LOCUS       NM_027280               4314 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus naked cuticle 1 (Nkd1), transcript variant 1, mRNA.
ACCESSION   NM_027280
VERSION     NM_027280.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4314)
  AUTHORS   Wei,S., Lin,L., Jiang,W., Chen,J., Gong,G. and Sui,D.
  TITLE     Naked cuticle homolog 1 prevents mouse pulmonary arterial
            hypertension via inhibition of Wnt/beta-catenin and oxidative
            stress
  JOURNAL   Aging (Albany NY) 15 (20), 11114-11130 (2023)
   PUBMED   37857014
  REMARK    GeneRIF: Naked cuticle homolog 1 prevents mouse pulmonary arterial
            hypertension via inhibition of Wnt/beta-catenin and oxidative
            stress.
REFERENCE   2  (bases 1 to 4314)
  AUTHORS   Govek,K.W., Chen,S., Sgourdou,P., Yao,Y., Woodhouse,S., Chen,T.,
            Fuccillo,M.V., Epstein,D.J. and Camara,P.G.
  TITLE     Developmental trajectories of thalamic progenitors revealed by
            single-cell transcriptome profiling and Shh perturbation
  JOURNAL   Cell Rep 41 (10), 111768 (2022)
   PUBMED   36476860
REFERENCE   3  (bases 1 to 4314)
  AUTHORS   Olbertova,K., Hrckulak,D., Kriz,V., Jesionek,W., Kubovciak,J.,
            Esner,M., Korinek,V. and Buchtova,M.
  TITLE     Role of LGR5-positive mesenchymal cells in craniofacial development
  JOURNAL   Front Cell Dev Biol 10, 810527 (2022)
   PUBMED   36133922
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4314)
  AUTHORS   Van Otterloo,E., Milanda,I., Pike,H., Thompson,J.A., Li,H.,
            Jones,K.L. and Williams,T.
  TITLE     AP-2alpha and AP-2beta cooperatively function in the craniofacial
            surface ectoderm to regulate chromatin and gene expression dynamics
            during facial development
  JOURNAL   Elife 11, e70511 (2022)
   PUBMED   35333176
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4314)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4314)
  AUTHORS   Creyghton,M.P., Roel,G., Eichhorn,P.J., Hijmans,E.M., Maurer,I.,
            Destree,O. and Bernards,R.
  TITLE     PR72, a novel regulator of Wnt signaling required for Naked cuticle
            function
  JOURNAL   Genes Dev 19 (3), 376-386 (2005)
   PUBMED   15687260
REFERENCE   7  (bases 1 to 4314)
  AUTHORS   Li,Q., Ishikawa,T.O., Miyoshi,H., Oshima,M. and Taketo,M.M.
  TITLE     A targeted mutation of Nkd1 impairs mouse spermatogenesis
  JOURNAL   J Biol Chem 280 (4), 2831-2839 (2005)
   PUBMED   15546883
  REMARK    GeneRIF: deletion of the EF-hand from Nkd1 reduces the number of
            the elongating spermatids at haploid stage
REFERENCE   8  (bases 1 to 4314)
  AUTHORS   Ishikawa,A., Kitajima,S., Takahashi,Y., Kokubo,H., Kanno,J.,
            Inoue,T. and Saga,Y.
  TITLE     Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression
            in the PSM under the control of Notch signaling
  JOURNAL   Mech Dev 121 (12), 1443-1453 (2004)
   PUBMED   15511637
REFERENCE   9  (bases 1 to 4314)
  AUTHORS   Wharton,K.A. Jr., Zimmermann,G., Rousset,R. and Scott,M.P.
  TITLE     Vertebrate proteins related to Drosophila Naked Cuticle bind
            Dishevelled and antagonize Wnt signaling
  JOURNAL   Dev Biol 234 (1), 93-106 (2001)
   PUBMED   11356022
REFERENCE   10 (bases 1 to 4314)
  AUTHORS   Yan,D., Wallingford,J.B., Sun,T.Q., Nelson,A.M., Sakanaka,C.,
            Reinhard,C., Harland,R.M., Fantl,W.J. and Williams,L.T.
