LOCUS       NM_026472               1894 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus nucleolar protein interacting with the FHA domain of
            MKI67 (Nifk), mRNA.
ACCESSION   NM_026472
VERSION     NM_026472.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1894)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1894)
  AUTHORS   Magnusson,C., Norrby,M., Libelius,R. and Tagerud,S.
  TITLE     The nifk gene is widely expressed in mouse tissues and is
            up-regulated in denervated hind limb muscle
  JOURNAL   Cell Biol Int 27 (6), 469-475 (2003)
   PUBMED   12798774
  REMARK    GeneRIF: NIFK, an RNA-binding nucleolar protein interacting with
            the fork-head associated domain of the proliferation marker protein
            Ki-67, is widely expressed in adult mouse tissues and up-regulated
            in denervated hind limb muscle
REFERENCE   3  (bases 1 to 1894)
  AUTHORS   Takagi,M., Sueishi,M., Saiwaki,T., Kametaka,A. and Yoneda,Y.
  TITLE     A novel nucleolar protein, NIFK, interacts with the forkhead
            associated domain of Ki-67 antigen in mitosis
  JOURNAL   J Biol Chem 276 (27), 25386-25391 (2001)
   PUBMED   11342549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY289326.1, BC058559.1 and BB727432.1.
            
            On Mar 11, 2009 this sequence version replaced NM_026472.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081486.1, AK077770.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BY289326.1         6-26
            22-1653             BC058559.1         1-1632
            1654-1894           BB727432.1         219-459
FEATURES             Location/Qualifiers
     source          1..1894
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 52.14 cM"
     gene            1..1894
                     /gene="Nifk"
                     /gene_synonym="C130020J04Rik; Mki67ip"
                     /note="nucleolar protein interacting with the FHA domain
                     of MKI67"
                     /db_xref="GeneID:67949"
                     /db_xref="MGI:MGI:1915199"
     exon            1..155
                     /gene="Nifk"
                     /gene_synonym="C130020J04Rik; Mki67ip"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1004
                     /gene="Nifk"
                     /gene_synonym="C130020J04Rik; Mki67ip"
                     /note="mNIFK; nucleolar protein interacting with the FHA
                     domain of pKI-67; Mki67 (FHA domain) interacting nucleolar
                     phosphoprotein"
                     /codon_start=1
                     /product="MKI67 FHA domain-interacting nucleolar
                     phosphoprotein"
                     /protein_id="NP_080748.3"
                     /db_xref="CCDS:CCDS15222.1"
                     /db_xref="GeneID:67949"
                     /db_xref="MGI:MGI:1915199"
                     /translation="MAGLAGPAKPSLALNPQEDSQFEKALTQIQGRTKKPQQKKKEKL
                     NRGVVYLGHLPSTLSESHIYNYCAQFGDISRFRLSRSKRTGNSKGYAFVEFESEDVAK
                     IVAETMDNYLFGERLLSCKFMPRKKVHKDLFSQRNALFHRPSFPAVKRYNRKRGHLQM
                     LKMEYRFKKKEKLLRKKLAAKGIDYSFPSLVLPKPKNIAVAHRDSEGNQVLPDQKEGL
                     SGEPRRKEKMMKEDISNNIPKKRKRSRRKKSSVDSQGPTPVCTPTFLERRKSQVMEVG
                     GDKDDEIILKLPVPPVKEDTQKTPTSASPGGKRPRKRKSKQ"
     exon            156..299
                     /gene="Nifk"
                     /gene_synonym="C130020J04Rik; Mki67ip"
                     /inference="alignment:Splign:2.1.0"
     exon            300..408
