LOCUS       NM_027116               3101 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus NTPase, KAP family P-loop domain containing 1 (Nkpd1),
            transcript variant 1, mRNA.
ACCESSION   NM_027116 XM_133219 XM_905358
VERSION     NM_027116.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3101)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3101)
  AUTHORS   Pinto,C.S., Jinnah,H.A., Shirley,T.L., Nyhan,W.L. and Seifert,R.
  TITLE     Altered membrane NTPase activity in Lesch-Nyhan disease
            fibroblasts: comparison with HPRT knockout mice and HPRT-deficient
            cell lines
  JOURNAL   J Neurochem 93 (6), 1579-1586 (2005)
   PUBMED   15935074
  REMARK    GeneRIF: altered membrane NTPase activity is a biochemical hallmark
            of HPRT deficiency, but species and cell-type differences have to
            be considered
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149052.3.
            
            [WARNING] On Aug 28, 2024 this sequence was replaced by
            NM_027116.3.
            
            On May 6, 2022 this sequence version replaced NM_027116.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC118925.2 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               AC149052.3         128230-128570       c
            342-432             AC149052.3         127375-127465       c
            433-882             AC149052.3         125945-126394       c
            883-1014            AC149052.3         124131-124262       c
            1015-3101           AC149052.3         121139-123225       c
FEATURES             Location/Qualifiers
     source          1..3101
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.92 cM"
     gene            1..3101
                     /gene="Nkpd1"
                     /gene_synonym="2310015G09Rik"
                     /note="NTPase, KAP family P-loop domain containing 1"
                     /db_xref="GeneID:69547"
                     /db_xref="MGI:MGI:1916797"
     exon            1..341
                     /gene="Nkpd1"
                     /gene_synonym="2310015G09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..2819
                     /gene="Nkpd1"
                     /gene_synonym="2310015G09Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NTPase KAP family P-loop domain-containing protein 1"
                     /codon_start=1
                     /product="NTPase KAP family P-loop domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_081392.1"
                     /db_xref="CCDS:CCDS52059.1"
                     /db_xref="GeneID:69547"
                     /db_xref="MGI:MGI:1916797"
                     /translation="MQKNYNVHFTKNARTPNERYLLDPELGHQKGCCRQWYQDPVATH
                     THGPYQLSPQAHWQQTYHSHRGGSGCRRCPQPLIPQRQRRQQQQRQPPPLPPSPLRQR
                     LGPVRGAQKGSPAIAAARMEPASAPKPVTSTPTAVSATASSGPALPSAAGALLEPSEP
                     TEARPLPAPAACGSFTSYGADILTEDDVYCSCLAKTLCHVPVPVTVGFYAPFGCRLHL
                     MLDKIMTLMQQEAAQRESEELQRVQWQPRRVRGWGVPKLLWFLVFLQPVITELHLRRR
                     NVRFLFIRFSAWQYAGTDKLWAGLVTTLCEGIRHHYGALPFSVYSVLGNKPCGPRDGL
                     CQREWHCRRRVCLALLALLAALCLGVGLLYLSLGGHAPGHGERGVLKALGGAATTLSG
                     SGLLMAVYSVGKHLFVSQRKKIERLVSREKFGSQLGFMCEVKKEVELLTDFLCFLEIY
                     QRRRLRVVLEVTGLDTCYPERVVGVLNAINTLLSDSHAPFIFILVVDPSILAACLESA
                     GNMKGTADNGYLFLNRTVTLPFSVPIMGRRTKLQFLHDAVRSRDDLLFRELTIKLQPQ
                     SPGNLGAGEGTQLLAVETQGDAERTQGRVDAEAARRIQEALCCLHDEGDCLYEYVPDN
                     VVSMRRIVNTVPITVRLLQQQQQQQPDRVGPTPRHAVAWVVLANQWPCRLSWVLQCLE
                     DRQQAGGAPEGRSRLWDVFCDNSRELHTMTKALQNVLDLDGDPELFERFLGTDFPFTV
                     AEAQSLLRCTVNLDHSIRRRMGLIRAVSALKPPSPPKSPSQDGPQASPRAIIAAGTSH
                     AGQGSGHSKEAHQTRDRTHGGKPRPMA"
     exon            342..432
                     /gene="Nkpd1"
                     /gene_synonym="2310015G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            433..882
                     /gene="Nkpd1"
                     /gene_synonym="2310015G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1014
                     /gene="Nkpd1"
                     /gene_synonym="2310015G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..3101
                     /gene="Nkpd1"