  TITLE     Cell autonomous regulation of multiple Dishevelled-dependent
            pathways by mammalian Nkd
  JOURNAL   Proc Natl Acad Sci U S A 98 (7), 3802-3807 (2001)
   PUBMED   11274398
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK166564.1, BC034838.1 and AC126054.5.
            
            On Aug 6, 2009 this sequence version replaced NM_027280.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082367.1, AK076164.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AK166564.1         4-29
            27-1075             BC034838.1         1-1049
            1076-1076           AC126054.5         188446-188446
            1077-1753           BC034838.1         1051-1727
            1754-4314           AC126054.5         189124-191684
FEATURES             Location/Qualifiers
     source          1..4314
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 43.36 cM"
     gene            1..4314
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
                     /note="naked cuticle 1"
                     /db_xref="GeneID:93960"
                     /db_xref="MGI:MGI:2135954"
     exon            1..188
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1579
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein naked cuticle homolog 1; mNkd; mNkd1; naked-1;
                     naked cuticle 1 homolog"
                     /codon_start=1
                     /product="protein naked cuticle homolog 1 isoform 1"
                     /protein_id="NP_081556.3"
                     /db_xref="CCDS:CCDS22511.1"
                     /db_xref="GeneID:93960"
                     /db_xref="MGI:MGI:2135954"
                     /translation="MGKLHSKPAAVCKRRESPEGDSFAVSAAWARKGIEEWIGRQRCP
                     GSVSGPRQLRLAGTVGRGTRELVGDTSREALGEEDEDDFPLEVALPPEKIDSLGSGDE
                     KRMERLSEPGQASKKQLKFEELQCDVSVEEDSRQEWTFTLYDFDNNGKVTREDITSLL
                     HTIYEVVDSSVNHSPTSSKTLRVKLTVAPDGSQSKRSVLFNHTDLQSTRPRADTKPAE
                     ELRGWEKKQRAPLRFQGDSHLEQPDCYHHCVDENIERRNHYLDLAGIENYTSQFGPGS
                     PSVAQKSELPPRISNPTRSRSHEPEAAHIPHRRPQGVDPGSFHLLDTPFAKASELQQR
                     LRGTQDGSKHFVRSPKAQGKNMGMGHGARGARSKPPLVPTTHTVSPSAHLATSPALLP
                     TLAPLGHKKHKHRAKESQASCRGLQGPLAAGGSTVMGREQVRELPAVVVYESQAGQAV
                     QRHEHHHHHEHHHHYHHFYQP"
     exon            189..221
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
                     /inference="alignment:Splign:2.1.0"
     exon            222..355
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
                     /inference="alignment:Splign:2.1.0"
     exon            356..422
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
                     /inference="alignment:Splign:2.1.0"
     exon            423..529
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
                     /inference="alignment:Splign:2.1.0"
     exon            530..625
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
                     /inference="alignment:Splign:2.1.0"
     exon            626..773
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
                     /inference="alignment:Splign:2.1.0"
     exon            774..858
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
                     /inference="alignment:Splign:2.1.0"
