LOCUS       NM_024253                813 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus natural killer cell group 7 sequence (Nkg7), mRNA.
ACCESSION   NM_024253
VERSION     NM_024253.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 813)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 813)
  AUTHORS   Lelliott,E.J., Ramsbottom,K.M., Dowling,M.R., Shembrey,C.,
            Noori,T., Kearney,C.J., Michie,J., Parish,I.A., Jordan,M.A.,
            Baxter,A.G., Young,N.D., Brennan,A.J. and Oliaro,J.
  TITLE     NKG7 Enhances CD8+ T Cell Synapse Efficiency to Limit Inflammation
  JOURNAL   Front Immunol 13, 931630 (2022)
   PUBMED   35874669
  REMARK    GeneRIF: NKG7 Enhances CD8+ T Cell Synapse Efficiency to Limit
            Inflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 813)
  AUTHORS   Li,X.Y., Corvino,D., Nowlan,B., Aguilera,A.R., Ng,S.S., Braun,M.,
            Cillo,A.R., Bald,T., Smyth,M.J. and Engwerda,C.R.
  TITLE     NKG7 Is Required for Optimal Antitumor T-cell Immunity
  JOURNAL   Cancer Immunol Res 10 (2), 154-161 (2022)
   PUBMED   35013002
  REMARK    GeneRIF: NKG7 Is Required for Optimal Antitumor T-cell Immunity.
REFERENCE   4  (bases 1 to 813)
  AUTHORS   Morikawa,Y., Murakami,M., Kondo,H., Nemoto,N., Iwabuchi,K. and
            Eshima,K.
  TITLE     Natural Killer Cell Group 7 Sequence in Cytotoxic Cells Optimizes
            Exocytosis of Lytic Granules Essential for the Perforin-Dependent,
            but Not Fas Ligand-Dependent, Cytolytic Pathway
  JOURNAL   Immunohorizons 5 (4), 234-245 (2021)
   PUBMED   33911019
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 813)
  AUTHORS   Ng,S.S., De Labastida Rivera,F., Yan,J., Corvino,D., Das,I.,
            Zhang,P., Kuns,R., Chauhan,S.B., Hou,J., Li,X.Y., Frame,T.C.M.,
            McEnroe,B.A., Moore,E., Na,J., Engel,J.A., Soon,M.S.F., Singh,B.,
            Kueh,A.J., Herold,M.J., Montes de Oca,M., Singh,S.S., Bunn,P.T.,
            Aguilera,A.R., Casey,M., Braun,M., Ghazanfari,N., Wani,S., Wang,Y.,
            Amante,F.H., Edwards,C.L., Haque,A., Dougall,W.C., Singh,O.P.,
            Baxter,A.G., Teng,M.W.L., Loukas,A., Daly,N.L., Cloonan,N.,
            Degli-Esposti,M.A., Uzonna,J., Heath,W.R., Bald,T., Tey,S.K.,
            Nakamura,K., Hill,G.R., Kumar,R., Sundar,S., Smyth,M.J. and
            Engwerda,C.R.
  TITLE     The NK cell granule protein NKG7 regulates cytotoxic granule
            exocytosis and inflammation
  JOURNAL   Nat Immunol 21 (10), 1205-1218 (2020)
   PUBMED   32839608
  REMARK    GeneRIF: The NK cell granule protein NKG7 regulates cytotoxic
            granule exocytosis and inflammation.
            Erratum:[Nat Immunol. 2024 Apr;25(4):716. doi:
            10.1038/s41590-024-01770-8. PMID: 38360937]
REFERENCE   6  (bases 1 to 813)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   7  (bases 1 to 813)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 813)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 813)
  AUTHORS   Angata,T., Margulies,E.H., Green,E.D. and Varki,A.
  TITLE     Large-scale sequencing of the CD33-related Siglec gene cluster in
            five mammalian species reveals rapid evolution by multiple
            mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 101 (36), 13251-13256 (2004)
   PUBMED   15331780
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC149091.3.
            
            On Mar 21, 2007 this sequence version replaced NM_024253.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010872.1, BC055882.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               AC149091.3         236963-237285
            324-470             AC149091.3         237362-237508
            471-605             AC149091.3         237600-237734
            606-813             AC149091.3         237864-238071
FEATURES             Location/Qualifiers
     source          1..813
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.25 cM"
     gene            1..813
                     /gene="Nkg7"
                     /gene_synonym="2500004F03Rik"
                     /note="natural killer cell group 7 sequence"
                     /db_xref="GeneID:72310"
                     /db_xref="MGI:MGI:1931250"
     exon            1..323
                     /gene="Nkg7"
                     /gene_synonym="2500004F03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..664
                     /gene="Nkg7"
                     /gene_synonym="2500004F03Rik"
                     /note="natural killer cell protein 7"
                     /codon_start=1
                     /product="protein NKG7"
                     /protein_id="NP_077215.2"
                     /db_xref="CCDS:CCDS21169.1"
                     /db_xref="GeneID:72310"
                     /db_xref="MGI:MGI:1931250"
                     /translation="MEPCRSLALFAGSLGLTSSLIALTTDFWIVATGPHFSAHSGLWP
                     TSQETQVAGYIHVTQSFCILAVLWGLVSVSFLVLSCIPALSAPGRGPLVSTVMAFSAA
                     LSILVAMAVYTSMRWSQTPFSQVQTFFSWSFYLGWVSFILFLFAGCLSLGAHCRTRRA
                     EYETL"
     exon            324..470
                     /gene="Nkg7"
                     /gene_synonym="2500004F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            471..605
                     /gene="Nkg7"
                     /gene_synonym="2500004F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            606..813
                     /gene="Nkg7"
                     /gene_synonym="2500004F03Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagatcaga cagaggactc ctggacaaag ccgctgcttg ctagctgctt ctctggctca
       61 gaagacgagg aattcgggtg catggccttt ttctttttct aagagccaac agtctgggtc
      121 atctgtgtct ttgtccccta agaagtggaa acccagagct gtgtccatgg agccctgccg
      181 gtccctggcc ctgtttgctg gctctctggg cctgacttct tctctgattg ctctgaccac
      241 tgatttctgg atagtggcca caggtcctca cttctctgcc cactctggcc tctggccaac
      301 aagccaagag actcaagtag caggttatat ccatgtgaca cagagcttct gtatcctggc
      361 tgtcctgtgg ggcctggtgt ctgtgagctt cctggttctg tcttgcatcc cagccctgtc
      421 tgctcccggc cgtggccctc tggtctcaac tgtcatggct ttttctgcag ctctctccat
      481 attagtggct atggcagtgt acaccagtat gagatggagc cagactccat tttctcaagt
      541 ccagacattc ttctcctggt ccttctacct aggctgggtc tccttcatcc tcttcctctt
      601 tgcaggctgc ctgagcctgg gtgctcactg tagaacccgt cgggctgagt atgaaacctt
      661 gtgaacagca gccaaggaca gcagggtcat caggatgttt ggagcctgtc ctctcaggag
      721 ctacaaaagg aatgcagaat tctgtctctg tccctcccac cttgccttat ccttcattgg
      781 tttcttcaca cactcaataa agaagcatgc ttg
//