                     /gene="Nifk"
                     /gene_synonym="C130020J04Rik; Mki67ip"
                     /inference="alignment:Splign:2.1.0"
     exon            409..620
                     /gene="Nifk"
                     /gene_synonym="C130020J04Rik; Mki67ip"
                     /inference="alignment:Splign:2.1.0"
     exon            621..677
                     /gene="Nifk"
                     /gene_synonym="C130020J04Rik; Mki67ip"
                     /inference="alignment:Splign:2.1.0"
     exon            678..812
                     /gene="Nifk"
                     /gene_synonym="C130020J04Rik; Mki67ip"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1894
                     /gene="Nifk"
                     /gene_synonym="C130020J04Rik; Mki67ip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1631..1636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nifk"
                     /gene_synonym="C130020J04Rik; Mki67ip"
                     /note="hexamer: AATATA"
     polyA_site      1653
                     /gene="Nifk"
                     /gene_synonym="C130020J04Rik; Mki67ip"
                     /note="major polyA site"
ORIGIN      
        1 acgtcacttc cgaaggctcc gcgtggattg acttgttcgg gttctccagc atggctgggt
       61 tagcaggccc cgcgaagccg agtctggcat tgaacccgca ggaagactcg cagtttgaga
      121 aggctctgac gcagatccaa gggcgcacga agaagcctca gcaaaagaag aaagaaaaac
      181 ttaaccgtgg agtagtttat ctgggccacc taccttcaac actttctgaa agccacatct
      241 ataactactg tgcccagttt ggcgacatta gcagattcag attgtctaga agtaagcgga
      301 ctggaaacag caaaggctat gcctttgtgg agtttgagtc tgaggatgtt gccaagatag
      361 ttgcagaaac aatggataac tacctttttg gtgaaagact tctatcatgt aaatttatgc
      421 cacgaaaaaa agtccataaa gaccttttca gccagaggaa tgctctgttt caccggccat
      481 cattcccagc agtgaagcgc tataatcgga aacgaggaca tttgcagatg ttgaagatgg
      541 agtataggtt taagaagaag gaaaaattac tccggaagaa actagctgca aaggggattg
      601 attatagttt tccctcactg gtcctaccta agccaaagaa cattgctgtc gctcatagag
      661 attctgaggg taaccaggtt ttacctgacc aaaaagaagg gctttcgggt gaacctagga
      721 gaaaggagaa gatgatgaaa gaggacattt ccaataacat tcctaagaag cgtaagaggt
      781 ctaggaggaa gaagtcgtct gtggacagcc agggtcccac accagtttgt acaccgacgt
      841 ttttggagag gcgaaaatcg caggtgatgg aagtcggtgg cgataaagat gatgaaatca
      901 ttctcaagct gcctgtgccc ccagtgaaag aagacacaca aaagacccca acatctgcaa
      961 gccctggggg aaaaagaccg agaaaaagga agagcaagca gtgatcccgc cagcgttctg
     1021 tgcatagttc taggcagatg tgttgttata agggactact atattttact aagtgcagtg
     1081 acttgcaagc acagacaaga ctgttggagg aagaatacat gtttggtttt ccagtgagga
     1141 aagccactgg gaacctgact gtgccctttc ctgtcctgaa tttgtcttca ggcttcatcg
     1201 gtccctcagt tttactatcc ttatgaaact caggcttaac taccaccaaa caaccgattg
     1261 gtgctgtttg gacggtgtgt agttgtgtat ctaaacccct ccaaaatatg tcaggcttca
     1321 gcctcagaca tctgaaactg gaaatgaaat ccagagagtg agagggcagt tctggtttag
     1381 atttccacat gtgtccagga gctgaggagg agtccgaaat gacccacagt tactgcagct
     1441 aagctagtgt gtaggtgtca caaatcagtt tcagcagttg tattcaagat tcactgacca
     1501 gacttttcta cagtttattt gtgtacaaga gaacctaaga actttgtggg gaagtaagaa
     1561 atgtcaccat ctcctgttgt aagtttctgt accctttcta tgcttttgtt ttactaattt
     1621 gggtttcttg aatataactg tcaatctcct tgattaagct tcctttttgt ccagttgtgg
     1681 ggccagttgt ggggtatgag tgagtgtaca tgctgtgtgt gttcctgaag ggaaatcact
     1741 tgtcttctag acctctgccc cttaatcatc tgacatagga ctctggttag acagtttttc
     1801 tctatgttgt cctgactatc ctggaactca cttactctat ccacctacca ctgcctccca
     1861 actgctgaga ttaaagaagc tggcttgaag tggg
//