                     /gene_synonym="2310015G09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3078..3083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkpd1"
                     /gene_synonym="2310015G09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3101
                     /gene="Nkpd1"
                     /gene_synonym="2310015G09Rik"
                     /note="major polyA site"
ORIGIN      
        1 agcaatgagg aagctgaggc tcagagagat gaagtcactg acccacagtc acacagctgg
       61 gtgacagagg aactcgcaga ccgggtctat ttgagattca ttctgcctcc acccaacccg
      121 aagaggtgcc cagaaatctg gtgtgagggt tgctgtggac tctccacccc ctcctgggtt
      181 catcctgtca ggggcatcca gtcctcgaga gcagcatccc gggcgcctgc ccaaagggcg
      241 gggacacacg caggagaacc ggccgagcgg gcgccactgg gctccagcca ggcctgcgcg
      301 gggccacggg cagggagctg gggccgcggg gccaccacca gatgcagaag aactacaatg
      361 tgcacttcac caagaacgcc cggaccccca atgaacgata ccttttggat cccgagttgg
      421 ggcaccaaaa aggatgctgc cgtcagtggt accaggaccc ggtggccact cacacccatg
      481 ggccctatca gctgtccccc caggctcact ggcagcagac ctaccatagc caccgaggtg
      541 gcagcggctg tcgccggtgt ccccagcccc tcattccgca gcgacagcgg cggcagcagc
      601 agcagcgaca acccccaccc ctacctccca gccctctgcg gcagcggctc ggtccagttc
      661 gcggggccca gaaggggtca cccgcgatcg ccgctgcccg catggaacca gccagcgccc
      721 ccaagcctgt cacctccaca cccaccgcag tatcagccac ggccagcagc ggcccagccc
      781 taccctctgc agccggcgcc ctcctggagc ccagcgagcc caccgaggcg cggccactgc
      841 ctgcaccggc agcctgcggc tccttcacct cctacggcgc cgacatcctg acagaggatg
      901 atgtctactg cagctgtctg gctaaaactc tgtgtcacgt gcccgtccct gtgacggtgg
      961 gtttctacgc tcccttcggc tgccgtcttc acttgatgtt ggataaaatc atgacgctga
     1021 tgcagcagga ggccgcgcag cgtgagagcg aggagctgca gcgcgtgcag tggcagccac
     1081 gtcgcgtgcg cggctggggc gtcccgaagc tgctgtggtt cctggtgttt ctgcagcccg
     1141 tgatcacgga gctgcacctg cggcgcagga atgtgcgctt cctgttcatc cgcttcagcg
     1201 cctggcagta cgcgggcacc gacaagctgt gggccgggct ggtgaccacg ctgtgtgagg
     1261 gcatccgcca ccactacggc gcgctgccct ttagcgtgta ctcggtgcta ggcaacaagc
     1321 cctgtggccc gcgtgatggc ctctgccaac gcgagtggca ctgccgacgt cgcgtgtgcc
     1381 tggcgctgct ggcgctgctg gccgcgctgt gcctgggtgt ggggctgctg tacctgtcgc
     1441 tgggaggcca cgcgccgggc cacggagagc gtggtgtgct caaagcgctg ggcggcgcgg
     1501 ccaccacgct atccggctca gggctgctca tggccgtgta ctccgtgggc aagcatctgt
     1561 tcgtgagcca gcgcaagaag atcgagcgcc tggtgtcgcg tgagaagttt ggcagccagt
     1621 tgggcttcat gtgcgaggtg aagaaggagg tggaactgct cacggatttc ctgtgcttcc
     1681 tggagatcta ccagcgacgc cggctgcgtg tggtcctcga ggtcactggg ttggacacgt
     1741 gctacccaga gcgcgtggtg ggcgtcctaa acgccatcaa cactctgctg tccgacagcc
     1801 acgctccctt catcttcatc ctggtggtgg accccagcat tctggccgcg tgcctggaga
     1861 gcgcgggtaa catgaagggc acagcagaca acggctacct gttcctcaac cgcacagtca
     1921 cgctaccctt ctccgtgccg attatgggcc gtcgcaccaa gttgcagttc ctgcacgatg
     1981 cggtgcgtag ccgggacgat ctgctgttcc gggaattgac gatcaagcta cagccgcaga
     2041 gccccgggaa cttgggcgca ggtgagggta ctcagctgct ggcggtggag acgcaggggg
     2101 acgccgagcg cacacagggc cgcgtggacg cggaggcggc gcggcgtatc caggaggcgc
     2161 tgtgctgcct gcatgacgag ggtgattgcc tgtatgagta cgtgcccgac aacgtggtgt
     2221 ccatgcggcg cattgtcaac acggtgccca tcaccgtgcg cctgttgcag cagcagcagc
     2281 agcaacagcc cgaccgcgtg ggacccacac cgcgccacgc ggtggcctgg gtcgtcctcg
     2341 ctaaccagtg gccttgtcgc ctcagctggg tgctgcaatg cctggaggac cggcagcagg
     2401 cagggggcgc gccagagggg cgctcgcgtc tctgggatgt cttctgcgac aatagtcgcg
     2461 agctgcacac catgaccaag gccttgcaga acgtactgga cctggatggc gaccctgagc
     2521 tttttgagcg ctttctaggc actgatttcc ccttcaccgt ggccgaggcg cagagtttgc
     2581 tgcgctgcac agtcaacctg gaccattcca tccgccgccg catgggcctc atcagggccg
     2641 tcagcgcgct caagccgccc agcccaccca agtccccatc ccaggacggt ccccaggcca
     2701 gtcccagagc cattatcgcc gcaggcacgt cccatgcggg ccaaggatca ggacacagta
     2761 aagaggcaca tcagacccgg gaccggaccc atgggggcaa gccaaggccg atggcctaag
     2821 tccttaaatt tcaggagcgt agaggctgtt tgggtgtggg atggagaaca ccagccacgg
     2881 gagacagcaa catccctcct gacctgatga gggtgtgagg gcaagagggg ctcaaaacca
     2941 atggggtatg gccacacacc ctgatgactt tggaagccaa ggggaagcag gtactactag
     3001 cttcctggag taggcagctt ctacaccagt gtctgagtga gcagaggagt cagtgaggaa
     3061 cacagagtca aagaagcaat aaaggaagct gtggaaagcc a
//
