LOCUS       NM_028024               2013 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus NFKB inhibitor interacting Ras-like protein 2
            (Nkiras2), mRNA.
ACCESSION   NM_028024
VERSION     NM_028024.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2013)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2013)
  AUTHORS   Postler,T.S., Wang,A., Brundu,F.G., Wang,P., Wu,Z., Butler,K.E.,
            Grinberg-Bleyer,Y., Krishnareddy,S., Lagana,S.M., Saqi,A.,
            Oeckinghaus,A., Rabadan,R. and Ghosh,S.
  TITLE     A pan-cancer analysis implicates human NKIRAS1 as a
            tumor-suppressor gene
  JOURNAL   Proc Natl Acad Sci U S A 120 (46), e2312595120 (2023)
   PUBMED   37931099
REFERENCE   3  (bases 1 to 2013)
  AUTHORS   Tago,K., Ohta,S., Aoki-Ohmura,C., Funakoshi-Tago,M., Sashikawa,M.,
            Matsui,T., Miyamoto,Y., Wada,T., Oshio,T., Komine,M., Matsugi,J.,
            Furukawa,Y., Ohtsuki,M., Yamauchi,J. and Yanagisawa,K.
  TITLE     K15 promoter-driven enforced expression of NKIRAS exhibits tumor
            suppressive activity against the development of DMBA/TPA-induced
            skin tumors
  JOURNAL   Sci Rep 11 (1), 20658 (2021)
   PUBMED   34667224
  REMARK    GeneRIF: K15 promoter-driven enforced expression of NKIRAS exhibits
            tumor suppressive activity against the development of
            DMBA/TPA-induced skin tumors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2013)
  AUTHORS   Beel,S., Kolloch,L., Apken,L.H., Jurgens,L., Bolle,A., Sudhof,N.,
            Ghosh,S., Wardelmann,E., Meisterernst,M., Steinestel,K. and
            Oeckinghaus,A.
  TITLE     kappaB-Ras and Ral GTPases regulate acinar to ductal metaplasia
            during pancreatic adenocarcinoma development and pancreatitis
  JOURNAL   Nat Commun 11 (1), 3409 (2020)
   PUBMED   32641778
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2013)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2013)
  AUTHORS   Oeckinghaus,A., Postler,T.S., Rao,P., Schmitt,H., Schmitt,V.,
            Grinberg-Bleyer,Y., Kuhn,L.I., Gruber,C.W., Lienhard,G.E. and
            Ghosh,S.
  TITLE     kappaB-Ras proteins regulate both NF-kappaB-dependent inflammation
            and Ral-dependent proliferation
  JOURNAL   Cell Rep 8 (6), 1793-1807 (2014)
   PUBMED   25220458
REFERENCE   7  (bases 1 to 2013)
  AUTHORS   Tago,K., Funakoshi-Tago,M., Sakinawa,M., Mizuno,N. and Itoh,H.
  TITLE     KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits
            NF-kappaB activation through the suppression of transcriptional
            activation of p65/RelA
  JOURNAL   J Biol Chem 285 (40), 30622-30633 (2010)
   PUBMED   20639196
  REMARK    GeneRIF: KappaB-Ras2 is a nuclear-cytoplasmic small GTPase that
            inhibits NF-kappaB activation through the suppression of
            transcriptional activation of p65/RelA.
REFERENCE   8  (bases 1 to 2013)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   9  (bases 1 to 2013)
  AUTHORS   Hertlein,E., Wang,J., Ladner,K.J., Bakkar,N. and Guttridge,D.C.
  TITLE     RelA/p65 regulation of IkappaBbeta
  JOURNAL   Mol Cell Biol 25 (12), 4956-4968 (2005)
   PUBMED   15923614
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL591469.9.
