LOCUS       NM_008698               1944 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus nipsnap homolog 1 (Nipsnap1), mRNA.
ACCESSION   NM_008698
VERSION     NM_008698.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1944)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1944)
  AUTHORS   Liu,Y., Qu,Y., Cheng,C., Tsai,P.Y., Edwards,K., Xue,S., Pandit,S.,
            Eguchi,S., Sanghera,N. and Barrow,J.J.
  TITLE     Nipsnap1-A regulatory factor required for long-term maintenance of
            non-shivering thermogenesis
  JOURNAL   Mol Metab 75, 101770 (2023)
   PUBMED   37423391
REFERENCE   3  (bases 1 to 1944)
  AUTHORS   Princely Abudu,Y., Pankiv,S., Mathai,B.J., Hakon Lystad,A.,
            Bindesboll,C., Brenne,H.B., Yoke Wui Ng,M., Thiede,B., Yamamoto,A.,
            Mutugi Nthiga,T., Lamark,T., Esguerra,C.V., Johansen,T. and
            Simonsen,A.
  TITLE     NIPSNAP1 and NIPSNAP2 Act as 'Eat Me' Signals for Mitophagy
  JOURNAL   Dev Cell 49 (4), 509-525 (2019)
   PUBMED   30982665
REFERENCE   4  (bases 1 to 1944)
  AUTHORS   Okuda-Ashitaka,E., Minami,T., Tsubouchi,S., Kiyonari,H.,
            Iwamatsu,A., Noda,T., Handa,H. and Ito,S.
  TITLE     Identification of NIPSNAP1 as a nocistatin-interacting protein
            involving pain transmission
  JOURNAL   J Biol Chem 287 (13), 10403-10413 (2012)
   PUBMED   22311985
  REMARK    GeneRIF: NIPSNAP1 is an interacting molecule of NST and plays a
            crucial role in pain transmission.
REFERENCE   5  (bases 1 to 1944)
  AUTHORS   Tummala,H., Li,X. and Homayouni,R.
  TITLE     Interaction of a novel mitochondrial protein,
            4-nitrophenylphosphatase domain and non-neuronal SNAP25-like
            protein homolog 1 (NIPSNAP1), with the amyloid precursor protein
            family
  JOURNAL   Eur J Neurosci 31 (11), 1926-1934 (2010)
   PUBMED   20497468
  REMARK    GeneRIF: Data suggest that amyloid precursor proteins may affect
            mitochondrial function through a direct interaction with NIPSNAP1
            as well as with other mitochondrial proteins.
REFERENCE   6  (bases 1 to 1944)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1944)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   8  (bases 1 to 1944)
  AUTHORS   Qiu,Y., Cavelier,L., Chiu,S., Yang,X., Rubin,E. and Cheng,J.F.
  TITLE     Human and mouse ABCA1 comparative sequencing and transgenesis
            studies revealing novel regulatory sequences
  JOURNAL   Genomics 73 (1), 66-76 (2001)
   PUBMED   11352567
REFERENCE   9  (bases 1 to 1944)
  AUTHORS   Wertz,K. and Herrmann,B.G.
  TITLE     Large-scale screen for genes involved in gonad development
  JOURNAL   Mech Dev 98 (1-2), 51-70 (2000)
   PUBMED   11044607
REFERENCE   10 (bases 1 to 1944)
  AUTHORS   Seroussi,E., Pan,H.Q., Kedra,D., Roe,B.A. and Dumanski,J.P.
  TITLE     Characterization of the human NIPSNAP1 gene from 22q12: a member of
            a novel gene family
  JOURNAL   Gene 212 (1), 13-20 (1998)
   PUBMED   9661659
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY712531.1, AK031804.1, AK013140.1 and BP771057.1.
