LOCUS       NM_023175               1292 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus nitrilase family, member 2 (Nit2), mRNA.
ACCESSION   NM_023175
VERSION     NM_023175.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1292)
  AUTHORS   Jaisson,S., Veiga-da-Cunha,M. and Van Schaftingen,E.
  TITLE     Molecular identification of omega-amidase, the enzyme that is
            functionally coupled with glutamine transaminases, as the putative
            tumor suppressor Nit2
  JOURNAL   Biochimie 91 (9), 1066-1071 (2009)
   PUBMED   19596042
  REMARK    GeneRIF: Data conclude that mammalian nitrilase 2 is omega-amidase.
REFERENCE   2  (bases 1 to 1292)
  AUTHORS   Barglow,K.T., Saikatendu,K.S., Bracey,M.H., Huey,R., Morris,G.M.,
            Olson,A.J., Stevens,R.C. and Cravatt,B.F.
  TITLE     Functional proteomic and structural insights into molecular
            recognition in the nitrilase family enzymes
  JOURNAL   Biochemistry 47 (51), 13514-13523 (2008)
   PUBMED   19053248
REFERENCE   3  (bases 1 to 1292)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 1292)
  AUTHORS   Pace,H.C., Hodawadekar,S.C., Draganescu,A., Huang,J.,
            Bieganowski,P., Pekarsky,Y., Croce,C.M. and Brenner,C.
  TITLE     Crystal structure of the worm NitFhit Rosetta Stone protein reveals
            a Nit tetramer binding two Fhit dimers
  JOURNAL   Curr Biol 10 (15), 907-917 (2000)
   PUBMED   10959838
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF284573.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF284573.1, BC020153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1292
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 34.22 cM"
     gene            1..1292
                     /gene="Nit2"
                     /gene_synonym="1190017B19Rik; D16Ertd502e"
                     /note="nitrilase family, member 2"
                     /db_xref="GeneID:52633"
                     /db_xref="MGI:MGI:1261838"
     exon            1..52
                     /gene="Nit2"
                     /gene_synonym="1190017B19Rik; D16Ertd502e"
                     /inference="alignment:Splign:2.1.0"
     exon            53..171
                     /gene="Nit2"
                     /gene_synonym="1190017B19Rik; D16Ertd502e"
                     /inference="alignment:Splign:2.1.0"
     exon            172..292
                     /gene="Nit2"
                     /gene_synonym="1190017B19Rik; D16Ertd502e"
                     /inference="alignment:Splign:2.1.0"
     exon            293..381
                     /gene="Nit2"
                     /gene_synonym="1190017B19Rik; D16Ertd502e"
                     /inference="alignment:Splign:2.1.0"
     exon            382..475
                     /gene="Nit2"
                     /gene_synonym="1190017B19Rik; D16Ertd502e"
                     /inference="alignment:Splign:2.1.0"
     exon            476..550
                     /gene="Nit2"
                     /gene_synonym="1190017B19Rik; D16Ertd502e"
                     /inference="alignment:Splign:2.1.0"
     exon            551..629
                     /gene="Nit2"
                     /gene_synonym="1190017B19Rik; D16Ertd502e"
                     /inference="alignment:Splign:2.1.0"
     exon            630..728
                     /gene="Nit2"
                     /gene_synonym="1190017B19Rik; D16Ertd502e"
                     /inference="alignment:Splign:2.1.0"
     exon            729..784
                     /gene="Nit2"
                     /gene_synonym="1190017B19Rik; D16Ertd502e"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1286
                     /gene="Nit2"
                     /gene_synonym="1190017B19Rik; D16Ertd502e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1022..1027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nit2"
                     /gene_synonym="1190017B19Rik; D16Ertd502e"
                     /note="hexamer: ATTAAA"
     polyA_site      1047
                     /gene="Nit2"
                     /gene_synonym="1190017B19Rik; D16Ertd502e"
                     /note="major polyA site"
     regulatory      1126..1131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nit2"
                     /gene_synonym="1190017B19Rik; D16Ertd502e"
                     /note="hexamer: ATTAAA"
     polyA_site      1146
                     /gene="Nit2"
                     /gene_synonym="1190017B19Rik; D16Ertd502e"
     regulatory      1263..1268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nit2"
                     /gene_synonym="1190017B19Rik; D16Ertd502e"
                     /note="hexamer: ATTAAA"
     polyA_site      1286
                     /gene="Nit2"
                     /gene_synonym="1190017B19Rik; D16Ertd502e"
ORIGIN      
        1 gactggcagg agtccctgtg gcctgcggtg caccgtggaa gagccatgtc tactttccgc
       61 ctggccctca tacagcttca agtttcttcc attaaatcag ataaccttac ccgggcttgt
      121 agcctagtgc gggaggcagc aaagcaaggt gccaacatag tttctctgcc tgagtgcttc
      181 aattctccat atggaacaac ctactttcct gactatgcag agaagattcc tggagagtcc
      241 acacaaaagc tttctgaagt agcaaaggag agcagcatat atctcattgg aggctccatc
      301 cctgaagagg atgctgggaa actgtataat acctgctctg tgtttgggcc tgatggaagt
      361 ttactggtaa agcacaggaa gatccatctg tttgacattg atgttcctgg gaaaattacg
      421 tttcaagaat ctaaaacatt gagccctggt gatagtttct ccacatttga tacgccttac
      481 tgcaaagtgg gcctgggcat ctgctatgat atgcgcttcg cggagcttgc acaaatctat
      541 gcacaaagag gctgccagct cttggtgtat cctggagctt tcaatctgac cacaggacca
      601 gcccactggg agctgcttca gcgagcccgg gctgttgata atcaggtgta tgtggctaca
      661 gcctctcctg ctcgggatga caaagcctcg tatgtggcct ggggacacag cactgttgtg
      721 gatccttggg ggcaggtcct aaccaaagct ggcacggagg aaacaatcct gtactcagac
      781 atagacctga agaagctggc tgaaattcgg cagcaaatcc ccattttaaa acagaaacga
      841 gcagacctct atacagtgga atcaaagaag ccttgatatc tgtttcaaaa atgtcaccaa
      901 caggatgatg ctctgtcaga tgatcaactc tactacatct cttttttttg gagggagggg
      961 ggaacagggc catttcatgt taattctatc aatgatctgt gccacaaggt cccctatttt
     1021 aattaaaagt ttcatcttta attaaaatgt gcttggtaac aatgttctag ctcttaacta
     1081 gtctgatggt tcctaggcat ttcagtccca agatcctttt gaacaattaa aaactgaagc
     1141 ctctaagcat tgtttccatg tgtggtgggc tggtcccatc tgtctgagaa aatgtacatt
     1201 taccagaaca ctaattttca tggtgctaat atcccatcaa catgacactt ttaaaacttt
     1261 ttattaaaaa ttgttttcat acaataaaaa aa
//
