LOCUS       NM_028186               4016 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus naked cuticle 2 (Nkd2), transcript variant 1, mRNA.
ACCESSION   NM_028186
VERSION     NM_028186.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4016)
  AUTHORS   de Lemos,L., Dias,A., Novoa,A. and Mallo,M.
  TITLE     Epha1 is a cell-surface marker for the neuromesodermal competent
            population
  JOURNAL   Development 149 (6) (2022)
   PUBMED   35299237
REFERENCE   2  (bases 1 to 4016)
  AUTHORS   Perera,S.N., Williams,R.M., Lyne,R., Stubbs,O., Buehler,D.P.,
            Sauka-Spengler,T., Noda,M., Micklem,G., Southard-Smith,E.M. and
            Baker,C.V.H.
  TITLE     Insights into olfactory ensheathing cell development from a
            laser-microdissection and transcriptome-profiling approach
  JOURNAL   Glia 68 (12), 2550-2584 (2020)
   PUBMED   32857879
REFERENCE   3  (bases 1 to 4016)
  AUTHORS   Hauser,B.R., Aure,M.H., Kelly,M.C., Hoffman,M.P. and Chibly,A.M.
  CONSRTM   Genomics and Computational Biology Core
  TITLE     Generation of a Single-Cell RNAseq Atlas of Murine Salivary Gland
            Development
  JOURNAL   iScience 23 (12), 101838 (2020)
   PUBMED   33305192
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4016)
  AUTHORS   Pan,X., Karner,C.M. and Carroll,T.J.
  TITLE     Myc cooperates with beta-catenin to drive gene expression in
            nephron progenitor cells
  JOURNAL   Development 144 (22), 4173-4182 (2017)
   PUBMED   28993399
REFERENCE   5  (bases 1 to 4016)
  AUTHORS   Ajima,R., Bisson,J.A., Helt,J.C., Nakaya,M.A., Habas,R.,
            Tessarollo,L., He,X., Morrisey,E.E., Yamaguchi,T.P. and Cohen,E.D.
  TITLE     DAAM1 and DAAM2 are co-required for myocardial maturation and
            sarcomere assembly
  JOURNAL   Dev Biol 408 (1), 126-139 (2015)
   PUBMED   26526197
REFERENCE   6  (bases 1 to 4016)
  AUTHORS   Lei,H., Juan,A.H., Kim,M.S. and Ruddle,F.H.
  TITLE     Mouse naked cuticle 2 (mNkd2) as a direct transcriptional target of
            Hoxc8 in vivo
  JOURNAL   J Exp Zool A Ecol Genet Physiol 307 (1), 1-6 (2007)
   PUBMED   17094106
  REMARK    GeneRIF: Mouse naked cuticle 2 (mNkd2) is a direct transcriptional
            target of Hoxc8 in vivo.
REFERENCE   7  (bases 1 to 4016)
  AUTHORS   Kurek,D., Garinis,G.A., van Doorninck,J.H., van der Wees,J. and
            Grosveld,F.G.
  TITLE     Transcriptome and phenotypic analysis reveals Gata3-dependent
            signalling pathways in murine hair follicles
  JOURNAL   Development 134 (2), 261-272 (2007)
   PUBMED   17151017
REFERENCE   8  (bases 1 to 4016)
  AUTHORS   Li,Q., Ishikawa,T.O., Miyoshi,H., Oshima,M. and Taketo,M.M.
  TITLE     A targeted mutation of Nkd1 impairs mouse spermatogenesis
  JOURNAL   J Biol Chem 280 (4), 2831-2839 (2005)
   PUBMED   15546883
REFERENCE   9  (bases 1 to 4016)
  AUTHORS   Ishikawa,A., Kitajima,S., Takahashi,Y., Kokubo,H., Kanno,J.,
            Inoue,T. and Saga,Y.
  TITLE     Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression
            in the PSM under the control of Notch signaling
  JOURNAL   Mech Dev 121 (12), 1443-1453 (2004)
   PUBMED   15511637
REFERENCE   10 (bases 1 to 4016)
  AUTHORS   Wharton,K.A. Jr., Zimmermann,G., Rousset,R. and Scott,M.P.
