LOCUS       NM_001403832            9923 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus ninein (Nin), transcript variant 7, mRNA.
ACCESSION   NM_001403832 XM_006515529
VERSION     NM_001403832.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9923)
  AUTHORS   Gnatowski,E.R., Jurmain,J.L., Dozmorov,M.G., Wolstenholme,J.T. and
            Miles,M.F.
  TITLE     Ninein, a candidate gene for ethanol anxiolysis, shows complex
            exon-specific expression and alternative splicing differences
            between C57BL/6J and DBA/2J mice
  JOURNAL   Front Genet 15, 1455616 (2024)
   PUBMED   39323865
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9923)
  AUTHORS   Gilbert,T., Gorlt,C., Barbier,M., Duployer,B., Plozza,M.,
            Dufrancais,O., Martet,L.E., Dalbard,E., Segot,L., Tenailleau,C.,
            Haren,L., Verollet,C., Bierkamp,C. and Merdes,A.
  TITLE     Loss of ninein interferes with osteoclast formation and causes
            premature ossification
  JOURNAL   Elife 13, e93457 (2024)
   PUBMED   38836552
  REMARK    GeneRIF: Loss of ninein interferes with osteoclast formation and
            causes premature ossification.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9923)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 9923)
  AUTHORS   Langner,E., Cheng,T., Kefaloyianni,E., Gluck,C., Wang,B. and
            Mahjoub,M.R.
  TITLE     Cep120 is essential for kidney stromal progenitor cell growth and
            differentiation
  JOURNAL   EMBO Rep 25 (1), 428-454 (2024)
   PUBMED   38177914
REFERENCE   5  (bases 1 to 9923)
  AUTHORS   Dang,H., Martin-Villalba,A. and Schiebel,E.
  TITLE     Centrosome linker protein C-Nap1 maintains stem cells in mouse
            testes
  JOURNAL   EMBO Rep 23 (7), e53805 (2022)
   PUBMED   35599622
REFERENCE   6  (bases 1 to 9923)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   7  (bases 1 to 9923)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 9923)
  AUTHORS   Mogensen,M.M., Malik,A., Piel,M., Bouckson-Castaing,V. and
            Bornens,M.
  TITLE     Microtubule minus-end anchorage at centrosomal and non-centrosomal
            sites: the role of ninein
  JOURNAL   J Cell Sci 113 (Pt 17), 3013-3023 (2000)
   PUBMED   10934040
REFERENCE   9  (bases 1 to 9923)
  AUTHORS   Hong,Y.R., Chen,C.H., Chang,J.H., Wang,S., Sy,W.D., Chou,C.K. and
            Howng,S.L.
  TITLE     Cloning and characterization of a novel human ninein protein that
            interacts with the glycogen synthase kinase 3beta
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 513-516 (2000)
   PUBMED   11004522
REFERENCE   10 (bases 1 to 9923)
  AUTHORS   Bouckson-Castaing,V., Moudjou,M., Ferguson,D.J., Mucklow,S.,
            Belkaid,Y., Milon,G. and Crocker,P.R.
  TITLE     Molecular characterisation of ninein, a new coiled-coil protein of
            the centrosome
  JOURNAL   J Cell Sci 109 (Pt 1), 179-190 (1996)
   PUBMED   8834802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112146.3 and AC116574.6.
