LOCUS       NM_016718                849 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus ninjurin 2 (Ninj2), transcript variant 1, mRNA.
ACCESSION   NM_016718 XM_917434
VERSION     NM_016718.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 849)
  AUTHORS   Zhang,J., Kong,X., Yang,H.J., Zhang,W., Chen,M. and Chen,X.
  TITLE     Ninjurin 2 Modulates Tumorigenesis, Inflammation, and Metabolism
            via Pyroptosis
  JOURNAL   Am J Pathol 194 (5), 849-860 (2024)
   PUBMED   38325550
  REMARK    GeneRIF: Ninjurin 2 Modulates Tumorigenesis, Inflammation, and
            Metabolism via Pyroptosis.
REFERENCE   2  (bases 1 to 849)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 849)
  AUTHORS   Zhang,J., Kong,X., Yang,H.J., Mohibi,S., Lucchesi,C.A., Zhang,W.
            and Chen,X.
  TITLE     Ninjurin 2, a Cell Adhesion Molecule and a Target of p53, Modulates
            Wild-Type p53 in Growth Suppression and Mutant p53 in Growth
            Promotion
  JOURNAL   Cancers (Basel) 16 (1), 229 (2024)
   PUBMED   38201656
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 849)
  AUTHORS   Wang,Y., Wang,P., Yu,Y., Huang,E., Yao,Y., Guo,D., Peng,H.,
            Tian,B., Zheng,Q., Jia,M., Wang,J., Wu,X., Cheng,J., Liu,H.,
            Wang,Q.K. and Xu,C.
  TITLE     Hepatocyte Ninjurin2 promotes hepatic stellate cell activation and
            liver fibrosis through the IGF1R/EGR1/PDGF-BB signaling pathway
  JOURNAL   Metabolism 140, 155380 (2023)
   PUBMED   36549436
  REMARK    GeneRIF: Hepatocyte Ninjurin2 promotes hepatic stellate cell
            activation and liver fibrosis through the IGF1R/EGR1/PDGF-BB
            signaling pathway.
REFERENCE   5  (bases 1 to 849)
  AUTHORS   Peng,H., Yu,Y., Wang,P., Yao,Y., Wu,X., Zheng,Q., Wang,J., Tian,B.,
            Wang,Y., Ke,T., Liu,M., Tu,X., Liu,H., Wang,Q.K. and Xu,C.
  TITLE     NINJ2 deficiency inhibits preadipocyte differentiation and promotes
            insulin resistance through regulating insulin signaling
  JOURNAL   Obesity (Silver Spring) 31 (1), 123-138 (2023)
   PUBMED   36504350
  REMARK    GeneRIF: NINJ2 deficiency inhibits preadipocyte differentiation and
            promotes insulin resistance through regulating insulin signaling.
REFERENCE   6  (bases 1 to 849)
  AUTHORS   Sun,Y., Chen,X., Yue,C., Yang,W., Zhang,S., Ou,Z. and Chen,Y.
  TITLE     Ninj2 regulates Schwann cells development by interfering
            laminin-integrin signaling
  JOURNAL   Theranostics 12 (17), 7307-7318 (2022)
   PUBMED   36438492
  REMARK    GeneRIF: Ninj2 regulates Schwann cells development by interfering
            laminin-integrin signaling.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 849)
  AUTHORS   Sun,Y., Chen,X., Ou,Z., Wang,Y., Chen,W., Zhao,T., Liu,C. and
            Chen,Y.
  TITLE     Dysmyelination by Oligodendrocyte-Specific Ablation of Ninj2
            Contributes to Depressive-Like Behaviors
  JOURNAL   Adv Sci (Weinh) 9 (3), e2103065 (2022)
   PUBMED   34787377
  REMARK    GeneRIF: Dysmyelination by Oligodendrocyte-Specific Ablation of
            Ninj2 Contributes to Depressive-Like Behaviors.