  TITLE     Vertebrate proteins related to Drosophila Naked Cuticle bind
            Dishevelled and antagonize Wnt signaling
  JOURNAL   Dev Biol 234 (1), 93-106 (2001)
   PUBMED   11356022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY087192.1, AK146667.1, CT030152.4 and AW124327.1.
            
            On Nov 30, 2016 this sequence version replaced NM_028186.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146667.1, AK158350.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BY087192.1         2-20
            20-2164             AK146667.1         2-2146
            2165-3792           CT030152.4         96645-98272         c
            3793-4016           AW124327.1         16-239              c
FEATURES             Location/Qualifiers
     source          1..4016
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.15 cM"
     gene            1..4016
                     /gene="Nkd2"
                     /gene_synonym="2210403L10Rik; mNkd2"
                     /note="naked cuticle 2"
                     /db_xref="GeneID:72293"
                     /db_xref="MGI:MGI:1919543"
     exon            1..229
                     /gene="Nkd2"
                     /gene_synonym="2210403L10Rik; mNkd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1590
                     /gene="Nkd2"
                     /gene_synonym="2210403L10Rik; mNkd2"
                     /note="isoform a is encoded by transcript variant 1;
                     protein naked cuticle homolog 2; naked cuticle 2 homolog;
                     naked-2; naked cuticle 1 homolog"
                     /codon_start=1
                     /product="protein naked cuticle homolog 2 isoform a"
                     /protein_id="NP_082462.3"
                     /db_xref="CCDS:CCDS26636.1"
                     /db_xref="GeneID:72293"
                     /db_xref="MGI:MGI:1919543"
                     /translation="MGKFQSKHAAAACKRRESPEGDSFVVPAYGSGRRGAEETDRRAG
                     SGVEHRSRDKQELLNGDPKEGPFWDDKGSLEVVLPPEKSEGHEGQGQLFSTDDGEKAA
                     SREGPLRLSKKHLNIDALQCDVSVEEDNRQEWTFTLYDFDNSGKVTREDMSSLMHTIY
                     EVVDASVNHSSGSSKTLRVKLTVSPEPSSKKECPLTGQDREPTRGRTEIELTDEPRVA
                     DRRLSAYSRKPNADPQPCSVRVPYCVDENTERRNHYLDLAGIENYTSKFGPGSPPEQA
                     RQEHHGRATHIPSRSRSQESDAHAIHHRRSQVLAEHVIPANEPATRALAAQPRIKGQE
                     KQFLRSPKGPGKPLGTPGSGKPGKALSYCLQAVPLPQSAQDGHHLPQPPPQPPPQPYG
                     HKRYRQKAREGHSPLKGHGQPTMVEHEVVRDLPPMLGPEGYVMPVVQRHEHHHHHEHH
                     HHHHHHHFHPS"
     exon            230..265
                     /gene="Nkd2"
                     /gene_synonym="2210403L10Rik; mNkd2"
                     /inference="alignment:Splign:2.1.0"
     exon            266..369
                     /gene="Nkd2"
                     /gene_synonym="2210403L10Rik; mNkd2"
                     /inference="alignment:Splign:2.1.0"
     exon            370..430
                     /gene="Nkd2"
                     /gene_synonym="2210403L10Rik; mNkd2"
                     /inference="alignment:Splign:2.1.0"
     exon            431..558
                     /gene="Nkd2"
                     /gene_synonym="2210403L10Rik; mNkd2"
                     /inference="alignment:Splign:2.1.0"
