata
     3421 tgacttttaa acaaattcta gtcttcatgc tgagagagca ctactgagag agatgtcgaa
     3481 aagtttccaa aaagccttga ttcaatcaga agaaagaaag cttgaactgt ttgttcttgg
     3541 tgccttgcag agagactcag agcaactctc cattgtagct ttcacatggt ttgtgcacca
     3601 cacccaaggc aaccatagct gtggtagagc ttggtaaaag actgaagata cactggtgct
     3661 ttgatgaaaa aggtcagttg gctggttccc ctctcaaaaa gcttattact cccaaagcca
     3721 actttgtaac atacttaaaa ctgctatttt cgcttatttc tggaatgtaa aaatgtataa
     3781 aaataagagt tagtgtatgc ttcctgaata aaaaggagcc aaagttgatc aaaattagtg
     3841 ctgtaattat ttctggagag cagcctagta gcaacacttt gggtttttga aagtgatgat
     3901 tgcacaaaat gtttcagtta gagttagagc acacacagat aaatgtaatg atttagcaaa
     3961 tgggagcaga ctctgtcact catcacattt tggggggtgt tttttttcct tgaatgccaa
     4021 tattctggct tatcaaatct ttgggtgttt agttttatgt ggttttattg tatcgtaaat
     4081 gaatcaacta aaatccagca atacagcaaa taaatattaa tatttagtta actccagaga
     4141 aatgatggta aggactctta ggctgtttgc aatatctttt aaaaaaagat ttattttttt
     4201 ataatgtgtg gatgtctgtg agggggttat atgcatgtga gtgcatatgc ccatggagcc
     4261 cagaagtgtc agttggagcc tcctgatgtg ggtgctggaa actgaactct ggtcctctga
     4321 aagagcagta tatgttctta actgctgagc cagctcttga gcacccattt gcagtgtcca
     4381 tgtttggcat acaagtggtt caccgtacat ggtaaattcc tttttgccct ccccttttct
     4441 atttaatgct aaaaggctag agtaaaagac tatttaaaca tatcaattag cttttacacc
     4501 tggatctctt aacttagatg cacctctatt ggctagcaca gtacagcatc agccttctgc
     4561 ttgttttcca taccatagtc tacatacgaa cgttagtttt agtaaaagag atgtacattt
     4621 tactttggtg cttaatactt tagcaaaagc agagaactac gatagaattt tgtgattata
     4681 attatttttt tgtacctgcc aaaattcact cccattttgg aaagttgtgg ttcgggtact
     4741 tagaacactg tgtccttggt tctgagtgac aaaaggtggg ttttagagac tacaagatat
     4801 ggaaacttgg tttgcattct cgatgtacgt cttcctccca gaatgttttg ttgttgtttg
     4861 gttttggtgg aaaaatggta gaaaatccaa agtcaggttt gttgataaaa gtgtaataaa
     4921 gcagatgaat tacacttaag gctttgtgat aaattgagta tttaagaatt gggttcattt
     4981 taggggccca gataacttgg taaagcagct ttcatatcaa tgtagaatta gaacaaagtc
     5041 accaactgcc agagaataaa gtaatgtgga gagatgaggt tgaggaatga gctgctgaca
     5101 actgttgcag tgtgcagttg cccctcttgt tggtccttgc attttccttt tctaagacat
     5161 agcagtcatt tttagttgag gaactttgct gtaaaacctg acagtatggg ggctggagag
     5221 atggctcagt ggttaagagc accgactgct cttctgaagg tcctgagttc aaatcccaca
     5281 accacctgta atgagatctg acgccctctt ctggtgcatc tgaaaacagc tacagtgtac
     5341 ttagatataa taataaataa atctttaaaa aaatctgaca gta
//
