LOCUS       NM_023526               4610 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus NFKB inhibitor interacting Ras-like protein 1
            (Nkiras1), transcript variant 1, mRNA.
ACCESSION   NM_023526
VERSION     NM_023526.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4610)
  AUTHORS   Postler,T.S., Wang,A., Brundu,F.G., Wang,P., Wu,Z., Butler,K.E.,
            Grinberg-Bleyer,Y., Krishnareddy,S., Lagana,S.M., Saqi,A.,
            Oeckinghaus,A., Rabadan,R. and Ghosh,S.
  TITLE     A pan-cancer analysis implicates human NKIRAS1 as a
            tumor-suppressor gene
  JOURNAL   Proc Natl Acad Sci U S A 120 (46), e2312595120 (2023)
   PUBMED   37931099
REFERENCE   2  (bases 1 to 4610)
  AUTHORS   Beel,S., Kolloch,L., Apken,L.H., Jurgens,L., Bolle,A., Sudhof,N.,
            Ghosh,S., Wardelmann,E., Meisterernst,M., Steinestel,K. and
            Oeckinghaus,A.
  TITLE     kappaB-Ras and Ral GTPases regulate acinar to ductal metaplasia
            during pancreatic adenocarcinoma development and pancreatitis
  JOURNAL   Nat Commun 11 (1), 3409 (2020)
   PUBMED   32641778
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4610)
  AUTHORS   Oeckinghaus,A., Postler,T.S., Rao,P., Schmitt,H., Schmitt,V.,
            Grinberg-Bleyer,Y., Kuhn,L.I., Gruber,C.W., Lienhard,G.E. and
            Ghosh,S.
  TITLE     kappaB-Ras proteins regulate both NF-kappaB-dependent inflammation
            and Ral-dependent proliferation
  JOURNAL   Cell Rep 8 (6), 1793-1807 (2014)
   PUBMED   25220458
REFERENCE   4  (bases 1 to 4610)
  AUTHORS   Hertlein,E., Wang,J., Ladner,K.J., Bakkar,N. and Guttridge,D.C.
  TITLE     RelA/p65 regulation of IkappaBbeta
  JOURNAL   Mol Cell Biol 25 (12), 4956-4968 (2005)
   PUBMED   15923614
REFERENCE   5  (bases 1 to 4610)
  AUTHORS   Yang,Y. and Seed,B.
  TITLE     Site-specific gene targeting in mouse embryonic stem cells with
            intact bacterial artificial chromosomes
  JOURNAL   Nat Biotechnol 21 (4), 447-451 (2003)
   PUBMED   12627171
REFERENCE   6  (bases 1 to 4610)
  AUTHORS   Fenwick,C., Na,S.Y., Voll,R.E., Zhong,H., Im,S.Y., Lee,J.W. and
            Ghosh,S.
  TITLE     A subclass of Ras proteins that regulate the degradation of IkappaB
  JOURNAL   Science 287 (5454), 869-873 (2000)
   PUBMED   10657303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY332128.1, AK028539.1, AC154489.2, BC054390.1 and AW490494.1.
            
            On Oct 24, 2015 this sequence version replaced NM_023526.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148040.1, AK028539.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BY332128.1         1-20
            21-1345             AK028539.1         3-1327
            1346-1346           AC154489.2         33647-33647
            1347-2546           AK028539.1         1329-2528
            2547-4534           BC054390.1         315-2302
            4535-4610           AW490494.1         1-76                c
FEATURES             Location/Qualifiers
     source          1..4610
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 7.08 cM"
     gene            1..4610
                     /gene="Nkiras1"
                     /gene_synonym="2400004O09Rik; kappaB-Ras1; KBRAS1"
                     /note="NFKB inhibitor interacting Ras-like protein 1"
                     /db_xref="GeneID:69721"
                     /db_xref="MGI:MGI:1916971"
     exon            1..188
                     /gene="Nkiras1"
                     /gene_synonym="2400004O09Rik; kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            189..299
                     /gene="Nkiras1"
                     /gene_synonym="2400004O09Rik; kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..784
                     /gene="Nkiras1"
                     /gene_synonym="2400004O09Rik; kappaB-Ras1; KBRAS1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     I-kappa-B-interacting Ras-like protein 1; NF-kappa-B
