LOCUS       NM_013610               1150 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus ninjurin 1 (Ninj1), mRNA.
ACCESSION   NM_013610
VERSION     NM_013610.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1150)
  AUTHORS   Song,C.H., Kim,N., Nam,R.H., Choi,S.I., Jang,J.Y., Kim,E.H., Ha,S.,
            Shin,E., Choi,H., Kim,K.W., Jeon,S., Oh,G.T. and Seok,Y.J.
  TITLE     Ninjurin1 deficiency differentially mitigates colorectal cancer
            induced by azoxymethane and dextran sulfate sodium in male and
            female mice
  JOURNAL   Int J Cancer 156 (4), 826-839 (2025)
   PUBMED   39417611
REFERENCE   2  (bases 1 to 1150)
  AUTHORS   Pourmal,S., Truong,M.E., Johnson,M.C., Yang,Y., Zhou,L., Alegre,K.,
            Stowe,I.B., Gupta,S., Chen,P.A., Zhang,Y., Rohou,A., Newton,K.,
            Kayagaki,N., Dixit,V.M. and Deshpande,I.
  TITLE     Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture
  JOURNAL   Nature 637 (8045), 446-452 (2025)
   PUBMED   39476863
REFERENCE   3  (bases 1 to 1150)
  AUTHORS   David,L., Borges,J.P., Hollingsworth,L.R., Volchuk,A., Jansen,I.,
            Garlick,E., Steinberg,B.E. and Wu,H.
  TITLE     NINJ1 mediates plasma membrane rupture by cutting and releasing
            membrane disks
  JOURNAL   Cell 187 (9), 2224-2235 (2024)
   PUBMED   38614101
REFERENCE   4  (bases 1 to 1150)
  AUTHORS   Ramos,S., Hartenian,E., Santos,J.C., Walch,P. and Broz,P.
  TITLE     NINJ1 induces plasma membrane rupture and release of
            damage-associated molecular pattern molecules during ferroptosis
  JOURNAL   EMBO J 43 (7), 1164-1186 (2024)
   PUBMED   38396301
REFERENCE   5  (bases 1 to 1150)
  AUTHORS   Han,J.H., Karki,R., Malireddi,R.K.S., Mall,R., Sarkar,R.,
            Sharma,B.R., Klein,J., Berns,H., Pisharath,H., Pruett-Miller,S.M.,
            Bae,S.J. and Kanneganti,T.D.
  TITLE     NINJ1 mediates inflammatory cell death, PANoptosis, and lethality
            during infection conditions and heat stress
  JOURNAL   Nat Commun 15 (1), 1739 (2024)
   PUBMED   38409108
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1150)
  AUTHORS   Ahn,B.J., Le,H., Shin,M.W., Bae,S.J., Lee,E.J., Wee,H.J., Cha,J.H.,
            Park,J.H., Lee,H.S., Lee,H.J., Jung,H., Park,Z.Y., Park,S.H.,
            Han,B.W., Seo,J.H., Lo,E.H. and Kim,K.W.
  TITLE     The N-terminal ectodomain of Ninjurin1 liberated by MMP9 has
            chemotactic activity
  JOURNAL   Biochem Biophys Res Commun 428 (4), 438-444 (2012)
   PUBMED   23142597
  REMARK    GeneRIF: the N-terminal ectodomain of mouse Ninjurin1, which may
            act as a chemoattractant, is cleaved by MMP9.
REFERENCE   7  (bases 1 to 1150)
  AUTHORS   Lee,H.J., Ahn,B.J., Shin,M.W., Jeong,J.W., Kim,J.H. and Kim,K.W.
  TITLE     Ninjurin1 mediates macrophage-induced programmed cell death during
            early ocular development
  JOURNAL   Cell Death Differ 16 (10), 1395-1407 (2009)
   PUBMED   19557008
  REMARK    GeneRIF: Ninj1 protein has an important role in vascular regression
            mediated by macrophages during early eye development and suggest
            the biological relevance of Ninj1 on vascular homeostasis.
REFERENCE   8  (bases 1 to 1150)
  AUTHORS   Trimarchi,J.M., Cho,S.H. and Cepko,C.L.
  TITLE     Identification of genes expressed preferentially in the developing
            peripheral margin of the optic cup
  JOURNAL   Dev Dyn 238 (9), 2327-2329 (2009)
   PUBMED   19449303
REFERENCE   9  (bases 1 to 1150)
  AUTHORS   Moon,A.R., Oh,G.T., Kim,J.W., Choi,Y.J. and Choe,I.S.