            
            On Apr 5, 2022 this sequence version replaced XM_006515529.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AC112146.3         82977-83150         c
            175-221             AC112146.3         82559-82605         c
            222-425             AC112146.3         73774-73977         c
            426-507             AC112146.3         61659-61740         c
            508-677             AC112146.3         49235-49404         c
            678-717             AC112146.3         33812-33851         c
            718-908             AC112146.3         32274-32464         c
            909-1055            AC112146.3         27775-27921         c
            1056-1223           AC112146.3         26995-27162         c
            1224-1360           AC112146.3         26430-26566         c
            1361-1501           AC112146.3         25954-26094         c
            1502-1676           AC112146.3         25511-25685         c
            1677-1787           AC112146.3         22263-22373         c
            1788-1877           AC112146.3         21788-21877         c
            1878-2016           AC112146.3         20147-20285         c
            2017-2138           AC112146.3         18276-18397         c
            2139-2629           AC112146.3         16270-16760         c
            2630-4750           AC112146.3         13255-15375         c
            4751-4876           AC112146.3         11878-12003         c
            4877-4946           AC112146.3         11710-11779         c
            4947-5159           AC112146.3         9662-9874           c
            5160-5273           AC116574.6         189988-190101       c
            5274-5396           AC116574.6         186488-186610       c
            5397-5510           AC116574.6         185714-185827       c
            5511-5657           AC116574.6         184817-184963       c
            5658-5837           AC116574.6         182843-183022       c
            5838-5987           AC116574.6         181585-181734       c
            5988-6089           AC116574.6         180211-180312       c
            6090-6287           AC116574.6         175665-175862       c
            6288-6401           AC116574.6         172404-172517       c
            6402-9923           AC116574.6         166266-169787       c
FEATURES             Location/Qualifiers
     source          1..9923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 28.94 cM"
     gene            1..9923
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /note="ninein"
                     /db_xref="GeneID:18080"
                     /db_xref="MGI:MGI:105108"
     exon            1..174
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            175..221
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            222..425
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..6611
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /note="isoform 4 is encoded by transcript variant 7"
                     /codon_start=1
                     /product="ninein isoform 4"
                     /protein_id="NP_001390761.1"
                     /db_xref="GeneID:18080"
                     /db_xref="MGI:MGI:105108"
                     /translation="MDEVEEDQHEARLKELFDSFDTLGTGSLGQEELTDLCHVLCLED
                     VGPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSSEEHFEESDCSPEAQPKYVRGG
                     KRYGRRSLPEFQESGEEIEEVTVLEPLEEEARSSPIPAGDCGEHWKTQRSEEYEAEGQ