                     inhibitor-interacting Ras-like protein 1; kappa B-Ras
                     protein 1"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor-interacting Ras-like
                     protein 1 isoform 1"
                     /protein_id="NP_076015.2"
                     /db_xref="CCDS:CCDS26836.1"
                     /db_xref="GeneID:69721"
                     /db_xref="MGI:MGI:1916971"
                     /translation="MGKGCKVVICGLLSVGKTAILEQLLYGNHTIGMEDCETLEDVYM
                     ASVETDRGVKEQLHLYDTRGLQKGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKK
                     EIDKFKDKKEVAIVVLGNKLDLSEQRQVDADVAQQWARSEKVKLWEVTVTDRRTLIEP
                     FTLLASKLSQPQSKSSFPLPGRKNKGNSNPEN"
     exon            300..541
                     /gene="Nkiras1"
                     /gene_synonym="2400004O09Rik; kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            542..4598
                     /gene="Nkiras1"
                     /gene_synonym="2400004O09Rik; kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1014..1019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkiras1"
                     /gene_synonym="2400004O09Rik; kappaB-Ras1; KBRAS1"
                     /note="hexamer: AATAAA"
     polyA_site      1047
                     /gene="Nkiras1"
                     /gene_synonym="2400004O09Rik; kappaB-Ras1; KBRAS1"
                     /note="major polyA site"
     regulatory      4513..4518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkiras1"
                     /gene_synonym="2400004O09Rik; kappaB-Ras1; KBRAS1"
                     /note="hexamer: AATAAA"
     polyA_site      4534
                     /gene="Nkiras1"
                     /gene_synonym="2400004O09Rik; kappaB-Ras1; KBRAS1"
                     /note="major polyA site"
ORIGIN      
        1 gcttccggat gctctcccaa gctctcagca gtgctcctga gctgccaagg ctgcggaaag
       61 tgagaggcgg cgagtttgct tacgtcacgt caaggggccg gaggaagcag gtcggggacc
      121 ggctccagag ggacgccttc ggaccgcggt gacctgcgtg ctgctgtctc actgccctgc
      181 agtgtcagtg ctgccctagg agaagatggg gaagggttgc aaggttgtca tttgtgggtt
      241 gctgtctgtt gggaaaactg caattttgga gcaactcctt tatgggaatc acactattgg
      301 gatggaagac tgtgaaacgc tggaagacgt gtacatggca tctgtagaga cagaccgtgg
      361 ggtgaaggag cagctgcact tgtatgacac ccgaggcctg cagaaaggcg tggagctgcc
      421 aaagcattac ttctcatttg ctgatggctt tgttcttgtg tatagtgtga ataaccttga
      481 gtccttccaa agagtggagc ttctgaagaa agagattgat aagttcaaag acaaaaagga
      541 ggtggcaatc gttgtgttag gaaacaaact ggacctttct gagcagagac aggtggatgc
      601 tgacgtggca caacagtggg caagaagtga gaaagtcaag ctgtgggagg tgacagtgac
      661 agaccggagg acactgattg aacccttcac tttactggcc agcaagcttt ctcagcccca
      721 gagcaaatcc agcttccctt tgcctgggag gaaaaacaaa gggaactcca atcccgaaaa
      781 ctgagtcaag ccttgaaatg tctgtagcct ggcatgaggt tacgatttaa cgtggccctt
      841 ctcagatcac ctctgggcct aatggaaccc ctaagtggta atttaatgca ctttctaatt
      901 aagttaatta ctttataatt aacctagttt attgctgttg gacattattt tttgccttta
      961 tttgaaacct gttcttattt tgttatttat tctgcacttg tcaataatag caaaataaaa
     1021 tttagagtat gcaatatacc atgggaactc ttccagcttg tcaggactct catactcatt
     1081 gtaattttat gcaaatgcct tatccttcca taaacgcatg aataacaggg gtggctgggc
     1141 tcgcttggca aagcgccttc cccactgagt cacaggccca gaactcttgt cttacacaga
     1201 gctagagaga ttgctcagca ggtaaggccg acgccttgca gaacttgtag cacctttaac
     1261 agattccaag ggatccagtg tcttctcttg gtttcttcag gcatttcata cacttagtgc
     1321 tcatatatac aagcagagaa aatcactcat acacatagaa taatatctaa ggttaatcat
     1381 ctaagattat agagcttggc aattgctttg tgtacttaaa ttgtcccaat aacaatctgg
     1441 atctctaaat tctcatttta cagaggcttt gctgaacaga acaagagtgg tggttttgtt
     1501 ttgctctatt aagtattaag atcttagggt taggacgagg tgcttttgta ttcagcgccc