REFERENCE   8  (bases 1 to 849)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   9  (bases 1 to 849)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 849)
  AUTHORS   Araki,T. and Milbrandt,J.
  TITLE     Ninjurin2, a novel homophilic adhesion molecule, is expressed in
            mature sensory and enteric neurons and promotes neurite outgrowth
  JOURNAL   J Neurosci 20 (1), 187-195 (2000)
   PUBMED   10627596
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113092.25 and AC156951.7.
            
            On Jan 23, 2023 this sequence version replaced NM_016718.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF205634.1, AK138486.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC113092.25        146063-146167
            106-337             AC156951.7         81844-82075
            338-522             AC156951.7         82584-82768
            523-849             AC156951.7         83954-84280
FEATURES             Location/Qualifiers
     source          1..849
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 56.9 cM"
     gene            1..849
                     /gene="Ninj2"
                     /note="ninjurin 2"
                     /db_xref="GeneID:29862"
                     /db_xref="MGI:MGI:1352751"
     exon            1..105
                     /gene="Ninj2"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..504
                     /gene="Ninj2"
                     /note="isoform 1 is encoded by transcript variant 1; nerve
                     injury-induced protein 2"
                     /codon_start=1
                     /product="ninjurin-2 isoform 1"
                     /protein_id="NP_057927.1"
                     /db_xref="CCDS:CCDS39612.1"
                     /db_xref="GeneID:29862"
                     /db_xref="MGI:MGI:1352751"
                     /translation="MESDRETIHLQHRHSMRGGNQRIDLNFYATKKSVAESMLDVALF
                     MSNAMRLKSVLQQGPFAEYYTTLVTLIIVSLLLQVVISLLLVFIAILNLNEVENQRHL
                     NKLNNAATILVFITVVINIFITAFGAHHAASMAARTSSNPI"
     exon            106..337
                     /gene="Ninj2"
                     /inference="alignment:Splign:2.1.0"
     exon            338..522
                     /gene="Ninj2"
                     /inference="alignment:Splign:2.1.0"
     exon            523..849
                     /gene="Ninj2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      828..833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ninj2"
                     /note="hexamer: TATAAA"
     polyA_site      849
                     /gene="Ninj2"
                     /note="major polyA site"
ORIGIN      
        1 agactgccca gctgaaaaat ccacgcaaac tgcagacact cggagggtgg cgagtggccc
       61 cagggcagca agatggagtc agaccgagaa accatccacc ttcaacacag gcactccatg
      121 cgcggaggga accagcgcat agacctgaac ttttatgcca ccaagaagag tgtggcagag
      181 agcatgctag acgtggcgct ctttatgtcc aatgccatgc ggctgaaatc agtgctgcag
      241 caagggccat tcgcggagta ctacaccacc ctagtcaccc tcatcattgt ctctctgctc
      301 ctgcaagtgg tcattagcct ccttcttgtg ttcatcgcca tcctgaacct gaatgaggta
      361 gagaaccaga ggcatttaaa taagctcaac aatgctgcca ccatcttggt cttcataacc
      421 gtggtcatca acatttttat cactgctttc ggagcacacc atgcagcctc catggctgcc
      481 aggacctcca gcaatcctat ttgatgacta cctaggtccc aggagctggg tctagagcca
      541 cttcagcctt tgtccctgac ttgtcaggat aactagcatt tcccacagcc tccaggagag
      601 cttcaagggc tacgaagaaa cccctgcctc ttgtccacag caccagaatt aaagtgggcc
      661 tctttcctgg gtgacgtaat tgcactttgg tctggaggcc cgagctgctt ccagcagcag
      721 taactcggtc tgttaaggca gctcctgcac agcctgcaca ctctgcactg ccttcttttc
      781 ctgtgctcca ggcctcaatg ttccctttct gcaaaatgga atctatctat aaagatatct
      841 gaaaattca
//
