LOCUS       NM_153578               1912 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus non imprinted in Prader-Willi/Angelman syndrome 1
            homolog (human) (Nipa1), mRNA.
ACCESSION   NM_153578
VERSION     NM_153578.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1912)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1912)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1912)
  AUTHORS   Adissu,H.A., Estabel,J., Sunter,D., Tuck,E., Hooks,Y.,
            Carragher,D.M., Clarke,K., Karp,N.A., Newbigging,S., Jones,N.,
            Morikawa,L., White,J.K. and McKerlie,C.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Histopathology reveals correlative and unique phenotypes in a
            high-throughput mouse phenotyping screen
  JOURNAL   Dis Model Mech 7 (5), 515-524 (2014)
   PUBMED   24652767
REFERENCE   4  (bases 1 to 1912)
  AUTHORS   Botzolakis,E.J., Zhao,J., Gurba,K.N., Macdonald,R.L. and Hedera,P.
  TITLE     The effect of HSP-causing mutations in SPG3A and NIPA1 on the
            assembly, trafficking, and interaction between atlastin-1 and NIPA1
  JOURNAL   Mol Cell Neurosci 46 (1), 122-135 (2011)
   PUBMED   20816793
REFERENCE   5  (bases 1 to 1912)
  AUTHORS   van der Zwaag,B., Staal,W.G., Hochstenbach,R., Poot,M.,
            Spierenburg,H.A., de Jonge,M.V., Verbeek,N.E., van 't Slot,R., van
            Es,M.A., Staal,F.J., Freitag,C.M., Buizer-Voskamp,J.E., Nelen,M.R.,
            van den Berg,L.H., van Amstel,H.K., van Engeland,H. and
            Burbach,J.P.
  TITLE     A co-segregating microduplication of chromosome 15q11.2 pinpoints
            two risk genes for autism spectrum disorder
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 153B (4), 960-966 (2010)
   PUBMED   20029941
REFERENCE   6  (bases 1 to 1912)
  AUTHORS   Zhao,J., Matthies,D.S., Botzolakis,E.J., Macdonald,R.L.,
            Blakely,R.D. and Hedera,P.
  TITLE     Hereditary spastic paraplegia-associated mutations in the NIPA1
            gene and its Caenorhabditis elegans homolog trigger neural
            degeneration in vitro and in vivo through a gain-of-function
            mechanism
  JOURNAL   J Neurosci 28 (51), 13938-13951 (2008)
   PUBMED   19091982
REFERENCE   7  (bases 1 to 1912)
  AUTHORS   Goytain,A., Hines,R.M., El-Husseini,A. and Quamme,G.A.
  TITLE     NIPA1(SPG6), the basis for autosomal dominant form of hereditary
            spastic paraplegia, encodes a functional Mg2+ transporter
  JOURNAL   J Biol Chem 282 (11), 8060-8068 (2007)
   PUBMED   17166836
REFERENCE   8  (bases 1 to 1912)
  AUTHORS   Chai,J.H., Locke,D.P., Greally,J.M., Knoll,J.H., Ohta,T., Dunai,J.,
            Yavor,A., Eichler,E.E. and Nicholls,R.D.
  TITLE     Identification of four highly conserved genes between breakpoint
            hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes
            deletion region that have undergone evolutionary transposition
            mediated by flanking duplicons
  JOURNAL   Am J Hum Genet 73 (4), 898-925 (2003)
   PUBMED   14508708
  REMARK    GeneRIF: indentification on mouse chromosome 7C
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102121.7.
