LOCUS       NP_997087               1394 aa            linear   ROD 08-AUG-2024
DEFINITION  ninein-like protein [Mus musculus].
ACCESSION   NP_997087 XP_355350 XP_358562
VERSION     NP_997087.2
DBSOURCE    REFSEQ: accession NM_207204.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1394)
  AUTHORS   Yeerken,D., Xiao,W., Li,J., Wang,Y., Wu,Q., Chen,J., Gong,W.,
            Lv,M., Wang,T., Gong,Y., Liu,R., Fan,J., Li,J., Zhang,W. and
            Zhan,Q.
  TITLE     Nlp-dependent ER-to-Golgi transport
  JOURNAL   Int J Biol Sci 20 (8), 2881-2903 (2024)
   PUBMED   38904019
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1394)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 1394)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1394)
  AUTHORS   Adissu,H.A., Estabel,J., Sunter,D., Tuck,E., Hooks,Y.,
            Carragher,D.M., Clarke,K., Karp,N.A., Newbigging,S., Jones,N.,
            Morikawa,L., White,J.K. and McKerlie,C.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Histopathology reveals correlative and unique phenotypes in a
            high-throughput mouse phenotyping screen
  JOURNAL   Dis Model Mech 7 (5), 515-524 (2014)
   PUBMED   24652767
REFERENCE   5  (residues 1 to 1394)
  AUTHORS   Shao,S., Liu,R., Wang,Y., Song,Y., Zuo,L., Xue,L., Lu,N., Hou,N.,
            Wang,M., Yang,X. and Zhan,Q.
  TITLE     Centrosomal Nlp is an oncogenic protein that is gene-amplified in
            human tumors and causes spontaneous tumorigenesis in transgenic
            mice
  JOURNAL   J Clin Invest 120 (2), 498-507 (2010)
   PUBMED   20093778
REFERENCE   6  (residues 1 to 1394)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY302641.1, BC067071.1, BU058995.1, CO427181.1 and BY715392.1.
            
            On Nov 24, 2007 this sequence version replaced NP_997087.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.96737.1,
                                           SRR9219380.63057.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1394
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.76 cM"
     Protein         1..1394
                     /product="ninein-like protein"
                     /calculated_mol_wt=157708
     Region          <1..71
                     /region_name="FRQ1"
                     /note="Ca2+-binding protein, EF-hand superfamily [Signal
                     transduction mechanisms]; COG5126"
                     /db_xref="CDD:444056"
     Region          77..99
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ12.3)"
     Region          126..166
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ12.3)"
     Site            149
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6ZQ12.3)"
     Region          213..260
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Region          <240..301
                     /region_name="XopAW"
                     /note="XopAW family type III secretion system
                     calcium-binding effector; NF041410"
                     /db_xref="CDD:469301"
     Region          299..>357
                     /region_name="PRK13589"
                     /note="flagellin A"
                     /db_xref="CDD:172158"
     Region          <382..>862
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          494..496
                     /region_name="KEN box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ12.3)"
     Region          578..602
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ12.3)"
     Region          632..640
                     /region_name="D-box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ12.3)"
     Region          866..977
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ12.3)"
     Region          <1079..1389
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1394
                     /gene="Ninl"
                     /gene_synonym="4930519N13Rik; Gm1004; Gm1634; mKIAA0980"
                     /coded_by="NM_207204.2:180..4364"
                     /db_xref="CCDS:CCDS50744.1"
                     /db_xref="GeneID:78177"
                     /db_xref="MGI:MGI:1925427"
ORIGIN      
        1 mdneeenhyv srlrdvyssc dttgtgfldq eeltqlctkl gleeqlpall hillgddrla
       61 rvnfeefkeg fvavlssgsg vepsdeegss sesatscavp pkymsgskwy grrslpelgd
      121 satatkygse qqakgsvkpp lrrsaslesv eslksdedae sakepqnelf eaqgqlrswg
      181 cevfgtlrks cspsfstpen lvqgiwhelg igssghlneq elavvcrsig lhslekqele
      241 elfskldqdg dgrvslaefq lglfghepps lpassslikp nrlwshyqee sgchttttss
      301 lvsvcsglrl fssvddgsgf afpeqvisaw aqegiqngre ilqsldfsvd ekvnlleltw
      361 aldnelltvd gviqqaalac yrqelsyhqg qvdqlvqerd karqdlekae krnldfvrem
      421 ddchsaleql tekkikhleq eyrgrlsllr sevemerelf weqarrqrav leqdvgrlqa
      481 eetslreklt lalkensrlq keiievvekl sdseklvlrl qsdlqfvlkd klepqsmell
      541 aqeeqftail ndyelkcrdl qdrndelqae leglrlrlpr srqspagtpg thrrripgrg
      601 padnlfvges tpvsleteim veqmkehyqe lrmqletkvn yyekeievmk rnfekdkkem
      661 eqafqlevsv legqkadlea lyaksqevil glkeqlqdaa qspepapagl ahccaqalct
      721 laqrlevemh lrhqdqllqi rqeaeeelnq klswleaqha acceslslqh qcekdqllqt
      781 hlqrvkdlaa qldlekgrre ereqevlahc rrqqlklqav mseeqaricr sftlekekle
      841 qtyreqvegl vqeadvlral lkngttvvsd qqertpssms lgpdsrqqpt arqavspdgr
      901 tgapaewpgp ekaegrdfpg qlcsidamps ptptllsrrs senlgvrdnh qrplnaeega
      961 ipkepepsar tltgqgqklp lpvhpqmlep slgttaldrk aasvgvqgqa segpvgdgeg
     1021 vqeawlqfrg eatrmrpslp cselpnpqea tvmpamsese mkdvkikllq ledvvralek
     1081 adsresyrae lqrlseenlv lksdlgkiql eletseskne vqrqeievlk rdkeqaccdl
     1141 eelstqtqky kdemsqlncr vlqlegepsg lhtqkeenhg aiqvlmkkle eagcreeqqg
     1201 dqiqnlkiel ervneecqyl rlsqaeltes leesrsqlys vqlrleaaqs qhgrivqrlq
     1261 eqmsqlvpga rvaelqhlln vkeeearrls aqqeeyrqql karedqveda earlrnvewl
     1321 lqekveelrk qfekntrsdl llkelyvena hlmkavqlte ekqrgaekkn cvleekvral
     1381 nkliskmapa slsv
//