            
            On Feb 17, 2018 this sequence version replaced NM_008698.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ001260.1, AK013140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BY712531.1         1-37
            38-1299             AK031804.1         2-1263
            1300-1434           AK013140.1         1254-1388
            1435-1944           BP771057.1         22-531              c
FEATURES             Location/Qualifiers
     source          1..1944
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.07 cM"
     gene            1..1944
                     /gene="Nipsnap1"
                     /note="nipsnap homolog 1"
                     /db_xref="GeneID:18082"
                     /db_xref="MGI:MGI:1278344"
     exon            1..153
                     /gene="Nipsnap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..910
                     /gene="Nipsnap1"
                     /note="4-nitrophenylphosphatase domain and non-neuronal
                     SNAP25-like protein homolog 1"
                     /codon_start=1
                     /product="protein NipSnap homolog 1"
                     /protein_id="NP_032724.1"
                     /db_xref="CCDS:CCDS24392.1"
                     /db_xref="GeneID:18082"
                     /db_xref="MGI:MGI:1278344"
                     /translation="MAPRLCIISAAARRLFTKPRPRAGDLAAAGAVRFYSKDSEGSWF
                     RSLFVHKVDPRKDAHSTLLSKKETSNLYKIQFHNVKPECLDAYNSLTEAVLPKLHLDE
                     DYPCSLVGNWNTWYGEQDQAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRKERSKMLL
                     SRRNQLLLEFSFWNEPQPRAGPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAV
                     GGFFSQIGELYVVHHLWAYKDLQSREETRNAAWRKRGWDENVYYTVPLVRHMESRIMI
                     PLKISPLQ"
     exon            154..281
                     /gene="Nipsnap1"
                     /inference="alignment:Splign:2.1.0"
     exon            282..327
                     /gene="Nipsnap1"
                     /inference="alignment:Splign:2.1.0"
     exon            328..422
                     /gene="Nipsnap1"
                     /inference="alignment:Splign:2.1.0"
     exon            423..493
                     /gene="Nipsnap1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..634
                     /gene="Nipsnap1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..666
                     /gene="Nipsnap1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..761
                     /gene="Nipsnap1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..845
                     /gene="Nipsnap1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1927
                     /gene="Nipsnap1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1911..1916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nipsnap1"
                     /note="hexamer: ATTAAA"
     polyA_site      1927
                     /gene="Nipsnap1"
                     /note="major polyA site"
ORIGIN      
        1 tgcccccagc cactgggctg aggcgtggct ttcctccaac ctgctccggt ccaacatggc
       61 tccgcggttg tgcatcatct ctgcagcggc acggcggcta ttcacgaagc cgagaccccg
      121 tgctggggac ctcgcggctg cgggtgctgt gcgcttctat tccaaggaca gtgaaggaag
      181 ctggttccgt tccctctttg tccacaaggt ggatcctcgg aaggacgccc actccactct
      241 gctgtccaag aaggagacta gtaatctcta caagatccag tttcacaacg tgaagcccga
      301 atgtctggat gcctacaaca gtctgacgga ggctgtactg cccaagctgc acctggatga
      361 ggactatccc tgctcgcttg tgggcaactg gaacacgtgg tacggggagc aggaccaggc
      421 agtacaccta tggcggttct caggtggcta cccggccctc atggactgca tgaacaagct
      481 aaaaaacaac aaggagtacc tggagttccg gaaggaacgg agcaagatgc tgctgtccag
      541 gagaaaccag ttgcttctgg agttcagctt ctggaatgag ccacagcccc gagctggccc
      601 caatatctat gagctgagga catataaact caagccagga accatgattg aatggggaaa
      661 caactgggct cgggccatca agtaccgtca ggagaaccag gaggcggtgg gaggcttctt
      721 ttcacaaata ggagagctct acgtggtaca ccacttatgg gcctacaaag atttgcaatc
      781 tcgggaggag actcgaaatg cggcctggag aaagaggggc tgggatgaaa atgtctacta
      841 cacagtcccc ttggttcgac acatggagtc acgaatcatg attcctctga agatttctcc
      901 tctccagtga agctggcact gcctccacct ccttcccttt ctcctgtgga ctagcctgga
      961 aaggaggcgc ttctaggcca cctggcacag ttttctctga actctggaag acttctgatg
     1021 ggtggtgttc agcttcgaca aagatgacgt tttctgagaa cttagtccgt ccgtacccag
     1081 ctaacctctc tcccatgctg gatgaagaag ttcttaactt cccaagctgc agaatagcaa
     1141 ccttttaagc tttcacacac tttcctctta agatccgtca tctccaggac ataagtcccc
     1201 agctcccaac tgtggccatg gcttagttgc ataaaagcag gcatgactgg ctgttaggag
     1261 gtatggtgtg aaagggtatc agtccaggta tggcccggga actctctggt gtctacttgt
     1321 taaaaaagca agcctgagtc tttaaaaaaa aataaataaa aatcctggaa ctgccataaa
     1381 gtctgaagtc gtgacagtca ggaggaaatc cagaagttat cagtgtcagt aggtggtcca
     1441 gaagtctact taaagggcta ggaaaagggt gggagtggga aggatctggg tacatgagac
     1501 agccttgaag caggaaccct tcacaagtgg gcacatagga ttcagaattt aaaatacaga
     1561 attgggaaga caggacagag gtgacagagg atcttaaggg agcaccctgt tcctagacag
     1621 atggagaggc gtatccatgt tttcctacat aatgtggtta aaacttgaat ttgtgcttca
     1681 gctcttctgt acttcttcct tcctacaggc aaaaacacag gctgagacct atagttccat
     1741 caaattcttt ctttcccttc ttgacattgt cccccaaacc ctcattttgc agaaacacta
     1801 ggtctgtgga gtaggttgtg attctggggt ctcttcaatg accccggtac ctcatgaacc
     1861 cctgcttagc atggttgtgc taccatccag gagaatgttg atggaaccaa attaaatatt
     1921 tactgtaaaa aaaaaaaaaa aaaa
//