            
            On Jun 9, 2018 this sequence version replaced NM_153578.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055828.1, AY098645.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415126 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AC102121.7         114116-114307       c
            193-240             AC102121.7         92223-92270         c
            241-331             AC102121.7         91141-91231         c
            332-492             AC102121.7         80111-80271         c
            493-1912            AC102121.7         73191-74610         c
FEATURES             Location/Qualifiers
     source          1..1912
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 33.42 cM"
     gene            1..1912
                     /gene="Nipa1"
                     /gene_synonym="1110027G09Rik; A830014A18Rik; FSP3; Spg6"
                     /note="non imprinted in Prader-Willi/Angelman syndrome 1
                     homolog (human)"
                     /db_xref="GeneID:233280"
                     /db_xref="MGI:MGI:2442058"
     exon            1..192
                     /gene="Nipa1"
                     /gene_synonym="1110027G09Rik; A830014A18Rik; FSP3; Spg6"
                     /inference="alignment:Splign:2.1.0"
     exon            193..240
                     /gene="Nipa1"
                     /gene_synonym="1110027G09Rik; A830014A18Rik; FSP3; Spg6"
                     /inference="alignment:Splign:2.1.0"
     exon            241..331
                     /gene="Nipa1"
                     /gene_synonym="1110027G09Rik; A830014A18Rik; FSP3; Spg6"
                     /inference="alignment:Splign:2.1.0"
     exon            332..492
                     /gene="Nipa1"
                     /gene_synonym="1110027G09Rik; A830014A18Rik; FSP3; Spg6"
                     /inference="alignment:Splign:2.1.0"
     exon            493..1912
                     /gene="Nipa1"
                     /gene_synonym="1110027G09Rik; A830014A18Rik; FSP3; Spg6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1894..1899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nipa1"
                     /gene_synonym="1110027G09Rik; A830014A18Rik; FSP3; Spg6"
                     /note="hexamer: AATAAA"
     polyA_site      1912
                     /gene="Nipa1"
                     /gene_synonym="1110027G09Rik; A830014A18Rik; FSP3; Spg6"
                     /note="major polyA site"
ORIGIN      
        1 gcgcacgcgc agcggagggc ggcgcgggcg gcatggggac tgcggcggcg gctgcggcgg
       61 ccggggaggg ggcgcgcggc ccgagccccg ccgccgtgtc gctcggcctg ggcgtggctg
      121 tggtgtccag cctagtgaac gggtccacgt tcgtgctgca gaagaagggc attgtgcgcg
      181 ctaaaaggcg aggtacttcc tacctaacag acattgtgtg gtgggctggc acaattgcaa
      241 tggctgtcgg ccagattgga aactttctag cttacactgc ggtccctaca gtcctggtga
      301 ctcccttagg tgcccttgga gtaccgtttg ggtccatttt agcttcttac cttctgaagg
      361 aaaagctcaa catcttgggc aagttgggct gtctgctaag ctgcgcaggt tctgtcgtgc
      421 tgatcatcca ttccccgaag tctgagagtg tgaccacgca ggccgagttg gaggagaagc
      481 tgaccaatcc agtgtttgtg ggctacctgt gcatcgtgct gctcatgctg ctgctgttga
      541 tcttctggat cgcaccagcc cacgggccca ccaacatcat ggtctacatc agcatctgct
      601 ccttgctggg gagtttcact gtgccttcca ccaagggcat tgggctggca gcccaagaca
      661 tcttgcacaa caatccatcc agtcagagag ccctctgcct gtgcctggtg ctcctggctg
      721 tcctgggctg cagcatcatt gtccaattca ggtacatcaa caaggccctg gagtgcttcg
      781 actcctctgt atttggggcc atctactacg ttgtgtttac cacgctggtc ctactggctt
      841 cagccatcct cttccgggag tggagcaatg tgggcctggt ggacttcttg ggcatggcct
      901 gtggatttac aactgtctcc gtgggaattg tcctcataca agtgttcaaa gaattcaact
      961 tcaaccttgg agagatgaac aaatccaata tgaaaacaga ctaagatgca accaaggggt
     1021 gggggtttga ggaacaggca ttggaggggg tctgtggttc ttactacatg tcacgtagaa
     1081 gagactctcg gtgagcattg cctgtgaact aataatccag tggacaatag gctttgcacc
     1141 agggtgaggt ccagacctct gcagcacaga gctcccgatg gttggttggg tgtaaactct
     1201 ctctgatgag acaaattctg ttttcatttc cattaaccta gaagctttca ttcattgatt
     1261 gtttaaaaca ttttaacatg atttaccaga agataaggat gagtctttct agttagtctg
     1321 tgtaggggag cagattctta gagtaccttg gaaaaggaag tgaaatctgg ctctctacag
     1381 taaacgtgag tgactttgtg cttgtgttaa gcatgtctag cattcaggta ttttactcaa
     1441 ataagcggta tgtgaatcga gttgttttta gtcctttaac aaccaggctc tcctacatgt
     1501 acccccaaag ccgaggtaag cagagagaga ggagttaatg acaatgacgc agagttccat
     1561 cgacagggcg actgtccgat agctcacatc agttttagtg cctttatcat ttgaattatt
     1621 ttaacttaat ttaactatta ttgtgtacat tgttaactgt tctaattaca gatacgtaaa
     1681 gtagttagaa aaatactatg gtcagtggaa ggtagcaaaa atctaaagct agaggacaat
     1741 ttgaaaagtg acccagatgt agattgtcat ccagttaagg acaactgagt aagtatgaag
     1801 agatatttaa tttgcactta acctctgtta cttggattca ttatgaaaaa cacctgcttt
     1861 ctgtttcagg cagtattgtg tccattcaga agaaataaag tattgaactt ga
//