                     LRFWNPDDLNASHGGSCPPPDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQN
                     VDGAMLEEVFLSLDPDGTMSVEDFFYGLFKTGKSLTPSASTPYRQLKRHLSMQSFDES
                     GRRTATSSAMTSTIGFRVFSCLDDGMGQASVERILDTWQEEGIENSQEILKALDFSLD
                     GNINLTELTLALENELLVTKNGIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDK
                     AEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRQEREQMLQQVGK
                     QRVELEQEIQKAKTEENYIRDRLALSLKENNRLETELLENAEKLAEYESLTQKLQRSL
                     ENVLAEKFGDLDPSSAEFFLQEERLAQMRNEYEQQCRLLQDQVDELQSELEEYQAQGR
                     VLRLPLKNSLSEELDGHSGGIEPDQGPGSEECNPLNMSIEAELVIEQMKEQHHRDLCH
                     LRLELEDKVRHYEKQLDDTRVASEQEQAAMKQKYEQGVHTLEKRVSELRSEIADLEGQ
                     AAVLREAHHKASCRHEEEKRQLQMAFDEEKAQLQEELRQEHERELQARLQQAAESFRQ
                     EREGLAQAAWTEEKVRGLEQSYQEQLLSLEEKHALEKEELREELSEHHRRELQEGREE
                     METECNRRVSQIEAQCQADCEKVTEHCEQTLQSLEVRHRQELRDLLDQHLEERSQWEF
                     EKDELTQECTDAQEQLKEALQRERATAAAMKQEQEILERTYKDRLNILSTERKQLLQD
                     LKDLQNASESQHGLLSGQILELKRSQERELRDQGQALCQTGVSEQLASQQLERLRVEH
                     EQERREMTGKLAALESAHRASLERADQEKAEMSTEICRLQNTVKDMQQAASLLMLQGG
                     CQATAGEEAEGDGAMSLLQQGEQLLEENGDVLISLQRAHEHAVKENAKMATEISRLQQ
                     RLKKLEPGSVISSCLEEGTSEISGSSREQVEPIMKQGPATKHFLSDLGDHEARDLAST
                     GTSSVQRQECKTEASEASLDCFSELENSEDTRTESWDLKSQISQLREQLTVLRADCDR
                     ASERKQDLLFDISVLKKKLKMLERLPEASSRYKVLYEDAARENSCLQEELRLVETRYE
                     ESLDSNKELTAEVYRLQDEMKKMEEVMETFLSLEKSYDEVKVENEELRALVLRLQGKM
                     EKVLGRAALQGDSYALWEAPSENLEVASDEKMLELRQTPKECTPKVVSMHHIIEECTQ
                     ETQCCEQGSTKLLARIKAHEIAWFHRAIKTHPEKPSAQNRVIPEGSAALLGLQDKHLQ
                     QEATIAELELEKQKLQELTRNLRERVTALVRQKDAPSQGQKEEELKAMMQDLQITCGE
                     MQRKVELLRYESEKLQEENSILRNEITTLNEEDSISNLKLEELNGSQEELWQKIETIE
                     QEKASIQTMVEKLKKQVSDLKIKNQQLDSENIELSQKNSQNKEELKTLNQRLAEMLCQ
                     REEPGACTSEKWEQENASLKEELDHYKVQTSTLVSSLEAELSEVKLQTHVMEQENLLL
                     KDELERLKQLHRCPDLSDFQQKMSSILSYNEKLLKEKEVLSEELKSCADKLAESSLLE
                     HRIATMKQEQTAWEEQSESLKSQLAVSQAKVQNLEDVLQNVNLQMAEIESDLQVTRQE
                     KEALKQEVMSLHRQLQNAIDKDWVSETAPHLSGLRGQQRRLSWDKLDHLMNEEPQLLC
                     QESKRLQTVVQNTQADLTHSREKVRQLESNLLPTKHQKQLNQPCTVKSTEQEKLTLKR
                     ECEQSQKEQSPTSRKVGQMGSLERGLETIHLENEGLKKKQVRLDEKLMEMQPLRSTVT
                     RSPSSHWDLQLLQQQACPMVPREQFLQLQQQLLQAEKRSQHLQEELENRTSETNTPQG
                     NQEHLVNLMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKTDAVVKDLYVENAQL
                     LKALEMTEQRQKTAEKRNFLLEEKIASLSTIVRNLAPAPLTSMPPLRS"
     exon            426..507
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            508..677
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            678..717
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            718..908
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1055
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1223
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1360
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1501
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1676
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1787
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1877
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2016