     exon            859..986
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
                     /inference="alignment:Splign:2.1.0"
     exon            987..4314
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1736..1741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
                     /note="hexamer: AGTAAA"
     polyA_site      1753
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
                     /note="major polyA site"
     regulatory      2458..2463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
                     /note="hexamer: AATACA"
     polyA_site      2478
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
     regulatory      3007..3012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
                     /note="hexamer: AATGAA"
     polyA_site      3047
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
     regulatory      4292..4297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
                     /note="hexamer: AATAAA"
     polyA_site      4314
                     /gene="Nkd1"
                     /gene_synonym="2810434J10Rik; 9030215G15Rik; Nkd"
ORIGIN      
        1 gcgcccgggc gtcagtccgg ccgcggcgac ggcggcagga gcgcgtcccg gcgccgccta
       61 aggctgcgct cggcgcgcgg actgtgagga ggaggcgagc gaggctggcg cggggtcggc
      121 ggccggacgc atggcttagg acgctccgcc gccgcgcccc agcatgggga aacttcactc
      181 gaagccggcc gccgtgtgca agcgcaggga gagcccggaa ggtgacagct ttgctgtaag
      241 cgctgcttgg gcaaggaaag gcatcgagga gtggatcggg aggcagcgct gtccaggcag
      301 cgtctcagga ccccgtcagc tgagattggc aggcactgtt ggtcgaggca ctcgggaact
      361 cgtgggtgac acttctagag aggctctcgg tgaggaggac gaggacgact tccccctaga
      421 agtggccctg ccgcctgaga agattgacag cctaggtagt ggagatgaga agagaatgga
      481 gagactgagc gaacctggcc aggcctccaa gaagcagctc aagtttgaag agctgcagtg
      541 tgatgtctct gtggaggagg acagccggca agagtggact ttcactctat atgacttcga
      601 caacaatggc aaagtgaccc gtgaggacat taccagcttg ctgcatacca tctatgaagt
      661 ggttgactcc tctgtgaacc attcccccac atcaagcaag acactgcggg tgaagctcac
      721 cgtggctcct gacgggagcc agagtaagag gagcgtcctt ttcaaccata ccgatctgca
      781 gagcacaagg ccccgagcag acaccaaacc cgctgaggag ctgcgtggct gggagaagaa
      841 gcagcgagcc ccactcaggt tccagggtga cagccacctg gagcagccag actgctacca
      901 ccattgcgtg gatgagaaca ttgagaggag aaaccactac ctagacctgg cggggataga
      961 gaactacacg tctcagtttg gaccgggatc cccttcggtg gcccagaagt cagagctgcc
     1021 ccctcgaatc tccaacccca ctcgctctcg ctcccacgag ccagaagctg cccacatccc
     1081 acaccggagg ccccaaggtg tggacccagg ctccttccac ctccttgaca ccccatttgc
     1141 caaggcatca gagctccagc aacggctccg gggcactcag gatgggagca agcactttgt
     1201 gaggtccccc aaggcccagg gcaagaacat gggtatgggc cacggggcca gaggtgcaag
     1261 aagcaagcct ccactggtac ccaccaccca tactgtctcc ccctctgccc atctggccac
     1321 cagcccagcc cttctcccca ccctggcacc cctggggcac aagaaacaca agcatcgagc
     1381 caaggagagc caggcgagct gccggggcct gcagggcccc ctggctgcag gaggctccac
     1441 cgtcatgggg cgggagcagg tgagggagct gcctgccgtg gtggtgtacg agagccaggc
     1501 tgggcaggcc gtccagagac acgaacacca tcaccaccac gaacatcacc accattacca
     1561 ccacttctat cagccctaga ccccagcagg ctgccacggg aaggacccag cccacaccct
     1621 aaggcattat tattctatta attattgtta ttatggcaat tattgttatt aataattatt