            
            On Nov 17, 2006 this sequence version replaced NM_028024.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010371.1, AK083475.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AL591469.9         33870-33923
            55-162              AL591469.9         35107-35214
            163-404             AL591469.9         35858-36099
            405-2013            AL591469.9         36909-38517
FEATURES             Location/Qualifiers
     source          1..2013
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.47 cM"
     gene            1..2013
                     /gene="Nkiras2"
                     /gene_synonym="2410003M04Rik; 4930527H08Rik;
                     D630018G21Rik; KBRAS2"
                     /note="NFKB inhibitor interacting Ras-like protein 2"
                     /db_xref="GeneID:71966"
                     /db_xref="MGI:MGI:1919216"
     exon            1..54
                     /gene="Nkiras2"
                     /gene_synonym="2410003M04Rik; 4930527H08Rik;
                     D630018G21Rik; KBRAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            55..162
                     /gene="Nkiras2"
                     /gene_synonym="2410003M04Rik; 4930527H08Rik;
                     D630018G21Rik; KBRAS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..644
                     /gene="Nkiras2"
                     /gene_synonym="2410003M04Rik; 4930527H08Rik;
                     D630018G21Rik; KBRAS2"
                     /note="I-kappa-B-interacting Ras-like protein 2;
                     kappaB-Ras2; kappa B-Ras protein 2"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor-interacting Ras-like
                     protein 2"
                     /protein_id="NP_082300.1"
                     /db_xref="CCDS:CCDS25429.1"
                     /db_xref="GeneID:71966"
                     /db_xref="MGI:MGI:1919216"
                     /translation="MGKSCKVVVCGQASVGKTSILEQLLYGNHVVGSEMIETQEDIYV
                     GSIETDRGVREQVRFYDTRGLRDGAELPKHCFSCTDGYVLVYSTDSRESFQRVELLKK
                     EIDKSKDKKEVTIVVLGNKCDLQEQRRVDPDVAQHWAKSEKVKLWEVSVADRRSLLEP
                     FIYLASKMTQPQSKSAFPLSRKNKGSGSLDG"
     exon            163..404
                     /gene="Nkiras2"
                     /gene_synonym="2410003M04Rik; 4930527H08Rik;
                     D630018G21Rik; KBRAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            405..2013
                     /gene="Nkiras2"
                     /gene_synonym="2410003M04Rik; 4930527H08Rik;
                     D630018G21Rik; KBRAS2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtccggccc actccggggg gcacctcagc gggagtgctg cggggacccg ggaggttgaa
       61 agctaagcat ggggaagagc tgcaaggtgg tcgtgtgcgg ccaggcatct gtgggcaaaa
      121 cttcaatcct tgagcagctt ctgtacggga accatgtcgt gggttctgag atgatcgaga
      181 cccaggagga catctatgta ggctccatcg agacagaccg aggggtgcgg gagcaggtgc
      241 gtttctatga tacacggggt ctccgggatg gggccgagct gcccaagcac tgcttctcct
      301 gcaccgatgg ctacgtcctg gtctacagca cagacagccg agagtcgttc cagcgcgtcg
      361 agctgctcaa gaaggagatc gacaagtcca aggacaagaa ggaggtcacc atcgtggtcc
      421 ttggcaacaa gtgtgacctg caggagcagc gtcgcgtaga ccctgacgtg gcccagcact
      481 gggccaagtc cgagaaggtg aagctatggg aggtgtcggt ggctgaccga cgctccctcc
      541 tagagccttt catctacctg gccagcaaga tgacccagcc gcagagcaag tctgccttcc
      601 ccctcagccg caagaacaag ggcagcggct ccttggatgg ctgaatagct gcccttcttg
      661 cttcaccatt ccaagcccat tccgggatgg gtggcgagca cagggtgcat aagcaagctg
      721 ttcttcccag tcggtagggg agtgaccctc taggacagga agctgggctg gcccaggcca
      781 gtgccacctt tgtcctctct taactccaag aagtgcaagt gaacttgatt gttggccctc
      841 ccttgacctt ccataatagt tcccacccct cccccagctg accatatttt ctccactgtc
      901 acctagacac ttatgggtta gtgtcccttc catctgcctg gtgcaggaag cagggccgtc
      961 atgccaacgc gcccagtcca ggatctgcct cctatcaggg atcccaactc tgaatttcct
     1021 gccactaaca tacacacagt accagcctta aaacaaaaga ctaggtactg taagcataca
     1081 tttgtgcgag ctggcttagg gttggttcct catcctccac cctgaccttt cctctggcct
     1141 gttcaaggcc tggtaaagtc aggctcctgg gagtggcatt tcctgtttga cctctaccca
     1201 tctcccagtt gtttcacttc ctcttcctgt tccaggagca gaggtcttat tggctgaggt
     1261 agagtggagt gatgactggg ctgtcacatg ccctgagact tagcaagact cttctcccct
     1321 gagcgtcagt cttctcgtat gtgagttgac agaagcttgg atgtcaccta gagccacggg
     1381 tagcgctgtg acttttctaa agctggtggc ttgggcctcc tgtgtgtctt ctgcccctgc
     1441 tccaccctct ttaaggtgct acacctaccg gccctggagg ctggacggcc tctcttaacc
     1501 accagggggc aggggtgcac tctgctcagt gctgcgagcg agcggctgtc tattaacctg
     1561 cccaacaggg tagtgtccat ccctcctggt tggttttggc tagtagctgg actttatatt
     1621 tatactctct ctgtatttat gcacctgctg ctctggtgaa ggtgggataa gccgcgcccc
     1681 cagcccttct ttcttacctc agatgcctga agagaaccag gcagcccagt agcagcttcc
     1741 caggagctga caagccttcc atcagaggct tgtgctatca agtgagctta tcacccacaa
     1801 cctgcggtgc ccactccgtg cttctgatgt gcacacctca cacgggttaa acactatggc
     1861 caggccacct ccaataccct ctcctcctcc tagaacaggc gagggggggc tggtgcccag
     1921 gcctgggcaa ggagagtctg ggcacctaca ggctcaggct tgaagttcat ttattgatgt
     1981 gttggacaca ataaaaccac aactgctatt atc
//