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2138
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2629
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..4750
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            4751..4876
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            4877..4946
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            4947..5159
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            5160..5273
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            5274..5396
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            5397..5510
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            5511..5657
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            5658..5837
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            5838..5987
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            5988..6089
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            6090..6287
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            6288..6401
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     exon            6402..9923
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9902..9907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /note="hexamer: AATAAA"
     polyA_site      9923
                     /gene="Nin"
                     /gene_synonym="3110068G20Rik; mKIAA1565"
                     /note="major polyA site"
ORIGIN      
        1 gactcctccc tgcgcggcca ggctcttcct cccccgcggc ccgatctccg ggtggcggcg
       61 gctgagccgg gagcaagcgc gctgggcgcg gccgtcccgt gccgcccggc caagcccgag
      121 agtcccgcgg tcatggtctg tgcggtggcg cggggcgcct gagcccggga ctcgagctcc
      181 ggaggcggcc ggcgtgggcg ctccccagag gccgacggaa ggtgagcgct gtgggctatg
      241 ggatggatga ggtggaggag gaccagcatg aagcccgact caaggagctg tttgacagtt
      301 ttgacaccct gggaactggg tctctgggtc aagaggagct cactgacctc tgccacgtgc
      361 tgtgcttgga ggatgtgggc ccggtgctgc aacagacgct actccaggac aacctcttgg
      421 gcagggtaca ttttgaccaa tttaaagaag cattaatact tatcttgtct agaactctat
      481 ccagtgagga gcactttgag gagtcagact gttccccaga agctcagccc aaatatgtta
      541 gaggtgggaa gcgttatgga cgaagatcac tgcccgagtt tcaagagtct ggggaagaga
      601 tcgaggaggt gacagtgctt gagccactag aggaagaagc gaggtcatca cccatcccag
      661 ctggggactg cggcgagcac tggaagacac aacgcagtga ggagtatgaa gcagaaggcc
      721 agctgaggtt ttggaaccca gatgacctga atgcttcaca tggtgggtct tgccctcctc
      781 cagactggat agaagagaaa ctgcaagagg tttgtgaaga tctggggatc actcgagatg
      841 gtcacctgaa ccggaagaag ctggtttcca tctgcgaaca gtatggatta cagaatgtgg
      901 atggagcgat gctggaagag gtgtttctca gccttgatcc tgatggaaca atgagtgtgg
      961 aagacttttt ctatggtctg tttaagactg ggaaatccct cacgccatca gcatctactc
     1021 cctatagaca actgaaacgg catctctcta tgcagtcttt cgatgagagt ggacggcgga
     1081 ccgcaacctc gtcagcaatg acgagtacca ttggcttccg ggtcttctcc tgcttggatg
     1141 acgggatggg ccaggcgtct gtggagagga tactggacac ctggcaggaa gaaggcattg
     1201 agaacagtca ggagattctg aaggccctgg atttcagcct ggatggaaac atcaacctga
     1261 cagagctgac gctggctctg gagaatgaac ttttggttac caagaatggc attcaccagg
     1321 cagcactagc tagcttcaag gccgagatcc ggcacttgtt agaacgagtt gaccaagtag
     1381 tcagagaaaa ggagaagcta cggtcggacc tggacaaagc agaaaagctg aagtctctca
     1441 tggcttccga ggtggacgat caccacgcgg ccattgagcg gaggaatgaa tacaacctca
     1501 ggaaactgga tgaagaatac aaggagcgca tagcagcctt aaagaacgaa ctccgccagg
     1561 agagggaaca gatgttgcag caagtgggca agcagcgggt ggagctggaa caggaaattc