     1681 gttactccac taatatttag ccagccttca tgtagaagac acatggaaac acagaagtaa
     1741 acttttattt atacgttgtg gggatcatgt aactcaccaa gaagtgactc tgggtttgga
     1801 gggtccttgg gccaccccag ctgcagggtc tacacaggtc tccccaaacc acaggagccc
     1861 tgggctcaac ccccccactt cagttcttcc aggagagcac ccttgcctaa tccagcttcg
     1921 gagaccctca agagccccag aggacaacag ctgctacctc tcagtgttat ctggttcaac
     1981 tttgccctta attgattgta acacgctaca ggagatttca gtggactgcc attgcaccct
     2041 ctctcccctt gtgttctgac acctcaacct agacacctta gctgtgtttc cgggagttac
     2101 cgcctcccct atctaaaggg aactagccct tggcccaagc cagccctgtg ctttcttttg
     2161 tcctttgcca tgcacagtgt ggaagcgccc tctcttcctg tgcccccgtt ggctttggaa
     2221 ggatgcacct gtgtttaagg attgtccttg tagccagcct tctcagtttg ggaacaacta
     2281 cagagagaag cagccacatt aaaaaaaaaa aaaaagtagt gtggtttccc aagatggcac
     2341 cattgtgtga cggagggtgt gaaacctgag tttgccgtca gcaaatggtt tgtggctctc
     2401 tagccgcctt tgtagctagg tagatgctgc ctgtccatgt ctctgtatct ttctataaat
     2461 acactctcag gtatcctttc tggtgtgcag aaatcactgc cctgctctat ggaagctcct
     2521 gcaacccaga tgtacccgtg tggttcccaa aggctgcccg tccatcagat gaaaacagcc
     2581 acctccgtct cacttcctgg ggtctgaagt ctgtggtttt ggagagacct gcttgggtag
     2641 agagacttag ggtggaatgg gggtagccac tgagcagcat ccttgacaga ataggttttt
     2701 atcagacaag ggtccagggg accaaaaaag gtttactgtc aaatagttgg ggccccaaca
     2761 aaactcagat tacactccca ggtttaatta tttgaggagg gctcaacggg gatggctgcc
     2821 aacactggag caaagactgg gaggcagcag aacccagacc atcactgagc taccactgta
     2881 cctagctcca tacatgaagg gtgaagatcg agaggcacct aggagccatg gcattcattc
     2941 agagagcata gcaggctgtg tgaatgaatg aatgaatgaa tgaatgaatg aatgaatgaa
     3001 tgaataaatg aatttatcca ggggatgaat gcccctatac cctcccatgc ctgtttcaca
     3061 tccttctcta gtagcctcag ctgaaggcct tgagaggggg tgggactttt attcttgagg
     3121 gtccagaaag agtctgaccc cagaaggaag tctgcctgcc tgtctcctga gtttagcacg
     3181 gttggtaagc atgcactttg cagatagtga gcattcgttg ttttcatggt gttaattttc
     3241 ctgattgctg gtgtgcctgg gtctggttgg tgccatcctc aggacatcac tgtgacgaag
     3301 taggagtcct gggaatgtgt ctgaggcaca gagaggtcaa gaacctgttt gacacacatg
     3361 gcagatggca gtgctgggtc ctagccttca gggtccctaa cactgaagga tatgagccct
     3421 aagttttcct cctgggaagc tgtgtttcta tttggctaga ttccaactca gaggggacac
     3481 tgccacctac catgtgactg caaccacacc aaatgggcaa ggcattgtgg gagcttggct
     3541 tgagatgata ggatctggta tgaatgaagt agtttttgtc cttgagtcac cctgtgtcca
     3601 caggcctgag caactgacat tctgggtcca ggaccaggag gaaagaattt ctgggagaca
     3661 agagcttgat gagggaattg tgattgactg ggcttgggga aggtagtcac ccctggacca
     3721 gttacacaga tcatctggta tgtgaccacc tgcctcagga ggcaaggtca ccgcaatgag
     3781 gacagggata ggggaacccg caaacacaaa caaaaaccaa tggcctccag ggccacaatt
     3841 gccatgggca gctgcctagg gagtggaagc cactggtttt agaacacaga tcctcagcct
     3901 ggggaaggag gtcccctgct gctttaggat ttttgttaac ttcttgctct aactcttaaa
     3961 agtcacttat aaaaatagta ccacgtgttc acctgtaaga gatcaaggta gcgcataaag
     4021 gcttagagtc aaaggtaagt cagcaggctc catctcacat gctcagtctc cagaaaccca
     4081 ccccagcatc catccatgtc cagatgccct ccccccatcc tcccctccag gaccatgagc
     4141 gtggtgtagc ggttgtaaca cagactggtg tctggccatg ggtgctccag gcctgactcc
     4201 ccttcctcaa agcatgcact gcaagtgagg tgctgtgcct tggtttcccc cttgtgagtc
     4261 ctccccagat gttagttgtc ttcattcccg gaataaaagc atttttatag aata
//