  TITLE     Genomic DNA sequence and transcription factor binding sites of
            mouse ninjurin
  JOURNAL   DNA Seq 12 (5-6), 385-395 (2001)
   PUBMED   11913785
REFERENCE   10 (bases 1 to 1150)
  AUTHORS   Chadwick,B.P., Heath,S.K., Williamson,J., Obermayr,F., Patel,L.,
            Sheer,D. and Frischauf,A.M.
  TITLE     The human homologue of the ninjurin gene maps to the candidate
            region of hereditary sensory neuropathy type I (HSNI)
  JOURNAL   Genomics 47 (1), 58-63 (1998)
   PUBMED   9465296
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK159111.1 and BB756836.1.
            
            [WARNING] On Feb 12, 2025 this sequence was replaced by
            NM_013610.4.
            
            On Feb 5, 2019 this sequence version replaced NM_013610.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3224855.8693.1, U91513.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1143              AK159111.1         3-1145
            1144-1150           BB756836.1         527-533
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 25.14 cM"
     gene            1..1150
                     /gene="Ninj1"
                     /note="ninjurin 1"
                     /db_xref="GeneID:18081"
                     /db_xref="MGI:MGI:1196617"
     exon            1..109
                     /gene="Ninj1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..493
                     /gene="Ninj1"
                     /note="nerve injury-induced protein 1"
                     /codon_start=1
                     /product="ninjurin-1"
                     /protein_id="NP_038638.1"
                     /db_xref="CCDS:CCDS26497.1"
                     /db_xref="GeneID:18081"
                     /db_xref="MGI:MGI:1196617"
                     /translation="MESGTEEYELNGDLRPGSPGSPDALPPRWGLRNRPINVNHYANK
                     KSAAESMLDIALLMANASQLKAVVEQGNDFAFFVPLVVLISISLVLQIGVGVLLIFLV
                     KYDLNNPAKHAKLDFLNNLATGLVFIIVVVNIFITAFGVQKPVMDVAPRQ"
     exon            110..338
                     /gene="Ninj1"
                     /inference="alignment:Splign:2.1.0"
     exon            339..502
                     /gene="Ninj1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..1150
                     /gene="Ninj1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1124..1129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ninj1"
                     /note="hexamer: AATAAA"
     polyA_site      1144
                     /gene="Ninj1"
                     /note="major polyA site"
ORIGIN      
        1 aggccgtgtg ctgggcggcc cgggcggccg caccatggag tcgggcactg aggagtatga
       61 gctcaacggc gacctgcgcc cgggctcccc cggttccccc gacgccttgc caccccgctg
      121 gggtttgcgg aaccggccca tcaatgtaaa ccattatgcc aacaagaaga gcgctgcgga
      181 gagcatgctg gacatcgcgc tgctcatggc caacgcgtcg cagctgaagg ccgtggtgga
      241 gcagggcaat gatttcgcct tcttcgtgcc ccttgtggtc ctcatctcta tctccctcgt
      301 gctgcagata ggagtgggcg tgctgctcat cttcctggtc aagtatgacc tcaacaaccc
      361 ggccaagcac gccaagctgg actttcttaa caacctggcc acgggactgg ttttcatcat
      421 cgtcgtggtc aacatcttca ttacggcctt cggggtccag aagcctgtaa tggacgtggc
      481 gccccggcag tagaacgccc agagacttta agggtaccgg acctgcagcc cagctgacca
      541 gacccctgca actgctgtac ccccaaggta tccctctcct gtgtgcagag cccaaggtgg
      601 ccaccgctgg accatggtca gggacggact tccgtccaac tgtgaccgct gtgtgggcgg
      661 ccacctgaga catgtgggaa ccggatgcag ggccatgaag atcagaactg gacagctcca
      721 tagaaaccca agtccagaga atggtcactg cccacccaag gacatgcagc aaatccatga
      781 ttggacttga cgaggggcca gcactggcct ctgtctcagg acattccaga aggaccagga
      841 tatgcccctc cctttgctga tacaccagtg accctacttc tcatggagcc tgcccaggtc
      901 accctggaga ctgctgcctt tgttgtttct tgacccaggg accttggaca gccatcagta
      961 tctgctggct ccagcctcag tgcctgggct tggcagccat caagaggcag ccatgcccgt
     1021 gggggctgca ggtcatgctg gtacttcctg ccagtggtga cctgggtaga gccccagccc
     1081 tcaactcagg ggttcaggcc ccacttttct aatcaggaac gacaataaag cttatgtgct
     1141 tccctgctgg
//