     1621 aaaaggccaa gacggaagag aattacatcc gggaccgcct tgccctctcc ctgaaggaaa
     1681 acaatcgcct ggagactgag cttctggaaa acgcagagaa gttggcagag tacgagagcc
     1741 tgacgcagaa gctccagcgc agtttggaaa atgtgttagc agaaaagttt ggtgacctcg
     1801 atcccagcag tgctgagttc tttcttcaag aggagaggct ggcgcagatg agaaatgaat
     1861 atgagcaaca gtgcaggcta ttacaagacc aagtggatga gcttcagtct gaactagaag
     1921 aataccaggc tcaaggcagg gtgctcagac tccccttgaa gaactcgctg tcagaagaac
     1981 tcgacggtca cagtggtggt attgagcccg accaagggcc tggatctgaa gagtgcaacc
     2041 ccctgaatat gagcattgag gcagagctgg tcatcgagca gatgaaggag cagcaccacc
     2101 gggacctgtg tcacctgaga ctggagctgg aagacaaagt gcgccactat gaaaagcagc
     2161 tggatgatac cagggtcgcc tctgaacagg agcaggcagc catgaagcag aagtatgagc
     2221 agggagtgca caccttggag aagcgagtca gcgagcttcg gagtgagatt gcagacctgg
     2281 aagggcaggc agccgtgctg agggaggccc accacaaggc cagctgcagg cacgaggagg
     2341 aaaagagaca actgcaaatg gcgttcgatg aggaaaaggc tcagctccag gaggagctgc
     2401 ggcaggagca tgagagggag ctccaggcca ggctgcagca ggcagcggag agctttcgcc
     2461 aggagagaga gggactcgcc caggctgcct ggactgagga gaaggtgaga ggcttggagc
     2521 aatcttacca ggagcagctg ctgagcctgg aggagaagca tgctctagag aaagaagagc
     2581 tgagggaaga gctctcggaa catcaccgaa gggaactcca ggagggaagg gaagaaatgg
     2641 aaacagagtg taatagaaga gtctctcaga tagaagccca gtgccaggct gactgtgaga
     2701 aagtcactga gcactgtgaa caaactctgc aaagcctcga ggttcgccac cgccaggagc
     2761 tgagggacct cttggaccag cacctggagg aaaggtctca gtgggagttt gagaaggatg
     2821 agcttacaca agagtgcaca gatgcccagg agcagctgaa ggaggcgctc cagagggaga
     2881 gggcgaccgc tgcggccatg aagcaggaac aggagatact ggagaggaca tacaaggacc
     2941 gtttgaatat cctgagcacg gaaagaaagc agctgctgca agacctgaaa gacctacaga
     3001 acgcatctga gagccagcat ggcctcctgt ctggccagat acttgagctg aagagaagtc
     3061 aggagagaga actgagggac caagggcagg cgctatgcca gacgggggtc tctgagcagc
     3121 tggccagcca gcagctcgaa aggctccggg ttgagcatga gcaagagagg cgagaaatga
     3181 cgggcaagct tgccgccctg gagagcgccc acagagcaag ccttgagaga gcagatcaag
     3241 agaaggcgga gatgagcaca gaaatctgca ggcttcagaa tacagtcaag gacatgcagc
     3301 aggcagcatc tctcttgatg cttcagggtg gctgccaggc aacggcaggg gaggaggcag
     3361 aaggagatgg agccatgtcc ctgcttcagc aaggcgagca gctattggaa gaaaacggag
     3421 atgtcctcat cagcctgcag agagctcacg agcatgcagt gaaggaaaat gcaaagatgg
     3481 ctactgaaat ttcccgattg cagcagaggc tgaagaagtt agagccgggg tcggtgatct
     3541 cgtcttgttt ggaggagggg acgtctgaga tttctggaag ttccagggaa caagtagaac
     3601 ccataatgaa acaaggtcca gccaccaagc acttcctgag cgatctagga gaccacgagg
     3661 cccgggacct ggcaagtacc gggacaagct ccgttcagag gcaggagtgc aaaaccgagg
     3721 cgtcggaagc ttccctggac tgcttttctg agcttgaaaa cagtgaagac accaggaccg
     3781 agtcctggga cctcaagagt cagatcagcc agcttcggga gcaactgacg gtcttgcgag
     3841 cagactgcga tcgggcttcc gagaggaaac aggacctgct tttcgatatc tctgtgctga
     3901 aaaagaaact gaagatgctg gagagactcc cggaggcatc ttccaggtat aaggtattat
     3961 acgaggatgc cgcccgagaa aactcctgcc ttcaggagga gctgagactt gtagagacgc
     4021 gctacgagga gtcgctggac agcaacaaag agcttacggc ggaggtctac aggttgcagg
     4081 atgagatgaa gaaaatggag gaggtgatgg agacgttcct cagcctggag aagagttacg
     4141 atgaggtcaa agtggaaaat gaggaactcc gtgctctggt gttgagactt caagggaaga
     4201 tggagaaggt gctgggaagg gccgccctgc agggtgacag ctacgccctc tgggaagccc
     4261 cttcagaaaa cctggaggtc gcctcggatg aaaagatgct tgaactccgt cagactccga
     4321 aagagtgtac gcccaaggtc gtgagcatgc accacatcat agaagagtgt acacaagaaa