     exon            559..654
                     /gene="Nkd2"
                     /gene_synonym="2210403L10Rik; mNkd2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..799
                     /gene="Nkd2"
                     /gene_synonym="2210403L10Rik; mNkd2"
                     /inference="alignment:Splign:2.1.0"
     exon            800..884
                     /gene="Nkd2"
                     /gene_synonym="2210403L10Rik; mNkd2"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1012
                     /gene="Nkd2"
                     /gene_synonym="2210403L10Rik; mNkd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..4016
                     /gene="Nkd2"
                     /gene_synonym="2210403L10Rik; mNkd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1947..1952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkd2"
                     /gene_synonym="2210403L10Rik; mNkd2"
                     /note="hexamer: AATAGA"
     polyA_site      1973
                     /gene="Nkd2"
                     /gene_synonym="2210403L10Rik; mNkd2"
     regulatory      3995..4000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkd2"
                     /gene_synonym="2210403L10Rik; mNkd2"
                     /note="hexamer: AATAAA"
     polyA_site      4016
                     /gene="Nkd2"
                     /gene_synonym="2210403L10Rik; mNkd2"
                     /note="major polyA site"
ORIGIN      
        1 gtcgcgggcg cgcgcgctca gagggaggcc ggccgctgcc cgcgccggtg tctccggttg
       61 ccgggccaag cctcgccaga ctgcccggcc ccggatccag gctccacgag ttgctctcag
      121 ctcgggattc acgcaccccg ggctcgaacc tcggacgcac acctgagagc tcggccggag
      181 ggtgggtcca ggcccagcgg agacatgggg aaatttcagt ccaagcacgc cgcagcagcc
      241 tgcaagagga gagagagtcc cgaaggggac agcttcgtgg tgcctgcgta cgggagcggt
      301 cgcaggggag cggaagaaac ggaccggcgc gcgggcagcg gtgtggaaca tcgctcacgg
      361 gacaagcagg agctgctcaa tggagaccct aaggaggggc ctttctggga cgacaagggt
      421 tccctagaag ttgtgctgcc ccctgagaag tctgagggcc atgagggcca gggccagctc
      481 ttcagcacag atgatgggga gaaggcagca agccgtgagg gtccactgag acttagcaag
      541 aagcacttga acattgacgc actgcagtgt gacgtctcag tggaagaaga caaccgccaa
      601 gaatggacat tcacattgta tgactttgac aacagtggga aagtcaccag agaggacatg
      661 tccagcctga tgcacaccat ctacgaggtt gtcgatgcct ctgtcaatca ctcctccggc
      721 agcagcaaga cccttcgagt gaagctaact gtcagccctg aaccctccag caagaaggaa
      781 tgtcctctca ctggccaaga ccgggagccc actcgtggca gaacagagat tgagctcaca
      841 gatgagcccc gagtggctga cagaaggcta tccgcctaca gcaggaagcc caatgctgat
      901 ccccagccct gctctgtgcg agtgccctac tgtgtggatg agaacacaga gcgcagaaac
      961 cactacctag accttgctgg catcgagaac tacacatcta agtttggtcc tgggtcacca
     1021 cctgagcagg ccaggcaaga acatcatggc agggccacac acattccaag caggtcccga
     1081 tcacaagagt cggatgccca cgctatacac caccgcaggt ctcaagtcct ggctgagcat
     1141 gtcataccag ctaatgagcc tgccacccgg gccctggctg cacagccccg gatcaagggg
     1201 caggagaagc agttcctcag gtctcctaag ggtccaggaa aacctcttgg gacaccaggc
     1261 agtggcaagc cagggaaagc tctcagctat tgcctgcagg ccgtgccatt gccccagagt
     1321 gctcaggatg gccaccacct tcctcagccc ccaccacagc ctccaccgca gccctatggt
     1381 cacaagcggt accggcagaa agccagagaa ggccactcac cacttaaggg gcatggccag
