LOCUS       NM_001256130            3269 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus non imprinted in Prader-Willi/Angelman syndrome 2
            homolog (human) (Nipa2), transcript variant 2, mRNA.
ACCESSION   NM_001256130
VERSION     NM_001256130.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3269)
  AUTHORS   Zhao,W., Zhang,W., Ma,H. and Yang,M.
  TITLE     NIPA2 regulates osteoblast function by modulating mitophagy in type
            2 diabetes osteoporosis
  JOURNAL   Sci Rep 10 (1), 3078 (2020)
   PUBMED   32080264
  REMARK    GeneRIF: NIPA2 regulates osteoblast function by modulating
            mitophagy in type 2 diabetes osteoporosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3269)
  AUTHORS   Goytain,A., Hines,R.M. and Quamme,G.A.
  TITLE     Functional characterization of NIPA2, a selective Mg2+ transporter
  JOURNAL   Am J Physiol Cell Physiol 295 (4), C944-C953 (2008)
   PUBMED   18667602
  REMARK    GeneRIF: The isolation and characterization of Nipa2 in mouse
            distal convoluted tubule cells are reported.
REFERENCE   3  (bases 1 to 3269)
  AUTHORS   Chai,J.H., Locke,D.P., Greally,J.M., Knoll,J.H., Ohta,T., Dunai,J.,
            Yavor,A., Eichler,E.E. and Nicholls,R.D.
  TITLE     Identification of four highly conserved genes between breakpoint
            hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes
            deletion region that have undergone evolutionary transposition
            mediated by flanking duplicons
  JOURNAL   Am J Hum Genet 73 (4), 898-925 (2003)
   PUBMED   14508708
  REMARK    GeneRIF: indentification on mouse chromosome 7C
REFERENCE   4  (bases 1 to 3269)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK041427.1, BY144304.1, AB041581.1, BK001121.1 and AI119710.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1-4 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK041427.1, BK001121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN02415127
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AK041427.1         1-43
            44-63               BY144304.1         25-44
            64-1930             AB041581.1         1-1867
            1931-2659           AK041427.1         1932-2660
            2660-3147           BK001121.1         2597-3084
            3148-3214           AK041427.1         3150-3216
            3215-3269           AI119710.1         1-55                c
FEATURES             Location/Qualifiers
     source          1..3269
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 33.42 cM"
     gene            1..3269
                     /gene="Nipa2"
                     /gene_synonym="2600017P10Rik; 3830408P04Rik"
                     /note="non imprinted in Prader-Willi/Angelman syndrome 2
                     homolog (human)"
                     /db_xref="GeneID:93790"
                     /db_xref="MGI:MGI:1913918"
     exon            1..294
                     /gene="Nipa2"
                     /gene_synonym="2600017P10Rik; 3830408P04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            295..415
                     /gene="Nipa2"
                     /gene_synonym="2600017P10Rik; 3830408P04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            416..644
                     /gene="Nipa2"
                     /gene_synonym="2600017P10Rik; 3830408P04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             506..1585
                     /gene="Nipa2"
                     /gene_synonym="2600017P10Rik; 3830408P04Rik"
                     /note="isoform 1 is encoded by transcript variant 2;
                     magnesium transporter NIPA2; non-imprinted in
                     Prader-Willi/Angelman syndrome region protein 2 homolog"
                     /codon_start=1
                     /product="magnesium transporter NIPA2 isoform 1"
                     /protein_id="NP_001243059.1"
                     /db_xref="CCDS:CCDS21316.1"
                     /db_xref="GeneID:93790"
                     /db_xref="MGI:MGI:1913918"
                     /translation="MSLGRGKYDFYIGLGLAMTSSIFIGGSFILKKKGLLRLARKGSM
                     RAGQGGHAYLKEWLWWAGLLSMGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSY
                     FLNERLNLHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATFVVI
                     VALIFIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELLAGKPVLQHPLA
                     WILLFSLVVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPV
                     DDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPVSFRKDEKAMNGNLSSMYEVLNNN
                     EDDLPCGIEHTGENISRRNGNLPSF"
     exon            645..701
                     /gene="Nipa2"
                     /gene_synonym="2600017P10Rik; 3830408P04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            702..792
                     /gene="Nipa2"
                     /gene_synonym="2600017P10Rik; 3830408P04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            793..953
                     /gene="Nipa2"