     4381 cccagtgctg tgagcaggga agcacgaagc tcctagctag aataaaagca cacgaaatcg
     4441 cctggttcca cagagcaatt aagacacatc cggaaaagcc tagcgcgcag aaccgagtca
     4501 tcccggaggg aagtgctgct ctcctaggcc tacaagacaa gcatcttcag caggaggcca
     4561 ccatcgcaga gttagaacta gagaagcaaa agctacagga gctgactaga aatctgaggg
     4621 agcgagtcac tgcactagtt aggcaaaaag acgccccttc tcaagggcag aaggaggagg
     4681 agctgaaggc aatgatgcag gacctgcaga tcacgtgcgg ggagatgcag aggaaggttg
     4741 aactcctgag atatgaatct gaaaagcttc aagaggaaaa ttctattttg agaaatgaaa
     4801 ttactacttt aaatgaagaa gatagcatct ctaacctgaa attggaggaa ttaaatggct
     4861 ctcaggaaga attgtggcag aaaatagaaa ccatagagca ggaaaaagct tcaattcaga
     4921 caatggttga aaaattaaag aaacaggttt cagatttaaa aatcaaaaac caacagttgg
     4981 attcagaaaa tatagaactc agccaaaaga actcccaaaa caaggaagaa ctgaaaaccc
     5041 ttaatcaacg tctggcagaa atgctgtgcc agagggagga gccaggagct tgcacctctg
     5101 agaaatggga acaagaaaat gcaagcctca aagaagaact ggatcactac aaagtgcaga
     5161 cttccacttt ggtgtcttct ctggaggcag aactttccga agttaaactg cagactcacg
     5221 tcatggagca ggaaaacctc cttctcaaag atgaactgga gagactgaag caactgcaca
     5281 gatgtcctga cctctctgac ttccagcaaa aaatgtctag cattctaagc tacaatgaaa
     5341 aactgctgaa ggaaaaagaa gttctgagtg aagagttaaa gagctgtgca gataagctgg
     5401 cagagtcaag cctcttagag cacagaattg ctacaatgaa gcaggagcag accgcctggg
     5461 aagagcagag tgagagcctg aagtcacagc tggcagtgtc gcaggcaaag gttcagaact
     5521 tagaagatgt cctgcagaat gtcaaccttc agatggctga gattgaatca gatctccaag
     5581 tgactcgaca ggaaaaggag gcgctaaagc aggaagtgat gtcattacac agacagcttc
     5641 agaatgccat tgataaggac tgggtctcgg aaacagctcc ccatctctca gggctccggg
     5701 gccagcagag aaggctgtcc tgggacaaac tggaccatct gatgaatgag gaaccacagc
     5761 tgctttgtca agaaagcaag agactccaga ctgtggtaca gaatacccaa gcagatctca
     5821 cccactcccg ggagaaggtc cgtcaactgg aatccaacct ccttcccacc aaacaccaaa
     5881 aacaactcaa ccaaccatgt actgtgaagt ccacagaaca agaaaaactg accttaaaga
     5941 gagagtgtga acagtctcag aaagaacaat ctcctaccag caggaaggtg ggtcagatgg
     6001 gttcccttga gcgaggatta gaaacaatcc atttggaaaa cgaaggtctg aagaagaaac
     6061 aggtgagact ggacgagaag ctaatggaga tgcagcccct gaggtccact gtgacgcgta
     6121 gcccatcctc tcactgggat ctgcagttgc tccagcagca agcctgtccg atggtgccca
     6181 gggagcagtt tctgcagctt caacagcagc tgctgcaggc agaaaagaga agccagcacc
     6241 tgcaggagga gctcgaaaac agaacctccg aaaccaacac accacaggga aaccaggaac
     6301 accttgtaaa tctcatggaa gaacgaatga tagaagttga acaaaaacta aagctggtga
     6361 agagacttct tcaagaaaaa gtaaaccagc tcaaagaaca actctgcaag aacacaaaaa
     6421 cagatgccgt ggtgaaggat ttgtatgtcg aaaatgccca gttgttgaaa gctctggaga
     6481 tgactgaaca gcgccagaag acagcagaaa agagaaattt cctcctagaa gagaagattg
     6541 ccagcctcag taccatcgtc aggaacctgg caccagcacc actgacttct atgcctcctc
     6601 tgaggtcata gccagcccaa aggatgcaca ccaaagggcg cacttgcatt tgtgcgcttt
     6661 cctgacacta ttggaacgtc ttaataggct ctccgaaccc tctaaccaaa aattttcagc
     6721 ggcttgaaat caagcctacc cgaagtctgc cagcaatgga attggaggct ccaaatgggt
     6781 gcttattgga atttcacaaa tcactattta aatttcacta tttaaattac tcataagcac
     6841 tgaactttta cagtatgttc tggatagcta ccaagaatga aattaagtta aggaccttca
     6901 agtcctagtt tttaatgttt taaaactgct attatcggtg tatgcaatcc aggttctttt
     6961 taagtttgat atctaactaa agtggttatt attataattg tttttgaaaa catttaagta
     7021 ctgaaatcat tcggcttaca atactttagt ctctttgaat taatcggctg actgcagttg
     7081 tgttcagaga aggcttggcc agtagctagc cacccagtag ctagccaccg agatcagaga