     1441 cctaccatgg tggagcatga agtagtacgg gacctgcctc ccatgctggg gcctgagggc
     1501 tatgtgatgc ctgtggtcca gaggcatgaa caccaccatc accatgagca ccaccaccat
     1561 caccaccacc accacttcca cccatcctag cacccaaaca agcactctgc ccaaatgccc
     1621 ttgggaacag agcaggggct ggcatgtgcc cagtagagaa tacagcatcc cctggctcaa
     1681 caccagctgc agatgtcaag ggggcacacc agggagatgg caccaggctt ggatattcat
     1741 ggacaaagct acctttctcc atgccatttg gataccagta catttgatgc agctgatggt
     1801 taccagggac acgtgctcct gtgtcatcca gaaagcccat acatgagggc acaaaagcat
     1861 ctgttcctgc ttttgctgca gtgtgaccat gggatatttg aaggcatcct ttgtatcctc
     1921 atggttcttt gaccttcggg tacctgaata gaaaaggcaa tgctttttgt gaagtttcta
     1981 tgttgtaaag tcagtggact ggcttggaaa gtggttcttc ttcagtgtac catgttaaac
     2041 aaagcaaaac aaagaggcca gattatcagc aaatgtggag ggggcactgt tgagcagagg
     2101 gacagagtga cgttccgtgg gcagcatgag gcttggtgtc gagcttccag catcctaggt
     2161 agatatggat aagacccaga cgggttggga tgagaaggat caggtacaat gctggaggtc
     2221 ctcattcagg ctgtgcatag ccaagtgata cttagatgtc cctccataaa ggctgcaaag
     2281 gtatggggtc ctcaagaagc cacaattttc atggttccac cagcaggaca gaacaagagg
     2341 aactttttaa cctcttgtga gtttatgaaa gttgggcatg atgccttctt ggcataataa
     2401 agaattgtgc attctgtaac aaggcacaca tacccttgta ttaaaacact tttctgagag
     2461 cggtgggtag tgtactgaca caccgtagct gcaggtgaag atgacaggta cttgtggagg
     2521 gtgaatgctg tagaaccgtc ctggcttata ctgcttgacg cacacaactc catagcaatg
     2581 cttcttaata agggatttct agactaagaa aaaccagaac tctaaaccca gagttcagct
     2641 catgttaaca agaaacacca agctccagat ggactccgtg ggctccagct tatgcagact
     2701 gttgagaagc gacacaacct tatgtttatc tcctttcccc tcaaccccgt gcctattcta
     2761 aggaattccc gaagacctga atgtgatgtc tctgacctgg ggaccatcag tcctctgtag
     2821 gctgttcact gttagctaga catgctcccc aaaacgaaaa tgactagagt gtgtcaccct
     2881 ttccttacaa catgactaaa gtacccacgt catggatgta gagatggcat gtatgtgagg
     2941 ttccaccacc cacaccacag cagagggatt gaatcagcat ggccacccag tttctctctc
     3001 agtatgcagc actcttatat tgggcttgtg ctaagaggtc ctttcaggag gctgaagaga
     3061 tggctcagca gttaagaggc tgctcttcca gaggtcctgg gctcaattcc cagcaccccc
     3121 acatggcagt tcacaactgt ctgtaactcc aattctaggg cttccaacac cctcacacag
     3181 acatacatgt agataaaaca ccaatgaaca taagcttttt tcaaaaaaaa aaaaaaaaaa
     3241 gtcctttcag gccctgagag atgtcctaca ggatatcccc aatgacacct agggccatgg
     3301 tccagctgca gcagcatggg aagtggggag attcagccaa gcctgagccc tggcttcacg
     3361 ttttaaaaat gcagggcagg tggaagccct gacaagctca tggcaggggc cgagcacctg
     3421 ccactgtgtg agtgttaagt ggaggggggt acaccacccc agacagctga gagttctccc
     3481 tccgtaccat gataagacct aaagagatgg gaaagcactt gtgaagtaaa tgagaaacac
     3541 ccagaccatt tagttgggtg tggcagtgag agcttgtggg aggctacatc aagagctaca
     3601 atccaagacc agactggact atctagtgac accgcctccc ctgtccccaa actgctcatg
     3661 ttctccagca cgtagccact ctggacgtgg tcactagtgt ctgagaacag tggatctact
     3721 gagatgcagg aacttggctt gggataactc caggactacc tagtagtaaa actgcaatgt
     3781 tgaaaatgga gacagaggta agaaagatag aggtggtgat gcttagtcca ccctgtgctg
     3841 ggtgccagga tggtgtctct gtggcagttg gtagtacctg gcaacagacg acagtggctg
     3901 tggtgaggaa aataaccaac cttggctgtg tatgtggagg ttgtggctac tgtgtattct
     3961 tagaactcaa caacccgatc tatgtacatt cccaaataaa ctgtcgcagg agtgaa
//