                     /gene_synonym="2600017P10Rik; 3830408P04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            954..3235
                     /gene="Nipa2"
                     /gene_synonym="2600017P10Rik; 3830408P04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1909..1914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nipa2"
                     /gene_synonym="2600017P10Rik; 3830408P04Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1934
                     /gene="Nipa2"
                     /gene_synonym="2600017P10Rik; 3830408P04Rik"
     regulatory      3194..3199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nipa2"
                     /gene_synonym="2600017P10Rik; 3830408P04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3215
                     /gene="Nipa2"
                     /gene_synonym="2600017P10Rik; 3830408P04Rik"
                     /note="major polyA site"
ORIGIN      
        1 cgcgcgcggt ttacgtcact agtctgcgcc caggtttccc ggcaggttct cggcggctct
       61 tctggtgctg gccgcggtgc ggccgaaggc tgtccgaggt aggctcctct cggctctccc
      121 atggaggagg cggcgctcac tgcagtctcg gatgcacgaa cttcccgcgg gacgtcgccg
      181 gagacggtgg ctgtgtgcgc gcaggagcga gctgcctgcg tgggggtctg agcgggcacc
      241 ggggtcgcgt cccggaggga gccgagtcgc ccgccggcct gcgacggccc taagggtgga
      301 actactctgc cgtggttaaa tactttaaat gggaataaag gatagcgttt ccaagaaaat
      361 gagaatgaat aaatcatctc tgttttttaa aagaaagacc atattaaact tacatgtttg
      421 aggattgcgt caccttgtct cctgtacaag cagtttctct gttcggtgat caatgtcact
      481 cacaggaact taagtaacta acgaaatgag cctggggcgt ggaaaatatg atttttatat
      541 tggtctggga ttggctatga cctccagcat tttcattgga gggagtttca ttttgaaaaa
      601 aaaaggcctt ctgcgacttg ccaggaaagg ctcaatgaga gcaggtcaag gaggccatgc
      661 atatcttaag gaatggttgt ggtgggctgg actgctgtca atgggagccg gtgaagtggc
      721 caattttgct gcatatgcat ttgctccggc cacattagtg actccactag gtgcgctcag
      781 cgtcctcgta agtgccattc tgtcttcata cttcctaaat gaaagactta atcttcatgg
      841 gaaaattggg tgtttgctaa gtattctagg gtctacagtt atggtcattc atgctccaaa
      901 ggaagaggag attgagacct taaatgaaat gtcacataag ttaggtgatc caggttttgt
      961 ggtctttgca acatttgtgg tcattgtggc cttgatattc atctttgtgg tgggacctcg
     1021 acatggacag acaaacattc ttgtgtatat aacaatctgc tctgtgattg gagcattttc
     1081 agtctcctgt gtgaagggtt tgggtatcgc cataaaagag ttgttggctg gaaagcctgt
     1141 tctgcagcac cccctcgcct ggattcttct gtttagcctt gtggtctgtg tgagcacaca
     1201 gattaattac ctaaaccggg ctctggacat tttcaacact tccattgtga ctccaatata
     1261 ttatgtgttc tttacaactt cagttttgac ttgttcagct attcttttta aagaatggca
     1321 ggatatgcct gttgatgatg tcattgggac tttgagtggc ttcttcacaa tcattgtggg
     1381 gatatttttg ttgcatgcct ttaaagatgt cagttttagt ctagcaagtc tgccagtatc
     1441 ttttcgaaaa gatgaaaagg caatgaatgg caatctttct agtatgtatg aagttcttaa
     1501 taataatgaa gacgacttac cctgtggaat tgaacacact ggtgaaaata tttcccgtag
     1561 gaatggaaat ctgccatctt tttaaggaca tgtttgaaaa gttaacctat aattctgtta
     1621 taaagtgagt tttgagcatc agaatgtatc tgaaaaaatt atcctcaaat aatgtcctct
     1681 aaagacaatc tttttttaag ttttcactaa tttggatcaa gaaattactt ttcttatagt
     1741 taaacaatgg tagctcacta atatgacctc agtacatggc taatttctaa taacattgta
     1801 ttattgtaaa ggtattttac atttttattc attctccaga aatttaaatg cactaatgac
     1861 aagttttaag cttataaaaa tgttttattt tttccattgg tgatgaacat taaaatgtac
     1921 atttgtgatc cccattccat caatacctca tcatactaag gctttttgat tataaattat
     1981 gtgtgtgtga ttccaagaaa ataattctca ggtggtgatt tgtcacccaa acatctggtt
     2041 tcccgcacac atctgctggc ccccttttgg aaaaacccac tgtgctatca gttagtactt
     2101 gctgtttcca tggtgactgg atctctgtgt catcttatgg agctcttgga cctctcagtg
     2161 tggttcagaa tgggctagat tgtcattcag cccttaactc tgccttatca acagaaactt
     2221 gagtttcctt aaatttagaa actcgtgctt gcataaaatg gcaggttgga acaaaatctt
     2281 tattttgatc ctaattgctt aggtttaaaa tgtttgtaaa ataggtctct ttgaaccaag
     2341 tgatttattt tgcttcagag tttgcttttt ttttttaaat agaaactgtg aaaaaatgtt
     2401 tatagaaaaa atacaagcag gtacaaaaag gttaggccaa tgtaaggaac actctccagc
     2461 tttagactcg cccacttcaa agtcatgtac tagcttaaaa aaaaaccact cccctccatc
     2521 ctatccctca ctgacaggaa gagctgaagc tgtttcctgg tcctgcccat ggttgtatag
     2581 tagcttagta ctggttttgt ggggggaaaa aaagtttttt ttggagtggg ggtagctttg
     2641 ttctatttat tattggcact cttaaggatt cttgccttct tttcctctga ctccctctat
     2701 gtaagtcctt ttcgggccat acttggtttc agtcacagga cctagtatat tctacacaat
     2761 tgttctaaaa ctgagctaca gttccagcct tcctatataa cttataaatg tcagacagaa
     2821 taggcttccc ccttaccctc gcagatataa tttatgtctg ttttatgtac tgtatgtctt
     2881 attttgcaca taaaaaaaaa gccaatgttc attcccttgg gggtgaagag tttcctcatt
     2941 gagaatgtgt gttgtacata caacacttta tacgtacgga atcttgtatg caagcatttt
     3001 atttggcctg tcacttggta atatagttgt taacttttaa aatctacact tcatagggtc
     3061 agtacagatg ccattacgac tattcatatc aacaaaaata ttttaggtaa ctttttgata
     3121 aataggcttg tttaaaatgt tactcaggtt tacagtacag ctggatagta cctgtgtttt
     3181 attttctgtg taaaataaag ctcaaagctt ttggactttg gggtttccca gcccaaaaaa
     3241 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