     7141 agtccaagtt ctataaaact ctgacttctg atgccattct tcctactctt gctgtacaac
     7201 agattcagaa cttactcagc tgcactctta actaaggata aagctttact ttctttaaac
     7261 agccctttct cctcctccta aagcttttgt ttgggaccct gtcttctaaa aaattgttaa
     7321 aactgtactc gtaacattac tgaactatag tgagcctacg gacagaccga ccactttgga
     7381 gtaaaaagcc actcttggaa gaagatcacg tggagcgtgg tggacgtagt ttcgtctctc
     7441 ccaagccttg gagttcgtga catacctttg agtttgtatc aaaagctcag ggaatgattt
     7501 ttaaactgtc ttcctgaact acttgctgcc tggcctaaga actgtgtact gacatcattc
     7561 ggcttacaat actttagtct ctttgaatta atcggctggc tgcagttctg ttcagagaag
     7621 gcttggccag agatgtgtaa accacacaac cttttttgtc ttatatatta acagccatag
     7681 actttttact tctacgtttt agtgcactta attatctgta aaggccttga ctgtagagtt
     7741 aaaaacctct cctacttatg aagagttttt actgtttgtt taatacaggt caagaattcc
     7801 gtgcttctga ccttttgata cctcatatat ctgaacttac gaatttcgta ctgtggaaaa
     7861 cattggctat caagggtaaa ggggagaaat tagagcgtca ctttacaagg ggtacaagag
     7921 aaaagtaaac cgctgtgttt gggaagggac acaagacaag tcaggctgag aagtgacatg
     7981 actgtgagga aatcttgagc catttccatt ccaccatgac tctttgggac ccaactatcg
     8041 agacccacca gcacagagct ccctctacca agttcattac actgtctgtg ctccagcagt
     8101 tcacactggg tttgcactac tatgcctatc agaagatcct gatttcccac tggggaaaga
     8161 atcaatcttt ccctagagtc atacatctaa atatttgacc actggcacta tgcctcctct
     8221 aaatctttct actcagtact tgtattagct ttagcagaaa actgtgtcga ggcctagact
     8281 caggtcagag gtaaactgtg tcgtatgaag tagtcctgtg gaagcttcag gttctgaagg
     8341 ttaatttcac tggaactaaa cagcaagcac atttctccaa cagctgcctg ccatggggcc
     8401 ttctgtgtgt gcttcttaat tttattttat attataaaaa gtataggttg gtgtttctta
     8461 taaatttgta ttcatgtgta cataaagagt tgtacaatga ctgtaaatat gattttttga
     8521 aaagttttag agttcattta gaattgtttc acccaaaatc aaaatgctac tttagtaaaa
     8581 tgttaatttc ttgctttacc ccacttacta aatagggagg agggaagatc aatatgagaa
     8641 atgtctatag atatcttaaa cttatacatt catgcagcag tttatatttt agaaatcttt
     8701 tagcaaggga gtttaactgc catgtagaat atagcttaaa gctttaaaaa catcaaatgt
     8761 aaaatcatac aatcatgtgt tgatttaact ctcagacttt cttcccagtg gcgctctcca
     8821 aaatcacaag ttatgtgttt tatggccata gctacttttt ctttttcttt tcctttttct
     8881 ttttcaagca ctgggtttag actctaagac attgctggga agcgctccat tgccctgtct
     8941 gctgtcttct catttttaaa agccttactc tgttgtttcc cctaagggga gaaaggattt
     9001 attttatcca aaggcctttt ctcttaaagt gagtttgtga ggggagagaa gtctgtgtgc
     9061 tttaggatga agaacagtat tttcatttgt tttcaaaagc tctaatttca gctaagccgt
     9121 tttaaatgtg aatccctcct tgaaactgca atgtgctatt tgtatatttg actatcagca
     9181 tgttttatat aaacagatta tgaaagacat cttacaggtc tagagtttca gtaataaatc
     9241 aatattcagg gcaggtattg agaaacttta aaaaaaaaaa agaaataact aaggcttctt
     9301 ggcaaacttt ttttaacatg tggaaaataa atgtgtgatt cccccctttt acttcgctga
     9361 gtaaagaaaa agagagcact gctattgtca gcatctctta aaggcattcc ctgtcacaaa
     9421 agtctgagtc cagtgttagt cgagtcctgt tctgaatggg ttgcctgcaa tgctatagca
     9481 ttccagtgag tcattagcca agccaaaagc tgggtcgaag cctgaggagc aaagcactcg
     9541 ctggaaaggc agtcaggaga gcgtggctgc ccctacttga acatcttagc actgtgaaga
     9601 tggagtttca ggcagctgga cagctattta atagcaaatt aaagttgtgc cttttcattt
     9661 tgtttttttg gatgatgcaa ggtaagttta ttctcattgt gagaacatta ccataacatg
     9721 acttaaagga atattgatga aaaacaaaac aattaaaacc cagaagtaaa accaaaatta
     9781 gctggagtta atctagaacc caccccggaa ttgttttctg ttcaagatta atgtaaatat
     9841 gtttatattg gttttgtaat ttcactttag tcactgtatc ccagaaagag tttaaaatgt
     9901 aaataaataa ttttgcaaac atg
//