     1561 tgattttatt ctataagcta ggcctgtgct ggtgataaaa ttaaatacta gagggtcttt
     1621 tgaaaatggc taggctggag aacagggaaa catccctttt cttctaataa ccttgccata
     1681 tacaataaaa tgccagaaat agagttacca ttagttttcc atattaatct gagtttacaa
     1741 tttaatttat ggaaaatctt ttaaaaaaga ttgccaaccc tatacaaaga actaggaaat
     1801 aagttgttta gtgttttcaa ctgtaaataa tctttaacca tttaactgaa aagcaaaata
     1861 tgaaacaagg taaagaatgc attaagtacg gaaccttcct tcaaccatga gcattgctgc
     1921 tgcttgcttt tctgttggta ctgtagactg aactcaagct gtatcattag cctttttaag
     1981 gaagggtttg tttgtttatt ggcttttcga gacagggttt ttccctgtag ctctggctgt
     2041 cctggaactc attctggcct tgaactcagg aatcagcctg cctctgcctc ccaagtgctg
     2101 ggattaaagg tgtgtgccac cactgccggg cgagaaaggg tcttaataaa ttacccaggc
     2161 tttgaacttg gaatctttgt gcccagacac cctgaatact gggactacag ccacccggtt
     2221 tgcccttcat cccactaaac actggctggt tggaactatg tagaccaggc tagccttgat
     2281 ctcaagtcct cctcagctgg gattaaagtt ctgtaccatt atacacagtc ttggccaatt
     2341 ctttttttaa aaaaacatac ttttttggtt atctctcagg ttaagtcagc ccgcccttcc
     2401 aggtactttt ctctcagctt tgtcttctga tatattttat atagatcctg cctggtgttt
     2461 ctgttttttc ttttggctgc atttagatct tgtgctttaa tatacgtgga attgtttatg
     2521 taattaaaat gctttttgag actgggtgtc atgtagccta ggctagtctc aaacccagtg
     2581 tgtagctgag gatgactctg aactttaatc ctctggcatc caatcaccct gggatgaagg
     2641 tgtgtgaatg ctactatgct cagcgttcac ttgactgagg ctggagccat agccagcagc
     2701 agtgctactg agtcactgag cctgctctgc aagatgagca ccagctcacc agagtggctc
     2761 atttctcctg tgtctgctgc cacttcatct gcagatcaga aaatgctttg agcaacaggc
     2821 attgagtata tctttgacgc tttagctggc ttacactgtt ttgttttttg agacagggtt
     2881 tctttgtgta gccctggctg tcctggaact cactttgtag accaggctgg ccttgaactc
     2941 agaaatccac ttgcctctgc ctcccaagcc tgggattaaa ggcgtgcacc accactgcct
     3001 ggctgtttat tgtttttaag atatctccag ggggctaaag agatggctca ggggttaaga
     3061 gcactgacta cttcttccag aggtcctgag ttcaatggcc agcaaccaca accatcttta
     3121 aaggatctga tgccctcttc tggtgtgtct gaagacagct acagtatctt tatttataca
     3181 cataaataaa gtcataaaaa gacatctcca aaatgtgctg tgtaagtatc agctctggca
     3241 tatattaagt gataagtatt ccttaacctg ctttcagaag caaagactgc agagaggaaa
     3301 tgaacacagc agggtcagta gttgttctta atattgttta ttagcacaaa tgcagacgta
     3361 agaagtctaa accaattgac tgaacaattc ctattccaca cttacagtta acagcttaag
     3421 gtatttcact acaggtttcc acaaattgtg attcaaccct tgaagtaatt tgcatataag
     3481 ataaaataca ttaactacat ggtgtcttgt agccaggtgt ccattttaca tatacgaggt
     3541 aacaaactca tctttgcaaa cttgttaaat accattgttt ccttttaaga aggaaaaaca
     3601 aattccattt tttttgaaca agaaaatagg actttacata aatgacatgt acctatacaa
     3661 atttaagctg atcaatggaa cacaagtatc tacacatgct ttcttttgta ctaaaagtca
     3721 gctaatcttg caaagtttca gctctaaaag tcgctattac cagtttgtct actgtagcaa
     3781 gataccttaa gttacaacaa aatcctggga agtaagactg aataatatct gatatagaaa
     3841 tagcctactc tttaccaact cccaccccca ccctttcaaa atcataagca gctctcttct
     3901 gtgacagaca agtcatgtaa gaactgaaaa cccagtttat gtagcgtatc tcttggtcca
     3961 ctgtctggcc attctgtcgt gttctgctct gttggtcatg tactgagtgg caatacttcc
     4021 caccaaaggg tcagctggaa gaaaaacatg tatgttactt tggagaaaga aaatcagata
     4081 ctttgcccat gtctgaaaca ctcactgtca gaaggtgttt tcttctaatc tttaaaaaca
     4141 gtttttaaaa aggtttattt tatgtttttg ggtactctgt ttgcaggtta tggatgtggg
     4201 cccctagtgg gtgctggaag ctgaacccct ctgcaagaac acttgctctt cagctgggcc
     4261 actgttttag cccttcatct aatcttatct agaagggtgg gaggagtggc cttggcttca
     4321 ttttcttatt ctactttagt tctctctcaa caagtgacac tctttgttct ccatgtgtat
     4381 gaccaaggct ccaagaccaa ctttgttcaa ccaattagag ctgtagatat tgggaagtct
     4441 ctctggctgg tgcaattggc agtatctatt gtataatgta tacctagaaa aggccaaaaa
     4501 cccagacttc caaataaatg tgtttctctg aaaatggaat gcctagttaa atttgtatat
     4561 ttaagcagaa aaataaataa tttctttctt tttaaaaaaa aaaaaaaaaa
//
